6" International Symposium on “CURRENT TRENDS IN DRUG DISCOVERY & RESEARCH” (CTDDR-2016) (25%-28" February, 2016) CSIR-Central Drug Research Institute (New Campus) Sector 10, Jankipuram Extension, Sitapur Road, Lucknow-226031, UP, India SCIENTIFIC PROGRAMME 25" February, 2016 14,00 onwards REGISTRATION ‘Venue: CDRI auditorium Inaugural Session Venue: CDRI auditorium Facilitator: Dr. Aamir Nazir, contact no. +91 9198472863; [email protected] 17.30— 17.45 Dr. Madhu Dikshit, Director CSIR-CDRI Welcome Address 1745 — 18.45 [Inaugural lecture by Prof. Tan Gilbert (UK) Title: Drug discovery for neglected diseases IAS — 19.15 Presidential Address by Prof. T. K. Chakraborty (India) 19.15- 19.20 Dr. Arun K. Sinha, Organizing Secretary, CTDDR-2016 Vote of Thanks 19.40 onwards DINNER (CSIR-CDRI Lawn) 26th February, 2016 Session I - Tools for Drug Discovery Chairpersons: Prof. Lesley Marson (USA) & Prof. A. K. Tripathi (India) Venue: CDRI auditorium Vacilitator: Dr. Niti Kumar, contact no, +91 9565612288; [email protected] 09,00 — 09.35 [Plenary Lecture by Prof. Thomas Wirth (UK) Title: Safe Synthesis using Flow Chemistry. 09.35 ~ 10.05 Prof. Klaus Theodor Wanner (Germany) Title: MS Binding Assays as a tool in drug discovery: 10.05 ~ 1035 Dr. Andreas Bender (UK) a Tide: Integrating Chemical and Biological Data for Drug Discovery. 10,35 11.15 TEA/COFFEE BREAKSession II - Infectious Diseases (DNDi Session) Chairpersons: Dr. C.M. Gupta (India) & Prof. Louis Maes (Belgium) Venue: CDRI auditorium Facilitator: Dr. Aamir Nazir; contact no, +91 9198472865; [email protected] 11.15- 11.50 Plenary Lecture by Dr. Robert Don (Switzerland) Title: Changing landscape of ND drug discovery research. 11.50 — 12.20 Dr. Graeme Bilbe (Switzerland) Title: DNDi NCE porfolio for leishmaniasis. 12.20 12.50 Dr. Suman Rijal (DNDi, India) Title: Diversity of visceral leishmaniasis treatments in different regions and disease niches 13.00- 14.00 LUNCH ‘Session III - Filaria and Other Helminth Infections Chairpersons: Dr. Burkhard Konig (Germany) & Dr. Graeme Bilbe (Switzerland) Facilitator: Dr. Mrigank S} Venue: CDRI auditorium stava; contact +91 8853258888; [email protected] 14.00 - 14.35, Plenary Lecture by Prof. Mark Taylor (UK) Title: The discovery and development of macrofilaricides: The AWOL experience. 14.35 - 15.05 Prof, Eileen Devaney (Scotland) Title: MicroRNAs as tools to understand nematode biology and as targets [for control. 15.05 ~ 15.35 Dr. Shailja Misra-Bhattacharya (India) Title: Trehalose-6-phosphate-phosphatase of Brugia malayi shows promise as antifilarial vaccine candidate. ‘Session III (Parallel) - Bone Biology Chairpersons: Dr. Sanjeev Galande (India) & Dr. Rakesh Maurya (India) Venue: CDRI Hall 1 Facilitator: Dr. Maddi Sridhar Reddy; contact no, +91 7897582222; [email protected] 14.00 - 14.35 Plenary Lecture by Prof, Ravinder Goswami (India) Title: Vitamin D deficiency in Indians: Myth or reality. 14.35 - 15.05, Dr. Ritu Trivedi (India) Title: Humble tree hiding surprising secrets: Translating Dalbergia sissoo into product for osteoporasis 15.05 — 15.35 Dr. Naibedya Chattopadhyay (India) Title: Discovery of an osteoanabolic compound from an endangered Himalayan plant: Adiponectin receptor | as the possible molecular mediator of its action. 15.35 - 15.55 TEA/COFFEE BREAKChairpersons: Dr. Ranjit Desai (India) and Prof. Briine Bernhard (Germany) Session IV- Diabetes Venue: CDRI auditorium itor: Dr. Namrata Rastogi; contact no. 9670258538; [email protected] 20.00 onwards _ 15.55 - 16.30 Plenary lecture by Prof. Jean-Francois Tanti (France) Title: Stress pathways involved in adipose tissue dysfunction and insulin resistance in obesity and Type IT diabetes. 16.30 — 17.00 Prof. Milind G. Watve (India) Title: Why diabetes is incurable: Reflections on research in medicine. 17.00 — 1730 Prof. Dwaipayan Bharadwaj (India) Title: Complex disease genetics is absolute confusion: Type II diabetes is a study. 17.30 19.00 POSTER SESSION 19.00 20.00 CULTURAL PROGRAMME DINNER (CSIR-CDRI Lawn) Chairpersons: Dr. V. P. Kamboj (India) & Prof. Stephen Husbands (UK) 27" February, 2016 Session V - Cancer Biology ‘Venue: CDRI auditorium Facilitator: Dr. Dipankar Kol ley, contact +91 9936263170; [email protected] |09.00 09.35 Plenary Lecture by Prof. Ashok Venkitaraman (UK) Title: Extending the reach of target discovery for cancer and other diseases, 09.35 — 10.05 Prof. Brine Bernhard (Germany) Title: Macrophage polarization in the tumor microenvironment, 10.05 ~ 10.35 Dr. Roopa Rai (USA) Title: Temozolomide (TMZ) analogs with improved brain/plasma ratios ~ exploring the possibility of improving the therapeutic index of TMZ. 10.35 — 11.05 Prof. Sanjeev Galande (India) Title: Regulation of chromatin organizer SATBI in colorectal tumorigenesis: A novel role of Wns signaling. 11.05 ~ 11.35 Dr. David A. Wink Jr.(USA) Title: The oncogenic properties of the redox inflammatory protein inducible nitric oxide synthase in ER(-) breast cancer. Session V (Parallel) Young Scientists’ Oral Presentation (Competitive) Chairpersons: Prof. Dwaipayan Bharadwaj (India) & Dr. Anil Chauhan (USA) Each: 8+2 minutes Venue: CDRI Hall 1 Facilitator: Dr. Ashish Arora, contact no, +91 9793162555; [email protected] 9.00 - 11.30 1. Ms. Jyotsana Pandey, CDRI, Lucknow |2. Dr. Mohd. Saguib, University of Allahabad, Allahabad a LT3. Dr. Neelam Kumari, Delhi Univ., Delhi 4, Dr. NN. Anil Kumar, Manipal Univ., Manipal 5. Mr. Dhameliya Tejas, NIPER, Mohali 6. Ms. Preeti Vishwakarma, CDRI, Lucknow 7. Ms. Neotu Dayal, NIPER, Mohali 8. Ms, Sonal Shree, MSB, CDRI, Lucknow 9. Dr. Bijay Kumar, BHU, Varanasi 10, Mr, Pankaj Sharma, CDRI, Lucknow 11. Dr. Jyotiranjan Acharya, DRDE, Gwalior 12. Ms. Sonia Gera, NIPER, Hyderabad 13. Ms. Neha Hura, NIPER, Mohali 14. Ms. Divya Thomas, University of Madras, Chennai, 15, Dr. Baljinder Grewal, CSIR-NCL, Pune 11.35 — 11.55 ‘TEA/COFFEE BREAK _ Session VI - Biochemical Targets Chairpersons: Prof. U.N. Dwivedi (India) & Prof. Anthony James Hickey (USA) Venue: CDRI auditorium Facilitator: Dr. Mrigank Srivastava; contact +91 8853258888; [email protected] 1158-1230 Plenary Lecture by Prof. Martin Scheffner (Germany) Title: The ubiquitin-conjugation system and its role in human disease. 12.30 13.00 Prof, Rajendra Prasad (India) Title: Multidrug transporters in clinical drug resistance. 13.00 13.30 Dr. Sabine Amslinger (Germany) Title: Chemical reactivity tuning for drug development. 1330-1430 LUNCH ‘Session VII - Malaria Chairpersons: Dr. S. K. Puri & Prof. Eileen Devaney (Scotland) Venue: CDRI auditorium Facilitator: Niti Kumar, contact +91 9565612288; [email protected] 14.30 — 15.05 Plenary Lecture by Prof. B. L. Tekwani (USA) Title: Chiral switches for new drug discovery: Molecular pharmacology and safety of 8-aminoguinoline antimalarials. 15.05- 15.35, Dr, Saman Habib (India) Title: Protein translation and [Fe-S] cluster biogenesis in organelles of the malaria parasite. 15.35 — 15.55 ‘TEA/COFFEE BREAKSession VIII - Chemical Tools Chairpersons: Dr. David A. Wink Jr. (USA) & Dr. R.P. Tripathi ‘Venue: Auditorium Facilitator: Dr. Maddi Sridhar Reddy, contact no. +91 7897582222; [email protected] 15,55 ~ 16.30 Plenary lecture by Prof. Koichi Kato(Japan) Title: Structural views of functional glycans of pharmaceutical interest. 16,30 ~ 17.00 Prof. Dr. Burkhard Kénig (Germany) Title: Synthesis and control of bioactive molecules using visible light. 17.00 ~ 17.30 Prof. Manabu Abe (Japan) Title: Design and synthesis of a new chromophore with two-photon absorption property, 2-(4-nitrophenyl) benzofuran, and its application to ‘two-photon uncaging reaction using near IR light. 17.30-19.00 POSTER SESSION 10,00 onwards DINNER (CSIR-CDRI Lawn) 28" February, 2016 Session IX - CVS and CNS Disorders Chairpersons: Prof. Klaus Theodor Wanner (Germany) & Prof. U. K. Mishra (India) ‘Venue: CDRI auditorium Facilitator: Dr. Aamir Nazir, contact no. +91 9198472865; [email protected] 09,00 09.35 Plenary Lecture by Prof. Howard S. Kruth (USA) Title: Atherosclerosis and macrophage deposition of extracellular cholesterol: Elucidation of mediators and inhibition by probucol. 09.35 ~ 10.05 Dr. Anil K. Chauhan (USA) Title: Genetic ablation of extra domain A of fibronectinin hypercholesterolemic mice improves stroke outcome by reducing thrombo- inflammation. 10.05 ~ 10.38 Prof. Stephen Husbands (UK) Title: Opioid polypharmacology: Towards treatments for drug abuse, depression and pain, 10.35 — 11.05 Prof. Lesley Marson (USA) Title: Challenges facing drug development for urological disorders in healthy individuals and after neurofogical damage. 11.05 ~ 11.25 TEA / COFFEE BREAK Session X - Leishmaniasis Chairpersons: Prof. Manabu Abe (Japan) & Dr. Anuradha Dubey (India) a Venue: CDRI auditorium Dr. Mrigank Srivastava; contact +91 8853258888; [email protected] 11.25 ~ 12.00 Plenary Lecture by Prof. Hira L. Nakhasi (USA) Title: Ufin1 mediated protein modification pathway as drug target in the uman protozoan parasite Leishmania donovani. aS12.00 - 12.30 Prof. Louis Maes (Belgium) Title: Genomic and molecular characterization of miltefosine resistance in Leishmania infantum strains with either natural or acquired resistance through experimental selection at intracellular amastigote level 12.30- 13.00 Prof. Rosa M. Reguera (Spain) Title: A drug discovery “ex vivo” platform against visceral leishmaniasis 13.00— 14.00 LUNCH Chairpersons: Prof. Facilitator: Dr. Namrata Rast Session XI - Tuberculosis Surya Kant Tripathi (India) & Prof. Rosa M. Reguera (Spain) Venue: CDRI auditorium contact no. +91 9670258538; namrataiit@gmail 14.00 14.40 Keynote lecture by Prof. Mone Zaidi (USA) Title: Genes, diseases and new medicines. 14.40-15.10 Prof. Anthony James Hickey (USA) Title: Inhaled aerosols for the treatment of infectious disease. 15.10 - 16.30 VALEDICTORY FUNCTION & PRIZE DISTRIBUTION Facilitator: Dr. Aamir Nazir (+91 9198472865); [email protected] 16.30 HIGH TEA