Permanent Residence Petition for Dr.

John Doe

Immigrant Petition for Alien Worker Dr. John Doe

for the Alien with Extraordinary Ability in Science (EB-1A)

TABLE OF CONTENTS

1. Form G-1450 Authorization of Credit Card Transactions ($700 for Form I-140)

2. Form G-1450 Authorization of Credit Card Transactions ($2500 for Form I-907)

3. Form G-1145 e-Notification of Application/Petition Acceptance.

4. Form I-140, Immigrant Petition for Alien Worker with the $700 filing fee.

5. Form I-907, Request for Premium Processing Service with the $2,500 filing fee.

6. Photocopies of the Passport, F1 visa, Form I-20, EAD Card, H1-B visas, Form I-797, and
most recent Form I-94.

7. Initial Evidence in Support of the I-140 Immigrant Petition.

8. Statement from Dr. John Doe detailing plans on how he intends to continue work in the
United States.

9. List of Exhibits.

10. Exhibits 1–34.

11. Form ETA-750B.

Permanent Residence Petition for Dr. John Doe

John Doe
Address: 1234 Road,
XYZ City, XXX State
Email: [email protected]

Date: XXX XX, XXXX

USCIS Texas Service Center

Attn: I-140 Premium Processing
6046 N. Belt Line Rd. Suite. 140
Irving, TX 75038-0014

Initial Evidence in Support of the I-140 Immigrant Petition

Petitioner and Beneficiary: John Doe

Classification Sought: Employment-Based Immigration, First Preference,
Extraordinary Ability in Science (EB-1A).
Sec. 203(b)(1) INA [8 U.S.C. 1153].

To Whom It May Concern:

This initial evidence is the attachment to Dr. John Doe’s I-140 Immigrant Petition for Alien
Worker. This evidence shows that Dr. Doe is an alien of extraordinary ability in the sciences,
specifically in Physics, Biological Physics, and Computational Neuroscience, who has sustained
national and international acclaim and his achievements have been recognized in the field of his
expertise.

1) Dr. Doe has a level of expertise indicating that he is one of that small percentage who has
risen to the very top of the field of Physics, Biological Physics, and Computational
Neuroscience. (Please refer to Sections 1.1, 1.2, 1.5 - 1.8.)

2) Dr. Doe provides evidence that he satisfies five of ten criteria listed in 8 CFR Section
204.5(h)(3). A minimum of three are required to petition for eligibility under this category.

i. Evidence of Dr. Doe’s original scientific and scholarly contributions of major

significance in the field. (Please refer to Section 1.3.)

ii. Evidence of Dr. Doe’s authorship of scholarly articles in the field. (Please refer to
Section 1.4.)

iii. Evidence that Dr. Doe has been asked to judge the work of other professionals. (
Please refer to Section 1.9.)

iv. Evidence that Dr. Doe has performed in a critical role for organizations that have a
distinguished reputation. (Please refer to Section 1.10.)

v. Evidence of receipt of lesser nationally or internationally recognized prizes or

awards for excellence. (Please refer to Section 1.11.)
Permanent Residence Petition for Dr. John Doe

3) In the United States, Dr. Doe plans to continue work in his area of expertise. (Please refer
to the Statement from Dr. John Doe detailing plans on how he intends to continue work in
the United States and to Exhibit 6, his current job.)

Pursuant to 8 CFR, Section 204.5(h)(1), Dr. Doe may file an I-140 visa petition for classification
under Section 203(b)(1)(A) of the Act as an alien of extraordinary ability in the sciences on his own
behalf.

Pursuant to 8 CFR, Section 204.5(h)(5), neither an offer for employment in the United States nor a
labor certification is required for this classification.
Permanent Residence Petition for Dr. John Doe

SECTION 1. Dr. John Doe is an alien of exceptional ability in Physics, who will substantially
benefit prospectively the national economy, educational interests, and welfare of the United
States.

Dr. John Doe is an assistant professor in the tenure-track at the Department of Physics at North
Carolina Agricultural and Technical State University (NC A&T). His research interests are in the
areas of statistical physics, biological physics, and computational neuroscience (Exhibit 1:
Curriculum Vitae of Dr. John Doe). His research projects are aimed at understanding signal
processing in living systems, from the cellular to organismal level. Results from his research can be
applied to immunology, human olfaction, and human vision, and bring immediate as well as long term
benefits to the national interests and national security of the United States. This section provides
details of his expertise, contributions, and recognitions.

1.1 Dr. Doe is an expert in Physics with over 10 years of research experience in his area of
employment.

Dr. Doe started his career in the field of Physics in India as an undergraduate student at St.
Stephen’s College in 2005. He received a BS in Physics (Honors) from St. Stephen’s College,
Delhi, India in 2008 (Exhibit 2). He also received a MS in Physics from Indian Institute of
Technology, Kanpur in 2010 (Exhibit 3). He was among the top ranked students at these two
premier institutes of higher education in India. He came to the USA in 2010 to do his doctoral
research in Physics at Emory University, Atlanta. He performed his doctoral research in the areas
of statistical physics and biological physics and received a Ph.D. in Physics in 2015 (Exhibit 4).
After completing his Ph.D., he went to the University of Pennsylvania to do his postdoctoral
research. He worked as a researcher in the Department of Physics at the University of
Pennsylvania for four years from September 2015 to August 2019 (Exhibit 5). Since August
2019, he has been working as an assistant professor of Physics at North Carolina Agricultural and
Technical State University (Exhibit 6).

1.2 Dr. Doe’s contributions to the fields of Physics are well-recognized by expert scholars in his
field.

Dr. Doe’s research work has been extensively recognized by independent scholars. Nationally and
internationally renowned experts in the field of physics, statistical physics, biological physics, and
computational neuroscience have provided letters supporting his permanent residency application.
These researchers belong to prestigious institutions such as Emory University, McGill University
(Canada), University of Pittsburgh, and University of Pennsylvania (Exhibit 7-11). The submitted
support letters include two independent advisory opinions from scientists who have not worked
with Dr. Doe and who do not know Dr. Doe personally, but rather are familiar with Dr. Doe’s
research work (Exhibit 9-10). Below is the list of experts in the field who have provided letters to
support Dr. Doe’s petition:

1.2.1 Dr. XXX XXXX, Professor of Physics at XXX University, co-director of the XXX
Institute, a Principal Investigator on a dozen federal grants, author of nearly a hundred papers
in top scientific journals, past Chair of the Division of Biological Physics (DBIO) of the
American Physical Society, past Chair of The q-bio Conference Advisory Board, a Fellow of
American Physical Society, and a James S. McDonnell 21st Century Science Initiative Fellow.
(Exhibit 7)
Permanent Residence Petition for Dr. John Doe

The letter states, in pertinent parts (emphasis added):

“I am writing with an enthusiastic support of Dr. John Doe’s petition for the
permanent residency in the United States. He has made important contributions to
biological physics, and to education of the next generation of scientists, and he can
contribute a lot more in the future if given an opportunity. It is thus clear that
granting him the permanent residency is in the best interests of this country.”

“Dr. Doe has demonstrated outstanding capabilities as a scientist and an educator.

He has made a number of seminal discoveries that have advanced and will continue
to advance the fields of theoretical biophysics. His work has reshaped our
understanding of complex cellular sensing, including in our own olfactory system. I
have interacted with many young scientists in my career, and I truly believe that Dr.
Doe is one of the exceptional scientists in the field of theoretical biophysics, and I
highly recommend him for permanent residency as a researcher of extraordinary
ability. The scientific community, and our country as a whole, will benefit from his
presence, and from his efforts and wisdom. I extend my full support for granting
permanent residence to Dr. Doe.”

1.2.2 Dr. XXX, Professor of Physics at XXX University, Chairman of the Physics
department, author of 140 peer-reviewed articles in leading international journals, invited
speaker to many international conferences throughout the Americas, Europe, and Asia,
elected Fellow of the American Physical Society, and the editorial board member of APS’
Physical Review E. (Collaborator of Dr. John Doe). (Exhibit 8)

The letter states, in pertinent parts (emphasis added):

“Dr. Doe joined my group in Fall 2010 on a research rotation to work on extending
renormalization group ideas to the analysis of complex networks. During his time in
my group he made significant contributions to the study of complex networks. He
carried out highly original research that lead to 3 publications in top scientific
journals.”

“In his still young career, Dr. Doe is also emerging as a promising talent, with
already some significant contributions, in the areas of biological physics and
computational neuroscience. His work on cellular sensing has provided novel
understanding to the processing of chemical signals at cellular scales. His work on
visual signal processing has provided understanding on how humans perceive
objects and color. His insights have led to several original articles in international
scientific journals, most notably in the Proceedings of the National Academy of
Sciences, Physical Review Letters, Physical Review E and PLOS Computational
Biology. It is remarkable that he is the lead author on all these articles!”

“Dr. Doe is highly skilled in the areas of statistical physics, biological physics and
computational neuroscience. He already has made several landmark contributions
and is exceedingly likely to continue to do so in the future. He should be allowed to
remain in U.S. permanently and prospectively benefit the United States in his
Permanent Residence Petition for Dr. John Doe

extremely valuable field of endeavor. I strongly recommend U.S. Permanent

Residency for this exceptionally capable individual.”

1.2.3 (Independent Assessment) Prof. XXX XXXX, Professor Department of Physics and
Astronomy at the XXX University, author of nearly 40 peer-reviewed articles in leading
international journals, invited speaker to many international conferences and institutes
including Institut Curie, the Banff International Research Station, and Princeton, Yale, and
Rice Universities, a Principal Investigator on many grants from National Institute of Health,
National Science Foundation, the Simons Foundation, and Human Frontier Research
Program, and guest editor for PLOS Computational Biology. (Exhibit 9).

The letter states, in pertinent parts (emphasis added):

“Dr. Doe has made significant original contributions to the field of Biological Physics.”

“During his career, Dr. Doe has worked on cutting edge problems in several research
areas and provided original scientific contributions, pioneering new research directions.
He has published original research articles as the lead author in high impact scientific
journals with international circulation. His work has been well received and been used
by other scientists as reflected by over 190 citations of his publications. His expertise in
statistical physics, biological physics, and computational neuroscience gives him a
unique set of skills through which he can provide fundamental understanding of
biological processes, as well as practical solutions to medical and technological
problems. I believe that Dr. Doe will pioneer many more research directions.”

1.2.4 (Independent Assessment) Prof. XXX XXXX, Professor Physics Department XXXX
University, Chairman of the Physics department, author of nearly 40 peer-reviewed articles in
leading international journals, invited speaker to many international conferences such as
American Physical Society March Meetings (2010, 2015, 2018), SysBio meeting (2020), and
the Pan American Society for Evo-Devo biology meeting (2017), editor of for Physical
Biology and associate editor for Development, a Principal Investigator on many federal grants
from the Canadian research agencies, as well as, from Simons Foundation and the Human
Frontier Research Program. (Exhibit 10)

The letter states, in pertinent parts (emphasis added):

“He has made significant contributions to several important problems in cellular,

olfactory and visual signal processing, publishing original research articles as lead
author in international journals.”

“… His contributions to this field are truly pioneering.”

“… Dr. Doe has the background and skills to conduct high caliber research in the area
of biological physics. These skills have been developed during his long career in
theoretical physics … He has performed research at the top tier of a range of fields, has
authored original research articles in scientific journals with international circulation,
and his scientific contributions have been useful to other scientists, including my own
work.”
Permanent Residence Petition for Dr. John Doe

1.2.5 Prof. XXX XXXX, Professor, Physics Department and Neuroscience Department at
XXXX University, visiting Professor at the XXXX University in Belgium, and the
International Center for Theoretical Physics in Italy, author of over 150 articles in physics,
computer science, and neuroscience that have been cited over 14000 times, Principal
Investigator on many federal grants with over millions of dollars in funding, and an elected
Fellow of the American Physical Society. (Collaborator of Dr. John Doe) (Exhibit 11)

The letter states, in pertinent parts (emphasis added):

“Dr. Doe worked on the extremely challenging problem of understanding how neural
circuits sense and process odors in a naturalistic setting … Dr. Doe made major
progress on these problems by using his exceptional skills in biophysics. … The
interdisciplinarity of Dr. Doe’s work makes him an important asset to the research
establishment in the United States.”

“Dr. Doe’s research is having an impact on basic science and with relevance to human
health, in ways that will continue to contribute to the national security and economic
competitiveness of the United States.”

1.3 Dr. Doe has made several original and significant scientific contributions to the field of
statistical physics, biological physics, and computational neuroscience.

Due to his strong background in physics, Dr. Doe has made several significant, impactful, and
original contributions to many diverse research areas, such as statistical physics, biological
physics, and computational neuroscience. A list of his original scientific contributions is below:

1.3.1 Original Scientific Contribution - Renormalization Group Analysis of Complex Networks

As a Ph.D. student, Dr. Doe started his research in statistical physics where he applied
renormalization group methods to analyze complex networks. In this work, he developed the
mathematical apparatus to explore peculiar, novel phase transitions in hyperbolic complex
networks. He discovered a simple model of so-called “explosive” percolation transitions. He
carried out highly original research in this area that led to three peer-reviewed publications in
high-impact scientific journals Nature and Physical Review E (Exhibit 12-14). These
publications have been cited over a hundred times (Exhibit 15).

Prof. XXX of XXX University writes about this work:

“During his time in my group he made significant contributions to the study of complex
networks. He carried out highly original research that led to 3 publications in top scientific
journals.” (Exhibit 8)

1.3.2 Original Scientific Contributions -Information processing in biological cellular networks

During his Ph.D., Dr. Doe also applied his theoretical physics expertise to understand
information processing in biological cellular networks. He developed information theoretic
Permanent Residence Petition for Dr. John Doe

methods to study chemical signaling in biological receptor networks. His valuable insights
provided a novel understanding of encoding and decoding of chemical signals by receptor
networks. His findings were published in the journals Physical Review E (Exhibit 16) and
PLOS Computational Biology (Exhibit 17). These results were significant in the
understanding of how our immune system recognizes allergens and antigens.

Dr. XXX of XXX University writes about his work:

“Dr. Doe is also emerging as a promising talent, with already some significant contributions,
in the area of biological physics and computational neuroscience. His work on cellular
sensing has provided novel understanding to the processing of chemical signals at cellular
scales. His work on visual signal processing has provided understanding on how humans
perceive objects and color. His insights have led to several original articles in international
scientific journals, most notably in the Proceedings of the National Academy of Sciences,
Physical Review Letters, Physical Review E and PLOS Computational Biology.” (Exhibit 8)

Prof. XXX of XXX University says about these works:

“Dr. Doe has discovered that a similar improvement is not seen in molecular signaling
systems due to conservation of molecule numbers. This paper has been selected as a spotlight
at the recent q-bio Conference, an honor that not too many submissions achieve, and it has
been published in PRE.” (Exhibit 7)

“His original work showed that it is possible for a cell to measure concentrations of more
than one ligand by using one receptor type – by using the entire time series of binding and
unbinding times to the receptor rather than the time-averaged receptor occupancy.” (Exhibit
7)

“A very interesting result, which should take us a step closer towards understanding the
progression of complex diseases.” (Exhibit 7)

Prof. XXX of XXX University writes:

“Dr. Doe has made significant original contributions to the field of Biological Physics. His
work in the area of cellular signaling, published in the journal PLOS Computational Biology,
provided novel insights on the processing of chemical signals in cellular networks.” (Exhibit
9)

Dr. Doe's original scientific and scholarly research contribution is highly recognized
internationally by numerous scientists in the field. Prof. XXX XXX at the XXX University,
Montreal, Canada – said (Exhibit 8):

“Dr. Doe provided a profound insight that the time sequence of binding and unbinding of
chemical molecules on a cellular receptor contains information about the identity of the
receptors and can be used to estimate the concentrations of multiple chemicals with the same
receptor. This work provided a mechanistic explanation to how the FceR1 receptor provides
immunity both from allergens and parasites simultaneously, and thus is highly significant.”

Dr. Doe's original and interesting results on important and timely research problems in
cellular sensing was highly praised by a peer-review expert on his 2020 Physical Review
Letter (PRL) paper (the peer-review is an anonymous process thus the name of the expert
cannot be provided.),
Permanent Residence Petition for Dr. John Doe

“the paper addresses an important and timely issue and produces a number of interesting
results. I think that overall the paper deserves to be published in the PRL” (Exhibit 18)

1.3.3 Original Scientific Contributions – Visual perception of object shape and color

Dr. Doe has developed neural network models to understand the neural computations
involved in human visual object recognition. He developed a novel physics-style approach to
study collective neural computation in the primary visual cortex. His results were published in
PLOS One (Exhibit 19). He has also developed a novel computational machine learning
method to understand color perception in humans. This work was published in Journal of
Vision (Exhibit 20).

Prof. XXX at XXX University says the following about the significance and applications of
these works:

“Dr. Doe used a novel approach from the physics of liquid crystals to develop a solution that
could simultaneously fill the gaps in the contour as well as remove clutter, making it possible
to correctly detect the contour of objects in the image. This was a significant step in the
understanding of visual object recognition, which for the first time, showed that contour
detection can be performed in the primary visual cortex area of the brain.” (Exhibit 9)

“In his recent work, published in the Journal of Vision in 2018, Dr. Doe used a novel
computational machine learning approach to identify the mathematical computations
necessary for identifying the color of objects in an image. This line of research has not only
provided a novel understanding of the biophysical mechanism of visual perception, but also
developed practical algorithms that will find tremendous application in many areas such as
cameras, displays, and navigation systems of self-driving cars.” (Exhibit 9)

1.3.4 Original Scientific Contributions – Biophysical model of interaction between olfactory

receptors and odor molecules

During his postdoctoral research at the University of Pennsylvania, Dr. Doe started a
collaboration between the University of Pennsylvania and the Monell Chemical Sense Center
to study processing of natural odors by the olfactory system. During this collaboration, he
developed a biophysical model of interaction between odor molecules and cellular receptors
of the olfactory system. His model correctly predicted the experimentally measured response
of a large set of mammalian olfactory receptors to complex odor mixtures. This result is
highly significant because there are hundreds of receptors in our olfactory system and over
ten thousand chemicals in our olfactory environment. Experimental characterization of all
these receptors to all possible chemical mixtures is an impossible task. His model provided a
systematic approach to characterize the response of receptors to odor mixtures. This highly
significant research was published in the Proceedings of the National Academy of Sciences
(Exhibit 21). This work has already been cited 35 times. Dr. Doe was invited to speak about
this research at two international conferences, the annual meeting of the Association for
Chemoreception Sciences and the American Physical Society March Meeting (Exhibit 20 and
21), which shows the significance and impact of this work.

Prof. XXX XXX of XXX University write about this work:

Permanent Residence Petition for Dr. John Doe

“(Dr. Doe) developed a biophysical model of molecular sensing by olfactory receptors and
showed that it gave an excellent account of the experimentally measured responses. Dr.
Doe’s work was published in the prestigious journal, Proceedings of the National Academy
of Science, and represents a fundamental advance in our understanding of the sense of
smell.” (Exhibit 11)

The recommendation letters from experts in the statistical physics, biological physics, and

computational neuroscience (Exhibit 7 - 11) and Dr. Doe’s published research papers (Please refer to
Section 1.4) establish that his original scientific contributions are of major significance to these fields.

1.4 Evidence of Dr. Doe’s authorship in the fields of statistical physics, biological physics, and
computational neuroscience.

Dr. Doe’s research work addresses several important issues in basic science and medicine
research. He has an extensive documented record of authorship in his field of endeavor (Exhibit
1: Dr. Doe’s CV). His original research work has resulted in 10 peer-reviewed scientific articles
(Exhibits 12, 13, 14, 16, 17, 19, 20, 21, 24, 25) in some of the most prestigious and high impact
journals in the field such as Nature, Proceedings of the National Academy of Sciences (USA),
Physical Review, PLOS Computational Biology. He has served as first/leading author on nine out
of these ten articles. These publications have been cited more than 190 times with one of them
cited nearly 100 times, and three others cited more than 10 times each. The citation number
continues to grow (Exhibit 15). The list of Dr. Doe’s publication (in reverse chronological order)
is below:

10. V Singh, M Tchernookov, V Balasubramanian. What the odor is not: Estimation by

elimination. Physical Review E, 104, 024415, 2021. (Exhibit 25)

9. V Singh, I Nemenman. Universal Properties of Concentration Sensing in Ligand-Receptor

Networks. Physical Review Letters, 124(2), 028101, 2020. (Exhibit 24)

8. V Singh, N Murphy, V Balasubramanian, J Mainland. Competitive binding predicts nonlinear

responses of olfactory receptors to complex mixtures. Proceedings of the National Academy of
Sciences, 116(19), 9598-9603, 2019. (Exhibit 21)

7. V Singh, N Cotarris, B Heasly, D Brainard, J Burge. Computational Luminance Constancy

from Naturalistic Images. Journal of Vision, 18(19), 2018. (Exhibit 20)

6. V Singh, I Nemenman. Simple Biochemical Networks allow Accurate Sensing of Multiple

Ligands with a Single Receptor. PLOS Computational Biology, 13 (4), 2017. (Exhibit 17)

5. V Singh, M. Tchernookov, I Nemenman. Effects of Receptor Correlations on Molecular

Information Transmission. Physical Review E 94, 022425, 2016. (Exhibit 16)

4. V Singh, C T Brunson, S Boettcher. From Explosive to Infinite-Order Transitions on a

Hyperbolic Network. Physical Review E 90, 052119, 2014. (Exhibit 14)

3. V Singh, M. Tchernookov, R Butterfield and I Nemenman. Director Field Model of the

Primary Visual Cortex for Contour Detection. PLOS ONE 9, e0108991, 2014. (Exhibit 19)

2. V Singh, S Boettcher. Scaling of Clusters near Discontinuous Percolation Transitions in

Hyperbolic Networks. Physical Review E 90, 012117, 2014. (Exhibit 13)
Permanent Residence Petition for Dr. John Doe

1. S Boettcher, V Singh and RM Ziff. Ordinary Percolation with Discontinuous Transitions.

Nature Communications 3, 787, 2012. (Exhibit 12)

1.5 Dr. Doe’s work has been published in high-ranking scientific journals.

While publication is a relatively common activity for researchers, and thus it is not necessarily
indicative of one’s outstanding ability, the fact that Dr. Doe’s work has consistently been
published in top-ranked journals demonstrates that his work has been recognized as some of the
best in the field. These journals are extremely selective with a rigorous peer review process,
making publication in them a rare accomplishment achieved by only the very best researchers in
the field. Dr. Doe has published his work in the following top-ranked journals:

1) Nature Communications: Impact Factor: 11.80. Ranked 7th among all journals and 3rd among
Life Sciences and Earth Sciences journals by Google Scholar.
2) Proceedings of the National Academy of Sciences of the USA: Impact factor 9.580. Ranked
13th among all journals and 3rd among Health and Medical Sciences journals by Google
Scholar.
3) Physical Review Letters: Impact Factor 9.20. Ranked 1st among Physics and Mathematics
journals and 16th among all journals by Google Scholar.
4) Physical Review E: Impact Factor 2.37. Ranked 10th among Physics and Astronomy journals
by Scimago Journal and Country Rank.
5) PLOS One: Impact Factor 2.87. Ranked 5th among Health and Medical Sciences journals by
Google Scholar.
6) PLOS Computational Biology: Impact Factor 4.380. Ranked 34th among 596 Neuroscience
journals by Scimago Journal and Country Rank.
7) Journal of Vision: Impact Factor 4.380. Ranked 34th among 596 Neuroscience journals by
Scimago Journal and Country Rank.

These highly selective journals have consistently accepted Dr. Doe’s research for publication
which shows that his research work is amongst the best in the field. He is conducting important
original research and his research is considered essential by the editors of the top journals in the
field.

1.6 Dr. Doe has presented his work at major international conferences.

Dr. Doe has been invited by the American Physical Society and the Association for
Chemoreception Sciences to present his work at their annual meetings in 2019 (Exhibit 22 and
23). He has also contributed over 16 presentations at various meetings of the American Physical
Society, Society for Neuroscience, Vision Science Society, and Association for Chemoreception
Sciences (Exhibit 1: Dr. Doe’s CV has the information about the date and location of each
conference presentation).
1.7 Dr. Doe’s research has been supported by major funding agencies.

Dr. Doe’s research at North Carolina A&T State University is supported by National Science
Foundation and the National Institute of Health. His research proposal titled “Predicting
computations that lead to a stable perception of object lightness under spectral variabilities of the
visual scene” was funded by National Science Foundation on April 26, 2021 (Exhibit 26). This
Permanent Residence Petition for Dr. John Doe

project aims at understanding color perception by the human visual system. Dr. Doe has received
$373,588 from the National Science Foundation for his research.

Dr. Doe’s research proposal titled “Predicting computations necessary for the decoding of odor
mixtures by the olfactory system” was funded by National Institute of Health on May 01, 2021
(Exhibit 27). This work is aimed at understanding odor perception by the human olfactory system.
Dr. Doe has received $432,000 for three years from the National Institute of Health for this
project.

1.8 Dr. Doe’s original research contributions have influenced the work of other scientists
According to Google Scholar, Dr. Doe’s research work has been cited 194 times in other peer-
reviewed journal articles (Exhibit 15). The citation to Dr. Doe’s original research comes from
researchers both in the United States and from around the world. These researchers hail from
prestigious and widespread institutes such as:

● McGill University (Canada), 

● Juelich Research Center (Germany), 
● National Research Council of Italy (Italy), 
● Ecole Normale Superieure (France), 
● Harvard University (USA), 
● IBM T J Watson Research Center (USA), 
● Colorado State University (USA), 
● John Hopkins University (USA), and
● University of Michigan (USA), among others (Exhibit 19). 

This clearly and objectively demonstrates the national and international influence of Dr. Doe’s
research work, as well as the widespread actual implementation of his research work in the field.
With the continued dissemination of his original research through publications, the benefits of his
work continues to impact all parts of the nation by providing a foundation for further
developments in biological physics and computational neuroscience.

Prof. XXX XXX of XXX University, Montreal, Canada has written about Dr. Doe’s influence in
his research:

“… (Dr. Doe) has performed research at the top tier of a range of fields, has authored original
research articles in scientific journals with international circulation, and his scientific
contributions have been useful to other scientists, including my own work.” (Exhibit 10)

Prof. XXX XXX of University of Pennsylvania write about the impact of Dr. Doe’s work
(Exhibit 11):

“Dr. Doe’s research is having an impact on basic science and with relevance to human health, in
ways that will continue to contribute to the national security and economic competitiveness of the
United States.”

An anonymous reviewer of Dr. Doe’s research article has said the following about the importance
of Dr. Doe’s published work in Physical Review Letters to the field:
Permanent Residence Petition for Dr. John Doe

“the paper addresses an important and timely issue and produces a number of interesting results.
I think that overall the paper deserves to be published in the PRL” (Exhibit 18)

1.9 Dr. Doe has been asked to a judge of the work of other professionals in his research field.

1.9.1 Peer review: Peer review of articles for prestigious journals and conferences requires that
the reviewer must be an eminent scientist who is an internationally recognized expert in the field.
This is because invitations to join the peer review process are generally sent based on the
reviewer’s international reputation and eminence in the field. Dr. Doe is active in the scientific
community as a peer reviewer for highly acclaimed journals and conferences, and has already
conducted at least 8 reviews (Exhibit 28) for high impact journals, including:

1) Proceedings of the National Academy of Sciences of the USA (Impact Factor: 9.580)
2) PLOS Computational Biology (Impact Factor: 4.428)
3) Physiology and Behavior (Impact Factor: 2.635)
4) Perception (Impact Factor: 1.503)
5) Journal of the Optical Society of America A (Impact Factor: 1.861)

1.9.2 Session chair at international conferences: To be chosen as the chair of a session at

international scientific conferences requires the person to be an eminent scientist who is an
internationally recognized expert in the field. Dr. Doe has chaired two sessions at American
Physical Society March Meetings on invitation. (Exhibits 29 and 30)

Dr. Doe chaired the session on Biological Dynamics and Networks at the American Physical
Society March Meeting 2015 at San Antonio, Texas. (Exhibits 29)

Dr. Doe chaired the session on Physics of Neural Systems II at the American Physical Society
March Meeting 2019 at Boston, Massachesetts. (Exhibits 30)

1.9.3 Reviewing abstracts at international conferences: Reviewing abstracts, selecting them for
presentation at conferences, and assigning the selected abstracts to appropriate scientific sessions
requires expertise in the scientific field. Dr. Doe was selected for reviewing and sorting the
abstracts for the American Physical Society March Meeting 2020. (Exhibits 31)

1.10 Dr. Doe has performed critical role in projects in organizations of distinguished reputation.

Dr. Doe has performed critical role in several National Science Foundation, National Institute of
Health, and Army Research funded projects at Emory University and University of Pennsylvania.

“Dr. Doe joined my group in Fall 2010 on a research rotation to work on extending
renormalization group ideas to the analysis of complex networks. During his time in my group he
made significant contributions to the study of complex networks. He carried out highly original
research that lead to 3 publications in top scientific journals. Through his diligent efforts, we
were able to make progress on developing the apparatus to explore peculiar, novel phase
transitions in the behavior of hyperbolic networks, which stretched over entire domains in
parameter space. … Many researchers had been looking for such a transition at that time, and
our model turned out to be the first one, and one for which we could prove such a transition. …
Dr. Doe was still a beginning student then, but his footwork was instrumental in getting this
research done.” (Prof. XXX XXX, XXX University, Exhibit 8)
Permanent Residence Petition for Dr. John Doe

“Dr. Doe solved a variety of important scientific problem during his stay in my group. First, he
proposed a new physics-style way of approaching an age-old problem of understanding the
neural computation involved in human visual object recognition. This became a paper in PLOS
ONE.” (Prof. XXX XXX, XXX University, Exhibit 7)

“Later Dr. Doe shifted his interests towards what became the core of his graduate research work:
understanding collective (Multiple Inputs – Multiple Outputs, or MIMO) information processing.
This is a crucial problem in cellular biophysics … brought into the public view by the ongoing
COVID-19 epidemics … Dr. Doe considered the case of multiple equivalent receptors competing
for the same ligand molecules diffusing near the cell surface and studied whether this competition
improves the accuracy with which the chemical concentration can be estimated. This paper has
been selected as a spotlight at the recent q-bio Conference, an honor that not too many
submissions achieve, and it has been published in PRE.” (Prof. XXX XXX, XXX University,
Exhibit 7)

“With me, Dr. Doe worked on the extremely challenging problem of understanding how neural
circuits sense and process odors in a naturalistic setting. … this is a problem of great interest to
brain science as well as to bioengineers building electronic systems to detect and process odors.
During his time at XXX, Dr. Doe made major progress on these problems by using his
exceptional skills in biophysics. First, he developed a biophysical model of molecular sensing by
olfactory receptors and showed that it gave an excellent account of the experimentally measured
responses. Dr. Doe’s work was published in the prestigious journal, Proceedings of the National
Academy of Science, and represents a fundamental advance in our understanding of the sense of
smell. In a second paper published in Physical Review E, Dr. Doe presented an elegant and
efficient algorithm for decoding the responses of olfactory receptors to determine what mixture of
molecules is present in the air. The techniques introduced in these papers will be useful in the
design of electronic noses for, e.g., the sensing and detection of biohazards. This breakthrough
offers a wonderful example of the synergies that result when sharp minds with training in one
field work on problems at the interface with another field.” (Prof. XXX XXX, XXX University,
Exhibit 11)

1.11 Evidence of receipt of lesser nationally or internationally recognized prizes or awards for
excellence

1.11.1 Dr. Doe’s has received a research award Excellence in Research from the National
Science Foundation for his vision research (Exhibit 26). He was awarded $373,588 from the
National Science Foundation as a part of this research award.

1.11.2 Dr. Doe’s has been awarded the Support of Competitive Research award by the
National Institute of Health (Exhibit 27). He received $432,000 as a part of this research
award.
1.11.3 Dr. Doe’s research publication was selected as the spotlight in the international q-bio
conference organized at St. John's College, Santa Fe, New Mexico, USA. This is an honor
that only select few researchers in the field of biological physics receive.

“Dr. Doe has discovered that a similar improvement is not seen in molecular
signaling systems due to conservation of molecule numbers. This paper has been
selected as a spotlight at the recent q-bio Conference, an honor that not too many
submissions achieve, and it has been published in PRE.” (Prof. XXX XXX, XXX
University, Exhibit 7)
Permanent Residence Petition for Dr. John Doe

In summary, Dr. Doe has over ten years of experience in research and teaching in statistical physics,
biological physics, and computational neuroscience (Sections 1.1, 1.3, 1.4). He has established a track
record of excellence in these areas (Sections 1.5, 1.6, 1.7). His research is internationally recognized
(Section 1.2, 1.8, 1.11). He is well known in his field and has been invited to judge the work of other
professionals (Section 1.9). He will continue to work in the field of his expertise (Please see Dr.
Doe’s Statement).
Permanent Residence Petition for Dr. John Doe

SECTION 2: Dr. Doe’s proposed endeavor has both substantial merit and national importance

3.1 Biological Physics or Biophysics is an area of substantial merit.

Dr. Doe’s main area of research is biological physics or biophysics. The description of this research
area is provided on the webpage of Biophysical Society (Exhibit 32):

“Biophysics is the field that applies the theories and methods of physics to understand how
biological systems work. Biophysics has been critical to understanding the mechanics of how
the molecules of life are made, how different parts of a cell move and function, and how
complex systems in our bodies—the brain, circulation, immune system, and others— work.
Biophysics is a vibrant scientific field where scientists from many fields including math,
chemistry, physics, engineering, pharmacology, and materials sciences, use their skills to
explore and develop new tools for understanding how biology—all life—works.” (Exhibit 32)

Biological physics is an interdisciplinary science that requires expertise in two or more areas. The
Biophysical Society webpage states:

“Physical scientists use mathematics to explain what happens in nature. Life scientists want
to understand how biological systems work. These systems include molecules, cells,
organisms, and ecosystems that are very complex. Biological research in the 21st century
involves experiments that produce huge amounts of data. How can biologists even begin to
understand this data or predict how these systems might work?

This is where biophysicists come in. Biophysicists are uniquely trained in the quantitative
sciences of physics, math, and chemistry and they are able tackle a wide array of topics,
ranging from how nerve cells communicate, to how plant cells capture light and transform it
into energy, to how changes in the DNA of healthy cells can trigger their transformation into
cancer cells, to so many other biological problems.”

On the importance of biophysics in society, the webpage states:

“Biophysicists work to develop methods to overcome disease, eradicate global hunger,

produce renewable energy sources, design cutting-edge technologies, and solve countless
scientific mysteries. In short, biophysicists are at the forefront of solving age-old human
problems as well as problems of the future.

Biophysics is a scientific field at the forefront of research that is transforming our

understanding of biology and the practice of medicine in magnificent ways.”

Dr. Doe has presented his research 7 times at the annual meeting of American Physics Society in the
Division of Biological Physics. The description of the Division of Biological Physics provides a
summary of the importance of Biological Physics:

“The Division of Biological Physics, established in 1973, is composed of individuals who are
interested in the study of biological phenomena using physical approaches and in
investigations into the physical principles and mechanisms by which living organisms
survive, adapt, and grow. The rich phenomena of life gives biological physics a very broad
Permanent Residence Petition for Dr. John Doe

scope, from answering fundamental questions about life to advancing the biomedical sciences
by developing new drugs and diagnostics equipment. Members of DBIO are affiliated with a
broad range of departments, including Physics, Biophysics, Biochemistry, Mathematics as
well as Schools of Medicine, federal research centers, and the biomedical industry.” (Exhibit
33)

3.2 Dr. Doe’s research will be beneficial to the United States

“Dr. Doe has consistently demonstrated creativity and rigor in his approach to scientific
questions. His continuing presence in the United States will substantially benefit the
American research establishment. His discoveries in biophysics are going to be of significant
importance in the continued growth of biotechnology, and his research will establish him as
an important scientist. Dr. Doe is an outstanding young scientist in the theoretical sciences,
and is now in a faculty position where he will train the next generation of scientists. As a
dedicated teacher and mentor he will be very effective in these roles, too. John Doe is and
will continue to be a significant asset to the United States.” (Exhibit 11, Letter from Prof.
XXX, XXX University)

“Dr. Doe is highly skilled in the area of statistical physics, biological physics and
computational neuroscience. He already has made several landmark contributions and has
exceedingly likely to continue to do so in the future. He should be allowed to remain in U.S.
permanently and prospectively benefit the United States in his extremely valuable field of
endeavor.” (Exhibit 8, Letter from Prof. XXX XXX, XXX University)

“Dr. Doe has demonstrated outstanding capabilities as a scientist and an educator. He has
made a number of seminal discoveries that that have advanced and will continue to advance
the fields of theoretical biophysics. His work has reshaped our understanding of complex
cellular sensing, including in our own olfactory system. I have interacted with many young
scientists in my career, and I truly believe that Dr. Doe is one of the exceptional scientists in
the field of theoretical biophysics, and I highly recommend him for permanent residency as a
researcher of extraordinary ability. The scientific community, and our country as a whole,
will benefit from his presence, and from his efforts and wisdom.” (Exhibit 7, Letter from Prof.
XXX XXX, XXX University)

“Dr. Doe has worked on cutting edge problems in several research areas and provided
original scientific cotributions, pioneering new research directions. He has published
original research articles as the lead author in high impact scientific journals with
international circulation. His work has been well received and been used by other scientists
as reflected by over 190 citations of his publications. His expertise in statistical physics,
biological physics, and computational neuroscience gives him a unique set of skills through
which he can provide fundamental understanding of biological processes, as well as,
practical solutions to medical and technological problems. I believe that Dr. Doe will pioneer
many more research directions.” (Exhibit 9, Letter from Prof. XXX XXX, XXX University)
Permanent Residence Petition for Dr. John Doe

CONCLUSION

Dr. John Doe is an Assistant Professor in tenure-track at the Department of Physics, North Carolina
A&T State University. He has an advanced degree in Physics from a US university. Dr. Doe has made
several original and significant contributions to research in the areas of statistical physics, biological
physics, and computational neuroscience (Section 1). His work has been well recognized (Section 1),
and he will continue to work in his area of expertise (Section 2). Dr. Doe research is in an area of
substantial intrinsic merit and the benefits of his work are in national scope (Section 2). Dr. Doe is
well positioned to continue his research (Section 1) and his unique set of skills provides him the
ability to perform high-quality research significantly above many of his peers (Section 1).

Dr. Doe has earned the support of distinguished researchers within his field of expertise. The excerpts
below express their strong support for his permanent residency petition:

“Dr. Doe is one of the exceptional scientists in the field of theoretical biophysics, and I highly
recommend him for permanent residency as a researcher of extraordinary ability. The scientific
community, and our country as a whole, will benefit from his presence, and from his efforts and
wisdom. I extend my full support for granting permanent residence to Dr. Doe.” (Exhibit 7, Letter
from Prof. XXX XXX, XXX University)

“Dr. Doe will pioneer many more research directions. I fully support and recommend that his petition
for U.S. permanent residence status in EB1 - Extraordinary Ability in Science be granted.”
(Exhibit 9, Letter from Prof. XXX XXX, XXX University)

“Dr. Doe has consistently demonstrated creativity and rigor in his approach to scientific questions.
His continuing presence in the United States will substantially benefit the American research
establishment. His discoveries in biophysics are going to be of significant importance in the
continued growth of biotechnology, and his research will establish him as an important scientist. Dr.
Doe is an outstanding young scientist in the theoretical sciences, and is now in a faculty position
where he will train the next generation of scientists. As a dedicated teacher and mentor he will be
very effective in these roles, too. John Doe is and will continue to be a significant asset to the United
States.” (Exhibit 11, Letter from Prof. XXX XXX, XXX University)

“Dr. Doe has the background and skills to conduct high caliber research in the area of biological
physics. These skills have been developed during his long career as in theoretical physics, as a
graduate student at Emory University, a post-doctoral researcher at University of Pennsylvania, and
an assistant professor at North Carolina A&T State University. He has performed research at the top
tier of a range of fields, has authored original research articles in scientific journals with
international circulation, and his scientific contributions have been useful to other scientists,
including my own work. In consideration of these facts, I fully support his application for U.S.
permanent residence status in EB1 Extraordinary Ability in Science.” (Exhibit 10, Letter from Prof.
XXX XXX, XXX University, Canada)

“Dr. Doe is highly skilled in the area of statistical physics, biological physics and computational
neuroscience. He already has made several landmark contributions and has exceedingly likely to
continue to do so in the future. He should be allowed to remain in U.S. permanently and prospectively
benefit the United States in his extremely valuable field of endeavor.” (Exhibit 8, Letter from Prof.
XXX XXX, XXX University)
Permanent Residence Petition for Dr. John Doe

The initial evidence presented in Sections 1 and 2 and in the attached Exhibits shows that Dr. John
Doe qualifies under five criteria required for aliens of extraordinary ability in science:

(i) Dr. Doe has received internationally recognized prizes and awards for excellence in biological
physics.

(iii) Dr. Doe served as a judge and an expert in the field of physics by reviewing multiple manuscripts
submitted by other scientists.

(iv) Dr. Doe made original contributions of major significance in the field of physics.

(v) Dr. Doe is an author of multiple scholarly articles in physics that are published in major
professional journals

(viii) Dr. Doe has performed in a critical role for research projects at Emory University and the
University of Pennsylvania.

Dr. Doe is a well-recognized expert in the scientific field of Biological Physics who has always
performed at the top of his peers. He is going to continue working in the field of his expertise in the
United States. Supporting letters from experts in the field state that Dr. Doe’s discoveries and
contributions would be beneficial to the United States in research, biomedical applications, and
national security.

Thus, Dr. Doe fully satisfies all requirements and regulations listed in INA Section 203(b)(1)(A) and
8 CFR Section 204.5(h) and I ask the reviewer to approve Dr. John Doe’s petition for the permanent
residence under the category of an alien of extraordinary ability.

Please contact me at the following address for any additional evidence.

Yours Sincerely,

[Sign the document]

John Doe
Address: 123 Road, Apt XX
XYX City, XX State, XXXX.
Ph: 123-456-7890.
 
Permanent Residence Petition for Dr. John Doe

Statement of Dr. John Doe’s proposed work in the United States

I, John Doe, am an Assistant Professor in the Department of Physics at University, City, State
(Exhibit 6). I started my current position in August 2019. Over the last two years, I have established a
biological physics research group in the physics department at XXX Univeristy. In my independent
biophysics research group, I have pursued two research directions in the areas of biological physics.
These research directions are: (1) Understanding human color vision and color perception and (2)
Understanding chemical signaling in biological systems, specifically by the human olfactory system.
These two research directions have been supported by the National Science Foundation and National
Institute of Health. I currently have two active grants totaling over $800,000 in research funds from
these sources (Exhibit 26, 27). My research group currently has six members, four undergraduate
students and two graduate students. I have established research-collaborations at XXX Univeristy and
at other universities across the USA, such as the University of Pennsylvania, University of Wisconsin,
Monell Chemical Sense Center, and Emory University. These collaborations have resulted in two
peer-reviewed publications in the last two years (Exhibit 24, 25). I have the qualifications, resources,
personnel, and funding to carry out my research agenda in biological physics (Exhibit 26, 27). I will
continue to perform research in my area of expertise.

As an assistant professor, I regularly teach undergraduate and graduate level courses in physics and
mentor students in their research (Exhibit 1). I have proposed new physics courses, improved existing
courses in my department, and applied new teaching pedagogies in my classes. Students have rated
my teaching to be well over 80% in all my courses. I enjoy teaching and interacting with students and
find teaching to be a rewarding and satisfying job. I will continue to teach both undergraduate and
graduate level physics courses in the future.

I have been a member of the American Physical Society, the largest organization for physicists across
the world, since 2012 (Exhibit 33). As a member of the society, I have attended its annual conferences
every year. I have presented my work at these conferences (Exhibit 1) and have been invited multiple
times to chair sessions (Exhibit 29 and 30) and to present my research (Exhibit 23). I have also helped
organize the conference for the society (Exhibit 31). In addition, I am regularly invited to review
manuscripts for scientific journals in my area of expertise (Exhibit 28). I enjoy these services to my
scientific community. These services have helped me grow my scientific network across the USA. I
will continue to be an active member of the physics research community in the USA.

I have a good track record in teaching. I have the expertise, resources, personnel, and funding to carry
out my research agenda. I have established a track record of excellence in research, and I am
recognized internationally as outstanding in the field of biological physics. I will continue to work in
the field of my expertise, and I am well positioned to carry out a successful career as a scholar in
physics.

[Sign the document]

Permanent Residence Petition for Dr. John Doe

INDEX TO EXHIBITS

Exhibit 1: Curriculum Vitae of Dr John Doe

Exhibit 2: BS Transcript of Dr John Doe
Exhibit 3: MS Transcript of Dr John Doe
Exhibit 4: PhD Degree of Dr John Doe
Exhibit 5: Evidence of Dr John Doe's Employment at XXX XXX University
Exhibit 6: Evidence of Dr John Doe's Employment at XXX XXX University
Exhibit 7: Recommendation Letter and CV of Dr. XXX XXX, Professor, XXX University
Exhibit 8: Recommendation Letter and CV of Dr. XXX XXX, Professor, XXX University
Exhibit 9: Recommendation Letter and CV of Dr. XXX XXX, Professor, XXX University
Exhibit 10: Recommendation Letter and CV of Dr. XXX XXX, Professor, XXX University
Exhibit 11: Recommendation Letter and CV of Dr. XXX XXX, Professor, XXX University
Exhibit 12: First page of peer-reviewed journal publication of Dr. John Doe, “Ordinary percolation
with discontinuous transitions” Nature Communications, vol. 3, pp. 787, Apr. 2012
Exhibit 13: First page of peer-reviewed first-authored journal publication Dr. John Doe, “Scaling of
clusters near discontinuous percolation transitions in hyperbolic networks” Physical Review E, vol.
90, pp. 012117, July 2014
Exhibit 14: First page of peer-reviewed first-authored journal publication Dr. John Doe, “From
explosive to infinite-order transitions on a hyperbolic network” Physical Review E, vol. 90, pp.
052119, Nov 2014
Exhibit 15: Google Scholar citation record of Dr. John Doe
Exhibit 16: First page of first-authored journal publication Dr. John Doe, “Effects of receptor
correlations on molecular information transmission” Physical Review E, vol. 94, pp. 022425, Aug
2016
Exhibit 17: First page of first-authored journal publication Dr. John Doe, “Simple biochemical
networks allow accurate sensing of multiple ligands with a single receptor” PLOS Computational
Biology, vol. 13(4), pp e1005490, April 2017
Exhibit 18: Comments of anonymous referees on Dr. John Doe's paper in Physical Review Letters
Exhibit 19: First page of first-authored journal publication Dr. John Doe, “Director Field Model of the
Primary Visual Cortex for Contour Detection” PLOS ONE, vol. 9(10), pp e108991, Oct 2014
Exhibit 20: First page of first-authored journal publication Dr. John Doe, “Computational luminance
constancy from naturalistic images” Journal of Vision, vol. 18(13), pp 1-7, Dec 2018
Exhibit 21: First page of first-authored journal publication Dr. John Doe, “Competitive binding
predicts nonlinear responses of olfactory receptors to complex mixtures” PNAS, vol. 116(19), pp
9598-9603, May 2019
Exhibit 22: First page and page with information on Dr. John Doe's invited talk at ICHEMS
conference in April 2019
Permanent Residence Petition for Dr. John Doe

Exhibit 23: Information on scheduled invited talk of Dr. John Doe at APS March meeting in March
2019
Exhibit 24: First page of first-authored journal publication Dr. John Doe, “Universal Properties of
Concentration Sensing in Large Ligand-Receptor Networks” Physical Review Letters, vol. 124, pp
028101, Jan 2020
Exhibit 25: First page of first-authored journal publication Dr. John Doe, “What the odor is not
Estimation by elimination” Physical Review E, vol. 104, pp 024415, Aug 2021
Exhibit 26: NSF Award to Dr. John Doe NSF BCS 2054900 - Excellence in Research Predicting
computations that lead to a stable perception of object lightness under spectral variabilities of the
visual scene
Exhibit 27: NIH Award to Dr. John Doe NIH 1SC2GM140945-01 Predicting computations necessary
for the decoding of odor mixtures by the olfactory system
Exhibit 28: Evidence of reviews performed by Dr John Doe
Exhibit 29: Evidence of Dr. John Doe’s Chaired Sessions at International Conference in 2015
Exhibit 30: Evidence of Dr. John Doe’s Chaired Sessions at International Conference in 2019
Exhibit 31: Evidence of Dr. John Doe’s Abstract Review for International Conference in 2020
Exhibit 32: Information about Biophysical Society
Exhibit 33: Information about Division of Biology, American Physical Society
Exhibit 34: Dr. John Doe's Presentation at American Physical Society Annual Meeting in 2012
Permanent Residence Petition for Dr. John Doe

LIST OF ADDITIONAL DOCUMENTS

A 1: I-797 A Notice of Action: Approval Notice (HIB) XXX Unviersity.

A 2: I-797 A Notice of Action: Approval Notice (HIB) XXX University.
A 3: Most recent I-94 of Dr. John Doe.
A 4: Copy of passport of Dr. John Doe.
A 5: Copy of US visas of Dr. John Doe.