OURLADYOFFATI MAUNI VERSITY ofCy t

ot oxi cTcel lsandv irusi nf ectedcel l?

Col
legeofMedi calLabor
atorySci
ence A. CTLat tachest ot heMHCcl assImol ecul eandCD8ser ves
Medi
calTechnologyAssessmentProgram ascor ecept or
Virology–Quiz8 B. CTLi sact ivat edbyCD4+Thel percel lsandcy tokines
C. CTLr eleasesper for insandgr anzy mest ol ysev i
rus
Gener
alInst
ruct
ion:Selectt
hebestorcorr
ectanswerto i
nf ect edcel ls
eachoft hequest i
onsbelow.Inyourbubblecard, D. Noneoft hese
shadethecircl
ethatcor
respondst
othelet
terofy
our 10.Whi choft hef ollowi ngar er easonsf orhowv irusesi sabl e
choi
ce toev adet hei mmunesy st em?
A. Vi rusescaneasi lymut atemaki ngt hem ant i
geni cal l
y
1. Sel ectt he st atementt hati s correct concerni ng the unr ecogni zabl ebyant ibodi es
i
nf luenzav i
ruses B. Vi rusescanent eral atencyper iodi nwhi chi tcanper si
st
A. humansar etheonl yani mal hostforinfl
uenzavir
uses fory ear sunr ecogni zedbyt hei mmunesy stem
B. pandemi csar echar acteri
sticall
yproducedbyinfl
uenzaA C. Vi rusescansuppr esst hei mmunesy stem by
C. thei ncidenceofi nfectionpeaksi nthesummermont hs downr egul at ingexpr essi onofMHCcl assImol ecules
D. theyar eDNAv i
ruses D. Onl yAandBonl yar ecor r ect
2. Whi choft hef ollowi ngmaybeassoci atedwithr ubell
a E. Al l oft hesear ecor rect
virus? 11.I nter feronsdef endsourbodyagai nstv iral i
nf ectionsby …
A. ADNAv ir
us A. Enhancest heact iv ityofNKcel ls
B. amemberoft hesamet axonomi cfami l
yasmeasl esv ir
us B. Tr anscr i
pt ssev er al geneswhi chcodesf orant i
vi
ral acti
vit
y
C. abl et opr oducedef ectsinf etusesdur i
ngtheearl
yst ages C. Act ivat esNKcel lsf oropsoni zat i
on
ofpr egnancy D. Onl yAandBar ecor rect
D. transmi t
tedbyanar thropodv ector E. Al l oft hesear ecor r
ect
3. Oppor tunisti
cdi seasest hatar ecloselyassoci
at edwi th 12.Ant ibodi esdef endsourbodyagai nstv iral i
nfect i
ons
AIDSi ncludeal lofthef ollowingexcept by …
A. Act ingasopsoni nst of acili
tatephagocy t
osis
A. Cr
ypt
ococcosi
s B. Act ivat est hecompl ementpat hwayt oinduce
ly sis
B. Cr
ypt
ospor
idi
osi
s C. I nducesoxi dat ivebur stwi thinaphagosome
D. Onl yAandBar ecor rect
C. Mal
ari
a E. Al l oft hesear ecor r
ect
13.Whi choft hef ol lowi nghasbeendecl ar eder adi cat
ed
D. My
cobact
eri
osi
s byt heWor l
dHeal thOr gani zation?
A.Smal l
pox
4. Whichofthef
oll
owingi
sapr
ogr
essi
veneur
ologi
cdi
sor
der B.HumanTcel l l
y mphot ropi cv i
rus
associ
atedwi
thpri
ons? C.Hepat itisGv irus
D.East er nequi neencephal iti
s
A. Cr
eut
zfel
d-Jakobdi
sease 14.Themol ecul arr ecept oroft hev i
ruscausi ngacqui red
immunedef i
ci encysy ndr omei s
B. Dengue A.CD4
B.CDS
C. Hepat
it
isC C.Fcr ecept or
D.Compl ementr ecept or
D. Shi
ngl
es 15.Thi sv irusbel ongst ot hef ami l
yoff lav i
v i
rusesandi t
s
reservoiri sst rictlyhuman.Tr ansmi ssioni sbl ood- bor nesot he
5. Vir
useshavebeensuccessful
lydet
ect
edbyt
heuseofal
l
bloodsuppl yi sr out i
nel yscr eenedf ort hisv irus.
ofthef
oll
owingtechni
quesexcept
A.Hepat itisA
B.Hepat iti
sB
A. CPE
C.Hepat itisC
D.Hepat itisD
B. ELI
SA
E.Hepat iti
sE
C. I
F 16.Thi shepat iti
sv irusi sacal ici
v irus.Ther eser v oirisi npigs,
andhumansacqui rei tv iat hef ecal -or alrout e.
D. gr
owt
honsel
ect
ivemedi
a A.Hepat itisA
B.Hepat iti
sB
6. Alphav i
rus causes whi ch one of the f
oll
owi
ng v
iral C.Hepat itisC
di
seases? D.Hepat itisD
A. Mar burgvirusdisease E.Hepat iti
sE
B. St.Louisencephal i
ti
s 17.Recent l
yappear ingi nt heUni tedSt ates, thi sv irusi scarri
ed
C. West ernequineencephalit
is bybirds,t ransmi ttedbymosqui t
oes,andi nf ect shumansand
D. Dengue horses.
E. Yell
owf ev
er A.Humanpapi llomav irus
7. Aclinicaltestusedforthedetect
ionand B.WestNi lev i
r us
C.Tick-bor neencephal itisv irus
i
dent
if
icat
ionofv
iral
inf
ect
ionsot
hert
han D.Pol yomav irus
E.SSPE
cul
tur
eis: 18.Thi sv i
rusi sasi ngl e- strandedRNAor thomy xov ir
us.Annual
vaccinat ioni snecessar ybecauseofant igeni cdr i
ftandshi ft.
A.Hemaggl
uti
nat
ion A.Measl esv irus
B.Infl
uenzav irus
B.Hemadsor
pti
on C.Respi r ator ysy ncy t i
al virus
D.Par ainf l
uenzav i
rus
C.Vi
ral
ant
igendet
ect
ion E.Adenov ir
us
19.Thi si sapar amy xov i
rusandcausest hesy ndr omeknown
D.Alloftheseopt i
ons ascroup.
8. Whicht echniqueisusedf ortheconfi
rmationofinf
ecti
on A.Measl esv irus
wit
hhumani mmunodefi
ciencyvi
rus(
HIV-1)? B.Infl
uenzav irus
A.West ernblot(i
mmunobl ot
)assay C.Respi r ator ysy ncy t i
al virus
B.Enzyme- l
inkedimmunosorbentassay(ELISA) D.Par ainf l
uenzav i
rus
C.Compl ementf i
xati
on E.Adenov ir
us
D.p24Ant igentesti
ng 20.Whi chv irusi st hemostcommonet iologi calagentofv i
ral
9. Whichoft hef ol
l
owingdoesnotoccurinthei nt
eract
ions respi
rat or ydi seasesi ni nf ant sandchi ldren?
 A.Respi
ratorysyncyt
ial
vir
us(
RSV) C.PRNT
B.Measlesv i
rus
C.CoxsackieAv i
rus D.Bot
hAandBar
ecor
rect

D.Cox sacki eBv i

rus E.Al
loft
hesear
ecorr
ect
21.Achi ldpr esent edwi thhi ghgr adef everandchi ll
s.Hisski
n 34.Whi choft hefol
l
owingis/
areseeni
nChi
kunguny
a
hasnot i
ceabl er asheswi thpr edomi nanceont hefaceand i
nfecti
on?
scalp. A. Leukocytopenia
a.monkey pox
b.smal l
pox B. Ly
mphopeni
a
c.chickenpox
d.cowpox C. Thr
ombocy
topeni
a
22.Oneoft hemostcommonsexual l
yt ransmi tt
eddi seases
thatmayl eadt ocer vical car cinomai scausedbywhi chofthe D. BandCar
ecor
rect
foll
owi ngv iruses?
a.Cy tomegal ov i
rus E. All
ofthesearecorr
ect
b.Papi ll
omav irus 35.Whichoft hef
ollowingtestf
orZikavi
ruscandetet
ct
c.Epst ein- Bar rv i
rus thepresenceofv i
rus-speci
fi
cneut
rali
zi
ngantibodi
esin
d.Her pessi mpl exv i
rus pai
redserum sampl
es
23.Subst ancest hati nducei nterfer onr eleaseexcept : A.MACELI SA
a.virus
b.bact er i
a B.I
mmunohi
stochemi
cal
stai
ning
c.Either
d.Nei ther C.PRNT
24.Whi chi smor esuper iorinv i
ral hostdef ense
a.Tl ymphocy tes D.r
RT-
PCR
b.Bl ymphocy tes
c.Either E.All
ofthesearecorrect
d.Nei ther 36.Inthedetecti
onofZi kavir
ususi
ngrRT-
PCR,whati s
25.Thef ollowi ngor gani smsar et ransmi ttedindirectl
yexcept: thesampleofchoi ceifpat
ient
sar he10th dayaf
eatt ter
a.HSV theonsetofi
ll
ness?
b.HAV A. Serum
c.HBV
B. Ur
ine
d.Noneoft heabov e
26.Al lar et rueofRNAv irusesex cept :
C. Fi
xedTi
ssue
a.Areenv el oped
b.Hav ehel ical capsi ds
D. Allofthesear ecor r
ect
c.Either
37.Int hedi agnost ical gor it
hm f orFl avi
vir
uses,ifIgM is
d.Nei ther
positi
vewhatt estshoul dbedonet oconf ir
mt hediagnosis
27.Non- speci fi
ci mmunedef enseexcept :
i
nser um sampl escol lect edmor et han7day sf rom the
a.changesi npH
onsetofi l
lness?
b.phagocy tosi s
A. PRNT
c.Either
B. IgGELISA
d.Nei ther
C. RT-PCR
28.Mul tipleor gansar ei nfect edt her eis:
D. Allofthesear ecor r
ect
a.local i
zedi nfect ion
E. OnlyAandBar ecor rect
b.gener alizedi nfect ion
38.I n diagnosi s ofMar burgi nfect i
on,whi ch oft he
c.Either
fol
lowing t est i s r ecommended f or post mor t
em
d.Nei ther
examinat i
onofbl ood?
29.Wheni st her ightt i
met ogi v
et heseconddoseofHepat it
is
A. I mmunohi st ochemi stry
Bv acci ne?
B. PCR
a.Bef ore2mont hs
C. Vi ral cul t
ur e
b.Aft er2mont h
D. Bot hAandBar ecor rect
c.Bef ore1mont h
E. Al l oft hesear ecorrect
d.Aft er1mont h
39.Buny av i
ri
dae i s compr i
sed of3 ssRNA segment s
30Thi sist hel argestknownv i
rus:
knownas
a.Picor nav irus
A. S, L, M
b.Smal l
poxv irus
B. A, B, C
c.HSV
C. A, C, E
d.CMV
D. M, N, O
31.HBsAgnegat ive, anti-HBc( t
otal )negat ive,Anti-
HBsposi t
ive.
40.Whi choft hef ollowi ngi s/arev ectorofCr i
meanCongo
Theser esul tsar ei ndi cat i
v eof :
haemor rhagicf ev er
a.pasti nf ect i
onwi thHepat iti
sBi nf ection
A. Aedes
b.suscept iblet oHepat i
tisBi nfect ion
B. Cl uex
c.hasHepat iti
sBv acci nat i
on
C. I xodes
d.NOTA
D. Anophel es
32.Whi choft hef ollowi ngt estcandi stingui shbet ween
E. Der macent or
pr i
mar yandsecondar yDenguev irusi nfecti
on?
41.Whi choft hef ol
lowi ngv i
rusescancausehemor r
hagic
A. MACELI SA
feverwithr enal sy ndrome( HFRS) ?
A. Dobr ava
B. I
gGELI
SA
B. Seoul v i
rus
C. Andes
C. PRNT
D. Al l oft hese
D. Bot
hAandBar
ecor
rect E. AandBonl y
42.Thef oll
owi ng ar eassoci ated wi th South Amer i
can
E. Alloft
hesearecorrect hemor rhagicfev er sexcept
33.Thisassayi sthemostspeci f
icserol
ogi
calt
oolfort
he A. Juni nhemor rhagicf ever
deter
minat
ionofdengueant i
bodi
es,i
tisusedt
odeter
minet
he B. Guanar i
tov irus
i
nfecti
ngseroty
peinconval
escentsera C. Lassaf ev er
A.MACELI SA D. Sabi av i
rus
B.IgGELISA E. AandBonl y
43.Whi choft hef oll
owi ngt y
pesofEbol aisconsideredto
 behighl yv i
rul entt ohumans?
A. Tai for est
B. Bundi bugy o
C. Rest on
D. Zai re
44.Whi choft hef ollowi ngt y pesofEbol ai sconsi deredto
beoflowpat hogeni cityt ohumans?
A. Tai for est
B. Bundi bugy o
C. Rest on
D. Zai re
E. Bi rds
45.Acl ini cal speci meni sr eceiv edi nv ir
al tr
anspor t
medi um f orv iral isolat i
on.Thespeci mencannotbe
processedf or72hour s.Atwhatt emper at ureshoul di
t
best or ed?
A.-70° C
B.-20° C
C.4° C
D.22° C
46.Ay oungmanhasr etur nedf rom ashor ttriptoMexi co
wherehewasbi ttenbyadog.Ei ghtweeksaf terreturning
hedev elopedexcessi vesal i
v at
ion, av ersiont odr inki
ng
water,andhal luci nat ionsanddi edi ncar diacar rest.Whi ch
ofthef oll
owi ngmeasur esmi ghthav epr ev entedt his
deathifi mpl ement eduponhi sret urn?
A.Int erleuki n2i nf usions
B.Acy clov i
rpr ophy l
axi s
C.Speci ficv acci neadmi ni
stration
D.Gammagl obul int her apy
E.Ci prof loxaci npr ophy laxis
47.Whi choneoff ollowi ngcont ainsl ipidi nitsv i
rion?
A.Adenov irus
B.Par vov irus
C.Pi cor nav i
rus
D.Par vov irus
E.Ret rov irus
48.A30- year -ol dmanhashadf ev erandasor et hroatfor
aweek.Onexami nat ionhehasbi later alcer vi
cal
l
ymphadenopat hy .Whi choft hef oll
owi ngisl eastl i
kelyto
causet hesecl inical findi ngs?
A.Epst ein- Bar rv irus
B.Var i
cel la-zost erv irus
C.Coxsacki eAv irus
D.Adenov irus
E.Par ainf l
uenzav i
rus
49.BONUSShadeE
50.BONUSShadeE