Maternal SL Notes
Maternal SL Notes
Maternal SL Notes
Head down-Facing up
Baby is presenting headfirst (cephalic) with its
head facing up (occiput posterior). In this
position, the baby might have a harder time
extending his or her head from under the
pubic bone.
Lying sideways
This baby is in a transverse le-positioned
horizontally across the uterus, rather than
vertically, in a transverse lie, the baby's back
might be positioned:
Down, with the back facing the birth canal.
With one shoulder pointing toward the birth
canal
Up, with the hands and feet facing the birth
canal
Twins
Twins can usually be delivered vaginally if the
lower twin is presenting headfirst (cephalic).
If only the lower twin is head first, as shown
here, your health care provider might deliver
the lower twin vaginally.
If the lower twin isn't positioned headfirst or
neither twin is headfirst, both twins are
usually delivered by C-section.
ABNORMAL PRESENTATION
FACE ABNORMAL PRESENTATION:
- The fetus face is aligned with the uterus.
BROW ABNORMAL PRESENTATION
- The fetus forehead is aligned with the uterus.
TWINS
- The first baby is positioned cephalic and the
other is breech.
LEOPOLD’S MANEUVER
PREPARATIONS
1. Prepare the client.
a. Explain the procedure.
b. Instruct the client to empty her bladder.
c. Position the woman supine with knees slightly 1ST MANEUVER
flexed. Place a small pillow or rolled towel under one
side.
d. Wash your hands using warm water.
e. Observe the woman's abdomen for longest diam-
eter and where fetal movement is apparent.
2. Perform the first maneuver.
a. Stand at the foot of the client, facing her, and place
both hands flat on her abdomen.
b. Palpate the superior surface of the fundus. Deter-
mine consistency, shape, and mobility.
3. Perform the second maneuver.
a. Face the client and place the palms of each hand on
either side of the abdomen.
b. Palpate the sides of the uterus. Hold the left hand 2ND MANEUVER
stationary on the left side of the uterus while the right
hand palpates the opposite side of the uterus from
top to bottom. Then hold the right hand steady, and
repeat palpation using the left hand on the left side.
4. Perform the third maneuver.
a. Gently grasp the lower portion of the abdomen just
above the symphysis pubis between the thumb and
index finger and try to press the thumb and finger
together. Determine any movement and whether the
part is firm or soft.
5. Perform the fourth maneuver.
a. Place fingers on both sides of the uterus approxi-
mately 2 inches above the inguinal ligaments, pressing 3RD MANEUVER
downward and inward in the direction of the birth
canal. Allow fingers to be carried downward.
PELVIMETRY
Pelvimetry is the assessment of the
dimensions & capacity of adult female
pelvis in relation to the birth of a
baby.
Pelvimetry was heavily used in leading
the decision of natural, operative
vaginal delivery or CS.
Diagonal conjugate
The distance between the anterior surface of
the sacral prominence and the anterior
surface of the inferior margin of the
symphysis pubis
TYPES of PELVIS If the measurement obtained is more than 5"
Gynecoid or 12.5cm, the pelvic inlet is considered
Female pelvis found in 50% of women adequate for childbirth
Anterioposterior & transverse diameters are
relatively equal, with straight pelvic sidewalls Steps in measuring diagonal conjugate
Ischial spines are not usually prominent; wide 1. To measure it, introduce two fingers vaginally
pubic arch Round in shape and press inward and upward until your
Android middle finger touches the sacral prominence
Male pelvis; heart-shaped
Obstetric Conjugate
Distance between midpoint of inner surface
of symphysis pubis to midpoint of sacral
promontory transverse sacral promontory
The True Conjugate = 11 cm
The Obstet. Conjugate = 10.5cm
The Diagonal Conjugate = 12 cm
Ischial tuberosity
The transverse dm of the pelvic outlet
This measurement is made at the medial and
lowermost aspect of the ischial tuberosities,
at the level of the anus
A diameter of 10.5cm or 4 1/4" is considered
adequate for passage of the fetal head
through
the outlet
a. To provide energy; 4. To replace cells. Most cells live only a short time.
b. To build and repair tissues; and The body must build new cells to replace those that
c. Regulate life processes die.
Skin is the good example. The outside layer of
the skin is already dead. All the time new cells are
growing under the dead sells to preplace them. When
a person washes and dry the skin, it removed the
All nutrients are equally and dead cells.
physiologically important in the body regardless On the other hand, wearing shoes for a long
of their concentration. It has adverse effects time caused holes in the soles. But walking without
shoes, do not caused holes in the feet, because new
when taken in excessive amounts and when
skin cells grow under the old cells to replace them.
intake is insufficient, can lead to deficiency
disorder. 5. To repair tissues. After injury or illness, the body
Note: No one nutrient is more important makes new cells to repair the damaged tissues.
than the others. Each nutrient does specific jobs.
The nutrients work together to keep us healthy. 6. To provide energy. The body burns nutrients to
make energy for the body’s activities including the
brain and muscle functions. The energy-giving
HOW DOES THE BODY USE nutrients yield calories when metabolized in the body.
NUTRIENTS?
Using Nutrients to Build the Body
1. For Growth. A child starts to grow as a single cell
Lesson 2:
inside its mother. The cell absorbs nutrients; it grows CLASSIFICATION OF
and divides into two cells. The cell uses nutrients as
building materials for a new cell and other nutrients NUTRIENTS
for energy to do the work of building. Each cell then There are two main classification of nutrients
absorbs more nutrients to grow larger and divide – the Macro and Micro Nutrients and there are six
again. The cells continue to absorbs nutrients and to essential nutrients that the body needs. It is
grow and divide until there are millions of cells which important that these nutrients consume by everyone
form different tissues such as skin, muscle and bone. on a daily basis to help build and maintain healthy
The child’s body also makes fluids such as blood, body. Deficiencies, excesses and imbalances in diet
which nourishes and protects the cells. can produce negative impacts on health, which may
cause development of certain illness or disease.
2.For Pregnancy. During Pregnancy, a woman
needs body building nutrients to: A. Macronutrient
a. Provide the baby and placenta with nutrients Macro means large, these are nutrients which people
to grow need to eat regularly and in a fairly large amount. It
b. Increase the size of her uterus and breasts includes the carbohydrates, protein, fats and water. It
b) c.Make more blood and stores of fat that can provides a lot of calories but the number or amount of
be mobilized during lactation, and other calories provided varies, depending on food source.
nutrients. These are needed for the supply of energy and
growth, for metabolism and other body functions.
3. To secrete fluids. The body has to keep making
fluids such as saliva, digestive juices, tears and TERMS TO REMEMBER
breastmilk because they are continually used up.
Calorie (kcal) – is the energy required to raise the 6. Act as Structural component
temperature of one kilogram of water one degree
Celsius. A unit of heat used to indicate the amount of
energy that foods will produce in the human body.
Metabolism – means the process involved in the
generation of energy and all the building blocks
required to maintain the body and its functions.
Note: Each gram of carbohydrate and protein
provides four calories while fat provides nine calories It is important to know he classes of
for each gram. carbohydrates to enable to give relevant advice to
B. Micronutrient patients with special needs like diabetes, this
Micro means small, these are nutrients which people condition has problems regulating the amount of
need only small amount in their diet. These include glucose in the body.
trace minerals and vitamins. Although most foods are Monosaccharides and disaccharides are
mixtures of nutrients, many of them contain a lot of referred to as simple sugars or simple carbohydrates
one nutrient and a little of the other nutrients. that the body can easily utilize. For this reason, people
with diabetes mellitus shouldn’t eat too many of
Six Essential Nutrients these carbohydrates. (e.g. sugar, honey, sweet fruits
1) Carbohydrates and sugar cane)
provide most of the energy in the majority of
human diets. Glucose – known as dextrose sugar or grape sugar;
are organic compounds composed of carbon, the circulating sugar in the body
hydrogen, and oxygen which provide the Fructose – found in fruits and honey; the amount of
major source of energy. fructose in fruits depends on the degree of ripeness
carbohydrates containing the most nutrients Galactose – the component of lactose
are the complex carbohydrates, such as Sucrose – known as the table sugar
unrefined grains, tubers, vegetables, and Lactose – the sugar in milk
fruits Maltose – the intermediate product of starch
simple carbohydrates or sugars should be digestion
eaten in moderation, since they are high in Polysaccharides are called complex carbohydrates and
calories but low in nutrients. need to be broken down into simple sugars to be used
Recommended Intake of Carbohydrates by the body. This can be consumed by diabetic
recommended intake of CHO: 55-70% patients without restriction.
(majority come from complex carbohydrate)
Recommended intake of dietary fiber: 25- Two Types:
30g/day 1. Digestible Polysaccharides – complex
Example: A 5’3” individual needing 200 kcal/day will carbohydrates that can be broken down into sugar
have a carbohydrate allowance of 300g. units like starch and dextrin.
How: 2000 x 0.60 = 1200kcal=300grams 2. Nondigestible or Nonstarch Polysaccharide – are
4kcal/g complex carbohydrates that contain sugar units held
Functions of Carbohydrates: together by bonds that human digestive system
1. Protein sparer cannot break, thus they yield little energy (if any).
2. Fat sparer They are also known as dietary fiber which has two
3. Sole energy source for the brain and nerve classes:
tissues a. Insoluble Fiber – do not dissolve in
4. Reserve fuel supply water due to tough, fibrous structures
5. Regulator of normal bowel movement of fruits, grains and vegetables.
BALDO, MYKA MARGARETTE L.
BSN 2-D
Republic of the Philippines
UNIVERSITY OF NORTHERN PHILIPPINES
Tamag, Vigan City
Functions of CHON:
1. Building antibodies
2. Building enzymes, hormones and other compounds
3. Maintaining fluid and electrolyte balance
4. Maintaining acid-base balance
5. Providing energy
6. Transforming energy
BALDO, MYKA MARGARETTE L.
BSN 2-D
Republic of the Philippines
UNIVERSITY OF NORTHERN PHILIPPINES
Tamag, Vigan City
They act as thermal insulators for skin and 4. Using minimal water in cooking vegetables
protector pads inside body cavity to protect 5. Storing cut up foods, especially vitamin C rich foods
organs from shock in airtight wrappers and juices in closed storage
Essential fatty acids are required for the body Safe Upper Limit of Intake for Adults (19-70years)
growth and structural integrity. Thiamine 50mg Vitamin C 1000mg
Health Effects if Fats Rivoflavin 200mg Vitamin A 10,000
1. Eating high-fat diets regularly may exceed energy I.U.
needs and gain weight leading to obesity. Niacin 35mg Vitamin D 2000 I.U.
2. Insufficient fat in the diet results in weight loss and Vitamin B6 100mg Vitamin E 1200 I.U.
thinness causes undernutrition. Vitamin 3000mg Vitamin K 30mg
3. Inadequate fat in the diet leads to fat-soluble B12
vitamin deficiencies because fat is necessary for the Folic Acid 1000mg Pantothenic 1000mg
proper utilization of these vitamins. Acid
Biotin 2500mg
4. Trans-fatty acids influence blood cholesterol the sae
5) Mineral
way saturated fats do. Bad LDL cholesterol will raise
are necessary for body-building, for building
and lower good HDL cholesterol.
of bones, teeth and structural parts of soft
Lipoprotein – lipids in combination with protein
tissues.
which are formed in the liver and contain
also play a role in regulation of processes in
cholesterol, neutral fat and fatty acids
4) Vitamins
Vital factor in the diet – protective foods –
facilitators of body processes
Occurs in foods in small amount and are
needed by the body in small quantity as well
increase the breakdown and absorption of
proteins, carbohydrate, and fats – that release
energy from energy-yielding nutrients
Classifications of Vitamins:
1. Fat-soluble vitamins: ADEK – insoluble in water, so
these are utilized only if there is enough fat in the the body.
body Has 21 inorganic element, which are essential in
2. Water-soluble vitamins: C and B Complex (Thiamin, the growth, repair and healthy functioning of body
Rivoflavin, niacin, pantothenic acid, biotin, folate, B6, tissues
B12 – since soluble in the body, they cannot be stored In organic because the body cannot synthesize
them, they have to be provided by the diet
in the body
Needs vit d and parathormone for utilization
Note: Water-soluble vitamins are easily affected by
Calcium occurs in greatest amount among the
cooking process and exposure to air. minerals in the body = 1.5% and 2% of BW
Niacin – is the most stable of the B vitamins in normal Distribution + 99% in the hard tissues of the body;
cooking process 1% in the blood and soft tissues (lungs and heart);
Vitamin C – quickly destroyed by heat (dry or moist), soft tissue and blood plasma (9-11mg/dl)
exposure to air and presence of water 6) Water
Food must be handled carefully to preserve them by: serves as the solvent for nutrients and waste
1. Cutting fruits into serving bites only when they are products in the body
about to be eaten Importance of Water:
2. Not overcooking or adding baking soda on green 1. carries nutrients and waste products
vegetables throughout the body
3. Avoid prolonged storage
BALDO, MYKA MARGARETTE L.
BSN 2-D
Republic of the Philippines
UNIVERSITY OF NORTHERN PHILIPPINES
Tamag, Vigan City
Vitamin B6 (pyridoxamine, Helps the body use amino acids to Deficiency: anemia, irritability, depression,
pyridoxine) whole grains, form tissue proteins neuritis, convulsions, abnormal brain wave
poultry, meat fish and Helps make RBC pattern, muscle twitching, greasy
shellfish, seeds, liver, kidney, Supports the synthesis of dermatitis and rashes
milk, eggs, fruits, legumes, neurotransmitter and the myelin
green and leafy vegetables coating around nerves
Vitamin B12 (cyanocobalamin) Helps in the formation of new cells Deficiency: Megaloblastic or Pernicious
liver, meat, fish, poultry, eggs, including RBC anemia (due to lack of intrinsic factor),
none in plants Helps maintain nerve cells fatigue, deterioration of the nerves leading
to paralysis, hypersensitivity of the skin
Folic Acid (Vitamin B9, folate, Maturation of RBC, AA necessary for Megaloblastic anemia, glossitis
folacin, pteroylglutamic acid) utilization Heart burn, diarrhea or constipation,
beans, lentils, spinach, mental confusion, fainting
asparagus, lettuce, avocado,
brocolli, tropical fruits,
oranges, bread
Biotin (Vitamin H) milk, liver, Helps the body turn food into energy No known deficiency and toxic effects
egg yolk, and few Required in the making of fatty acids,
veggies amino acids and purine Needed for
the formation of glycogen in muscle
and liver
Pantothenic Acid (Vitamin B5) It helps to make fatty acids and Deficiency: irritability, numbness, fatigue,
liver, bran, sunflower seeds, cholesterol muscle cramps, weakness, paresthesia,
whey powder, mushrooms, apathy, hypoglycemia
caviar, cheese, sun-dried Excess: overdose is rare
tomatoes, fish, avocados
Vitamin C – red and green hot Needed in the formation and Deficiency: Scurvy, anemia, Tendency to
chili peppers, guavas, bell maintenance of intracellular bruise easily, Failure of wounds to heal,
peppers, fresh herbs, dark cementing Frequent infections, Bone fragility, joint
leafy green vegetables, Converts folic acid to its active form pain, Children: Moeller Barlow Disease
brocolli, cauliflower, kiwi Healing of wounds & bone fractures Excess: headache, fatigue, insomnia,
fruits, papaya, oranges, Prevents megaloblastic anemia & worsening gout
strawberries pinpoint hemorrhages
Building of body resistance
Production of steroid hormone
Improves iron absorption
Brain metabolism
Antioxidant
Vitamin A (retinol, retinoic Normal eyesight, for strong immune Deficiency: hypovitaminosis A, night
acid) liver, red pepper, sweet system by keeping the outer skin blindness, xeropthalmia, xerosis, cessation
potatoes, carrots, dark leafy of bone growth, painful joints, tendency
greens, butternut squash, for tooth decay, diarrhea, kidney stones
dried herbs, lettuce, dried and impaired growth
apricots, cantaloupe Excess: RBC breakage, nosebleeds, bone
pain, growth retardation, nausea and
vomiting, abdominal cramps, weight loss,
dry skin, rashes, and loss of hair
caviar, fortified soy products, Stimulates retention of kidneys Toxicity: nausea, diarrhea, polyuria, weight
salami, ham, sausages, For strong bones and teeth loss, demineralization of bones, renal
fortified dairy products, eggs, damage & uremia, hypercalcemia
mushrooms
Vitamin E (tocopherol) tofu, antioxidant functions, helps sustain Deficiency: hemolysis of RBC, weakness,
spinach, nuts, sunflower tissue integrity difficulty walking, leg cramps
seeds, avocados, shellfish, fish, Excess: general discomfort
plant oils, broccoli, squash and
pumpkin
Vitamin K maintenance of prothrombin level in Deficiency: bleeding tendencies,
☻Phylloquinone – vit. K1 blood plasma hemorrhagic disease
series formation of protein that binds Excess: hemolytic anemia and severe
☻Menaquinones – vit. K2 calcium in the bones jaundice, vomiting, albuminuria,
series kernicterus
☻Menadione – vit. K3 series
herbs,dark leafy greens, spring
onions, brussels sprouts,
broccoli, chili powder, curry,
asparagus, cabbage, pickled
cucumber, prunes
maintain a healthy weight, reduce the risk of Faye Glenn Abdellah identified twenty-one (21) key
chronic diseases, and promote the overall health. nursing problems related to health needs of people
Also, Good nutrition is one of the keys to a that include nutrition
healthy life and can improve health by keeping a
balanced diet. Classification of Nutrients
Good nutrition can help reducing the risk
Nutrients can be grouped into two categories:
of some diseases, including heart disease,
macronutrients and micronutrients.
diabetes, stroke, some cancers, and osteoporosis.
It reduces the high blood pressure and lowers Macro means big – big nutrients.
high cholesterol. It can also improve the well- Macronutrients are the main nutrients that make up
being, improve the ability to fight off illness and the foods we eat.
to improve the ability to recover from illness or Nutrients required in large amounts that provide the
injury. energy needed to maintain body functions and carry
out the activities of daily life.
Nutrition plays a critical role in human
resource development since deficiencies in Micronutrients are essential elements needed by life
essential nutrients lead to malnutrition, which in small quantities.
affects an individual's mental and physical state, Micronutrients, just like water do not provide energy,
resulting in poor health and poor work however, the body need adequate amount to ensure
performance. A well-nourished, healthy that all body cells function properly.
workforce is a pre- condition for sustainable Most of micronutrients are known to be essential
development. nutrients meaning can only be obtained from the food
in which we eat.
Nursing Theories and discovery related to
There are six nutrients that are further classified
Nutrition according to size and energy. Carbohydrate, protein,
The concept of metabolism, the transfer of food and fat are macronutrients while vitamins and
and oxygen into heat and water in the body, minerals including water are all micronutrients.
creating energy, was discovered in 1770 by
Macronutrients
Antoine Lavoisier, the “Father of Nutrition and
Chemistry.” Carbohydrates
Carl von Voit is considered by many to be the It is an organic compound containing C, H, O, Derived
"father" of modern dietetics. from the Greek word saccharide meaning
Abraham Maslow who postulated the Hierarchy starches and sugars and chiefly found in plants.
It is produced by the process of photosynthesis from -
of Basic Human Needs which consists of:
H2O, CO2 and sun.
1. Physiologic Needs; 2. Safety and Security; 3. The Total Energy Requirement is ranging from 50%
Love and belonging; 4. Self-Esteem Needs; 5. Self- to 70% of body energy needs is from CHO.
Actualization Needs. He mentioned that under CHO has one (1) gram of CHO which is equivalent to 4
Physiologic needs nutrition is third and explains calories upon complete hydrolysis. The building blocks
that physiologic needs must be filled up first are called monosaccharide.
before going to another level of human needs.
The digestion begins in the mouth with salivary
Virginia Henderson identified fourteen (14)
amylase released during the process of chewing
components of basic nursing needs and postulated
and are absorbed across the membrane of the small
that the unique function of the nurse is to assist the
intestine and transported to the liver distributed to
clients, sick or well, in the performance of those
the rest of the body.
activities contributing to health or its recovery.
The absorption process begins around 3-6 hours after
eating.
The classification of carbohydrates is the following: Republic Act 9288 – New born Screening Test
(1) monosaccharide considered as the simplest form DISACCHARIDES are sugars (carbohydrate molecules)
of sugar of sugar which is small molecules that require that form when two simple sugars i.e.
little or no digestion before they can be used by the monosaccharides combine to form a disaccharide. Or
body and the source is the digestive end product of two sugar molecules
lactose hydrolysis. Sucrose -”cane sugar”, “table sugar”, “beet sugar”
A. Glucose Sucrose = glucose + fructose
Along with fat, glucose is one of the body’s preferred Maltose -”malt sugar”, derived from the digestion of
sources of fuel in the form of carbohydrates. starch Maltose = glucose + glucose
People get glucose from bread, fruits, vegetables, Lactose -”milk sugar”, least sweet among sugars
and dairy products. You need food to create the Lactose = glucose + galactose
energy that helps keep you alive. While glucose is Source: milk and milk products
important, like with so many things, it’s best in
moderation. Glucose levels that are unhealthy or out COMPLEX CARBOHYDRATES OR POLYSACCHARIDES is
of control can have permanent and serious effects. a large molecule made of many smaller
You may know glucose by another name: “physiologic monosaccharides linked together.
sugar” or “blood sugar”,”dextrose” ”grape sugar”.
Glucose is key to keeping the mechanisms of the body A. Starch - Probably the most important storage
in top working order. It is the principal form used by polysaccharides on the planet, glycogen and starch
the body,moderate use of sweet sugar works for the are produced by animals and plants, respectively or a
body”s brain,nerve cells,RBC, Glucose stores last for storage form of carbohydrates in plants, It supplies
only hours Gluconeogenesis is the process where energy for a long period of time. Source: cereal grains,
rice, wheat
protein is converted to glucose, while Ketosis is
B. Dextrin is not found in free food, it is
known as less available CHO or very low in
intermediate product of starch digestion, maltose + 2
Carbohydrates for energy, more fats to be broken glucose units.
down to form ketone bodies, sources could be found Source: toasted bread + application of dry heat
abundantly in fruits, sweet corn, corn syrup C. Glycogen or known as “animal starch”, a storage
form of CHO in the body found in the liver and
Lycopene is a carotenoid, a natural pigment that gives
muscle, Muscle glycogen supplies energy directly to
some vegetables and fruits their red color.
surrounding tissues during work and exercise, Liver
Carotene is an orange and yellow pigment found in glycogen is converted to glucose to be used in the
plants and fruits, especially carrots and colorful body through the process called “GLYCOGENESIS”,
vegetables. Source: liver, oysters, muscle meat
Anthocyanin-are blue, red, brown or purple pigments
found in plants, especially flowers, fruits, and tubers. Fibers also known as roughage because they form
In acidic condition bulk of the diet is the part of plant-based foods
Cruciferae- commonly known as the mustards, the (grains, fruits, vegetables, nuts, and beans) that the
crucifers, or the cabbage family - white and green body can’t break down. It passes through the body
undigested, keeping your digestive system clean and
B. Fructose is a type of simple sugar, “fruit sugar”, healthy, easing bowel movements, and flushing
sweetest of all sugar, “levulose”, good sources are cholesterol and harmful carcinogens out of the body.
ripe fruits and honey It acts as broom in our digestive tract, indigestible
C. Galactose are not found in nature, not found in part of food and primary constituent of plant cell wall,
free foods, it is a sugar found in milk, It produced from it is not digested by human due to lack of enzyme that
lactose (milk sugar) by digestion and is converted to will split or break it. Daily requirement is 20-35 g
glucose
Galactosemia are rare genetic metabolic disorders, FUNCTIONS OF CARBOHYDRATES
Infants born with an inability to metabolize galactose. Carbohydrates is the Chief source of energy, protein
sparing, it supplies energy to the body and takes part
BALDO, MYKA MARGARETTE L.
BSN 2-D
Republic of the Philippines
UNIVERSITY OF NORTHERN PHILIPPINES
Tamag, Vigan City
in building body tissues to some limited extent. It acts a. most widely distributed
as the regulator of intestinal peristalsis and provider b. traces placed in liver, egg yolk and
of bulk. vegetable oil
LACK OF CARBOHYDRATE RESULTS TO: c. added to food products such as
Underweight and/or rapid weight loss, General cheese and margarine to aid
weakness. Poor physical performance, Fainting or emulsification Cephalin
collapse in severe deficiency, Hypoglycemia in acute d. needed to form thromboplastin for
carbohydrate deficiency blood clotting
EXCESSIVE CARBOHYDRATE MAY RESULS IN: e. Sphigomyelin - found in brain and
Dental caries, Obesity/overweight, Diabetes mellitus other nerve tissue; serves as insulator
and Gas formation around nerve fibers
2. Glycolipids - fatty acids combined with CHO
Health Effects of Starch and Fibers and nitrogen
1. Promote weight loss/ weight control – increase fibers, 3. Lipoprotein - lipids combination of protein
low fats and added sugar a. Chylomicrons - transport diet-derived
2. Protect against heart disease and stroke – high in lipids; mostly triglycerides
carbohydrates b. Pre-beta lipoprotein - VLDL (very low-
3. Protect against cancer – high in carbohydrates density lipoprotein); fat circulating in
4. Fight against diabetes – high in carbohydrates and low the blood during fasting state
fats control weight c. Beta lipoprotein - LDL (low density
5. Promote gastrointestinal health – increase fibers lipoprotein); transport in the artery wall
enhances healthy large intestine d. Alpha lipoprotein – scavengers; GOOD
CHOLESTEROL
FATS also known as Lipids, It is Organic nutrient
containing C,H,O attached in a glycerol base. One (1) III. Derived lipids – fat substances found
gram fat is equal to nine (9) calories, the total Energy produced ............ from fats and fat compounds
Requirement of 20%-30% is from fat. It remains in the 1. Fatty Acids – basic structural unit of fat
stomach for the longest period of time, A good a) Saturated fatty acids – palmitic and
approach when it comes to breaking up your fat stearic acids; examples are bacon,
calories is to eat 40 percent of your daily fat grams at butter, grated coconut, coconut cream,
breakfast, 40 percent between your midday meal, and coconut oil, margarine, mayonnaise,
20 percent at dinner. It is important to avoid fatty cream cheese, sandwich spread,
foods at night. It can take 2-4 hours for fat to digest, whipping cream, chicharon
so if you eat it too late in the evening, your body b) Monounsaturated – oleic acid;
won't have as much time to utilize this energy before examples are avocado, peanut butter,
storing it. Bile contains bile salts, which act as an peanut oil, pili nut, olive oil, shortening
emulsifier of lipids. This breaks the large fat droplets c) Polyunsaturated fatty acids – linoleic
into smaller droplets that are then easier for the fat- acid, vegetable oil: examples are corn,
digesting enzyme pancreatic lipase to digest. Fats are soybean, rapeseed, canola, sunflower,
mainly digested in the small intestine. Steatorrhea is sesame
the presence of excess fat in feces 2. Glycerol - water soluble component of
CLASSIFICATION OF FATS .................................triglycerides; available for the
I. Simple Lipids - neutral fats, chemical name is ..................................formation of .......glucose in the
triglycerides, glycerol is derived from a water ..............................diet
soluble form of CHO 3. Steroids - fat related substances that contain
II. Compound lipids - combination of fats with ........ sterols; main member is cholesterol
other components; important in human – important constituent of body cells
nutrition and tissues.
1. Phospholipids - fatty acids, phosphoric acids Foods rich in cholesterol: egg yolk, organ meats,
and nitrogenous base Lecithin shellfish dairy products, butter, milk cheese, ice
give energy but merely help convert food into energy, Food Sources: Liver, egg yolk, dairy product, green,
bile is needed for the absorption of fat-soluble yellow and orange fruits and vegetable
vitamins, Co-enzyme for energy metabolism of CHO, Vitamin D
CHON and fats Calciferol Precursor: Ergosterol
Terms Accounted with Vitamins It can be warmed or kept for long period of time
Precursors / Provitamins – compound that can be without deteriorating, calcium and phosphorous
changed to active vitamins absorption, bone mineralization
Preformed Vitamins – occurring vitamins that are Functions: It helps build and maintain strong bones
inactive form and ready for biological use and sound teeth, Absorbs calcium and phosphorus
Avitaminosis – lack of vitamins, deficiency And promotes normal growth and development.
Hypervitaminosis – vitamin toxicity, excessive Lack of Vitamin D results in: Tetany ( muscle
accumulation of vitamins in the body Vitamin twitching), Malformed or soft bones (rickets),Poor
malnutrition – mal – bad; too much or too little is not development of teeth, Stunted growth (osteomalacia,
good for the health Vitamin like compounds – osteoporosis), Lowered amount of calcium and
substances have physiological roles like vitamins but phosphorus in blood.
in large amounts partially synthesized in the body like Excess intake of Vitamin D results in: Loss of appetite,
inositol, choline etc. Nausea and vomiting, Intense thirst and frequent
Antivitamins or vitamin antagonist – substance that urination,Severe constipation and/or diarrhea,
interfere the normal functioning of the vitamin like Muscular weakness, Headache and drowsiness
dicumerol against Vitamin K, avidin against biotin. Food Sources: dairy products, eggs, yolks and fatty
CLASSIFICATION OF VITAMINS: fish
1. Fat soluble vitamins - dissolve in fat before they Vitamin E
are absorbed in the blood stream, not absolutely Tocopherol, stored in adipose tissue, aided by bile and
needed daily from food sources, It also have fats, stable to heat and acid
precursors, stored in the body and deficiency Functions: Vit E Maintains nerves, muscles and a
develops slowly. Example: Vitamins A, D, E, K healthy reproductive system, Helps protect tissues
2. Water soluble vitamins - dissolve in water and and membranes against the damage of oxidation,
are not stored in the body, absolutely needed daily Helps in the formation of red blood cells and in the
because excess excreted in the urine, do not have utilization of Vitamin K
precursor and deficiency develops fast Example: Food Sources: vegetable oils, nuts, seeds, whole
Vitamin B complex, Vitamin C grains
Fat-Soluble Vitamins Vitamin K
Vitamin A Retinol, Precusor: carotene, Absorbed Menadione, Pytomenadione, Phylloquinone
through lymphatic system and portal blood to liver Synthesized by normal intestinal flora, Maintenance
Functions: It helps maintain normal vision, keep lining of prothrombin level in blood plasma
of the mouth, nose, throat and respiratory tract Functions: Vit K helps in the normal clotting of the
healthy, helps skin and hair glossy, teeth strong, blood, Increases calcium absorption and Maintains
Promotes growth, Maintains the stability of the cell strong healthy bones
membrane and Assists in immune reaction. Lack of vitamin K results in: Slow clotting of blood, a
Lack of vitamin A results in: Biot’ s Spot ( mild form), Tendency to bleed easily, Hemorrhages following
Xeropthalmia ( severe form), Inability to see in dim operations or in the umbilical cord of newborn infants
light or “night blindness”, Eyes sensitive to bright Food Sources: green vegetables
light, Rough dry skin and membranes of nose and
throat, Low body resistance to disease Affects health Water Soluble Vitamins – fresh food vitamins
of skin, hair, nails and poor growth, Blindness in Vitamin C: Ascorbic Acid, Easily absorbed from small
severe deficiency intestines
Excess intake of Vitamin A results in: Yellow Functions: Vit C increases the body resistance to
discoloration of the skin or “carotenemia”, Dry, itchy infection ,helps keep gums and teeth healthy, Aids in
skin and coarse hair, Nausea, headache, Irritability the absorption of iron and calcium in the body, Helps
and Loss of appetite. in the formation of red blood cells, Prevents scurvy
and acts as an antioxidant. and fold of nose, itching burning eyes,Sore, swollen
Lack of Ascorbic Acid results in: Bleeding gums; loose and chapped lips, swollen, fissured, and painful
teeth, Skin hemorrhages (black and blue spots). Slow tongues and Retarded growth
wound healing, Bone changes, Anemia and Scurvy in Food Sources: pork, grains, cereal products, meats
severe deficiency fish, green leafy vegetables
Food Sources: citrus fruits, broccoli, cantaloupe, kiwi, Vitamin B3 Niacin / Nicotinic Acid, co-enzyme for
cabbage, strawberries, tomatoes, melons energy metabolism
Vitamin B Complex Functions: It promotes normal digestion and keep
Vitamin B complex is composed of eight B vitamins: nerve in healthy condition, Keeps skin healthy,and
B-1 (thiamine),B-2 (riboflavin), B-3 (niacin),B-5 Promotes growth
(pantothenic acid),B-6 (pyridoxine),B-7 (biotin),B-9 Lack of Niacin results in: Rough, red skin which later
(folic acid),B-12 (cobalamin), It has short life that becomes pigmented, Sore mouth, tongue and throat,
needs to be replaced continually Boiling meat – 15- Digestive and nervous disturbances, Loss of appetite
40% loss of Vitamin B and weight, Pellagra or “3D disease” (dementia,
Frying – 40-50% dermatitis, diarrhea) in severe deficiency, Irritability
Roasting – 30-60% and mental confusion
Remember: - lost vitamins are transferred to the Food Sources: whole grains, legumes, green
cooking liquids,It is best turn these liquids to sauces vegetables, meats, fish, nuts and eggs
and gravies. Vitamin B5 Panthothenic Acid
Vitamin B1 thiamin, or thiamine, enables the body to Functions: Essential for carbohydrate, protein and fat
use carbohydrates as energy. metabolism, Maintenance of normal growth, healthy
Functions: It is essential for glucose metabolism, and skin and integrity of CNS and Co-enzyme for energy
it plays a key role in nerve, muscle , Prevents beri- beri metabolism
/ nutritional polyneuritis, plays key role in nerves for a Lack of Panthothenic results in: Insomia , Tingling
healthy condition, muscle nerve function, Promotes sensation of the extremities, Muscle cramps ,and
good appetite and normal digestion and Promotes Vomiting
good growth Food Sources: liver, meats, eggs, milk cheese and
Lack of thiamine results in: Mental legumes
confusion/depression, Poor appetite, Nervousness, Vitamin B6 also known as pyridoxine, is one of eight
Loss of ankle and knee jerk reflexes, Painful calf vitamins in the B complex group.
muscles (cramps), Constipation, Fatigue, weakness, Functions: It aids in metabolism of amino acids and
Retarded growth Food Sources: whole grains, pork, protein, Helps the body use carbohydrate, fat and
cereals, legumes, seeds and nuts protein, Neurotransmitter synthesis, avoided to
Type of Beri-beri patient with parkinson’s, Supplemented in anti- TB
1. Infantile -occurs in infant 2 to 5 months of age therapy, Converts tryptophan to niacin and linoleic
and gets the disease from mother’s milk acid to arachidonic acid
suffering from beri-beri, symptoms are loss of Lack of pyridoxine results in: Loss of appetite, nausea
voice (aphoria) and cyanosis and vomiting ,Nervous irritability and convulsions,
2. Wet - edema on both extremities progress Dermatitis around the eyes, mouth, on the nose and
upwards to heart and lungs behind the ears
3. Dry – involves peripheral nerves - parasthesia Food Sources: whole grains, spinach, broccoli,
leading to paralysis legumes, vegetable oils of corn
Vitamin B2 Riboflavin, co-enzyme for energy Vitamin B9 Known as Folic Acid / Folate
metabolism, it is essential for protein, fat and Functions: It aids in metabolism of genetic material
carbohydrates metabolism, vitamin readily destroyed (DNA, RNA), Helps cure a form of anemia, poor
in cooking growth, birth defects, Synthesizes DNA which control
Functions: It keeps eyes and skin healthy, aids in cell function, heredity and tissue growth, and
normal functioning of nervous system and promotes Regenerates red blood cell and essential formation of
growth WBC in the bone marrow
Lack of riboflavin results in: Sores in angles of mouth Lack of folic acid results in: Poor growth, Fatigue,
depression and confusion, Macrocytic anemia, functioning of the body enzymes; Relaxes muscle after
Glossitis, Diarrhea, Malformation in the offspring contraction; Promotes resistance to tooth decay by
especially neural tube defect and Gastrointestinal holding calcium in the tooth enamel
disturbances
Food Sources: green leafy vegetables, nuts, legumes,
grain products LACK OF MAGNESIUM RESULTS IN: Irritability,
Vitamin B12 Known as Cyanocobalamin / Cobalamin, Emotional tension, depression Muscular weakness
Folate metabolism, nerve function, intrinsic EXCESS IN MAGNESIUM: Nausea and Vomiting
factor ,deficiency requires lifetime treatment Food Sources: whole grain, nuts, legumes, soy beans,
Functions: Facilitates maturation of red blood cells, dark green leafy vegetables
Protects the “myelin” or the fatty material that Sodium chief cation in the Extacellular Fluid (ECF)
transmit electrical impulses (messages) between blood serum normal value – 135 to 145 mEq/lite
nerve cells, helps metabolizes carbohydrate, protein, FUNCTIONS: Maintains proper water balance within
fat, nucleic and folic acid in the body and normal the body; Preserves the normal movement of the
functioning of all cells. muscles, nerve impulse transmission
Lack of Cobalamin results in: Pernicious anemia, LACK OF SODIUM RESULTS IN: Nausea Vertigo Mental
Changes in the nervous system, Retarded growth apathy; Muscular weakness Cramps
Food Sources: foods of animal in origin, fermented EXCESSIVE SODIUM MAY CAUSE: Edema
foods Minerals The element in their simple inorganic Hypertension Kidney disease
form Primary function of the small intestine is the Food Sources: spinach, celery, pickles, canned soup,
absorption of nutrients and minerals found in food. processed cheese, condiments
Phytates, Oxalates & Tannins which are compounds Potassium chief cation in the Intra-cellular Fluid (ICF)
found in foods that can bind to calcium, iron, zinc and blood serum normal value 3.5 to 5.5 mEq/liter
other minerals and interfere with their absorption. FUNCTIONS: Helps in muscle contraction, nerve
impulses, and the proper functioning of the heart and
Macronutrient minerals – Ca, Na, P, K, S, Cl, Mg kidneys; Regulates blood pressure and water balance
Micronutrient minerals – Fe, I, Zn, Se, Mn, Cu, Mo, in the cells Important in CHO and CHON metabolism
Co, Cr LACK OF SODIUM RESULTS IN: Hypokalemia/Muscular
weakness Increased nervous irritability Mental
Calcium (Ca) disorientation; Cardiac irregularities
99% is in the bone EXCESS POTASSIUM LEAD TO: Hyperkalemia, Heart
major component of renal calculi block
blood serum - normal value 4.5 to 5.5 mEq/liter
Food Sources: bananas, meat, milk, legumes,
FUNCTIONS: Build and maintain strong bones and
Bananas, oranges, cantaloupe, honeydew, apricots,
teeth
Promotes normal blood clotting, regular heartbeat, grapefruit (some dried fruits, such as prunes, raisins,
cell metabolism and other muscle contractions; and dates, are also high in potassium), cooked
Prevents rickets in children and osteomalacia in adults spinach, cooked broccoli, potatoes, sweet potatoes,
Lowers risk to fracture mushrooms, peas and cucumbers. Some low-
LACK OF CALCIUM RESULTS IN: Stunted growth; potassium foods include: berries, such as strawberries
Defective structure of teeth and bones called rickets and blueberries, apples, pineapple, cranberries and
in very young children Soft bones or osteomalacia in cranberry juice and cauliflower.
adults; Decreased bone density; Increased porosity Phosphorous (P) important in pH regulation
(demineralization) of the bones; called osteoporosis principal anion in the Intra-cellular cell
Low peak bone mass; Increased risk to fracture FUNCTIONS: Helps in proper bone and tooth
Food Sources: milk products, dark green leafy development; Facilitates quick release of energy for
vegetable, salmon, orange juice, tofu muscle contraction Transports lipids and fatty acid in
Magnesium (Mg) the blood; Transports nutrient in and out of the cell
blood serum normal value 1.5 to 3.0 mEq/liter Prevents rickets, demineralization of bone
FUNCTIONS: Helps regulate body processes including LACK OF PHOSPHORUS RESULTS IN: Weakness of the
regulation of normal heart rhythm Aids in the normal muscles Stunted growth; Defective structure of teeth
BALDO, MYKA MARGARETTE L.
BSN 2-D
Republic of the Philippines
UNIVERSITY OF NORTHERN PHILIPPINES
Tamag, Vigan City
and bones; Impairment of the body’s use of iron and survival, plays a role in making red blood cells and
calcium maintaining nerve cells and the immune system. It
Food Sources: milk products, meat and organ meat, also helps the body form collagen and absorb iron,
poultry, seafoods, legume, cheese, dried beans, and plays a role in energy production.
sunflower and pumpkin seeds, nuts and whole grains. FUNCTIONS: Helps the body to use iron; Helps build
Sulfur (S) - plays an important role in crucial functions hemoglobin in the blood; Takes part in the
in body, such as making protein, regulating gene metabolism of ascorbic acid in the body Helps the
expression, building and repairing DNA, and helping body use fatty acids
body metabolize food. LACK OF COPPER RESULTS IN: Anemia, anorexia,
FUNCTIONS: Determines the contour of protein hypotonia, edema and retarded growth (CNS
LACK OF SULFUR RESULTS IN: Lack of sulfur- abnormalities)
containing amino acid, in cases of severe deficiency EXCESS: Wilson’s disease - a genetic disorder in which
Food Sources: Protein containing foods excess copper builds up in the body. Symptoms are
Chloride (Cl) major anion in the Extracellular Fluid typically related to the brain and liver. Liver-related
(ECF) formation of gastric juice symptoms include vomiting, weakness, fluid build up
FUNCTIONS: Helps maintain the osmotic pressure and in the abdomen, swelling of the legs, yellowish skin
acid-base equilibrium in the body Helps balance the and itchiness.
ph level of the blood; Maintains the strong acidity of Food Sources: organ meat, egg yolk, oysters, nuts,
the stomach as part of HCl cereals, whole grains
EFFECTS of Chloride in the Body: Alkalosis - excessive Iodine (I) mineral component of the hormone
loss of Chloride ions from the gastric secretions; thyroxine
vomiting and gastric lavage or suctioning; Acidosis - FUNCTIONS: Helps in normal functioning of the
excessive supply of Chloride ions from the gastric thyroid gland in regulating energy metabolism Helps
secretions; diarrhea, during the state of NPO or diet in protein synthesis, tissue growth and reproduction;
Food Sources: pickles, canned soup, processed Prevents goiter
cheese, condiments LACK OF IODINE RESULTS IN: Enlarged thyroid gland
Iron (Fe) components of hemoglobin Ferrous SO4 – (Goiter) Painful swallowing; Cretinism (mental and
with meals – orange juice (Vitamin C)- black tarry physical retardation accompanied by irreversible
stools Z-track method – IM injection ferrous is better hearing and speech problem – insufficient of iodine
absorbed than ferric iron in green leafy vegetable is intake by the mother during pregnancy)
poorly absorbed coffee taking iron – iron absorption is Myxedema – adults who had problem with low iodine
reduced throughout their childhood and adolescence.
Type of Iron Increased risk of abortion, stillbirths, miscarriage and
-Heme Iron – found only in meat, fish and poultry infant deaths
-Non-Heme Iron – found in cereals and vegetables EXCESS IODINE RESULTS IN: Thyrotoxicosis Induced
FUNCTIONS: Helps build and maintain blood supply acne-like skin lesions Worsening of pre-existing acne
and give healthy red color to the blood Prevents Food Sources: seafood, seaweeds, iodized salt
simple anemia Manganese (Mn) constituents of vitamin B1
LACK OF IRON RESULTS IN: Nutritional anemia-IDA contributes to many bodily functions, including the
(iron deficiency anemia) Easy fatigability; General metabolism of amino acids, cholesterol, glucose, and
weakness; Poor physical performance; Paleness in the
carbohydrates. The human body cannot produce
face, conjuctiva, lips and fingernails; Weight loss
manganese, but it can store it in the liver, pancreas,
Koilonychia- spoon shaped nail, a nail deformity in
which the outer surface becomes concave bones, kidneys, and brain. A person usually obtains
EXCESS IRON MAY LEAD TO: High iron stores leading manganese from their diet.
to iron toxicity like hemochromatosis and FUNCTIONS: Is an essential constituent for bone
hemosiderosis structure, reproduction and normal functioning of
Food Sources: liver, red meat, organ meat, egg yolk, nervous system; Takes part in enzymatic actions in the
green and red mongo, soy beans body
Copper (Cu) - essential trace mineral necessary for LACK OF MANGANESE: Skeletal abnormality
Food Sources: nuts, cereals, legumes, dried fruits, LACK OF CHROMIUM RESULTS IN: Impaired action of
green leafy and non-leafy vegetables insulin Low blood glucose level
Cobalt (Co) constituents of B12 Food Sources: corn oil, clams, cereals, vegetables and
Deficiency: Pernicious Anemia meats
Excess: Polycythemia Vera
FUNCTIONS: Forms cobalamin or vitamin B12 that Nutrients to Take – or Avoid Taking – Together for
Best Absorption 5 Nutrient Absorption Guidelines
helps treat a certain type of anemia
Pair: Iron + Vitamin C
LACK OF COBALT RESULTS IN: Poor growth Poor
Pair: Vitamin D + Calcium. Pair: Vitamin B12 + Folate.
appetite Restlessness Pair: Vitamin D + Omega-3s. Avoid: Iron + Calcium.
Progressive emaciation Water
Food Sources: liver, oysters, clams, poultry, salt water 60-70% total body weight
fish deprivation of 10% water – illness; 20% - death next
Zinc (Zn) anti-oxidant mineral to O2 for maintenance of life
FUNCTIONS: Helps the body use protein and 45 liters – water found in the body of normal adult 30
carbohydrates; Is vital for growth and development, liters intracellular (inside or within the cells)
synthesis of cell protein (formation of DNA & RNA), 15 liters extracellular (outside the cells)
proper functioning of the immune system; Is vital for large intestine absorbs water and changes the waste
the development of male reproductive function, from liquid into stool.
specifically the formation of testosterone, making of Functions: Acts as solvent for all products of digestion
sperm Helps hasten wound healing Taste acuity (universal solvent); Carries nutrients to the tissues;
LACK OF ZINC RESULTS IN: Growth failure; Impaired Removes waste products from the tissue; Helps
wound healingImpaired sense of taste and smell regulate body temperature and the acid-base balance;
Sexual infantilism in teenagers Sends messages between cells so you can think, see,
EXCESS IN ZINC: Nausea and vomiting Abdominal touch, hear, feel and move
cramps Diarrhea Gastrointestinal irritation Lack water results in: Dehydration with the following
Food Sources: meat, milk, legumes, nuts, poultry, fish, symptoms: Fatigue decrease blood pressure increase
whole grain cereals and breadsFluoride (Fl) body temp Headache weight loss Collapse decrease
FUNCTIONS: Helps prevent tooth decay; Favors urine output
deposition of calcium thereby strengthening the Three possible sources of water for the body are:
bones LACK OF FLUORINE RESULTS IN: Lowered Water contained in foods; Fluids taken as such; Water
resistance to dental caries formed by the oxidation of foods in the body
EXCESS INTAKE OF FLUORINE: Mottling of the tooth INPUT: fluids in the form of water, juices, parenteral
enamel (dental fluorosis) Stained and corroded OUTPUT: urine, vomitus, feces, stomach content,
appearance of the teeth drainage, bleeding, perspiration Approximate Average
Food Sources: fluoridated water and toothpastes Daily Intake and Output – 2200 to 2500 ml/day
Selenium (Se) anti-oxidant mineral Abnormalities of Water Balance
FUNCTIONS: Serves as an integral component of
certain enzymes Acts as an antioxidants which help
fight cell damage Helps prevent certain types of
protein-energy malnutrition Regulates proper
immune response Aids in proper functioning of the
heart muscle
LACK OF SELENIUM Keshan’s disease, Cancer Less
able immune system to fight off diseases
EXCESS: Liver Damage
Food Sources: organ meats, cereals dairy products
Chronium (Cr)
FUNCTIONS: Takes part in glucose metabolism; Helps
the body use carbohydrates and fats; Stimulates
synthesis of fatty acids and cholesterol in the liver
BALDO, MYKA MARGARETTE L.
BSN 2-D
Republic of the Philippines
UNIVERSITY OF NORTHERN PHILIPPINES
Tamag, Vigan City
ex: thyroxine from porcine or bovine’s thyroid The Nurse's Role in Pharmacology
gland Appropriate assessment before, during
insulin from pancreas omega-3 from fish oil and after administering the drug
Synthetic Evaluating the safety of the drug for this
chemically manufactured in laboratories unique client
ex: Aspirin (chemically known as Minimizing and evaluating adverse effects
Acetylsalicylic Acid (ASA). Educating the client and/or family
Semi-synthetic
prepared by chemical modification of natural
drugs
ex: Ampicillin from Pencillin G
Biosynthetic 8 Questions
Prepared by cloning human DNA (Genetic 1. Why would a patient need this drug?
Engineering) 2. How would I know if this drug was doing what it
ex: Human insulin was intended to do?
Human growth hormones 3. How would I know if the patient was experiencing
Human erythropoieitin adverse effects because of this drug?
4. Are there any special lab tests I should monitor
DRUG NAME before or during treatment because of this
Chemical name medication?
The chemical constitution of the drug as well 5. Why should a patient not take this drug or only take
as the exact placement of its atoms or it with caution?
molecular groupings. 6. How does this drug impact other disease
Ex:6-[D(−)β-amino processes?
phydroxyphenylacetamido.] penicillanic acid 7. What would happen if the patient received "too
C16H19N3O5S much" of this drug?
Generic name 8. What do I need to teach the patient about this drug
is simpler than the chemical name. to keep them safe and increase the effectiveness of
It may be used in any country and by any this drug?
manufacturer.
Ex: amoxicillin
Brand name
is followed by the symbol ®
this symbol indicates that the name is
registered and that the use of the name is
restricted to the owner of the drug, which is
usually the manufacturer.
most drug companies place their products on
the market under brand names rather than
generic names.
Official Name
listed in the official compendia, United States
Pharmacopeia (USP) and National Formulary
(NF)
Usually they use the generic name/s of the
drug in the official list by the US FDA
E. Evaluation
F. Recording and Reporting
Drugs Affecting the Body System
A. Reproductive System
B. Cardiovascular
C. Respiratory
D. Gastro-intestinal
E. Endocrine
F. Renal System
G. Central Nervous System & Pheriperal
Nervous System
H. Other Drugs
1. Chemotherapeutic Agents
LESSON 1: FUNDAMENTAL 2. Drugs for Eye and Ear Disorders
CONCEPTS OF 3. Drugs Acting on the Immune Sys
4. Dietary Supplements
PHARMACOLOGY 5. Alternative & Complementary
A. Drug Definitions and Classification Therapies “Halamang Gamot”
B. Drug Standards and Drug Information PHARMACOLOGY
C. Pharmacodynamics - can be defined as the study of drugs and their
1. Therapeutic Index & Drug Safety origin, nature, properties, and effects on living
2. Graded Dose Response Relationship organisms.
& Therapeutic Response. - includes, history, source, physical and chemical
3. Potency & Efficacy properties, compounding, biochemical and
4. Cellular Receptors & Drug Action physiological effects, therapeutic and other uses,
5. Types of Drug Receptor Interactions precautions, adverse effects, interactions andcontra-
D. Pharmacokinetics indications of drugs.
1. Liberation HISTORICAL TRENDS
2. Absorption In 1920’s - discovery of Insulin and vitamins
3. Distribution In 1930’s - modern anaesthetics
4. Metabolism (Biotransformation) In 1940’s – penicillins
5. Excretion In 1950’s - antihypertensive drugs
E. Factors Influencing Responses to Drugs In 1960’s – neuroleptics
F. Drug Legislation Controlled Substances, In 1970’s - H2-blockers, anti-asthmatics
..........Generic Drugs, Orphan Drugs, & Over- In 1980’s – immunosuppressive and antiviral drugs
the-..........Counter Drugs Drug
Nursing Process in Pharmacology - is a word derived from a French word ‘Drogue’
A. Assessment which means dry herb.
1. Drug History - any substance that brings about a change in biologic
B. Planning function through its chemical action.
C. Intervention - can’t create new function but alter existing function.
1. Drug Administration Therapeutic effect
2. Medication Orders - is the primary effect intended that is the reason the
3. Medication Safety drug is prescribed.
4. Seven Rights Ex. Morphine sulfate- analgesia
5. Dosage Calculation Side effect of morphine sulfate
D. Client Education CNS: confusion, sedation, dizziness…
BALDO, MYKA MARGARETTE L.
BSN 2-D
Republic of the Philippines
UNIVERSITY OF NORTHERN PHILIPPINES
Tamag, Vigan City
the pharmaceutical drug must separate from • Drugs diffuse across a cell membrane from a
the vehicle or the excipient that it was region of high concentration to one of low
mixed with during manufacture. concentration.
“drug carrier” • Since the cell membrane is lipoid, lipid-soluble
is any substrate used in the process of drug drugs diffuse most rapidly.
delivery which serves to improve the • Small molecules tend to penetrate
selectivity, effectiveness, and/or safety of membranes more rapidly than larger ones.
drug administration. • Most drugs are weak organic acids or bases,
are primarily used to control the release of a existing in un-ionized and ionized forms in an
drug into systemic circulation. aqueous environment.
This can be accomplished either:
1. by slow release of the drug over a long period
of time (typically diffusion) or,
2. by triggered release at the drug's target by
some stimulus, such as changes in pH,
application of heat, and activation by light.
TYPE OF DRUG CARRIERS
liposomes The proportion of the un-ionized form present (and
micelles thus the drug’s ability to cross a membrane) is
microspheres determined by:
nanoparticles 1. Environmental pH
Liberation is the release of the drug from it's dosage (pH of body fluid)
form. 2. Drug’s pKa (acid dissociation constant)
Absorption - is the drug pH at which concentrations of ionized
the transfer of drugs from it sites of and un-ionized forms are equal.
administration to systemic circulation (blood
stream). FACILITATED PASSIVE DIFFUSION
Mechanisms of Drug Absorption • A carrier molecule in the membrane
Drug absorption is determined by the drug’s: combines reversibly with the substrate
physicochemical properties molecule outside the cell membrane, and the
dosage forms carrier-substrate complex diffuses rapidly
(e.g., tablets, capsules, solutions) across the membrane, releasing the substrate
formulation at the interior surface.
consisting of the drug plus other ingredients. ACTIVE TRANSPORT
route of administration • Active transport is selective, requires energy
(e.g. oral, buccal, sublingual, rectal, expenditure, and may involve transport
parenteral, topical, inhalational). against a concentration gradient.
Note:Regardless of route of administration, PINOCYTOSIS
drugs must be in solution to be absorbed. • in pinocytosis, fluid or particles are engulfed
Drugs may cross cell membranes by: by a cell.
Passive diffusion • The cell membrane invaginates, encloses the
Facilitated passive diffusion fluid or particles, then fuses again, forming a
Active transport vesicle that later detaches and moves to the
Pinocytosis cell interior.
PASSIVE DIFFUSION • Energy expenditure is required.
• Pinocytosis probably plays a small role in drug
transport, except for protein drugs.
BINDING
Clinical Significance
1. When drugs are given, each with a high affinity for
plasma protein, they compete for the available
binding sites
Tolbutamide- - which is normally 95% bound.
BALDO, MYKA MARGARETTE L.
BSN 2-D
Republic of the Philippines
UNIVERSITY OF NORTHERN PHILIPPINES
Tamag, Vigan City
Sulfonomide - - which has higher affinity for the “One of the features which is thought to distinguish
plasma protein. man from other animals is his desire to take
The 2nd drug will now displace the 1st drug. This will medicine“. - Sir William Osler (1849 – 1919)
lead to a rapid increase in concentration of free drug
(active drug) in the plasma (Now 100% free)
2. In hypoalbuminemia, binding may be reduced and DRUG METABOLISM
high concentrations of free drug may be attained. E.g.
Phenytoin and Furosemide Metabolism
3.Drugs that are highly plasma protein bound may - -is the metabolic breakdown of drugs by
have a longer duration of action and hence longer half living organisms, usually through
life because the drugs in bound form cannot be specialized enzymatic systems.
metabolized or excreted. Thus they require less - -The chemical modification of drugs with
frequent dosing. the overall goal of getting rid of the drug.
Chemical factors
- Enzyme induction
- it is the phenomenon of increased drug
metabolizing ability of enzymes by several
drugs & chemicals.
Biological Factors
Sex difference
- Metabolic differences between males &
females have been observed for certain
compounds.
- Such variation is generally observed following
puberty. So, sex related differences in the rate
DRUG EXCRETION
Kidney
- is the most important organ for the excretion
of drugs and/or their metabolites.
- drug excretion may involve one or more of
the following processes.
Kidney:
o Renal Glomerular Filtration
o Renal Tubular Secretion
o Renal Tubular Reabsorption
Clearance
- the volume of plasma that gets filtered of
drug per unit time.
Types of dose response curve Few drugs work without a receptor being
- Graded dose response curve involved.
- Quantile dose response curve - e.g., Mg (OH)2 for gastric acidity;
mannitol for diuretic; etc.
Types of receptors
Transcription Factors
(e.g., steroids, vitamin D, retinoids)
Ligand Gated Ion Channels
(e.g., GABAA, glutamate, aspartate, glycine, etc.)
G-Protein Coupled Receptors (GPCRs)
(e.g., neurotransmitters)
Enzyme-linked Receptors
(e.g., kinases)
Protease-Activated Receptors
(e.g., thrombin-cleavage…; TNFa converting
enzyme)
4 important Values DRR
Transcription Factors
Drug Efficacy
- (or sequence-specific DNA binding factor)
- Refers to the ability of drug to elicit a
- protein that controls the rate of
response when it binds to a receptor.
transcription of genetic information from
- e.g., Morphine produces a degree of analgesia
DNA to messenger RNA, by binding to a
not obtainable with any dose of aspirin hence
specific DNA sequence.
Morphine is more efficacious than aspirin.
Drug Potency
Transcription factors
- Refers to amount of drug needed to produce
- TF are proteins involved in the process of
a response.
converting, or transcribing, DNA into RNA.
- e.g., if 10mg of morphine is = 100mg of
pethidine, morphine is 10 times more potent
Ligand Gated Ion Channels
than pethidine
- also commonly referred to as ionotropic
Slope
receptors.
Variability
- are a group of transmembrane ion-channel
proteins which open to allow ions such as
Cellular Receptors & Drug Action
Na+, K+, Ca2+, and/or Cl− to pass through the
Receptors
membrane in response to the binding of a
- are specific proteins, situated either in cell
chemical messenger such as a
membranes or, in some cases, in the cellular
neurotransmitter.
cytoplasm.
- is the specific chemical constituent of the cell
G-Protein Coupled Receptors (GPCRs)
with which a drug interacts to produce its
pharmacological effects. - are the largest and most diverse group of
Most drugs work through a receptor. membrane receptors in eukaryotes.
- e.g., testosterone or steroidal sex - These cell surface receptors act like an inbox
hormones; calcium channel blockers; for messages in the form of light energy,
growth factors. peptides, lipids, sugars, and proteins.
Enzyme-linked Receptors
BALDO, MYKA MARGARETTE L.
BSN 2-D
Republic of the Philippines
UNIVERSITY OF NORTHERN PHILIPPINES
Tamag, Vigan City
Training of Individual Reservists and Reserve Units. – Selective Mobilization - shall be by authority of the
Maximum opportunity shall be afforded the reservists President. Selective mobilization may be ordered to
to update their skills for the purpose of enhancement meet a local threat or emergency situation. When so
of the readiness of the individual reservists and ordered, only selected units of the Ready Reserve of
reserve units to respond to the call to service the Localities involved are activated
Compulsory training - of not less than thirty (30) days
but not more than sixty (60) days for reserve units
and/or individual reservists in a given year.
Voluntary training subject to the capability of the
AFP to provide the training. Individual reservists,
commissioned and non-commissioned officers shall be
encouraged to undergo training on a voluntary basis
to upgrade their proficiency.
Auxiliary Service – For the purpose of helping
Administration maintain local peace and order, meeting local
insurgency threat, assisting in rescue and relief
Salient Provisions
operations during disasters and calamities, health
Status of Reservists on Training. – Reservists on
welfare activities and participating in local
compulsory training shall be subject to military law.
socioeconomic development projects.
They shall not receive pay but shall be entitled to
Civil Auxiliary Service - covers services rendered in
allowances and burial benefits as provided by law.
helping maintain law and order, assisting in rescue
Reservists on voluntary training are also subject to
operations, participating in socioeconomic
military law but shall not be entitled to allowances.
development projects, delivery of health services and
Accounting of Reservists. – All
any other non-military activity.
reservists, particularly those belonging to the Ready
and Standby Reserves, shall be accounted for, their records
Military Auxiliary Service. - covers service rendered in
and status updated and present where-about ascertained meeting local insurgency threat. Reservists serving
in order to ensure their readiness to the call to duty. under this category will be organized Ready Reserve
• PAF Reservist Database Management Information Units. They must be issued and allowed to carry
System (PRDMIS) firearms: provided, that these reservists will be
• Participation in National Reservist Week utilized only for the defense of their localities and will
• Assembly Test not be employed outside their localities.
Mobilization/Utilization Status of Reservists on Auxiliary Service. – A reservist
Salient Provisions performing auxiliary service shall not receive pay but
The utilization of the Reserve Force in times of shall be entitled to receive allowances and burial
emergency to meet threats to national security. benefits as provided by law.
Full Mobilization - shall be through the joint act of With his consent, a reservist on auxiliary service
Congress and the President. When full mobilization is whether civil or military, may continue to render such
ordered, all units of the Ready and Standby Reserves service without receiving the allowances due him. A
will be activated, the reservists constituting them are reservist serving military auxiliary service is subject to
called to active duty, and the units activated are military law. whereas, a reservist serving civil auxiliary
placed on operational readiness. service is not.
Partial Mobilization. – shall be through the joint act
of Congress and the President. When partial
mobilization is ordered, only the units of the Ready
Reserves are activated units and placed on
operational readiness.
RELIGIOUS COMMUNITIES
ONLINE COMMUNITIES
PROFESSIONAL/ OCCUPATIONAL
COMMUNITIES
TOPIC 1:
INTEREST-BASED COMMUNITY
EDUCATIONAL COMMUNITIES
COMMUNITY HEALTH NURSING (LEC)
HEALTH SUPPORT COMMUNITIES
Community Health Nursing – is a specialized field of
nursing that focuses on promoting and preserving the ENVIRONMENTAL AND CONSERVATION
health of individuals, families, and communities. COMMUNITIES
3 MAJOR CONCEPTS HOBBIES AND RECRRATIONAL
COMMUNITY COMMUNITIES
HEALTH PARENTING COMMUNITIES
NURSING ADVOCACY AND ACTIVIST COMMUNITIES
What Is a Community? SENIOR AND RETIREMENT COMMUNITIES
• A community is a group of people who are ECONOMIC OR BUSINESS COMMUNITIES
located in a particular space, have shared values, SPORTS COMMUNITIES
and interact within a social system. Community health nursing - is a specialized field of
The four components of community are: nursing that focuses on promoting and maintaining
-People -A location in space the health of populations within a community. - It
-Social interaction - Shared values involves working with individuals, families, and
communities to prevent disease, promote healthy
Attributes of a Community behaviors, and provide healthcare services.
Shared Identity
Basic Concept and Principles of Community
Social Interaction
Health Nursing
Common goal/Interest
POPULATION CENTERED CARE
Mutual Support
PRIMARY PREVENTION
Shared Values and Norms
HEALTH PROMOTION AND EDUCATION
Communication Channels
ASSESSMENT AND SURVEILLANCE
Leadership and Governance
COLLABORATION
Sense of Belonging
CULTURAL COMPETENCE
Geographical Location
ENVIRONMENTAL HEALTH
Cultural Diversity
ACCESS TO HEALTHCARE
Voluntary Membership
EMPOWERMENT
Shared History
ADVOCACY
Economic Activities
DISASTER PREPAREDNESS
Advocacy and Activism
CONTINUUM OF CARE
Generational Diversity
Celebrations and Traditions
ROLES OF A NURSE IN CARING FOR
COMMUNITIES AND POPULATION GROUPS
Types of Communities
ASSESSMENT
GEOGRAPHICAL COMMUNITY
HEALTH PROMOTION
CULTURAL OR ETHNIC COMMUNITIES
DISEASE PREVENTION
BALDO, MYKA MARGARETTE L.
BSN 2-D
Republic of the Philippines
UNIVERSITY OF NORTHERN PHILIPPINES
Tamag, Vigan City