Manual MORFOFISIOLOGIA+I SEM-02 SESIÓN-04 2023-2
Manual MORFOFISIOLOGIA+I SEM-02 SESIÓN-04 2023-2
Manual MORFOFISIOLOGIA+I SEM-02 SESIÓN-04 2023-2
!""#$$"%&'"()*"##+,
+$*-
./,/0/1234/,567820/9,:20;8<65/,9/,257/08=/:8>0,<69,:?65@2,A?3/02,60,B?0:8>0,<6,;?;,@/516;,2,;6736012;,@580:8@/96;C,?0,:?65@2,@580:8@/9D,E?6,;6,:23@206,<6,9/,:/F6=/D,
69,:?692,G,69,1520:2,H;?F<8I8<8<2,60,1>5/JD,/F<2360D,<25;2,G,@69I8;K@6580LMD,G,9/;,@/56N/;,<6,3863F52;,;?@658256;,6,80B658256;O,P2</;,9/;,@/516;,@580:8@/96;,@?6<60,
;?F<8I8<85;6,60,Q56/;,2,5678206;O,./,/0/1234/,567820/9,6;,69,3L12<2,@/5/,6;1?<8/5,9/,6;15?:1?5/,<69,257/08;32,:6015/0<2,9/,/160:8>0,60,?0/,<6165380/</,@/516,H@O,6NO,
./,:/F6=/MD,Q56/,H9/,:/5/M,2,5678>0,H25F81/58/,?,2:?9/5MD,6J/380/0<2,9/,<8;@2;8:8>0,G,9/;,569/:8206;,<6,9/;,<8I65;/;,6;15?:1?5/;,;8;1L38:/;,H3R;:?92;D,065I82;D,/51658/;D,
61:OM,E?6,:20186060D,G,9?672,A/F81?/936016,:20,69,6;1?<82,<6,9/;,5678206;,/<G/:6016;,60,?0/,;6:?60:8/,25<60/</O,HS681A,.O,T2256,UV,W<,X/7,YMO,
W0,6;1/,;6::8>0,56I8;/5632;,12<2,92,569/:820/<2,/9,6;1?<82,<69,:?65@2,A?3/02D,36<8/016,69,?;2,<6,@9/02;,G,@2;8:8206;,:20,9/,:2556:1/,/@98:/:8>0,<6,9/;,16538029274/;,
/0/1>38:/;O,Z;4,38;32,/0/98=/5632;,9/,257/08=/:8>0,6;15?:1?5/9,G,B?0:820/9,<6,9/,5678>0,<6,9/,:/F6=/,G,:?692,<69,:?65@2,A?3/02O,
"%*#$+$""$(["\
Z9,B80/98=/5,9/,;6;8>0D,69,6;1?<8/016,6J@98:/,92;,:20:6@12;,<6,/0/1234/D,08I696;,<6,257/08=/:8>0D,@9/02;D,@2;8:8206;D,5678206;D,;6736012;D,:/I8</<6;D,16538029274/;,
/0/1>38:/;,G,9/,257/08=/:8>0,6;15?:1?5/9,G,B?0:820/9,<6,9/,:/F6=/,G,:?692,<69,:?65@2,A?3/02D,I80:?9Q0<29/;,:20,;?;,/@98:/:8206;,:9408:/;D,/,15/IL;,<69,?;2,<6,
A655/38601/;,3612<29>78:/;,@/5/,80165@561/5,9/;,:20<8:8206;,B8;82@/129>78:/;,<6,3/065/,:9/5/,G,@56:8;/O,
]"#"%$"##'+++
^_`,32<692;,/0/1>38:2;,<6,1520:2,A?3/02,
^_`,32<692;,/0/1>38:2;,<6,:/F6=/,G,:?692,
^_`,32<692;,/0/1>38:2;,<6,:/F6=/,B61/9,
^_a,6;E?69612,A?3/02,
^Z9:2A29,b_c,
]"#"%$"#"%*$"
^T/0<89,F9/0:2,
^T/;:/589/,def,
^g?/016;,
^.Q@8=,
^T/0?/9,<6,@5/:18:/,
^h?/<6502,<6,/@?016;,
0123146789 1670941
!"#$%&'( )*+*,-./0-0*12-+-345/6-12
78#$%&' 9:25/+;3<12
=>?"%@A B<12*13;0/-+3*12*CD./6-+2.-12,*E/<+*1F2D.-+<1F2D<1/6/<+*12G23*,5/+<.<EH-12-+-345/6-12;3/./I-0-12*+2*.2*13;0/<20*.26;*,D<2J;5-+<2K/+6;.L+0<.-12-2
1;2-D./6-6/4+26.H+/6-F25*0/-+3*2.-2;3/./I-6/4+20*25<0*.<12-+-345/6<1F2-+-3<5H-2K/K-2G2KH0*<1M2
'!"87$$%A'?! NMB<12*13;0/-+3*12*+2*O;/D<120*.*E-,L+2P;+6/<+*12-26-0-25/*5Q,<20*.2*O;/D<2R;+26<<,0/+-0<,F26<+3,<.-0<,20*.23/*5D<2G21*6,*3-,/<SF20*Q*+2
/+3*,6-5Q/-,2,<.*1M2T-0-2*13;0/-+3*21*EU+2*.2,<.20*.*E-0<20*1-,,<.-2.-2-63/K/0-0M2
VMW0*+3/P/6-2*+2.-12/5LE*+*1F2./Q,<12<2-D./6-3/K<12.-12,*E/<+*1F2D.-+<1F2D<1/6/<+*12G23*,5/+<.<EH-12-+-345/6-120*.26;*,D<2J;5-+<M2X<5-2+<3-2
1<Q,*2.<20*16,/3<2O;*2-G;0-,L+2*+2.-2-D./6-6/4+26.H+/6-20*2.-12*13,;63;,-12*13;0/-0-12*+2*.2P;3;,<M2
(YZ"%[%\#']A[#!^7?'"?!]?%'^A8_#$%&']?[#=%=[%A"?$#@%8"7#[`""a!bcc$%?'"%^%$#Y8?_A"?d!Y$Ac?!c7!?8e_#"?8%#[?!f'A_=8#[#!8?g%A'?!]?[$7?8aA`7_#'A
?'?[]%=7>A#]>7'"Ae?da[%$#[#%_aA8"#'$%#$[h'%$#]?$#]#7'#]??[[#!b
0123146789 1670941
!"#$%&'(&)(%)%(#%%&*'#%%&$(+%&,!&#!(&&+!&#-&#!()%.!'%/
0- 1(+%&
234564547 7
839:;43:47 7
<;:=47 7
>4?4@7 7
AB=4@7 7
CD3E=:=47 7
F9GDH:54@7 7
IJ@K:=47 7
2454@7H6GB@437 7
L0&%#M#%/NBO637G67PQ74RD?7=D5745;6=6G65;6?7G67GD@D37;:SD7=T@:=D7657@4736U:T57G6@7V:SDU4?;3:D7W36U:T57:5X63:D37G6@749GDH65YZ736X:6367V4963?674B;DH6G:=4GD7=D57
45;:5X@4H4;D3:D?7V4=67B57G[47=D57@47=B4@7=4@H47@:U634H65;6Z7S36?65;45GD75B6KD76S:?DG:D7G67G:=VD7GD@D37HD;:KD7SD376@7=B4@74=BG67476H63U65=:4\7
]0!^#(,!&(M)(%__'$(+%`#%a
]b,!)%(M_(&#.%%%(a
0123146789 1670941
!"#$%"!#$&"'!#$"!$$(&$)*($
+,!$#"-#./0123452467489:;48<052484<:=;0>?:3@:4A8384328>@B83;24A:34A3@C2384D2B40=42E8C2=4524F8A8=@<:>8:0G4
HI&J%#$K"-!"L#)!L-!!$&%!%!L!"!#)!)&$L!M#N!)O
0123146789 1670941
!"#$"%"%&&#!%'"$!"(!'")$*$%&!+,-.,/01//0234/5116+788999:;<.1.=/:4<>893145?@A,BC9DEFGH.-
IJ$K%"L'"L"%&!"(!!'!&M!*"!!!%!"&!N
IOPL!L!L'"L"%!&%!&!L!M!*"!!Q$&!N
RIJ$K%"L'"L"%&!"(!!"#$"%"L!#N
0123146789 1670941
!"#$!%
&'( )*%+,-./01%
234567 801%#1/.9,!-/#1%#:;<,=!-%<!%0>?!-,$!=,@-%#1/>.=/.>!<%A%B.-=,0-!<%9#%<!%=!"#$!%C,-=.<D-90<!1%!%1.%!;<,=!=,@-%=<E-,=!F%+#9,!-/#%<!%./,<,$!=,@-%9#%+09#<01%
!-!/@+,=01F%!-!/0+E!%C,C!%A%CE9#01G%
H('75 IG801%#1/.9,!-/#1%#-%#J.,;01%9#<#?!>D-%B.-=,0-#1%!%=!9!%+,#+">0%9#<%#J.,;0%K.-%=00>9,-!90>F%=0-/>0<!90>%9#<%/,#+;0%A%1#=>#/!>,0LF%9#"#-%
,-/#>=!+",!>%>0<#1G%!9!%#1/.9,!-/#%1#?M-%#<%>0<%9#<#?!90%9#1!>>0<!%<!%!=/,C,9!9G%
NGO9#-/,B,=!%#-%<!1%,+D?#-#1F%<,">01%0%!;<,=!/,C01%<!1%#1/>.=/.>!1%9#%<!%>#?,@-%9#%<!%=!"#$!%9#<%=.#>;0%P.+!-0G%Q0+!%-0/!%10">#%<0%9#1=>,/0%
J.#%!A.9!>D-%#-%<!%!;<,=!=,@-%=<E-,=!%9#%<!1%#1/>.=/.>!1%#1/.9,!9!1%#-%#<%B./.>0G%
%
RSTUVW7UX'55W5X7(YW5U33U756('UZ[\]]5XS(5Y75^S7]5]'5(_Y5(U5`7Y3(U7Z'57W5U35VW5U'5([7
Z'Y755UW3'47W4'7_5^[UUY[7(Ua\
%
%
%
%
%
%
%
%
%
%
%
%
%
%
%
%
%
%
%
%
%
0123146789 1670941
!"#$"%"%&&#!%
'($)*$+&,!!&%!-!&!.
'/$0*$-&0.
12"$!"3!"#$"%4"*%%5667778$%$9-,67!%-*.4:;<8=1=>+%?@8&!&#$%!5
A
'BC$)!%#D!%&!%!4".
'/$0!"9-!$!%!!%#D!.
0123146789 1670941
!"#$%!&'!()*+!(!#,-(.
/
/
012-*!)$.(&)#!%(.(!3/4444444444444444444444444444444444444444444444444444/
52$!.!)+-)!(.!&-#6
789:;/ <=>?9@;>/ A9B?CDB/ EBF8GH?CDB/
IJ)&
I.)&#!
0123146789 1670941
!"#$%
&'( )*%+,-!.$/%
012345 6$/%"/.!7,8-."/%"9:#,;8-%#8%$<=8-,>8;,?-%"/.<!;.!<8#%@%A!-;,$-8#%7"#%;!"#$%B,-;!#C-7$#8/%8%/!%8:#,;8;,?-%;#D-,;8E%+"7,8-."%#8%!.,#,>8;,?-%7"%+$7"#$/%
8-8.?+,;$/E%8-8.$+D8%B,B8%@%BD7"$/F%
G('53 HF6$/%"/.!7,8-."/%"-%"I!,:$/%7"#"=8<C-%A!-;,$-"/%8%;878%+,"+J<$%7"#%"I!,:$%K!-%;$$<7,-87$<E%;$-.<$#87$<%7"#%.,"+:$%@%/";<".8<,$LE%7"J"-%
,-."<;8+J,8<%<$#"/F%878%"/.!7,8-."%/"=M-%"#%<$#%7"#"=87$%7"/8<<$#8%#8%8;.,B,787F%
NFO7"-.,A,;8%"-%#8/%,+C="-"/E%#,J<$/%$%8:#,;8.,B$/%#8/%"/.<!;.!<8/%7"%#8%<"=,?-%7"#%;!"#$%7"#%;!"<:$%P!+8-$F%Q$+8%-$.8%/$J<"%#$%7"/;<,.$%I!"%
8@!78<C-%"-%#8%8:#,;8;,?-%;#D-,;8%7"%#8/%"/.<!;.!<8/%"/.!7,878/%"-%"#%A!.!<$F%
RSTUV3W2'X5U1(T5Y(YT3(V5W3T'3TT5
%
%
%
%
%
%
%
%
%
%
Z
0123146789 1670941
!"#$%"&'$($")%*("'&#'+
,*("' -"#$%"
.*$"(
/*0
-*$"(
1%!('
2"&)$*'$&
2"&3*)$*'$&
4!"#$%"&)*#)*0!'*5 "30)6#'"*6$''&#'+
1)*#)* -"#$%"
7*)*$#*%)$&
8"9(*
:*6$'6('
0123146789 1670941
!"#$%&'()'*+,-'.*/'*01*$2345*&()'+6'4)&7$+'()'*4'*/'4+$8$9*:;'*<,=*+$('.$*63/.>$+34*7'.&?&%$.*<,'*@$*6$%&'()'*(3*)&'('*#$.3*%$./&$%3A*
BBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB
CD!EF!GHG!IEGIJKILFMFGNKIGHK!EFKH!OG"
P
P
P
P
P
0123146789 1670941
!"#$
%&'()*+,'-'.-,/*0*12-'+-'34)52-'.*02/*/-4+-2/6*+)7*(2/-8)94*.-920/'-.29-:2+:'5,29-('-*+*,2;<*=-+)8'.'9-('-2/6*+)7*:)>+=-5.*+29=-529):)2+'9=-/'6)2+'9=-9'6;'+,29=-
:*8)(*('9=-,'/;)+2.26<*9-*+*,>;):*9-?-.*-2/6*+)7*:)>+-'9,/4:,4/*.-?-@4+:)2+*.-('-.*-:*0'7*-?-:4'.2-('.-:4'/52-A4;*+2=-8)+:4.B+(2.*9-:2+-949-*5.):*:)2+'9-:.<+):*9=-
*-,/*8C9-('.-492-('-A'//*;)'+,*9-;',2(2.>6):*9-5*/*-)+,'/5/',*/-.*9-:2+():)2+'9-@)9)25*,2.>6):*9-('-;*+'/*-:.*/*-?-5/':)9*-
DEDDF!GG#EF!HIJKLMNJMOPJQRSKT
UVW*/:<*XY2//'/2-ZV[V-&V-\4/.C-ZV-?-]'+<,'7-Y*().*-WV-[+*,2;<*-A4;*+*-^_+-̀<+'*aV-&*(/)(b-&:W/*cX\).-_95*d*=-efUg-^:2+94.,*(2-Uh-i'0-efeeaV-
j)952+)0.'-'+b-A,,59bkk'.)0/2V+',V:)'+,)@):*V/';2,'l9V:2k'9k.:k4:94/k,),4.29kmfUnn-
eVo*+p-YVqV-[,.*9-('-*+*,2;<*-^_+-̀<+'*aV-]*/:'.2+*b-q2.,'/9-r.4c'/-\'*.,A=-effs-^:2+94.,*(2-Uh-i'0-efeeaV-j)952+)0.'-'+b-
A,,59bkk'.)0/2V+',V:)'+,)@):*V/';2,'l9V:2k'9k.:k4:94/k,),4.29kUemfge-
gV&):A*'.-ZV-i)9)2.26<*-A4;*+*-^_+-̀<+'*aV-&Cl):2=-jVib-_(),2/)*.-_.-&*+4*.-&2('/+2=-efUe-^:2+94.,*(2-Uh-i'0-efeeaV-j)952+)0.'-'+b-
A,,59bkk'.)0/2V+',V:)'+,)@):*V/';2,'l9V:2k'9k.:k4:94/k,),4.29kgstUU-
uV_9:4/'(2-v2(/<64'7-]V-_9,/4:,4/*-?-@4+:)>+-('.-:4'/52-A4;*+2-we*V-'(Vx-^_+-̀<+'*aV-&*(/)(b-&:W/*cX\).-_95*d*=-effe-^:2+94.,*(2-Ue-&*/-efeeaV-
j)952+)0.'-'+b-A,,59bkk'.)0/2V+',V:)'+,)@):*V/';2,'l9V:2k'9k.:k4:94/k,),4.29kmfgUu-
mV&22/'-rV-[+*,2;<*-:2+-2/)'+,*:)>+-:.<+):*V-wny-'(VxV-o2/2+,2b-q2.,'/-r.4c'/z-efUhV-
tVW4?,2+=-[-{-\*.=-ZV-i)9)2.26<*-&C():*-wUg'(Vx-_95*d*b-_.9'8)'/z-efUtV-
hV|',,'/=-iV-[,.*9-('-[+*,2;<*-\4;*+*V-wm,*-'(Vx-]*/:'.2+*b-_(),2/)*.-_.9'8)'/-&*992+z-efUUV-
nVv248)'/'=-\V=-j'.;*9=-[V-[+*,2;<*-\4;*+*V-wUU*-'(Vx-]*/:'.2+*b-_.9'8)'/-&*992+z-effsV-
-
0123146789 1670941
!""#$$"%&'"()*"##+,
+$*-
./,/0/1234/,567820/9,:20;8<65/,9/,257/08=/:8>0,<69,:?65@2,A?3/02,60,B?0:8>0,<6,;?;,@/516;,2,;6736012;,@580:8@/96;C,?0,:?65@2,@580:8@/9D,E?6,;6,:23@206,<6,9/,:/F6=/D,
69,:?692,G,69,1520:2,H;?F<8I8<8<2,60,1>5/JD,/F<2360D,<25;2,G,@69I8;K@6580LMD,G,9/;,@/56N/;,<6,3863F52;,;?@658256;,6,80B658256;O,P2</;,9/;,@/516;,@580:8@/96;,@?6<60,
;?F<8I8<85;6,60,Q56/;,2,5678206;O,./,/0/1234/,567820/9,6;,69,3L12<2,@/5/,6;1?<8/5,9/,6;15?:1?5/,<69,257/08;32,:6015/0<2,9/,/160:8>0,60,?0/,<6165380/</,@/516,H@O,6NO,
./,:/F6=/MD,Q56/,H9/,:/5/M,2,5678>0,H25F81/58/,?,2:?9/5MD,6J/380/0<2,9/,<8;@2;8:8>0,G,9/;,569/:8206;,<6,9/;,<8I65;/;,6;15?:1?5/;,;8;1L38:/;,H3R;:?92;D,065I82;D,/51658/;D,
61:OM,E?6,:20186060D,G,9?672,A/F81?/936016,:20,69,6;1?<82,<6,9/;,5678206;,/<G/:6016;,60,?0/,;6:?60:8/,25<60/</O,HS681A,.O,T2256,UV,W<,X/7,YMO,
W0,6;1/,;6::8>0,56I8;/5632;,12<2,92,569/:820/<2,/9,6;1?<82,<69,:?65@2,A?3/02D,36<8/016,69,?;2,<6,@9/02;,G,@2;8:8206;,:20,9/,:2556:1/,/@98:/:8>0,<6,9/;,16538029274/;,
/0/1>38:/;O,Z;4,38;32,/0/98=/5632;,9/,257/08=/:8>0,6;15?:1?5/9,G,B?0:820/9,<6,9/,5678>0,<6,9/,:/F6=/,G,:?692,<69,:?65@2,A?3/02O,
"%*#$+$""$(["\
Z9,B80/98=/5,9/,;6;8>0D,69,6;1?<8/016,6J@98:/,92;,:20:6@12;,<6,/0/1234/D,08I696;,<6,257/08=/:8>0D,@9/02;D,@2;8:8206;D,5678206;D,;6736012;D,:/I8</<6;D,16538029274/;,
/0/1>38:/;,G,9/,257/08=/:8>0,6;15?:1?5/9,G,B?0:820/9,<6,9/,:/F6=/,G,:?692,<69,:?65@2,A?3/02D,I80:?9Q0<29/;,:20,;?;,/@98:/:8206;,:9408:/;D,/,15/IL;,<69,?;2,<6,
A655/38601/;,3612<29>78:/;,@/5/,80165@561/5,9/;,:20<8:8206;,B8;82@/129>78:/;,<6,3/065/,:9/5/,G,@56:8;/O,
]"#"%$"##'+++
^_`,32<692;,/0/1>38:2;,<6,1520:2,A?3/02,
^_`,32<692;,/0/1>38:2;,<6,:/F6=/,G,:?692,
^_`,32<692;,/0/1>38:2;,<6,:/F6=/,B61/9,
^_a,6;E?69612,A?3/02,
^Z9:2A29,b_c,
]"#"%$"#"%*$"
^T/0<89,F9/0:2,
^T/;:/589/,def,
^g?/016;,
^.Q@8=,
^T/0?/9,<6,@5/:18:/,
^h?/<6502,<6,/@?016;,
0123146789 1670941
!"#$%&'( )*+*,-./0-0*12-+-345/6-12
78#$%&' 9:25/+;3<12
=>?"%@A B<12*13;0/-+3*12*CD./6-+2.-12,*E/<+*1F2D.-+<1F2D<1/6/<+*12G23*,5/+<.<EH-12-+-345/6-12;3/./I-0-12*+2*.2*13;0/<20*.26;*,D<2J;5-+<2K/+6;.L+0<.-12-2
1;2-D./6-6/4+26.H+/6-F25*0/-+3*2.-2;3/./I-6/4+20*25<0*.<12-+-345/6<1F2-+-3<5H-2K/K-2G2KH0*<1M2
'!"87$$%A'?! NMB<12*13;0/-+3*12*+2*O;/D<120*.*E-,L+2P;+6/<+*12-26-0-25/*5Q,<20*.2*O;/D<2R;+26<<,0/+-0<,F26<+3,<.-0<,20*.23/*5D<2G21*6,*3-,/<SF20*Q*+2
/+3*,6-5Q/-,2,<.*1M2T-0-2*13;0/-+3*21*EU+2*.2,<.20*.*E-0<20*1-,,<.-2.-2-63/K/0-0M2
VMW0*+3/P/6-2*+2.-12/5LE*+*1F2./Q,<12<2-D./6-3/K<12.-12,*E/<+*1F2D.-+<1F2D<1/6/<+*12G23*,5/+<.<EH-12-+-345/6-120*.26;*,D<2J;5-+<M2X<5-2+<3-2
1<Q,*2.<20*16,/3<2O;*2-G;0-,L+2*+2.-2-D./6-6/4+26.H+/6-20*2.-12*13,;63;,-12*13;0/-0-12*+2*.2P;3;,<M2
(YZ"%[%\#']A[#!^7?'"?!]?%'^A8_#$%&']?[#=%=[%A"?$#@%8"7#[`""a!bcc$%?'"%^%$#Y8?_A"?d!Y$Ac?!c7!?8e_#"?8%#[?!f'A_=8#[#!8?g%A'?!]?[$7?8aA`7_#'A
?'?[]%=7>A#]>7'"Ae?da[%$#[#%_aA8"#'$%#$[h'%$#]?$#]#7'#]??[[#!b
0123146789 1670941
!"#$%&'(&)(%)%(#%%&*'#%%&$(+%&,!&#!(&&+!&#-&#!()%.!'%/
0- 1(+%&
234564547 7
839:;43:47 7
<;:=47 7
>4?4@7 7
AB=4@7 7
CD3E=:=47 7
F9GDH:54@7 7
IJ@K:=47 7
2454@7H6GB@437 7
L0&%#M#%/NBO637G67PQ74RD?7=D5745;6=6G65;6?7G67GD@D37;:SD7=T@:=D7657@4736U:T57G6@7V:SDU4?;3:D7W36U:T57:5X63:D37G6@749GDH65YZ736X:6367V4963?674B;DH6G:=4GD7=D57
45;:5X@4H4;D3:D?7V4=67B57G[47=D57@47=B4@7=4@H47@:U634H65;6Z7S36?65;45GD75B6KD76S:?DG:D7G67G:=VD7GD@D37HD;:KD7SD376@7=B4@74=BG67476H63U65=:4\7
]0!^#(,!&(M)(%__'$(+%`#%a
]b,!)%(M_(&#.%%%(a
0123146789 1670941
!"#$%"!#$&"'!#$"!$$(&$)*($
+,!$#"-#./0123452467489:;48<052484<:=;0>?:3@:4A8384328>@B83;24A:34A3@C2384D2B40=42E8C2=4524F8A8=@<:>8:0G4
HI&J%#$K"-!"L#)!L-!!$&%!%!L!"!#)!)&$L!M#N!)O
0123146789 1670941
!"#$"%"%&&#!%'"$!"(!'")$*$%&!+,-.,/01//0234/5116+788999:;<.1.=/:4<>893145?@A,BC9DEFGH.-
IJ$K%"L'"L"%&!"(!!'!&M!*"!!!%!"&!N
IOPL!L!L'"L"%!&%!&!L!M!*"!!Q$&!N
RIJ$K%"L'"L"%&!"(!!"#$"%"L!#N
0123146789 1670941
!"#$!%
&'( )*%+,-./01%
234567 801%#1/.9,!-/#1%#:;<,=!-%<!%0>?!-,$!=,@-%#1/>.=/.>!<%A%B.-=,0-!<%9#%<!%=!"#$!%C,-=.<D-90<!1%!%1.%!;<,=!=,@-%=<E-,=!F%+#9,!-/#%<!%./,<,$!=,@-%9#%+09#<01%
!-!/@+,=01F%!-!/0+E!%C,C!%A%CE9#01G%
H('75 IG801%#1/.9,!-/#1%#-%#J.,;01%9#<#?!>D-%B.-=,0-#1%!%=!9!%+,#+">0%9#<%#J.,;0%K.-%=00>9,-!90>F%=0-/>0<!90>%9#<%/,#+;0%A%1#=>#/!>,0LF%9#"#-%
,-/#>=!+",!>%>0<#1G%!9!%#1/.9,!-/#%1#?M-%#<%>0<%9#<#?!90%9#1!>>0<!%<!%!=/,C,9!9G%
NGO9#-/,B,=!%#-%<!1%,+D?#-#1F%<,">01%0%!;<,=!/,C01%<!1%#1/>.=/.>!1%9#%<!%>#?,@-%9#%<!%=!"#$!%9#<%=.#>;0%P.+!-0G%Q0+!%-0/!%10">#%<0%9#1=>,/0%
J.#%!A.9!>D-%#-%<!%!;<,=!=,@-%=<E-,=!%9#%<!1%#1/>.=/.>!1%#1/.9,!9!1%#-%#<%B./.>0G%
%
RSTUVW7UX'55W5X7(YW5U33U756('UZ[\]]5XS(5Y75^S7]5]'5(_Y5(U5`7Y3(U7Z'57W5U35VW5U'5([7
Z'Y755UW3'47W4'7_5^[UUY[7(Ua\
%
%
%
%
%
%
%
%
%
%
%
%
%
%
%
%
%
%
%
%
%
0123146789 1670941
!"#$"%"%&&#!%
'($)*$+&,!!&%!-!&!.
'/$0*$-&0.
12"$!"3!"#$"%4"*%%5667778$%$9-,67!%-*.4:;<8=1=>+%?@8&!&#$%!5
A
'BC$)!%#D!%&!%!4".
'/$0!"9-!$!%!!%#D!.
0123146789 1670941
!"#$%!&'!()*+!(!#,-(.
/
/
012-*!)$.(&)#!%(.(!3/4444444444444444444444444444444444444444444444444444/
52$!.!)+-)!(.!&-#6
789:;/ <=>?9@;>/ A9B?CDB/ EBF8GH?CDB/
IJ)&
I.)&#!
0123146789 1670941
!"#$%
&'( )*%+,-!.$/%
012345 6$/%"/.!7,8-."/%"9:#,;8-%#8%$<=8-,>8;,?-%"/.<!;.!<8#%@%A!-;,$-8#%7"#%;!"#$%B,-;!#C-7$#8/%8%/!%8:#,;8;,?-%;#D-,;8E%+"7,8-."%#8%!.,#,>8;,?-%7"%+$7"#$/%
8-8.?+,;$/E%8-8.$+D8%B,B8%@%BD7"$/F%
G('53 HF6$/%"/.!7,8-."/%"-%"I!,:$/%7"#"=8<C-%A!-;,$-"/%8%;878%+,"+J<$%7"#%"I!,:$%K!-%;$$<7,-87$<E%;$-.<$#87$<%7"#%.,"+:$%@%/";<".8<,$LE%7"J"-%
,-."<;8+J,8<%<$#"/F%878%"/.!7,8-."%/"=M-%"#%<$#%7"#"=87$%7"/8<<$#8%#8%8;.,B,787F%
NFO7"-.,A,;8%"-%#8/%,+C="-"/E%#,J<$/%$%8:#,;8.,B$/%#8/%"/.<!;.!<8/%7"%#8%<"=,?-%7"#%;!"#$%7"#%;!"<:$%P!+8-$F%Q$+8%-$.8%/$J<"%#$%7"/;<,.$%I!"%
8@!78<C-%"-%#8%8:#,;8;,?-%;#D-,;8%7"%#8/%"/.<!;.!<8/%"/.!7,878/%"-%"#%A!.!<$F%
RSTUV3W2'X5U1(T5Y(YT3(V5W3T'3TT5
%
%
%
%
%
%
%
%
%
%
Z
0123146789 1670941
!"#$%"&'$($")%*("'&#'+
,*("' -"#$%"
.*$"(
/*0
-*$"(
1%!('
2"&)$*'$&
2"&3*)$*'$&
4!"#$%"&)*#)*0!'*5 "30)6#'"*6$''&#'+
1)*#)* -"#$%"
7*)*$#*%)$&
8"9(*
:*6$'6('
0123146789 1670941
!"#$%&'()'*+,-'.*/'*01*$2345*&()'+6'4)&7$+'()'*4'*/'4+$8$9*:;'*<,=*+$('.$*63/.>$+34*7'.&?&%$.*<,'*@$*6$%&'()'*(3*)&'('*#$.3*%$./&$%3A*
BBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB
CD!EF!GHG!IEGIJKILFMFGNKIGHK!EFKH!OG"
P
P
P
P
P
0123146789 1670941
!"#$
%&'()*+,'-'.-,/*0*12-'+-'34)52-'.*02/*/-4+-2/6*+)7*(2/-8)94*.-920/'-.29-:2+:'5,29-('-*+*,2;<*=-+)8'.'9-('-2/6*+)7*:)>+=-5.*+29=-529):)2+'9=-/'6)2+'9=-9'6;'+,29=-
:*8)(*('9=-,'/;)+2.26<*9-*+*,>;):*9-?-.*-2/6*+)7*:)>+-'9,/4:,4/*.-?-@4+:)2+*.-('-.*-:*0'7*-?-:4'.2-('.-:4'/52-A4;*+2=-8)+:4.B+(2.*9-:2+-949-*5.):*:)2+'9-:.<+):*9=-
*-,/*8C9-('.-492-('-A'//*;)'+,*9-;',2(2.>6):*9-5*/*-)+,'/5/',*/-.*9-:2+():)2+'9-@)9)25*,2.>6):*9-('-;*+'/*-:.*/*-?-5/':)9*-
DEDDF!GG#EF!HIJKLMNJMOPJQRSKT
UVW*/:<*XY2//'/2-ZV[V-&V-\4/.C-ZV-?-]'+<,'7-Y*().*-WV-[+*,2;<*-A4;*+*-^_+-̀<+'*aV-&*(/)(b-&:W/*cX\).-_95*d*=-efUg-^:2+94.,*(2-Uh-i'0-efeeaV-
j)952+)0.'-'+b-A,,59bkk'.)0/2V+',V:)'+,)@):*V/';2,'l9V:2k'9k.:k4:94/k,),4.29kmfUnn-
eVo*+p-YVqV-[,.*9-('-*+*,2;<*-^_+-̀<+'*aV-]*/:'.2+*b-q2.,'/9-r.4c'/-\'*.,A=-effs-^:2+94.,*(2-Uh-i'0-efeeaV-j)952+)0.'-'+b-
A,,59bkk'.)0/2V+',V:)'+,)@):*V/';2,'l9V:2k'9k.:k4:94/k,),4.29kUemfge-
gV&):A*'.-ZV-i)9)2.26<*-A4;*+*-^_+-̀<+'*aV-&Cl):2=-jVib-_(),2/)*.-_.-&*+4*.-&2('/+2=-efUe-^:2+94.,*(2-Uh-i'0-efeeaV-j)952+)0.'-'+b-
A,,59bkk'.)0/2V+',V:)'+,)@):*V/';2,'l9V:2k'9k.:k4:94/k,),4.29kgstUU-
uV_9:4/'(2-v2(/<64'7-]V-_9,/4:,4/*-?-@4+:)>+-('.-:4'/52-A4;*+2-we*V-'(Vx-^_+-̀<+'*aV-&*(/)(b-&:W/*cX\).-_95*d*=-effe-^:2+94.,*(2-Ue-&*/-efeeaV-
j)952+)0.'-'+b-A,,59bkk'.)0/2V+',V:)'+,)@):*V/';2,'l9V:2k'9k.:k4:94/k,),4.29kmfgUu-
mV&22/'-rV-[+*,2;<*-:2+-2/)'+,*:)>+-:.<+):*V-wny-'(VxV-o2/2+,2b-q2.,'/-r.4c'/z-efUhV-
tVW4?,2+=-[-{-\*.=-ZV-i)9)2.26<*-&C():*-wUg'(Vx-_95*d*b-_.9'8)'/z-efUtV-
hV|',,'/=-iV-[,.*9-('-[+*,2;<*-\4;*+*V-wm,*-'(Vx-]*/:'.2+*b-_(),2/)*.-_.9'8)'/-&*992+z-efUUV-
nVv248)'/'=-\V=-j'.;*9=-[V-[+*,2;<*-\4;*+*V-wUU*-'(Vx-]*/:'.2+*b-_.9'8)'/-&*992+z-effsV-
-