Open Access Maced J Med Sci electronic publication ahead of print,

published on August 15, 2018 as https://doi.org/10.3889/oamjms.2018.300

ID Design Press, Skopje, Republic of Macedonia

Open Access Macedonian Journal of Medical Sciences.
https://doi.org/10.3889/oamjms.2018.300
eISSN: 1857-9655
Dental Science

Prescription of Antibiotics for Periodontal Disease among

Dentists in the Region of Tirana

1* 2
Besian Abazi , Joana Mihani

1 2
Albanian University, Faculty of Medical Sciences, Department of Dentistry, Tirana, Albania; University of Medicine Tirana,
Department of Pharmacy, Tirana, Albania

Abstract
Citation: Abazi B, Mihani J. Prescription of Antibiotics for BACKGROUND: Periodontal disease has been and will be a challenge for dentists in the entirety of oral
Periodontal Disease among Dentists in the Region of
Tirana. Open Access Maced J Med Sci.
pathologies. To date, there is no data regarding the prescription of antibiotics for periodontitis in the district of
https://doi.org/10.3889/oamjms.2018.300 Tirana.
Keywords: Antibiotics; Dental prescriptions; Periodontitis
AIM: Evaluate aspects related to the pattern of prescription of antibiotics among dentists in Tirana region for
*Correspondence: Besian Abazi. Albanian University,
Faculty of Medical Sciences, Department of Dentistry, periodontitis.
Tirana, Albania. E-mail: [email protected]
Received: 10-Apr-2018; Revised: 07-Jun-2018; METHODS: Prescriptions from dental practitioners were collected from 25 pharmacies, randomly selected. The
Accepted: 04-Jul-2018; Online first: 15-Aug-2018 only prescription containing a diagnosis of periodontitis, with at least one antibiotic given, was included in the
Copyright: © 2018 Besian Abazi, Joana Mihani. This is study. Data analysis was done with SPSS 20.
an open-access article distributed under the terms of the
Creative Commons Attribution-NonCommercial 4.0 RESULTS: Out of 1159 initial prescriptions, only 314 met the selection criteria. The average age of patients was
International License (CC BY-NC 4.0)
39.91 ± 15.21 years. Mean duration of therapies was 5.57 ± 1.5 days. The most common form of prescription was
Funding: This research did not receive any financial
support one broad-spectrum antibiotic (74.5%), combined antibiotics therapy (22.3%) and narrow-spectrum antibiotic
Competing Interests: The authors have declared that no
(3.2%). Combined antibiotics involved the use of Metronidazole with Amoxicillin (12.1%) and Metronidazole with
competing interests exist Spiramycin (10.2%). Significant differences in the patterns of prescription were identified in relation with patient
age and therapy duration (P < 0.05). No statistical difference was found in the patient’s gender and the typology of
the therapy (P > 0.05).

CONCLUSIONS: Our study shows prescription characteristics of antibiotics for periodontal disease by dentists in
Tirana for the first time. Amoxycillin is the most prescribed antibiotic, followed by amoxicillin with clavulanic acid.
We found variation in dosage, frequency and duration for all antibiotics used, and perceptible discrepancies
between observed and recommended practice. Guidelines on rational antibiotic use are needed for dental
practitioners in Tirana and the Republic of Albania for better management of periodontitis and resistance
prevention.

Introduction nucleatum) and Prevotella intermedia (P. intermedia),

[2] [3] [4]. P. gingivalis is considered as the main
cause of chronic periodontitis, though no less
Periodontitis is an inflammatory disease which important is the A.a., which is recognised as the
affects the supporting tissues of the tooth. It leading cause of aggressive periodontitis [2] [5] [6].
constitutes one of the most frequent bacterial infection Difficulties faced by periodontists lie in the fact that the
in adults. There are hundreds of bacterial species restoration of normality for the periodontal tissues
associated with this disease, thus making it difficult to becomes difficult with time. If left untreated, it can
achieve a successful specific therapy for periodontitis progress into an irreversible situation [7]. There are
[1]. Among these the most relevant are some procedures and protocols aimed to prevent the
Aggregatibacter actinomycetemcomitans (A.a.), progression of the lesion, maintain current levels of
Porphyromonas gingivalis (P. gingivalis), Treponema periodontal tissues and restore periodontal health. To
denticola (T. denticola), Fusobacterium nucleatum (F. succeed in these procedures, in addition to manual
curettage and periodontal surgery, systemic antibiotic
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therapy is a key factor [8] [9] [10] [11]. Strong therapies (CT) consisting in a broad-spectrum
evidence exists to support benefits of manual antibiotic and a narrow-spectrum antibiotic and (c)
curettage to remove supra and subgingival plaque. 3.2% narrow-spectrum antibiotic (NSA) (Table 2).
Hence, without the use of antibiotics, this procedure is
unable to eradicate pathogenic bacterial species and Table 2: Frequency of type of antibiotic therapies
thus to maintain gingival levels of adhesion [8] [12] The pattern of antibiotic prescription Value %
Broad spectrum 234 74.5
[13]. To support such procedures, except Broad and narrow spectrum combination 70 22.3
monotherapy with antibiotics, dental practitioners use Narrow spectrum 10 3.2

a combination of antibiotics known as a combined

therapy or dual antibiotic therapy [14] [15] [16].
Among 234 BSA prescriptions, Amoxicillin is
To the best of our knowledge, to date, there is the most prescribed drug (32,5%), followed by
no data regarding the prescription of antibiotics for Amoxicillin-Clavulanic Acid (22%) and Spiramycin
periodontitis in the region of Tirana. (12.7%). Instead, Erythromycin (4.1%), Azithromycin
(1.6%) and Ciprofloxacin (1.6%) are less prescribed
drugs. CT involved the use of Amoxicillin with
Metronidazole (12.1%) and Spiramycin with
Materials and Methods Metronidazole (10.2%). Regarding the use of NSA,
only Metronidazole was prescribed (Table 3).

Table 3: Percentage of antibiotic prescription and

This retrospective drug utilisation study was characteristics of therapy duration
conducted over a period of 3 months, March-June
Therapy duration (days)
2016. It involved prescriptions collected from 25 Antibiotic
% Mean Maximum Minimum Mode
randomly selected pharmacies in the region of Tirana. Broad spectrum
Amoxycillin 32.5 5 7 3 5
We collected prescriptions dispensed by dentists and Amoxycillin with Clavulanic Acid 22 5 7 3 5
Spiramycin 12.7 5 7 3 5
selection criteria included prescriptions: (a) limited and Erythromycin 4.1 5 6 3 5
only for periodontitis in patients ≥18 years old; and (b) Ciprofloxacin
Azithromycin
1.6
1.6
5
5
7
5
4
5
4
5
with at least one antibiotic prescribed. Prescriptions Mixed spectrum
Metronidazole+Amoxycillin
with other systemic drugs or local medications were w/Clavulanic Acid
12.1 7 10 6 7

excluded from the study. Metronidazole+Spiramycin

Narrow spectrum
10.2 8 10 5 7

Metronidazole 3.2 6 7 6 6
Collected data were analysed using the
statistical software SPSS 20 (IBM, USA). Differences
between patterns of prescription, patient's age, gender
One-way ANOVA test indicated the
and treatment duration were compared using One-
statistically significant difference between the three
way ANOVA and Chi-square tests. P-values < 0.05
typologies of antibiotic therapy prescribed, patient's
were considered statistically significant.
age and treatment duration (Table 4).

Table 4: One Way ANOVA test results for patients age and
treatment duration about the type of therapy

Results Sum of
Squares
df Mean Square F Sig.
Age 3106.280 2 1553.140 6.962 0.001
Treatment
399.900 2 199.950 201.206 0.000
duration
From 1159 collected prescriptions, only 314
met the selection criteria. The gender ratio was 1:1.12
consisting of 148 Males (47.1%) and 166 Females Post Hoc test demonstrated that the single
(52.9%). The average age was 39.91 ± 15.21years BSA therapy and CT do not show significant
(18-81). Mean duration of therapies was 5.57 ± 1.5 differences in mean patients age, while NS therapy
days (3-10) (Table 1). presented significant difference compared with both
therapies (Table 5).
Table 1: Age and therapy duration variables parameters
Table 5: Multiple comparisons where the dependent variable is
Age of patients Duration of therapy patient age
Mean 39.91 5.57 95% Confidence
Median 36.00 5.00 Mean
(I) Antibiotic Std. Interval
Mode 25 5 (J) Antibiotic type Differenc Sig.
type Error Lower Upper
Standard deviation 15.21 1.50 e (I-J)
Bound Bound
Minimum 18 3 Broad Combined therapy 1.469 2.035 .751 -3.32 6.26
Maximum 81 10 spectrum
Metronidazole 17.912* 4.823 .001 6.55 29.27
antibiotic
Combined Broad spectrum antibiotic -1.469 2.035 .751 -6.26 3.32
therapy Metronidazole 16.443* 5.049 .004 4.55 28.33
Three patterns of antibiotic prescription were Narrow Broad spectrum antibiotic -17.912* 4.823 .001 -29.27 -6.55
observed: (a) 74.5% single therapies with a broad- spectrum
Combined therapy -16.443* 5.049 .004 -28.33 -4.55
antibiotic
spectrum antibiotic (BSA), (b) 22.3% combined
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 Abazi et al. Prescription of Antibiotics for Periodontal Disease among Dentists
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No statistical difference was found in the

Data shows that NSA like Metronidazole patient’s gender and the typology of the therapy (P >
tends to be prescribed to younger patients with a 0.05).
mean age of 23 years (Figure 1).

Discussion

This study shows that dentists in the Tirana

region tend to prescribe BSA in 74.5% of cases.
Amoxicillin alone and its combination with Clavulanic
acid are prescribed in more than half of cases
(54.5%). Amoxicillin is found to be useful in the
management of patients with aggressive periodontitis,
in both localised and generalised forms [17] [18]. Also,
its combination with Clavulanate potassium shows to
incline bacterial resistance. Also, Spiramycin is
Figure 1: Mean patients age frequently used. In 12.7% of prescription, it is used
alone for the management of periodontal disease.
Spiramycin has shown promising results in the
Furthermore, Post Hoc test showed the treatment of advanced forms of periodontitis, and as
statistically significant difference between all three an adjunct to thorough scaling and root planning,
types of antibiotic therapies regarding the duration of provides a statistically significant improvement in
therapies (Table 6). probing depths for up to 24 weeks when compared
with scaling and root planing alone. Furthermore, it
Table 6: Multiple comparisons where the dependent variable is produces a significant improvement in attachment
therapy duration level [18] [19] [20] [21].
95% Confidence
(I) Antibiotic
Mean
Std. Interval On the other hand, NSA alone, such as
(J) Antibiotic type Differenc Sig.
type
e (I-J)
Error Lower Upper Metronidazole remains a non-primary choice for the
Bound Bound
Broad Combined therapy -2.705* 0.136 0.000 -3.03 -2.39 pharmacological treatment of periodontal disease,
spectrum with only 3.2% of prescriptions. Although, the
Metronidazole -1.377* 0.322 0.000 -2.14 -0.62
antibiotic
Combined
Broad spectrum
2.705 *
0.136 0.000 2.39 3.03 literature shows that Metronidazole has a prominent
antibiotic
therapy
Metronidazole 1.329* 0.337 0.000 .53 2.12 effect on periodontitis, yet there is scepticism among
Narrow Broad spectrum dentists who are reluctant to prescribe it. However,
1.377* 0.322 0.000 .62 2.14
spectrum antibiotic
antibiotic Combined therapy -1.329* 0.337 0.000 -2.12 -0.53 Metronidazole alone it’s not the drug of choice for
treating A.a. infections. Instead, it’s a combination with
The single broad-spectrum antibiotic regime other antibiotics shows to be effective against these
has a mean duration of 4.92 days while Metronidazole bacteria [22] [23]. Also, it is effective against
therapy for 5 days. Dual therapy has the longest anaerobes such as P. gingivalis and P. intermedia
regimen, with a mean of 7.63 days (Figure 2). [24]. Studies have suggested that Metronidazole
combined with Amoxicillin or Amoxicillin–Clavulanate
potassium, it may be with great impact in the
management of patients with aggressive periodontitis
[23] [25] [26] [27] [28]. In our study, Metronidazole
was mostly used in combination with Amoxicillin
12.1% and with Spiramycin in 10.2%. Of the cases.
Clinical research suggests that Ciprofloxacin
with Metronidazole is a powerful antibiotic
combination against mixed infections. At present,
Ciprofloxacin is the only antibiotic in periodontal
therapy to which all strains of A.a. are susceptible [29]
[30] [31] [32]. Metronidazole targets obligate
anaerobes, and Ciprofloxacin targets facultative
anaerobes. This type of therapy can be of great
benefit for the patients since periodontal infections
Figure 2: Mean therapy duration contain a wide diversity of bacteria, and this scenario
makes it mandatory to use more than one antibiotic,
either serially or in combination [33] [34] [35] [36] [37].
Nevertheless, data shows that dentists in Tirana
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region do not use this combination. Based on WHO latest report, antimicrobial
resistance poses a "global health security threat" to
The duration of the treatment shows to be a
public health [45]. Subsequently, to benefit the most
problem itself, with a mean of 5.57 ± 1.5 days.
from these therapies, we must limit their use and
Dentists who prescribe only one antibiotic, prefer a 5-
prescribe the right dosage and duration of therapy to
days therapy. In contrast, dentists that have chosen a
prevent further resistance.
combination therapy have prescribed it for a longer
time, and this can be the case of chronic resistant In conclusion, our study shows prescription
periodontitis. Only the CT has a mean duration of 7.63 characteristics of antibiotics for periodontal disease by
days. None of the prescriptions had a prolonged dentists in Tirana for the first time. Most of the dentist
therapy for more than ten days. Therapies with BSA, in the district of Tirana, for periodontitis, prescribes
have a mean duration of 4.92 days and a therapy with only one broad-spectrum antibiotic. Amoxicillin was
NSA has a mean duration of 6.3 days. This is a short- the most preferable, followed by amoxicillin with
term therapy which may pose a risk regarding clavulanic acid. Metronidazole a narrow spectrum
antibiotic resistance rather than a successful antibiotic is prescribed more in young adults, while
treatment for the disease. This, especially in cases of combined therapies and broad-spectrum antibiotics
chronic periodontitis where the presence of tend to be prescribed with the increasing of patient’s
periodontal pathogens, specifically A.a., is known to age. We found variations in dosage and frequency for
endure in tissues after therapy and re-infect the all the antibiotics used, particularly concerning data
pocket. Thus, the use of systemic antibiotics was exists regarding the short duration of therapies
thought to be necessary to eliminate pathogenic prescribed. Perceptible discrepancies were observed
bacteria from the tissues [27]. between recommendations and practice. Therefore,
these observations highlight the need for dentists to
Interpretation of the processed data, not only
improve antibiotic prescribing practices for periodontal
does show that NSA like Metronidazole have a limited
problems. Guidelines on rational antibiotic use are
number of prescriptions, but it is more used in young
needed for dental practitioners in Tirana and in the
adults. Patients with a generalised form of the disease
Republic of Albania for a better management of
usually appear to be young, and they present
periodontitis and resistance prevention.
generalised attachment loss and poor antibody
response. Therefore, these patients often have a fair,
poor, or questionable prognosis, and they need an
effective systemic antibiotics therapy. This is in
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6 https://www.id-press.eu/mjms/index