Scribd Logo
Upload

Welcome to Scribd!

  • 91 views

    Monograph (Acetyl Salicylic Acid) : Group B - Pharmaceutical Chemistry Lab

    Uploaded by

    Hamdan afzal
    This document describes a procedure for assaying aspirin tablets using back titration. Aspirin, also known as acetylsalicylic acid, is a white crystalline solid used to reduce fever, pain, inflammation, and other conditions. The procedure involves titrating a sample of crushed aspirin tablets against sodium hydroxide with an indicator, then back-titrating the excess sodium hydroxide with hydrochloric acid to determine the amount of aspirin present. Calculations are made to find the purity percentage of the aspirin in the tablets based on the observed and standard amounts.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd

    Monograph (Acetyl Salicylic Acid) : Group B - Pharmaceutical Chemistry Lab

    Uploaded by

    Hamdan afzal
    91 views6 pages
    This document describes a procedure for assaying aspirin tablets using back titration. Aspirin, also known as acetylsalicylic acid, is a white crystalline solid used to reduce fever, pain, inflammation, and other conditions. The procedure involves titrating a sample of crushed aspirin tablets against sodium hydroxide with an indicator, then back-titrating the excess sodium hydroxide with hydrochloric acid to determine the amount of aspirin present. Calculations are made to find the purity percentage of the aspirin in the tablets based on the observed and standard amounts.

    Original Title

    6 DOCX

    Copyright

    © © All Rights Reserved

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    This document describes a procedure for assaying aspirin tablets using back titration. Aspirin, also known as acetylsalicylic acid, is a white crystalline solid used to reduce fever, pain, inflammation, and other conditions. The procedure involves titrating a sample of crushed aspirin tablets against sodium hydroxide with an indicator, then back-titrating the excess sodium hydroxide with hydrochloric acid to determine the amount of aspirin present. Calculations are made to find the purity percentage of the aspirin in the tablets based on the observed and standard amounts.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    91 views6 pages

    Monograph (Acetyl Salicylic Acid) : Group B - Pharmaceutical Chemistry Lab

    Uploaded by

    Hamdan afzal
    This document describes a procedure for assaying aspirin tablets using back titration. Aspirin, also known as acetylsalicylic acid, is a white crystalline solid used to reduce fever, pain, inflammation, and other conditions. The procedure involves titrating a sample of crushed aspirin tablets against sodium hydroxide with an indicator, then back-titrating the excess sodium hydroxide with hydrochloric acid to determine the amount of aspirin present. Calculations are made to find the purity percentage of the aspirin in the tablets based on the observed and standard amounts.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 6

    MONOGRAPH

    (Acetyl Salicylic Acid)

    GROUP B | PHARMACEUTICAL CHEMISTRY LAB


    GROUP B | PHARMACEUTICAL CHEMISTRY LAB
    EXPERIMENT NO. 6
    To perform the assay of aspirin tablet by back titration method BP.

    REQUIREMENTS
    Apparatus: Analytical balance, Beaker, Spatula, Burette, Conical flask, Retort stand, Measuring
    cylinder, Volumetric flask, Pipette.
    Reagents: HCL , phenol red , methyl orange , disilled water ,sodium hydroxide, sodium carbonate

    THEORY
    Aspirin:
    Aspirin is also known as acetylsalicylic acid.
    IUPAC name: 2-acetoxy benzoic acid
    It is a white crystalline solid at room temperature.

     Molecular Formula: C9H8O4


     Molar Mass: 241.158 g/mol
     Uses:
    1. Aspirin is known as a salicylate and a NSAID.
    2. Aspirin is used to reduce fever and relieve mild to moderate pain from conditions such as
    muscle aches, toothaches, common cold and headaches.
    3. It may be also used to reduce pain and swelling in conditions such as arthritis.
    4. It is anti-inflammatory, so it is also used to treat inflammation.

    PROCEDURE
    1. Rinse all the glassware.
    2. Prepare 0.5M HCL in 100ml and 0.5M NA2CO3 in 50ml.
    3. Fill the burette with HCL solution up to the mark.
    4. Take 10 ml of SODIUM CARBONATE solution in a conical flask. Add 2 drops of
    methyl orange / methyl red as an indicator.
    5. Standardize it against HCL solution until the color changes
    6. Note the reading of burette. Repeat the process 3 - times, take concordant reading and
    determine the correction volume
    7. Take 20 tablets and weigh them correctly.
    8. Transfer the weighted tablets to the mortar and pestle and crushed them into fine particles.
    9. Add 30ml of 0.5 molar NaOH in the same flask and label the flask as flask A. Heat the
    flask A for 10 mins until the mixture boils and cool up to the room temperature. In the
    meanwhile, fill the burette with 0.5M HCl.

    GROUP B | PHARMACEUTICAL CHEMISTRY LAB


    10. Take another flask add 0.5M NaOH 30ml in it. Add 2 drops of phenol red and mark the
    flask B. Titrate it with HCl filled in burette.
    11. When the flask A is cooled to room temperature, refill the burette with 0.5M HCl and
    titrate the flask A after adding 2 drops of phenol red as an indicator.

    WEIGHING THE ACTIVE INGREDIENT:


    1. Amount of aspirin in 1 tablet = 0.3gm
    2. Weight of 20 tablet = 5.966gm
    3. Amount of aspirin in 20 tablet = 20 x 0.3 = 6gm
    4. Therefore, we have 6gm of aspirin in gm of tablets
    5. For 1gm aspirin =
    6. For 0.5gm =
    7. Thus, 0.5 gm of aspirin will be in gm of tablets

    OBSERVATION
    1. Standardization of 0.5N Hydrochloric Acid with 0.5N Sodium Carbonate:
    s.no Initial reading Final reading Difference

    Concordant reading:

    2. Titration of blank by HCL


    s.no Initial reading Final reading Difference

    Volume consumed by blank:

    3. Back titration of sample by HCl


    S.no Initial Reading Final reading Difference

    Volume consumed by excess NaOH:

    GROUP B | PHARMACEUTICAL CHEMISTRY LAB


    CALCULATION
    1. Correction volume:

    C.F: Volume of primary standard (Na2CO3) / volume of secondary standard (HCl)

    2. To determine the burette reading :

    B.R = [ Flask A(B.R) x C.V] – [ Flask B ( B.R) x C.V]

    3. Titer factor:

    GROUP B | PHARMACEUTICAL CHEMISTRY LAB


    4. Observed amount:
    Observed amount: Titer factor x burette reading (assay)

    5. Purity:
    % Purity = Observed amount/ Standard amount x 100

    RESULT

    DISCUSSION

    GROUP B | PHARMACEUTICAL CHEMISTRY LAB

    You might also like