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B PHARM
(SEM-III) THEORY EXAMINATION 2020-21
PHARMACEUTICAL ORGANIC CHEMISTRY II
Time: 3 Hours Total Marks: 75
Note: 1. Attempt all Sections. If require any missing data; then choose suitably.

SECTION A

1. Attempt all questions in brief. 10 x 2 = 20

a. Define aromaticity.
b. Why phenol is acidic?
c. Why p-nitroaniline is less basic than aniline?
d. Write the definition of RM value.
e. Discuss the difference between drying and nondrying oil with example.
f. What do you understand by angle strain?
g. Write the different conformations of ethane.

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h. Illustrate the principle of saponification value. 0Q
i. Predict the structure and medicinal uses of DDT and Naphthalene.

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j. What is banana bonding.

2.
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SECTION B

5.
_Q

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2. Attempt any two parts of the following: 17 2 x 10 = 20
TU

a. Explain the methods of preparations and chemical reactions of Phenol.

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AK

b. Discuss in detail about the methods of preparations chemical reactions of naphthalene.

9

c. Write in detail about the methods of preparation and chemical reactions of

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cycloalkanes.
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SECTION C
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3. Attempt any five parts of the following: 5 x7 = 35

02

a. Explain effect of substituents on reactivity and orientation of mono substituted benzene

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compounds towards electrophilic substitution reaction.

ar
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b. Write about analytical, synthetic, and other evidence in the derivation of structure of
benzene.
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c. Discuss Basicity of amines and effect of substituents on basicity of amines.

d. Write a detailed note on Iodine value.
e. Discuss the Haworth synthesis of Anthracene and Phenanthrene.
f. Illustrate in detail about Baeyer’s Strain theory with its limitations.
g. What do you mean by fats, oils, and waxes? Discuss the chemical reactions of fats, oils
and waxes.

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B. PHARM
(SEM III) THEORY EXAMINATION 2019-20
PHARMACEUTICAL ORGANIC CHEMISTRY-II
Time: 3 Hours Total Marks: 75
Note: 1. Attempt all Sections. If require any missing data; then choose suitably.

SECTION A

1. Attempt all questions in brief. 10 x 2 = 20

a. Give structure and uses of DDT.
b. Give molecular orbital picture of benzene.
c. Why phenol is acidic in nature?
d. What is Friedal craft acylation? Explain with suitable reaction.
e. Give structure and uses of Naphthols.
f. Explain acid value.
g. Give Hawarth synthesis of phenanthrene.
h. Give stability order of cycloalkanes.
i. Draw any four aromatic structures.
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j. Give structure and uses of diphenylmethane.

SECTION B

2. Attempt any two parts of the following: 2 x 10 = 20

a. Give structure, preparation and properties of phenol.
b. Give analytical, synthetic and other evidences in derivation of structure of benzene.
c. Write a note on theory of strainless ring.

SECTION C
3. Attempt any five parts of the following: 5 x 7 = 35
a. Give Huckel’s theory with suitable examples.
b. Give structure, preparation and properties of benzoic acid.
c. Give effect of substituent on orientation of monosubstituted benzene compounds
towards electrophilic substitution reaction.
d. Explain saponification and iodine number.
e. Give reactions of fat and oils.
f. Give Baeyer’s strain theory and its limitation.
g. Give structure, preparation and properties of naphthalene.

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Printed Pages:1 Sub Code: BP301T
Paper Id: 150301 Roll No.

B PHARM
(SEM-III) THEORY EXAMINATION 2018-19
PHARMACEUTICAL ORGANIC CHEMISTRY –II
Time: 3 Hours Total Marks: 75
Note: 1. Attempt all Sections.

SECTION A

1. Attempt all questions in brief. 10 x 2 = 20

a. Write a short note on resonance structure of benzene.
b. Give the structure and uses of Saccharin.
c. What are phenols? Give physical properties of it.
d. Give resonance structure and uses of Resorcinol.
e. What is the difference between fats and oils?
f. Define Iodine number (Iodine value).
g. Define acetyl value. Give its signification.
h. What are the uses of triphenylmethane?
i. Give physical and chemical properties of naphthalene.
j. Define cycloalkanes.

SECTION B

2. Attempt any two parts of the following: 2 x 10 = 20

a. Explain aromatic electrophilic substitution reactions in Benzene with respect to
halogenation with mechanism.
b. Give structures, synthesis, reactions and uses of Anthracene derivatives.
c. Explain Baeyer strain theory of stability of Cycloalkanes and give its limitations.

SECTION C
3. Attempt any five parts of the following: 7 x 5 = 35
a. Give the structure and uses of DDT, BHC and Chloramine.
b. Define aromatic amines and give resonance structure of aniline. Explain basicity of
aromatic amines and effect of substituent.
c. Explain the principle involved in determination of saponification value of a fat/oil.
d. Why phenols are acidic in nature? Explain effect of substituents on acidity of phenols.
e. What is principle and procedure involved in estimation of acid value of fat/oil?
f. Give structure, synthesis and importance of diphenylmethane.
g. Explain Sache-Mohr theory of stability of cycloalkanes. Give reactions of cyclopropane
and cyclobutane.

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B PHARM
(SEM: III) THEORY EXAMINATION 2020-21
PHYSICAL PHARMACEUTICS I
Time: 3 Hours Total Marks: 75
Note: 1. Attempt all Sections. If require any missing data; then choose suitably.

SECTION A

1. Attempt all questions in brief. 10 x 2 = 20

a. Define Molarity and Normality.
b. Differentiate crystalline solid and amorphous solid.
c. Define critical solution temperature.
d. What is critical micelles concentration.
e. What are chelating agents?
f. Define buffer capacity.
g. Detergency.

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h. Define glassy state.
0Q

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i. What is liquid crystal? Name its two types.

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j. What is surface tension and surface free energy?

2.
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SECTION B
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5.
2. Attempt any two parts of the following: 2 x 10 = 20
_Q

a. Derive Raoult’s law and discuss deviation from Raoult’s law giving example.
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17
TU

b. Explain buffer action and application of buffer in pharmaceutical and biological

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AK

system.
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c. Classify complex compounds. Discuss chelates and cyclodextrin complexes with its
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application in pharmacy.
42

SECTION C
:
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3. Attempt any five parts of the following: 7 x 5 = 35

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a. Discuss diffusion mechanism in biological system with examples.

02

b. Discuss various method of analysis of complexation.

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ar

c. What are different methods of determining surface tension? Discuss construction,

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working principle of capillary rise method.

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d. Classify surface active agents. Discuss application of surface active agents in

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pharmaceutical system.
e. How will you determine optical activity? Explain.
f. Define Nernst potential and Zeta potential. Discuss the electrical properties at the
interface.
g. What are buffered isotonic solution? Write different method of adjusting tonicity of
solution.

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B. PHARM
(SEM-III) THEORY EXAMINATION 2019-20
PHYSICAL PHARMACEUTICS-I
Time: 3 Hours Total Marks: 75
Note: 1. Attempt all Sections. If require any missing data; then choose suitably.

SECTION A

1. Attempt all questions in brief. 10 x 2 = 20

a. Enlist limitations of distribution law.
b. Define salvation and association.
c. Define real solution.
d. Define diffusion.
e. What are chelate compounds?
f. State Raoult’s Law.
g. What is vapor pressure?
h. Define HLB scale.
i. What are surface and interfacial tensions?
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j. Define Sorensen’s pH scale.

SECTION B

2. Attempt any two parts of the following: 2 x 10 = 20

a. Describe solubility of liquid in liquids.
b. Describe determination and applications of dipole moment and dissociation constant.
c. Describe classification of complexation.

SECTION C
3. Attempt any five parts of the following: 5 x 7 = 35
a. Describe pharmaceutical and biological buffers.
b. Define buffered isotonic solution. Describe methods of adjustment tonicity.
c. Discuss protein binding.
d. Explain solubilization and detergency.
e. Describe sublimation critical point and eutectic mixtures.
f. Discuss critical solution temperature and applications.
g. Write short notes on liquid crystals and glassy states.

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Printed Pages: 01 Subject Code:BP302T
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B PHARM
(SEM III) THEORY EXAMINATION 2018-19
PHYSICAL PHARMACEUTICS -I
Time: 3 Hours Total Marks: 75
Note: 1. Attempt all Sections.

SECTION A
1. Attempt all questions in brief. 10 x 2 = 20
a. Define ideal solution?
b. A solution contains 0.25 mole of solute and 0.75 mole of solvent. Calculate mole
fraction of solvent in the solution?
c. What is Charles’s law? Explain it.
d. Explain eutectic mixtures.
e. Why drop of liquid hanging in air is spherical in shape?
f. Explain the term Solubilization.
g. Define complexation.
h. What are chelate compounds and chelation?
i. What is Sorensen’s pH scale?
j. Name the two important biological buffer systems.

SECTION B
2. Attempt any two parts of the following: 2 x 10 = 20
a. Explain ideal solubility parameters. What are its applications, advantage and limitation?
Describe briefly the methods for determination of ideal solubility parameters.
b. Define crystalline solid. What are the types of crystals? Enlist and explain
characteristics of crystals.
c. Define tonicity. Differentiate between isosmotic and isotonic solutions. Describe the
methods that are used to adjust pH and tonicity.

SECTION C

3. Attempt any five parts of the following: 7 x 5 = 35

a. Define solubility. Explain mechanism of solute solvent interaction. Mention the reason
of solubility in different type of solvents.
b. Explain critical solution temperature and its applications using suitable example.
c. Differentiate between crystalline solid and amorphous solid.
d. Define adsorption. Explain the factors affecting adsorption. Mention the characteristic
features of physisorption and chemisorptions.
e. Give the statement and postulates of kinetic molecular theory of ideal gases.
f. Discuss the thermodynamic treatment of stability constants.
g. Elaborate the electrometric and colorimetric pH determination methods.

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B PHARM
(SEM-III) THEORY EXAMINATION 2020-21
PHARMACEUTICAL MICROBIOLOGY
Time: 3 Hours Total Marks: 75
Note: 1. Attempt all Sections. If require any missing data; then choose suitably.

SECTION A

1. Attempt all questions in brief. 10 x 2 = 20

a. Differentiate between Pharmaceutical and Medical Microbiology.
b. Give the difference between Prokaryotic and Eukaryotic cell.
c. How will you define cell culture?
d. Write any four names of equipments for sterilization.
e. Give the contribution of Louis Pasteur in the field of Microbiology.
f. Enlist types of Microscopy.
g. Define Mechanical Sterilization with example.

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h. Give the difference between bacteriostatic and bactericidal.
0Q
i. Enumerate the sources of contamination in aseptic area.

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29

j. What is microbial spoilage?

2.
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SECTION B

5.
_Q

.5
2. Attempt any two parts of the following: 17 2 x 10 = 20
TU

a. Give the morphological classification of bacteria with suitable examples and diagram.
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AK

b. Write the mechanism, procedure and advantages of gram staining technique.

0

c. Discuss the applications of cell culture in pharmaceuticals and research.

:1
07
:

SECTION C
14

3. Attempt any five parts of the following: 7 x 5 = 35

1
02

a. Describe the bacterial growth curve with all phases.

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b. Discuss the methods for prevention of contamination in aseptic area.

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c. Give the principle, working and application of moist heat sterilizer.

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d. What are the factors influencing disinfection?

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e. Discuss the factors affecting microbial spoilage of pharmaceutical products.

f. Describe different types of sterility indicators for evaluation of sterilization.
g. How to preserve pharmaceutical products with the help of antimicrobial agent?

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B. PHARM
(SEM-III) THEORY EXAMINATION 2019-20
PHARMACEUTICAL MICROBIOLOGY
Time: 3 Hours Total Marks: 75
Note: 1. Attempt all Sections. If require any missing data; then choose suitably.

SECTION A

1. Attempt all questions in brief. 10 x 2 = 20

a. Define antiseptic and disinfectant.
b. Differentiate microbial spoilage of pharmaceutical product.
c. Define microbial assay with two examples.
d. What is disinfectant with two examples?
e. Enlist the different staining technique.
f. Differentiate bactericidal & bacteriostatic.
g. Define aseptic area.
h. Define microbial contamination.
i. Write application of cell culture.
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j. What is difference between yeast & moulds

SECTION B

2. Attempt any two parts of the following: 2 x 10 = 20

a. Write in detail about scope and application of pharmaceutical microbiology.
b. Write classification and mode of action of disinfectant.
c. Write principle, procedure & application of Ziehl Neelson staining.

SECTION C
3. Attempt any five parts of the following: 5 x 7 = 35
a. Explain ultra structure and morphological classification of bacteria.
b. Write principle, application, advantages and disadvantages of phase contract
microscopy.
c. Explain microbial assay of erythromycin.
d. Differentiate moist heat and dry heat sterilization.
e. Explain different source of contamination an aseptic area and method of prevention.
f. Explain cell cultures in pharmaceutical industry and research.
g. Describe the concept and design of clean and aseptic area.

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Printed Pages: 01 Sub Code: BP303T
Paper Id: 150303 Roll No.

B PHARM
(SEM III) THEORY EXAMINATION 2018-19
PHARMACEUTICAL MICROBIOLOGY
Time: 3 Hours Total Marks: 75
Note: Attempt all Sections.

SECTION A

1. Attempt all questions in brief. 10 x 2 = 20

a. Differentiate between Prokaryotes and Eukaryotes in two main aspects.
b. What is contribution of Alexander Flemming in Microbiology?
c. How will you define Pasteurization?
d. What do you understand by aseptic and clean area?
e. Draw a neat labeled diagram of a bacterial cell.
f. What is the difference between Yeast and Mould?
g. Enlist the vegetative modes of reproduction in Fungi.
h. Define Sterilization.
i. What do you understand by IMViC?
j. Enlist different types of phenol Coefficient tests.

SECTION B

2. Attempt any two parts of the following: 2 x 10 = 20

a. Enumerate the parameters required for designing of Aseptic area.
b. Describe the method for microbial standardization of Vitamin B 12 or streptomycin.
c. Discuss various types of animal cell cultures and write the procedure for isolation of
cells for in-vitro culture.

SECTION C
3. Attempt any five parts of the following: 7 x 5 = 35
a. Describe various factors affecting bacterial growth.
b. Explain the reproductive cycles of Virus.
c. Differentiate between dry and moist heat sterilization.
d. Write principle, procedure and applications of Ziehl-Neelson staining.
e. What are the various air flow patterns in laminar flow equipments?
f. Write principle, applications, advantages and disadvantages of Phase contrast
microscopy.
g. Elaborate various factors affecting microbial spoilage.

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Subject Code: BP304T
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B. PHARM.
(SEM: III) THEORY EXAMINATION 2020-21
PHARMACEUTICAL ENGINEERING
Time: 3 Hours Total Marks: 75
Note: 1. Attempt all Sections. If require any missing data; then choose suitably.

SECTION A
1. Attempt all questions in brief. 10 x 2 = 20
a. What is the significance of Reynold’s Number?
b. Define the terms Attrition & Impact?
c. Name any 2 mechanisms of Size Separation.
d. State and express Fourier’s Law of heat transmission with equation.
e. How evaporation differs from drying and distillation?
f. What do you understand by Molecular Distillation?
g. What do you mean by Eutectic Point?

P
h. Differentiate between Mixing & Blending with examples.0Q

1
i. How will you write Poiseuille’s and Darcy’s equation for theory of filtration?

13
29

j. What are Ferrous and Non-ferrous metals? Give 2 examples each.

2.
0E

24
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SECTION B

5.
_Q

.5
2. Attempt any two parts of the following: 17 2 x 10 = 20
TU

a. Give a neat sketch of two fluid manometers. Explain the construction and working principle of
|1

Simple Manometer,
AK

b. Describe principle, construction & working of Triple Effect Evaporator? What do you mean by
7

economy of multiple effect evaporators? Explain.

:5

c. Discuss in details about the principle, construction, working and uses of Freeze Dryer.
: 40
13

SECTION C
1

3. Attempt any five parts of the following: 7 x 5 = 35

02

a. What do you understand by Size Reduction? Describe the principle, construction, working and
-2

uses of Ball Mill.

ar

b. Define the term Distillation. Discuss about the principle, construction, working and uses of
M

Steam Distillation.
3-

c. Distinguish between Solid Mixing & Liquid Mixing. Add a note on the mechanisms of solid
mixing and liquid mixing.
|1

d. What are the factors influencing filtration? Explain the principle and working of Drum Filter
with the help of suitable diagram.
e. Classify Evaporators. What are the factors influencing evaporation? Discuss.
f. Describe the principle, construction working and uses of Non-Perforated Basket Centrifuge
g. What is Corrosion? Name the various types of corrosion. How can corrosion be prevented?

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AKTU_QP20E290QP | 13-Mar-2021 13:40:57 | 117.55.242.131
 Printed Page 1 of 1 Sub Code:BP304T
Paper Id: 150304 Roll No: 0 0 0 0 0 0 0 0 0 0 0 0 0

B. PHARM
(SEM-III) THEORY EXAMINATION 2019-20
PHARMACEUTICAL ENGINEERING
Time: 3 Hours Total Marks: 75
Note: 1. Attempt all Sections. If require any missing data; then choose suitably.

SECTION A
1. Attempt all questions in brief. 10 x 2 = 20
a. Differentiate between Fluid Statics & Fluid Dynamics.
b. Define Attrition & Impact?
c. What is the difference between Sedimentation & Elutriation?
d. State and express Fourier’s Law of heat transmission with equation.
e. How evaporation differs from drying and distillation?
f. Write the principle of Steam Distillation.
g. What do you mean by Sublimation?
h. Differentiate between Mixing & Blending. What do you understand by dead spot in solid
mixing?
i. Express the mechanisms of Impingement & Entanglement.
j. What is meant by under-driven and over-driven assembly? Give examples also.
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SECTION B
2. Attempt any two parts of the following: 2 x 10 = 20
a. State and derive Bernoulli’s equation.
b. What do you understand by Multiple Effect Evaporator? Describe construction & working of
triple effect evaporator? Add a note on economy of multiple effect evaporators.
c. Explain with the help of diagram the principle, working and applications of Flash Distillation.

SECTION C
3. Attempt any five parts of the following: 5 x 7 = 35
a. Describe Reynolds’s experiment elucidating different types of flow patterns.
b. Draw a neat and labeled diagram of a Shell & Tube Heat Exchanger and explain its
construction and working.
c. Describe the principle, construction, working and uses of Fluidized Bed Dryer.
d. Describe the principle, construction working and uses of Twin Shell Blender.
e. Explain theories of filtration. Add a note on objectives of filtration.
f. Describe the principle, construction working and uses of Perforated Basket Centrifuge.
g. Write a note on different types of Stainless Steel, its composition and its uses.

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Printed Pages:02 Sub Code: BP304T
Paper Id: 150304 Roll No.

B PHARM
(SEM-III) THEORY EXAMINATION 2018-19
PHARMACEUTICAL ENGINEERING
Time: 3 Hours Total Marks: 75
Note: 1. Attempt all Sections.
SECTION A

1. Attempt all questions in brief. 10 x 2 = 20

a. Why there is a need for size separation?
b. What is boundary layer?
c. Give some real examples for heat transfer process (conduction, convection & radiation)
d. What is the relation among boiling point, vapor pressure & evaporation?
e. Differentiate between surface filtration and depth filtration.
f. Which equipment is suitable for filtration of slurry containing high solid content and
why?
g. Write the principle of vacuum dryer.
h. Mention equipment suitable for semisolid mixing.
i. What is molecular distillation?
j. Give the properties of Chromium and Nickel.

SECTION B

2. Attempt any twoparts of the following: 2 x 10 = 20

a. Write in detail about factors influencing rate of filtration.
b. Write the applications of filtration, size reduction, mixing and distillation in pharma.

c. Elaborate the factors influencing evaporation rate. Write the principle, construction,
working and advantages of forced circulation evaporators.

SECTION C
3. Attempt any fiveparts of the following: 7 x 5 = 35
a. Write construction and working of Orifice meter and Rotometer.
b. Write the principle, construction, working, uses, merits and demerits of Ball mill.
c. What the principle of simple distillation. Write in detail about steam distillation.
d. Write the principle, construction, working, uses, merits and demerits of sigma blade
mixer.
e. Write the principle, construction, working, uses, merits and demerits of Spray dryer.
f. Write in detail about the factors affecting selection of a material.
g. What is corrosion? Write in detail about the theory of corrosion.

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