SAFETY DATA SHEET Version 6.

13
Revision Date 14.04.2023
according to Regulation (EC) No. 1907/2006 Print Date 24.04.2023
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers
Product name : Methanol
Product Number : 322415
Brand : Sigma-Aldrich
Index-No. : 603-001-00-X
REACH No. : 01-2119433307-44-XXXX
CAS-No. : 67-56-1

1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
1.3 Details of the supplier of the safety data sheet
Company : Merck Life Science (Pty) Ltd.
1 Friesland Drive
Longmeadow Business Estate
MODDERFONTEIN
1609
SOUTH AFRICA
Telephone : +27 +27 (0) 8600 63725
Fax : +27 +27 (0) 860 522 329
E-mail address : [email protected]
1.4 Emergency telephone
Emergency Phone # : 0-800-983-611

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Flammable liquids (Category 2), H225
Acute toxicity, Oral (Category 3), H301
Acute toxicity, Inhalation (Category 3), H331
Acute toxicity, Dermal (Category 3), H311
Specific target organ toxicity - single exposure (Category 1), Eyes, Central nervous system,
H370

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 For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram

Signal Word Danger

Hazard statement(s)
H225 Highly flammable liquid and vapor.
H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled.
H370 Causes damage to organs (Eyes, Central nervous system).
Precautionary statement(s)
P210 Keep away from heat, hot surfaces, sparks, open flames and
other ignition sources. No smoking.
P233 Keep container tightly closed.
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water.
P304 + P340 + P311 IF INHALED: Remove person to fresh air and keep comfortable
for breathing. Call a POISON CENTER/ doctor.
Supplemental Hazard none
Statements

Reduced Labeling (<= 125 ml)

Pictogram

Signal Word Danger

Hazard statement(s)
H370 Causes damage to organs.
H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled.
Precautionary statement(s)
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor.
P304 + P340 + P311 IF INHALED: Remove person to fresh air and keep comfortable
for breathing. Call a POISON CENTER/ doctor.
Supplemental Hazard none
Statements
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.

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SECTION 3: Composition/information on ingredients
3.1 Substances
Synonyms : Methyl alcohol

Formula : CH4O
Molecular weight : 32,04 g/mol
CAS-No. : 67-56-1
EC-No. : 200-659-6
Index-No. : 603-001-00-X
Component Classification Concentration
Methanol
CAS-No. 67-56-1 Flam. Liq. 2; Acute Tox. 3; <= 100 %
EC-No. 200-659-6 STOT SE 1; H225, H301,
Index-No. 603-001-00-X H331, H311, H370
Concentration limits:
>= 10 %: STOT SE 1,
H370; 3 - < 10 %: STOT
SE 2, H371;

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first-aid measures
Notes to physician
Dizziness Drowsiness metabolic acidosis Blurred vision Seizures. Coma Blindness death
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media
No data available
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Combustible.
5.3 Advice for firefighters
No data available
5.4 Further information
No data available

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SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
For personal protection see section 8.
6.2 Environmental precautions
No data available
6.3 Methods and materials for containment and cleaning up
No data available
6.4 Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
No data available
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters
Ingredients with workplace control parameters
Derived No Effect Level (DNEL)
Application Area Routes of Health effect Value
exposure
Workers Skin contact Long-term systemic effects 40mg/kg BW/d
Consumers Skin contact Long-term systemic effects 8mg/kg BW/d
Consumers Ingestion Long-term systemic effects 8mg/kg BW/d
Workers Skin contact Acute systemic effects 40mg/kg BW/d
Consumers Skin contact Acute systemic effects 8mg/kg BW/d
Consumers Ingestion Acute systemic effects 8mg/kg BW/d
Workers Inhalation Acute systemic effects 260 mg/m3
Workers Inhalation Acute local effects 260 mg/m3
Workers Inhalation Long-term systemic effects 260 mg/m3
Workers Inhalation Long-term local effects 260 mg/m3
Consumers Inhalation Acute systemic effects 50 mg/m3
Consumers Inhalation Acute local effects 50 mg/m3
Consumers Inhalation Long-term systemic effects 50 mg/m3
Consumers Inhalation Long-term local effects 50 mg/m3
Predicted No Effect Concentration (PNEC)
Compartment Value
Soil 23,5 mg/kg
Sea water 15,4 mg/l

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 Fresh water 154 mg/l
Fresh water sediment 570,4 mg/kg
Onsite sewage treatment plant 100 mg/kg
8.2 Exposure controls
Personal protective equipment

Skin protection
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN374 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: butyl-rubber
Minimum layer thickness: 0,7 mm
Break through time: 480 min
Material tested:Butoject® (KCL 898)
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN374 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Viton®
Minimum layer thickness: 0,7 mm
Break through time: 120 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)

Control of environmental exposure

Prevent product from entering drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
a) Physical state liquid
b) Color colorless
c) Odor characteristic
d) Melting Melting point/range: -98 °C
point/freezing point
e) Initial boiling point 64,7 °C
and boiling range
f) Flammability (solid, No data available
gas)
g) Upper/lower Upper explosion limit: 44 %(V)

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 flammability or Lower explosion limit: 5,5 %(V)
explosive limits
h) Flash point 9,7 °C - closed cup - Regulation (EC) No. 440/2008, Annex, A.9
i) Autoignition 455,0 °C
temperature at 1.013 hPa - DIN 51794
j) Decomposition Distillable in an undecomposed state at normal pressure.
temperature
k) pH No data available
l) Viscosity Viscosity, kinematic: 0,54 - 0,59 mm2/s at 20 °C

Viscosity, dynamic: > 0,544 - < 0,59 mPa.s at 25 °C

m) Water solubility 1.000 g/l at 20 °C - completely miscible
n) Partition coefficient: log Pow: -0,77 at 25 °C - (HSDB), Bioaccumulation is not
n-octanol/water expected.
o) Vapor pressure 169,27 hPa at 25 °C
p) Density 0,791 g/mL at 25 °C
Relative density 0,79 - 0,8 at 20 °C
q) Relative vapor 1,11
density
r) Particle No data available
characteristics

s) Explosive properties No data available

t) Oxidizing properties none
9.2 Other safety information
Minimum ignition 0,14 mJ
energy
Conductivity < 1 µS/cm
Relative vapor 1,11
density

SECTION 10: Stability and reactivity

10.1 Reactivity
No data available
10.2 Chemical stability
No data available
10.3 Possibility of hazardous reactions
Risk of explosion with:
Oxidizing agents
perchloric acid

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 perchlorates
salts of oxyhalogenic acids
chromium(VI) oxide
halogen oxides
nitrogen oxides
nonmetallic oxides
chromosulfuric acid
chlorates
hydrides
zinc diethyl
halogens
powdered magnesium
hydrogen peroxide
Nitric acid
sulfuric acid
permanganic acid
sodium hypochlorite
Exothermic reaction with:
acid halides
Acid anhydrides
Reducing agents
acids
Bromine
Chlorine
Chloroform
magnesium
tetrachloromethane
Risk of ignition or formation of inflammable gases or vapours with:
Fluorine
Oxides of phosphorus
Raney-nickel
Generates dangerous gases or fumes in contact with:
Alkaline earth metals
Alkali metals

10.4 Conditions to avoid

No data available
10.5 Incompatible materials
No data available
10.6 Hazardous decomposition products
In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects
Acute toxicity
Acute toxicity estimate Oral - 100,1 mg/kg
(Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
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 Symptoms: Nausea, Vomiting
Acute toxicity estimate Inhalation - 4 h - 3,1 mg/l - vapor

(Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Symptoms: Irritation symptoms in the respiratory tract.
Acute toxicity estimate Dermal - 300,1 mg/kg
(Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation
Remarks: (ECHA)
Remarks: Drying-out effect resulting in rough and chapped skin.
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation
Remarks: (ECHA)
Respiratory or skin sensitization
Sensitisation test: - Guinea pig
Result: negative
(OECD Test Guideline 406)
Germ cell mutagenicity
Based on available data the classification criteria are not met.
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative

Test Type: Micronucleus test

Species: Mouse
Cell type: Bone marrow
Application Route: Intraperitoneal injection
Method: OECD Test Guideline 474
Result: negative
Carcinogenicity
Did not show carcinogenic effects in animal experiments.
Reproductive toxicity
Based on available data the classification criteria are not met.
Specific target organ toxicity - single exposure
Causes damage to organs. - Eyes, Central nervous system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)

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 Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
11.2 Additional Information
Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain
components considered to have endocrine
disrupting properties according to REACH Article
57(f) or Commission Delegated regulation (EU)
2017/2100 or Commission Regulation (EU)
2018/605 at levels of 0.1% or higher.
RTECS: PC1400000
Acute effects:, Headache, Dizziness, Drowsiness, narcosis, Blindness, Impairment of vision,
irritant effects, Nausea, Vomiting, agitation, spasms, inebriation, Coma
Drying-out effect resulting in rough and chapped skin.
To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.
Systemic effects:

acidosis
drop in blood pressure
agitation, spasms
inebriation
Dizziness
Drowsiness
Headache
Impairment of vision
Blindness
narcosis
Coma

Symptoms may be delayed.

Damage to:

Liver
Kidney
Cardiac
Irreversible damage of the optical nerve.

Other dangerous properties can not be excluded.

This substance should be handled with particular care.

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SECTION 12: Ecological information
12.1 Toxicity
Toxicity to fish flow-through test LC50 - Lepomis macrochirus (Bluegill) - 15.400,0
mg/l - 96 h
(US-EPA)
Toxicity to daphnia semi-static test EC50 - Daphnia magna (Water flea) - 18.260 mg/l -
and other aquatic 96 h
invertebrates (OECD Test Guideline 202)
Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata (green algae) - ca.
22.000,0 mg/l - 96 h
(OECD Test Guideline 201)
Toxicity to bacteria static test IC50 - activated sludge - > 1.000 mg/l - 3 h
(OECD Test Guideline 209)
Toxicity to NOEC - Oryzias latipes (Orange-red killifish) - 7.900 mg/l - 200 h
fish(Chronic toxicity) Remarks: (External MSDS)

12.2 Persistence and degradability

Biodegradability Result: 99 % - Readily biodegradable.
(OECD Test Guideline 301D)
Biochemical Oxygen 600 - 1.120 mg/g
Demand (BOD) Remarks: (IUCLID)
Chemical Oxygen 1.420 mg/g
Demand (COD) Remarks: (IUCLID)
Theoretical oxygen 1.500 mg/g
demand Remarks: (Lit.)
Ratio BOD/ThBOD 76 %
Remarks: Closed Bottle test(IUCLID)
12.3 Bioaccumulative potential
Bioaccumulation Cyprinus carpio (Carp) - 72 d
at 20 °C - 5 mg/l(Methanol)

Bioconcentration factor (BCF): 1,0

12.4 Mobility in soil
Will not adsorb on soil.
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components
considered to have endocrine disrupting properties
according to REACH Article 57(f) or Commission
Delegated regulation (EU) 2017/2100 or Commission
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 Regulation (EU) 2018/605 at levels of 0.1% or higher.

12.7 Other adverse effects

Additional ecological Avoid release to the environment.
information
Stability in water at 19 °C83 - 91 % - 72 h
Remarks: Hydrolyzes on contact with water.Hydrolyzes readily.
- 2,2 yr
Remarks: reaction with hydroxyl radicals(IUCLID)

SECTION 13: Disposal considerations

13.1 Waste treatment methods
No data available

SECTION 14: Transport information

14.1 UN number
ADR/RID: 1230 IMDG: 1230 IATA: 1230
14.2 UN proper shipping name
ADR/RID: METHANOL
IMDG: METHANOL
IATA: Methanol
14.3 Transport hazard class(es)
ADR/RID: 3 (6.1) IMDG: 3 (6.1) IATA: 3 (6.1)
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
Tunnel restriction code : (D/E)
Further information : No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
Authorisations and/or restrictions on use
REACH - Restrictions on the manufacture, : Methanol
placing on the market and use of certain
dangerous substances, mixtures and articles

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 (Annex XVII)

National legislation
Seveso III: Directive 2012/18/EU of the European : ACUTE TOXIC
Parliament and of the Council on the control of
major-accident hazards involving dangerous
substances.
: FLAMMABLE LIQUIDS
: Methanol

15.2 Chemical Safety Assessment

A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.
H225 Highly flammable liquid and vapor.
H301 Toxic if swallowed.
H301 + H311 + Toxic if swallowed, in contact with skin or if inhaled.
H331
H311 Toxic in contact with skin.
H331 Highly flammable liquid and vapor.
H370 Toxic if swallowed, in contact with skin or if inhaled.
H371 Causes damage to organs (Eyes, Central nervous system).

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 Full text of other abbreviations
ADN - European Agreement concerning the International Carriage of Dangerous Goods
by Inland Waterways; ADR - Agreement concerning the International Carriage of
Dangerous Goods by Road; AIIC - Australian Inventory of Industrial Chemicals; ASTM -
American Society for the Testing of Materials; bw - Body weight; CMR - Carcinogen,
Mutagen or Reproductive Toxicant; DIN - Standard of the German Institute for
Standardisation; DSL - Domestic Substances List (Canada); ECx - Concentration
associated with x% response; ELx - Loading rate associated with x% response; EmS -
Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx -
Concentration associated with x% growth rate response; GHS - Globally Harmonized
System; GLP - Good Laboratory Practice; IARC - International Agency for Research on
Cancer; IATA - International Air Transport Association; IBC - International Code for the
Construction and Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half
maximal inhibitory concentration; ICAO - International Civil Aviation Organization;
IECSC - Inventory of Existing Chemical Substances in China; IMDG - International
Maritime Dangerous Goods; IMO - International Maritime Organization; ISHL - Industrial
Safety and Health Law (Japan); ISO - International Organisation for Standardization;
KECI - Korea Existing Chemicals Inventory; LC50 - Lethal Concentration to 50 % of a
test population; LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose);
MARPOL - International Convention for the Prevention of Pollution from Ships; n.o.s. -
Not Otherwise Specified; NO(A)EC - No Observed (Adverse) Effect Concentration;
NO(A)EL - No Observed (Adverse) Effect Level; NOELR - No Observable Effect Loading
Rate; NZIoC - New Zealand Inventory of Chemicals; OECD - Organization for Economic
Co-operation and Development; OPPTS - Office of Chemical Safety and Pollution
Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippines
Inventory of Chemicals and Chemical Substances; (Q)SAR - (Quantitative) Structure
Activity Relationship; REACH - Regulation (EC) No 1907/2006 of the European
Parliament and of the Council concerning the Registration, Evaluation, Authorisation and
Restriction of Chemicals; RID - Regulations concerning the International Carriage of
Dangerous Goods by Rail; SADT - Self-Accelerating Decomposition Temperature; SDS -
Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory; TECI - Thailand
Existing Chemicals Inventory; TSCA - Toxic Substances Control Act (United States); UN
- United Nations; UNRTDG - United Nations Recommendations on the Transport of
Dangerous Goods; vPvB - Very Persistent and Very Bioaccumulative

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