Anti Cancer Drugs

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ANTI-CANCER DRUGS

med.ulaa
1.
Drugs acting on cell
cycle

used in all
. Taxanes - Paclitaxel, Doxotaxel, 2. Arparginase
I
->

source:Ecoli
carbazitaxel
Hemorrhagicpancreatitis,
ADR:

coagulation

2. Vinka alkaloids -
vincristine,
CDK4/6 inhibitors
2.
vinblastine, vinovelbine ↳ Pablociclib. Abemaciclib,

Ribociclib

Ixabepilonel
3.
BreastCA in Breast CA.
used
>
4. Eribulin 3. Steroids ->
of
Apoptosis
5. Estramustine Prostate CA.
B 9 T cells

med.ulaa

"Trinotecan Iboomer
see
1. Anti-metabolites
<

Anticancer
3.
Bleomycin toxins
Antibody
2. Epi-podophyllo
↳ Etoposide
Teneposide I Topoisomerase
I
inhibitors

C.
Drugs independantofcell cycle

1.
Ankylating agents

2.
cisplatin

3. Anticancer antibiotics exceptBleomycin


I

Anti-metabolites. Pemetrexed, Trimetrexate


used in NSCLC, Mesothelioma

Anti-Folates ~ MIX

Inhibits CHFR+
Thymidylate synthase ADR:Hand Foot syndrome
↳ R:Dexamethasone

1. methotrexate

2. Pemetrexed
Raltitrexed
used in breastCA, mesothelioma, Colorectal CA
3. Trimetrexed

4. Pralatrexate

5. Raltitrexed

Methotrexate Purine Antagonists


cancer cell
1.
6-Thioguanine
DHF A
2. 6-mercaptopurine
MTX > MTX DHFR Sinhibits synthesis
DNA

Polyglutamate
3. Fludarabine
W

THEA 4. Cladvibine

5. Pentostatin
·
Resistance -> ↑
expression ofDHFR, Mutation ofD HFR

rapid efflux
Poor activation, poor entry
(TP-glycoprotein)

I
Fludarabine

·
Uses:ANTICANCER choriocarcinoma, All, verapamil USES:CLL,

Cladribine
Osteosarcoma, Lung CA,

Ovary CA
Hairy cell

IMMUNOSUPPRESSANT Psoriasis, RA
(7.5mglurk), Pentostatin Leukemia
Inflammatory BD.

cell leukemia
·

DOC
Hairy
ADR:Myelosuppression, mucositis, alopecia,

neurotoxic (intra-thecal) CLADRIBINE

↳ Derivatives:
COFARABINEE
Chr. low dose
therapy ->
Hepatotoxic in

Crystallizes acidic urine

CI
in Pregnancy ->
NTD

ANTIDOTE PENTOSTATIN
u sed in
Leucovorin, Folinic acid
Histiocytosis
↳ Except
neurotoxicity
↳ I in Renal disease

~X

Glucapidase
4
Mex metabolism

↳ RFT
I pTS
6-mercaptopurine Pyramidine Antagonists

6MP ↓. cytarabine

HGPRT 2. 5:Flurouracil

3. Floxuridine

> Thiosinic acid 4. Gemcitabine

5.
Capecitabine
RESISTANCE:Poor activation of
HGPRT

Def. of HGPRT - Lesch Nyhan Syndrome Cytarabine


USES:AML

METABOLISM:GMP ADR:BMt, Cerebellum #

Xanthine oxidase (Xanthine oxidase 8: ↳ ataxia, dysarthia

We
Allopurinol, Febuxostat]
Thiouric acid 5- Flurouracil
with
If
6mp is
given concurrently Thymidylate
8 synthase
Xanthine oxidase, ·
LEUCOVORIN-> ++ action
Mp dose should be 1 by 50-75%
USES:colorectal CA, Esophageal (A.

Stomach CA, Pancreatic CA

USES:SCLC, NHL, Inflam. BD keratosis, sup.


Topically -> BCC

ADR:BM1, Vasospasm ->


ACs/ m1,
Hand Footsyndrome.
Pulmonary toxicity
Hand Foot Syndrome Radiation Recall metabolite 5FU
COL
·
-
of

causing drugs Reaction -


Drugs
1. 5-Fluvouracil 1. Actinomycin - D
Capecitabine
2. Doxorubicin Doxorubicin
2. ↳ of5
Prodrug Fr

3. Interlukin-2 3. Mitoxantrone * ADR:Hand Foot syndrome


Remetrexed
4.

Gemcitabine
DOC:Pancreatic cancer

Radioprotective drug Radiosensitizer


ADR: 1 BM,
Amitostine

Radio sensitizer
↓ Gemcitabine

2. Metronidazole
Anticancer antibodies Actinomycin D
USES:choriocarcinoma. Ewigs, Wilm's tumor,

1.
Actinomycin D Kaposi sarcoma

I
2. Daunorubicin Antracyclines antibodies ADR:Radiation Recall Phenomenon (Max)
3. Doxorubicin Radiation Recall Phenomenon

4. Mitoxantrone
-

Topoisomerase II Daunorubicin
5.
Mitomycin USES:AML

6. Valrubicin
med.ulaa
7. Epirubicin Doxorubicin
USES:AmL, Breast
2.
Bleomycin ALL. CA. Multiple Myeloma,
9.
Mithramycin Kaposi Sarcoma, NHL, HL

ADR:Dilated Skin vesicant,


cardiomyopathy.

Mitomycin, valrubicin, epirubicin


Red urine

ANTIDOTE:Dexrazoxane a
+

tocophenol
↳ Vit
E
USES:
Urinary Bladder CA ↳ Iron

med.ulaa cheleator

miTomycIN:given
intravesicularly
-Prevents nasal
esophageal stenosis, post

surgical synechine, Laryngotracheal stenosis Metoxantrone


Due anti-fibroblastic
to
activity
USES:Multiple sclerosis, Am, Prostate CA,

Breast
CA
ADR:
Hemolytic Uremic syndrome
ADR:Dilated urine
cardiomyopathy. Blue

Bleomycin
BCG
->

only vaccine
given
USES:Testicular CA, NHL, HL
for R of
intravesicularly
Bladder (A
ADR:
Pulmonary Fibrosis -> due absence
to of
hydrolase enzyme
in the
lungs
Max destruction ->
Pneumocytes I

X
Mucocutaneous
flagellated skin
pigmentation

Raynaud's phenomenon

HTN

Mithramycin med.ulaa
used in
Hypercalcemia

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