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Abstract
Background: World population is living longer, demanding adjustments in public health policies. Body mass index
(BMI) is widely known and used as a parameter and predictor of health status although an adapted criterion for
older adults is usually overlooked. BMI has been extensively analysed in relation to mortality but fewer studies
address its association with cognition, functioning and depression in older adults. The present study aimed at 1)
comparing BMI distribution according to the ranges proposed by the World Health Organization (WHO) and the
United States National Research Council Committee on Diet and Health (CDH), 2) analysing their association with
cognitive functioning, physical functioning and depression and 3) analysing a possible, interaction of BMI criteria
with sex on the outcome measures.
Methods: This cross-sectional study included 395 participants recruited by convenience sampling; 283 (71.6%)
women and 112 (24.58%) men. Mean age was 74.68 (SD = 8.50, range: 60–98). Outcome measures included the
Short Portable Mental State Questionnaire for cognitive status, the Barthel’s Index of Activities of Daily Living for
physical functioning, and the Geriatric Depression Scale.
Results: WHO criterion classified most cases (65.3%) as overweight, followed by normal weight (32.2%) and
underweight (2.5%) whereas CDH criterion considered most (48.1%) as normal weight, and followed by overweight
(31.4%) and underweight (20.5%). Analysing cognitive status, independent physical functioning and depression
mean scores, significant differences (p ≤ .001) were found when comparing the three weight groups (underweight,
normal weight and overweight) using either the WHO- or the CDH criterion. Post-hoc tests revealed that in all
comparisons the underweight group scored the lowest in all three outcome measures. According to the CDH
criterion, overweight was favourable for females but unfavourable for males regarding cognitive status (interaction
F(2,389) = 4.52, p ≤ .01) and independent functioning (interaction F(2,389) = 3.86, p ≤ .05).
Conclusions: BMI and its associations to relevant outcome measures in the older adults must rely on criteria that
take into account the particular features of this population, such as the CDH criterion. Underweight was associated
with decremented cognition, less independent physical functioning and more depression. Overweight seemed
favourable for women but unfavourable for men.
Keywords: Body mass index, Mexican., Elderly., Cognition., Functioning., Depression., Older adults., Ageing.
* Correspondence: [email protected]
2
Hospital Regional de Alta Especialidad de la Península de Yucatán, Calle 7,
No. 433 por 20 y 22, Fraccionamiento Altabrisa. Mérida, 97130 Merida,
Yucatán, Mexico
Full list of author information is available at the end of the article
© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Estrella-Castillo and Gómez-de-Regil BMC Geriatrics (2019) 19:339 Page 2 of 8
on the scale platform and stand motionless for a couple (SD = 5.58, range: 17.26–51.61); no significant differ-
of seconds with weight equally distributed on both feet. ences were found for sex. None of the participants re-
Weight was recorded on kilograms. ported a health condition that might cause weight loss
Weight and height were considered to estimate the Que- or gain (e.g. cancer, heart failure, hypothyroidism).
telet BMI (kg/m2) and classify patients according to two cri- Distribution by BMI according to WHO criterion classi-
teria. The WHO criterion [19] classifies the status of body fies most cases from total (65.3%) sample and, from the
composition as: underweight ≤18.49 kg/m2, normal ≥18.50 male (63.4%) and female (66.1%) subsamples as over-
- ≤24.99 kg/m2, and overweight ≥25.0 kg/m2. The CDH weight. According to CDH criterion, 48.1% from the total
[20] considers weight ranges in people aged 55 to 65 as sample, 50.0% of male subsample and 47.3% of females
underweight < 23 kg/m2, normal 23–28 kg/m2, and over- subsample have a normal weight. Classification of people
weight > 28 kg/m2, and in people aged 66 or older as under- as with overweight by WHO criterion seems to have a
weight < 24 kg/m2, normal 24–29 kg/m2, and overweight > very low threshold in comparison with CDH criterion, as
29 kg/m2. the WHO percentages approximately double those of
Cognitive status was measured using the Short Portable CDH (e.g. 65.3% vs. 31.4%). On the other hand, percent-
Mental State Questionnaire (SPMSQ; Pfeiffer question- ages of underweight for total, male and female samples,
naire) [21]. The level of independent physical functioning according to WHO criterion, were 2.5, 0.0 and 3.5, re-
was assessed with the Barthel’s Index of Activities of Daily spectively. In contrast, according to CDH criterion, per-
Living [22]. Depression was measured with the Geriatric centages were 20.5, 17.9 and 21.6, respectively. See
Depression Scale (GDS) [23]. All three questionnaires Table 1 and Fig. 1.
were applied with their corresponding 10-item Spanish Significant differences were found when comparing
versions. Detailed features of these instruments can be the distribution of participants according to both (WHO
found in a previous report related to this study [24]. and CDH) BMI criteria (χ2(4) = 233.20, p ≤ .001), as they
only coincided in 190 (48.10%) cases. No significant as-
Statistical analysis sociations between sex and BMI categories, neither ac-
Data were collected and analysed with the SPSS v.20 soft- cording to WHO criterion (χ2(2) = 5.01, p = .08) nor to
ware. First, descriptive statistics (means, standard devia- CDH criterion (χ2(2) = .68, p = .71) were found.
tions, frequencies, and percentages) for BMI distribution Mean outcome scores were: cognitive status 7.31 (SD =
were obtained and possible differences by sex were ex- 2.56), independent physical functioning 85.28 (SD =
plored with t-test and chi-square test. Following, the inde- 17.37) and depression 2.38 (SD = 1.87). BMI correlated
pendent associations of BMI and sex with the three significantly with all three outcome measures; yet, a rele-
outcome measures were analysed with Pearson correla- vant correlation was only observed with cognitive status
tions and t-tests, respectively. To explore the sensitivity of (r = +.32, p ≤ .001). Men scored significantly higher than
criteria for the outcome, first a series of one-way analyses women in independent functioning (p ≤ .01) and lower
of variance (ANOVAs) was run, followed by analyses of in depression (p ≤ .001); they did not score significantly
covariance (ANCOVAs) adjusting by sex and age. Finally, higher in cognitive status (p = .50).
two-way ANOVAs explored the level of BMI range cri- Regarding BMI criteria, no extreme values were found
teria x sex interaction on the three outcome measures. for any outcome measure and significant differences
were found using either WHO or CDH criterion; yet,
Results the post-hoc tests showed distinct patterns. Regarding
The final sample included 395 participants, 283 (71.6%) cognitive status and depression, WHO criteria suggest
women and 112 (24.58%) men. Mean age was 74.68 that overweight is a favourable factor in older adults,
(SD = 8.50, range: 60–98) and mean BMI was 27.68 while CDH criteria suggest underweight is disfavorable.
WHO criteria coincided with CDH criteria about inde- between them. CDH criteria found a poorer condition of
pendent functioning; underweight older adults had a older people with underweight as they have lower cogni-
poorer performance in comparison to normal- and over- tive and independent functioning and more depression;
weight older adults, who showed no significant differences older people with overweight were in better conditions
Estrella-Castillo and Gómez-de-Regil BMC Geriatrics (2019) 19:339 Page 5 of 8
than older people with normal weight, though differences double if considering the CDH criteria. Furthermore, the
were not significant. WHO criteria found a better func- CDH criteria displayed a distribution wherein half of the
tioning in older people with overweight; particularly re- sample had a normal weight range. These differences in
garding cognitive status and depression. The associations distribution patterns, in concurrence with previous re-
of BMI (WHO and CDH criteria) with the three outcome search [5], bring into question the adequacy of the com-
measures remained significant even after adjusting by sex. mon practice of using the WHO criteria to classify
When adjusting by age, the associations were still signifi- normal BMI in older adults. The accuracy of BMI seems
cant for cognitive status and independent physical func- to diminish with age, as body composition changes in-
tioning, but not for depression. Table 2 summarizes the crease adiposity and sarcopenia (i.e. decreased muscle
results. mass) [25]. Valid, reliable and economical assessments
The interaction of WHO BMI criteria with sex was of BMI, with ranges adapted by age, are needed [5, 26].
not significant for any of the studied outcome measures. Analyses of the association of BMI criteria with cogni-
Yet, CDH BMI criteria seemed more sensible to differ- tive functioning, physical functioning and depression re-
ences as its interaction with sex found significant results vealed similar though not equivalent patterns.
for cognitive status (F(2,389) = 4.52, p ≤ .01, η2 = .023, Considering the WHO BMI criteria, overweight seems a
power = 0.769) and independent functioning (F(2,389) = protective factor. Results from some studies, mostly rely-
3.86, p ≤ .05, η2 = .019, power = 0.698). Underweight is ing on the WHO BMI criteria, suggest that overweight is
disfavorable for cognitive status and independent func- a protective rather than a risk factor (at least for mortal-
tioning, particularly in women (Fig. 2). There is a trend ity) in older people [27]. Yet, it has been questioned
for improvement as BMI goes from underweight to nor- whether this BMI paradox just reflects the WHO crite-
mal weight. Yet, regarding overweight, this seems ria’s low sensitivity for this segment of the population
favourable in women but not in men. No significant in- [25, 26]. Classifying sample by the CDH BMI criteria,
teractions were found for depression. adapted by age range, significant results point to the op-
posite direction; that is, underweight is disfavorable in
Discussion older people. This concurs with studies reporting low
This study aimed at comparing, in a sample of Mexican BMI to be disfavorable in older people, and highly asso-
older people, BMI distribution according to two alterna- ciated with infections, hospitalizations and predicting
tive ranges as proposed by the WHO and the CDH. Re- mortality [28, 29]. Also, a rapid and unintentional weight
sults showed that having the WHO criteria a lower loss may reflect underlying illness, social deprivation, de-
threshold for what is to be considered a normal weight mentia or depression [28].
in comparison to the CDH criteria; it classified more After the age of 60, average body weight and muscle
than half the participants as overweight, that is, the mass tend to decrease. As physical activity and energy
Table 2 Differences in Cognitive Status, Independent Physical Functioning and Depression Scores According to WHO- and CDH
Body Mass Index Criteria
Cognitive status Independent physical functioning Depression
Mean (SD) Mean (SD) Mean (SD)
WHO CDH WHO CDH WHO CDH
Underweight (U) 4.50 (2.84) 5.72 (2.77) 55.00 (15.99) 75.99 (20.86) 3.90 (2.28) 3.13 (2.34)
Normal weight (N) 6.50 (2.85) 7.62 (2.39) 83.43 (18.73) 86.63 (16.37) 2.74 (2.10) 2.24 (1.69)
Overweight (O) 7.81 (2.22) 7.86 (2.28) 87.36 (15.48) 89.27 (13.98) 2.14 (1.68) 2.10 (1.68)
F(2,392) 18.96*** 21.69*** 19.45*** 16.68*** 8.04*** 8.63***
Power 1.000 1.0000 1.000 0.999 0.909 0.970
Post-hoc U < N* U < N*** U < N*** U < N*** U>N U > N***
U < O*** U < O*** U < O*** U < O*** U > O** U > O***
N < O*** N<O N<O N<O N > O** N>O
Controlling by Sex
F(2,392) 18.85*** 21.49*** 18.24*** 16.37*** 7.88*** 8.34***
Controlling by Age
F(2,392) 7.70*** 10.09*** 9.39*** 5.26** 1.75 2.26
BMI: Body Mass Index
WHO World Health Organization Body Mass Index Criterion
CDH United States National Research Council Committee on Diet and Health Body Mass Index Criterion
*p ≤ .05, **p ≤ .01, ***p ≤ .001
Estrella-Castillo and Gómez-de-Regil BMC Geriatrics (2019) 19:339 Page 6 of 8
Fig. 2 Graphic distribution of the Significant Interactions of CDH criteria with Sex on Cognitive Status and Independent Functioning
expenditure also decrease there is a tendency to fat accu- overweight and obese older people [36] our results concur
mulation and fat redistribution [30]. Here, underweight with those finding lower BMI coinciding with a worse cog-
older people showed a disadvantageous performance, while nitive status [37]. Regarding physical functioning, studies
in other studies overweight older people showed a more tend to support that high BMI values are associated with
favourable status [27]. However, one must be cautious; greater functional impediments [38]; yet, it has also been
obesity in older people is a common and serious matter of found that both, low and high BMI are related to a greater
concern not to be overlooked. Not only can obesity lead to risk of functional impairment [39]. The present results
adverse health consequences and impair quality of life, but found poorer physical functioning in underweight older
also exacerbate the age-related decline in physical function people following the CDH criteria. Depressive symptoms in
and lead to frailty, disability and autonomy limitations [29, older adults seem less likely to occur in overweight/obese
31–33]. Treatment for obesity in older persons is contro- older people [40], and that is the case in our study if the
versial, mainly to the misinterpretation that it may not be WHO criterion is used. If the CDH criterion is used, under-
as harmful in older adults as it is in younger people, and weight older people seem more likely to report depressive
the concern about the potential adverse effects of weight symptoms, and that coincides with previous findings, par-
loss in this population [28, 31, 33–35]. Even small amounts ticularly in men [40]. Discrepancies in findings might be
of voluntary weight loss (between 5 and 10% of initial body due to the use of diverse measures for body composition,
weight) along with a healthy lifestyle may benefit older cognition, functioning, and depressive symptoms, and the
people [32]. Weight loss in overweight/obese older people fact that these outcome measures have not been previously
can improve risk factors, fat loss can ameliorate certain studied together.
catabolic conditions of aging through impacting muscle Regardless of BMI criteria, the group of underweight
protein synthesis and breakdown and lighter weight may older people had a disadvantageous outcome on all three
also ease the mechanical burden on weak joints and measures in comparison to the other groups. Further-
muscle, thus improving mobility [28]. Interventions aiming more, results showed that considering its interaction
at voluntary weight-loss in obese older people must follow with sex, underweight is disadvantageous for all, whereas
a combination of exercise and modest calorie restriction for overweight is favourable in women but disfavorable in
reducing intra-abdominal fat mass while muscle mass and men. These results evidence that a criterion overlooking
strength are preserved [30, 31, 33, 35]. Moreover, interven- age and sex differences in BMI may bias research find-
tions must consider comorbidities, polypharmacy, limita- ings and perhaps explain the so-called obesity paradox
tion of autonomy, and social issues with a focus on the in older adults. More complex models including covari-
underlying medical problems, functional status and living ates that might influence outcome, such as educational
environments [34]. level, regular cognitive stimulation, comorbidities, medi-
Cognitive status, independent physical functioning, and cation intake and mental health history should be con-
depression are three important outcome measures in older sidered to support or disclaim these results.
adults that have been found related to BMI. Although some Besides, underweight women stand out as the more vul-
studies have found a poorer cognitive performance in the nerable group regarding cognitive status and independent
Estrella-Castillo and Gómez-de-Regil BMC Geriatrics (2019) 19:339 Page 7 of 8
4. WHO Expert Committee on Physical Status. Physical status : the use of and Yesavage abreviado (GDS) para el despistaje de depresión en mayores de
interpretation of anthropometry, report of a WHO expert committee. 65 años: adaptación y validación. Medifam. 2002;12:26–40.
Geneva: World Health Organization; 1995. https://apps.who.int/iris/ 24. Estrella-Castillo DF, Alvarez-Nemegyei J, Gómez-de-Regil L. Association
bitstream/handle/10665/37003/WHO_TRS_854.pdf;jsessionid=4424BFC901 between body mass index with cognitive or physical functioning, and
882777BE31499962AB8772?sequence=1. Accessed 15 Nov 2018. depression in Mexican elderly: A cross-sectional study. Neuropsychiatry
5. Babiarczyk B, Turbiarz A. Body mass index in elderly people -do the (London). 2016;6. doi:https://doi.org/10.4172/Neuropsychiatry.1000149
reference ranges matter? Prog Heal Sci Pol Prog Heal Sci. 2012;2:58–67. 25. Batsis JA, Mackenzie TA, Bartels SJ, Sahakyan KR, Somers VK, Lopez-Jimenez
6. Instituto Nacional de Salud Pública. Encuesta nacional de salud y nutrición. F. Diagnostic accuracy of body mass index to identify obesity in older
Resultados nacionales 2012. México: Instituto Nacinal de Salud Pública; 2012. adults: NHANES 1999–2004. Int J Obes. 2016;40:761–7. https://doi.org/10.
https://ensanut.insp.mx/encuestas/ensanut2012/doctos/informes/ENSANUT2 1038/ijo.2015.243.
012ResultadosNacionales.pdf. Accessed 10 Oct 2018. 26. Ben-Yacov L, Ainembabazi P, Stark AH. Is it time to update body mass index
7. Arroyo-Acevedo P, Shamah-Levy T. Cuevas-Nasu L. Ríos-Cázares G. Estado standards in the elderly or embrace measurements of body composition?
de nutrición del adulto mayor en México: Cervantes-Turrubiates LA; 2013. Eur J Clin Nutr. 2017;71:1029–32. https://doi.org/10.1038/ejcn.2017.39.
http://www.geriatria.salud.gob.mx/descargas/publicaciones/foro- 27. Veronese N, Cereda E, Solmi M, Fowler SA, Manzato E, Maggi S, et al.
envejecimiento/FS_ESTADO_NUTRICION.pdf. Inverse relationship between body mass index and mortality in older
8. Aune D, Sen A, Prasad M, Norat T, Janszky I, Tonstad S, et al. BMI and all nursing home residents: a meta-analysis of 19,538 elderly subjects. Obes
cause mortality: systematic review and non-linear dose-response meta- Rev. 2015;16:1001–15. https://doi.org/10.1111/obr.12309.
analysis of 230 cohort studies with 3.74 million deaths among 30.3 million 28. Miller SL, Wolfe RR. The danger of weight loss in the elderly. J Nutr Health
participants. BMJ. 2016;4:i2156. doi:https://doi.org/10.1136/bmj.i2156. Aging. 2008;12:487–91 http://www.ncbi.nlm.nih.gov/pubmed/18615231.
9. Global BMI Mortality Collaboration, Di Angelantonio E, Bhupathiraju SN, 29. Seidell JC, Visscher TL. Body weight and weight change and their health
Wormser D, Gao P, Kaptoge S, et al. Body-mass index and all-cause implications for the elderly. Eur J Clin Nutr. 2000;54(Suppl 3):S33–9 http://
mortality: individual-participant-data meta-analysis of 239 prospective www.ncbi.nlm.nih.gov/pubmed/11041073.
studies in four continents. Lancet. 2016;388:776–86. https://doi.org/10.1016/ 30. Kennedy RL, Chokkalingham K, Srinivasan R. Obesity in the elderly: who
S0140-6736(16)30175-1. should we be treating, and why, and how? Curr Opin Clin Nutr Metab Care.
10. Anstey KJ, Cherbuin N, Budge M, Young J. Body mass index in midlife and 2004;7:3–9 http://www.ncbi.nlm.nih.gov/pubmed/15090896.
late-life as a risk factor for dementia: a meta-analysis of prospective studies. 31. Villareal DT, Apovian CM, Kushner RF, Klein S. Obesity in older adults:
Obes Rev. 2011;12:e426–37. https://doi.org/10.1111/j.1467-789X.2010.00825.x. technical review and position statement of the American Society for
11. World Health Organization. World Report on Ageing and Health. 2015. http:// Nutrition and NAASO, the Obesity Society. Am J Clin Nutr. 2005;82:923–34.
apps.who.int/iris/bitstream/10665/186463/1/9789240694811_eng.pdf?ua=1. . https://doi.org/10.1093/ajcn/82.5.923.
12. Gómez Pavón J, Martín Lesende I, Baztán Cortés JJ, Regato Pajares P, 32. Zamboni M, Mazzali G, Zoico E, Harris TB, Meigs JB, Di Francesco V, et al.
Formiga Pérez F, Segura Benedito A, et al. Preventing dependency in the Health consequences of obesity in the elderly: a review of four unresolved
elderly. Rev clínica española. 2008;208:361–2 http://www.ncbi.nlm.nih.gov/ questions. Int J Obes (Lond). 2005;29:1011–29. doi:https://doi.org/10.1038/sj.
pubmed/18625185. ijo.0803005.
13. Bruffaerts R, Demyttenaere K, Vilagut G, Martinez M, Bonnewyn A, De Graaf 33. Han TS, Tajar A, Lean MEJ. Obesity and weight management in the elderly.
R, et al. The relation between body mass index, mental health, and Br Med Bull. 2011;97:169–96. https://doi.org/10.1093/bmb/ldr002.
functional disability: a European population perspective. Can J Psychiatr. 34. Chau D, Cho LM, Jani P, St Jeor ST. Individualizing recommendations for
2008;53:679–88 http://www.ncbi.nlm.nih.gov/pubmed/18940036. weight management in the elderly. Curr Opin Clin Nutr Metab Care. 2008;
14. Bahat G, Tufan F, Saka B, Akin S, Ozkaya H, Yucel N, et al. Which body mass 11:27–31. https://doi.org/10.1097/MCO.0b013e3282f31744.
index (BMI) is better in the elderly for functional status? Arch Gerontol 35. Chapman IM. Obesity paradox during aging. Interdiscip Top Gerontol. 2010;
Geriatr. 2012;54:78–81. https://doi.org/10.1016/j.archger.2011.04.019. 37:20–36. https://doi.org/10.1159/000319992.
15. Ford DW, Jensen GL, Still C, Wood C, Mitchell DC, Erickson P, et al. The 36. Benito-León J, Mitchell AJ, Hernández-Gallego J, Bermejo-Pareja F. Obesity
associations between diet quality, body mass index (BMI) and health and and impaired cognitive functioning in the elderly: a population-based cross-
activity limitation index (HALex) in the Geisinger rural aging study (GRAS). J sectional study (NEDICES). Eur J Neurol. 2013;20:899–e77. https://doi.org/10.
Nutr Health Aging. 2014;18:167–70. https://doi.org/10.1007/s12603-014-0016-4. 1111/ene.12083.
16. Kim J, Noh J-W, Park J, Kwon YD. Body mass index and depressive 37. Kim S, Kim Y, Park SM. Body mass index and decline of cognitive function.
symptoms in older adults: a cross-lagged panel analysis. PLoS One. 2014;9: PLoS One. 2016;11:e0148908. https://doi.org/10.1371/journal.pone.0148908.
e114891. https://doi.org/10.1371/journal.pone.0114891. 38. Woo J, Leung J, Kwok T. BMI, body composition, and physical functioning in
older adults*. Obes. 2007;15:1886–94. https://doi.org/10.1038/oby.2007.223.
17. Forman-Hoffman VL, Yankey JW, Hillis SL, Wallace RB, Wolinsky FD. Weight and
39. Galanos AN, Pieper CF, Cornoni-Huntley JC, Bales CW, Fillenbaum GG.
depressive symptoms in older adults: direction of influence? J Gerontol B Psychol
Nutrition and function: is there a relationship between body mass index
Sci Soc Sci. 2007;62:S43–51 http://www.ncbi.nlm.nih.gov/pubmed/17284566.
and the functional capabilities of community-dwelling elderly? J Am Geriatr
18. Wild B, Herzog W, Lechner S, Niehoff D, Brenner H, Müller H, et al. Gender
Soc. 1994;42:368–73 http://www.ncbi.nlm.nih.gov/pubmed/8144820.
specific temporal and cross-sectional associations between BMI-class and
40. Chang H-H, Yen ST. Association between obesity and depression: evidence
symptoms of depression in the elderly. J Psychosom Res. 2012;72:376–82.
from a longitudinal sample of the elderly in Taiwan. Aging Ment Health.
https://doi.org/10.1016/j.jpsychores.2012.01.019.
2012;16:173–80. https://doi.org/10.1080/13607863.2011.605053.
19. World Health Organization. BMI classification. http://apps.who.int/bmi/index.
jsp?introPage=intro_3.html. .
20. National Research Council (US) Committee on Diet and Health. Diet and health: Publisher’s Note
implications for reducing chronic disease risk. Washington D.C.: National Springer Nature remains neutral with regard to jurisdictional claims in
Academies Press; 1989. http://www.ncbi.nlm.nih.gov/pubmed/25032333. published maps and institutional affiliations.
Accessed 18 Oct 2018.
21. Martínez de la Iglesia J, Dueñas Herrero R, Onís Vilches MC, Aguado Taberné
C, Albert Colomer C, Luque Luque R. [Spanish language adaptation and
validation of the Pfeiffer’s questionnaire (SPMSQ) to detect cognitive
deterioration in people over 65 years of age]. Med clínica. 2001;117:129–34.
http://www.ncbi.nlm.nih.gov/pubmed/11472684.
22. Cid-Ruzafa J, Damián-Moreno J. Valoración de la discapacidad física: el
indice de Barthel. Rev Esp Salud Publica. 1997;71:127–37. https://doi.org/10.
1590/S1135-57271997000200004.
23. Martínez De la Iglesia J, Onís Vilches M, Dueñas Herrero R, Albert Colomer C,
Aguado Taberné C, Luque Luque R. Versión española del cuestionario de