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    I Kadek Diki Dwipayana
    1) The document contains pharmacokinetic data from an experiment measuring drug concentration in plasma over time. It includes concentration values at various timepoints, as well as parameters calculated from the data like half-life, volume of distribution, dose, and area under the curve. 2) Graphs are presented showing the distribution curve based on measured concentration values fit to an exponential decay model, as well as the terminal curve calculated from the same model. 3) A second set of pharmacokinetic data is presented from another experiment, again including measured concentration values over time and calculated parameters like half-life, volume of distribution, dose, and area under the curve. Graphs of the distribution and terminal curves based on

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    Untitled

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    I Kadek Diki Dwipayana
    29 views6 pages
    1) The document contains pharmacokinetic data from an experiment measuring drug concentration in plasma over time. It includes concentration values at various timepoints, as well as parameters calculated from the data like half-life, volume of distribution, dose, and area under the curve. 2) Graphs are presented showing the distribution curve based on measured concentration values fit to an exponential decay model, as well as the terminal curve calculated from the same model. 3) A second set of pharmacokinetic data is presented from another experiment, again including measured concentration values over time and calculated parameters like half-life, volume of distribution, dose, and area under the curve. Graphs of the distribution and terminal curves based on

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    1) The document contains pharmacokinetic data from an experiment measuring drug concentration in plasma over time. It includes concentration values at various timepoints, as well as parameters calculated from the data like half-life, volume of distribution, dose, and area under the curve. 2) Graphs are presented showing the distribution curve based on measured concentration values fit to an exponential decay model, as well as the terminal curve calculated from the same model. 3) A second set of pharmacokinetic data is presented from another experiment, again including measured concentration values over time and calculated parameters like half-life, volume of distribution, dose, and area under the curve. Graphs of the distribution and terminal curves based on

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Download as xlsx, pdf, or txt
    29 views6 pages

    Untitled

    Uploaded by

    I Kadek Diki Dwipayana
    1) The document contains pharmacokinetic data from an experiment measuring drug concentration in plasma over time. It includes concentration values at various timepoints, as well as parameters calculated from the data like half-life, volume of distribution, dose, and area under the curve. 2) Graphs are presented showing the distribution curve based on measured concentration values fit to an exponential decay model, as well as the terminal curve calculated from the same model. 3) A second set of pharmacokinetic data is presented from another experiment, again including measured concentration values over time and calculated parameters like half-life, volume of distribution, dose, and area under the curve. Graphs of the distribution and terminal curves based on

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Download as xlsx, pdf, or txt
    of 6

    Waktu Konsentrasi Plasma cp terminal cp residual AUC

    0.5 19.3 19.4220926510619 0.12209265 9.2175


    1 17.57 17.6707585584125 0.10075856 13.072
    1.8 15.11 15.1911225516604 0.08112255 27.61
    4 9.99 10.0232882910466 0.03328829 15.408
    5.8 7.13 13.024
    8 4.71 13.86
    12 2.22 8.817
    18 0.719 2.847
    24 0.23
    103.8555
    Y=0,1494e-0,371+21,347e-0,189x

    Obat/Parameter ke T1/2 Vd D
    Antibiotik 0.189 3.66666666666667 70267.4849 1500000
    Kurva Distribusi
    0.15

    0.1 f(x) = 0.149370493325797 exp( − 0.37082807709097 x )


    R² = 0.995596759974024
    0.05

    0
    0 0.5 1 1.5 2 2.5 3 3.5 4 4.5
    0.5 0.122093
    1 0.100759
    1.8 0.081123
    4 0.033288

    Kurva Terminal
    AUC Cl F Cp0
    5
    103.8555 14443.1445614 1 21.347 4.5 f(x) = 21.3470669757816 exp( − 0.188645680574564 x )
    4 R² = 0.999992906015859
    3.5
    3
    2.5
    2
    1.5
    1
    0.5
    0
    6 8 10 12 14 16 18 20 22 24 26
    0574564 x )

    22 24 26
    t(jam) c (ug/mL) cp Terminal cp residual AUC
    0 54.05 9.0009 45.0491 2.1265
    0.05 31.01 8.700883500939 22.3091165 1.262
    0.1 19.47 8.410867101835 11.0591329 0.827
    0.15 13.61 8.130517481024 5.479482519 0.605
    0.2 10.59 0.48875
    0.25 8.96 0.42475
    0.3 8.03 0.387
    0.35 7.45 0.36225 0
    0.4 7.04 0.34425 0.05
    0.45 6.73 0.33 0.1
    0.5 6.47 0.3175 0.15
    0.55 6.23 0.306
    0.6 6.01 0.2955
    0.65 5.81 0.2855
    0.7 5.61 0.27575
    0.75 5.42 0.2665
    0.8 5.24 0.2575
    0.85 5.06 0.24875
    0.9 4.89 0.2405
    0.95 4.73 0.2325
    1 4.57
    AUC Total 9.8835

    Y= 45,04e-14,04+9,0009e-0,678x

    Obat/Parameter Ke T1/2 Vd D AUC


    Anti Nyeri 0.678 1.022123894 7221.5000722 65000 9.8835
    Kurva Distribusi
    50
    45
    40 f(x) = 45.0399013270341 exp( − 14.0439316690225 x )
    35 R² = 0.999999926230785
    30
    25
    20
    15
    45.0491 10
    22.309116499061 5
    0
    11.059132898165 0 0.02 0.04 0.06 0.08 0.1 0.12 0.14 0.16
    5.479482518976

    Kurva Teminal
    5.1
    5 f(x) = 9.00094102721739 exp( − 0.677653872325443 x )
    R² = 0.999960861765406
    4.9
    4.8
    4.7
    4.6
    4.5
    4.4
    4.3
    0.84 0.86 0.88 0.9 0.92 0.94 0.96 0.98 1 1.02

    CL F Cp0
    6576.6175949815 1 9.0009
    443 x )

    0.98 1 1.02

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