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    Rebuttal of Digestine

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    The document discusses several drugs for treating nausea, vomiting, heartburn, and lactation issues during and after pregnancy. It indicates that vitamin B6 is effective and safe for pregnancy-induced nausea and vomiting but has no role in other conditions like GERD. It asserts that doxylamine + vitamin B6, meclizine + vitamin B6, and dimenhydrinate are not recommended due to safety concerns or lack of efficacy for other issues. Anti-secretory drugs and antacids are not recommended for nausea and vomiting or lactation. Herbal medicines like malunggay are not proven to help conditions during pregnancy or lactation. Domperidone is not recommended due to safety warnings.

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    Rebuttal of Digestine

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    22 views2 pages
    The document discusses several drugs for treating nausea, vomiting, heartburn, and lactation issues during and after pregnancy. It indicates that vitamin B6 is effective and safe for pregnancy-induced nausea and vomiting but has no role in other conditions like GERD. It asserts that doxylamine + vitamin B6, meclizine + vitamin B6, and dimenhydrinate are not recommended due to safety concerns or lack of efficacy for other issues. Anti-secretory drugs and antacids are not recommended for nausea and vomiting or lactation. Herbal medicines like malunggay are not proven to help conditions during pregnancy or lactation. Domperidone is not recommended due to safety warnings.

    Original Description:

    Metoclopramide Resinate vs Conventional Metoclopramide

    Original Title

    REBUTTAL OF DIGESTINE

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    The document discusses several drugs for treating nausea, vomiting, heartburn, and lactation issues during and after pregnancy. It indicates that vitamin B6 is effective and safe for pregnancy-induced nausea and vomiting but has no role in other conditions like GERD. It asserts that doxylamine + vitamin B6, meclizine + vitamin B6, and dimenhydrinate are not recommended due to safety concerns or lack of efficacy for other issues. Anti-secretory drugs and antacids are not recommended for nausea and vomiting or lactation. Herbal medicines like malunggay are not proven to help conditions during pregnancy or lactation. Domperidone is not recommended due to safety warnings.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    22 views2 pages

    Rebuttal of Digestine

    Uploaded by

    Un Known
    The document discusses several drugs for treating nausea, vomiting, heartburn, and lactation issues during and after pregnancy. It indicates that vitamin B6 is effective and safe for pregnancy-induced nausea and vomiting but has no role in other conditions like GERD. It asserts that doxylamine + vitamin B6, meclizine + vitamin B6, and dimenhydrinate are not recommended due to safety concerns or lack of efficacy for other issues. Anti-secretory drugs and antacids are not recommended for nausea and vomiting or lactation. Herbal medicines like malunggay are not proven to help conditions during pregnancy or lactation. Domperidone is not recommended due to safety warnings.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
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    Rebuttal for Digestine

    VITAMIN B6

     Effective & safe for pregnancy-induced nausea & vomiting


     No role in GERD, heartburn & gastric stasis
     No role in post-partum lactation
     Rather has negative impact on lactation

    Doxylamine + Vit. B6 (Envepe)

     Doxylamine - antihistamine , not a specific anti-emetic


     Doxylamine – severe drowsiness is a most common side-effect
     Withdrawn from u.s in 1976 & from UK & other European countries in 1983
     Inconvenient dosage; 1 bid or 1+1+2 at bedtime
     No role in GERD, heartburn & gastric stasis
     No role in post-partum lactation

    Meclizine + Vit. B6 (Navidoxine)

     Antihistamine , not a specific anti-emetic


     Withdrawn from U.K in 2006
     No role in GERD, heartburn & gastric stasis
     No role in post-partum lactation
     Only being used for nausea & vomiting
     Not safe in pregnancy

    Dimenhydrinate (Gravinate)

     Combination of diphenhydramine (antihistamine) + chlorotheophylline (anti-


    asthmatic)
     Diphenhydramine – not a specific anti-emetic
     Chlorotheophylline – CNS stimulant
     Effective for generalized nausea & vomiting
     Not safe / not recommended in pregnancy
     No role in GERD, heartburn & gastric stasis
     No role in post-partum lactation
    Anti-Secretory drugs & Antacids (PPIs (Omeprazole, Rabeprazole), ds Antacids
    (Mucaine, Gaviscon)

     No role in nausea & vomiting


     No role in post-partum lactation
     Effective for GERD, heartburn but with limitations for usage during pregnancy
     PPIs & H2R- reduce acid secretion and antacids neutralize acid secretion leads to
    reduce iron absorption resulting in risk of anemia
     Omeprazole - FDA pregnancy category C
     Antacids may cause constipation or diarrhea

    Malunggay, Sajina, Swanjna (Hilacta)

     Herbal medicine
     Has anti-inflammatory effect
     No role in pregnancy-induced nausea & vomiting
     No role in GERD, heartburn & gastric stasis
     Claimed to improve post-partum lactation (no scientific evidence on mode of action)
     Anti-fertility & abortificient

    Domperidone (Motilium)

     Used for generalized nausea, vomiting, GERD, heartburn & gastric stasis
     Not recommended in pregnancy
     FDA – warning letter to pregnant mothers (unknown risk to mothers & infants-June
    2004)
     Increased risk of seizures in neonates
     Not safe to improve post-partum lactation
     Not FDA approved (not available in USA)

    Digestine
     An innovative sustained release metoclopramide resinate formulation
     Great advantage of OD dose in pregnancy
     Effective & safe even in 1st trimester of pregnancy
     Drug of choice for pregnancy-induced nausea & vomiting in several European
    countries
     Effective & safe for GERD, heartburn & gastric stasis (in general as well as in
    pregnancy)
     A logical treatment to promote post-partum lactation

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