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    SA Adme Poster

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    Uzy
    Charles River offers a complete range of in vitro and in vivo ADME and DMPK services with a team of over 400 scientists. Their services include absorption, distribution, metabolism, and excretion studies using in vitro assays with cell and tissue models as well as in vivo studies in animals. They provide metabolic stability testing, metabolite identification, and assessment of transporters, protein binding, and drug-drug interactions to support drug discovery and development. More details can be found at their website www.criver.com/ADME.

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    SA Adme Poster

    Uploaded by

    Uzy
    77 views1 page
    Charles River offers a complete range of in vitro and in vivo ADME and DMPK services with a team of over 400 scientists. Their services include absorption, distribution, metabolism, and excretion studies using in vitro assays with cell and tissue models as well as in vivo studies in animals. They provide metabolic stability testing, metabolite identification, and assessment of transporters, protein binding, and drug-drug interactions to support drug discovery and development. More details can be found at their website www.criver.com/ADME.

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    Charles River offers a complete range of in vitro and in vivo ADME and DMPK services with a team of over 400 scientists. Their services include absorption, distribution, metabolism, and excretion studies using in vitro assays with cell and tissue models as well as in vivo studies in animals. They provide metabolic stability testing, metabolite identification, and assessment of transporters, protein binding, and drug-drug interactions to support drug discovery and development. More details can be found at their website www.criver.com/ADME.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    77 views1 page

    SA Adme Poster

    Uploaded by

    Uzy
    Charles River offers a complete range of in vitro and in vivo ADME and DMPK services with a team of over 400 scientists. Their services include absorption, distribution, metabolism, and excretion studies using in vitro assays with cell and tissue models as well as in vivo studies in animals. They provide metabolic stability testing, metabolite identification, and assessment of transporters, protein binding, and drug-drug interactions to support drug discovery and development. More details can be found at their website www.criver.com/ADME.

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    © All Rights Reserved
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    ADME/DMPK Services

    With a team of more than 400 dedicated ADME scientists, Charles River offers a complete range of in vitro and in vivo metabolism studies in support of hit-to-lead,
    candidate discovery, and selection for preclinical testing and clinical development programs. To explore services in depth, visit www.criver.com/ADME.

    IN VITRO IN VIVO
    Absorption Absorption
    Permeability/drug transport Pharmacokinetics, (non-)radiolabelled
    Dermal absorption Dermal absorption

    Distribution Distribution
    Plasma protein binding Tissue distribution/QWBA
    RBC partitioning (blood/plasma ratio)
    Cerebral fluid collection
    Melanin binding Distribution
    Metabolite profiling/identification
    Uptake/Efflux transporters
    Barrier tissue models Pharmacokinetics, (non-)radiolabelled

    Metabolism Metabolism Metabolism


    Metabolic stability Metabolite profiling/identification
    Metabolite profiling/identification Pharmacokinetics, (non-)radiolabelled
    Drug-drug interaction Absorption
    CYP/UGT characterization Excretion
    CYP/UGT inhibition Metabolism cages
    CYP induction Bile cannulation
    Excretion
    Reactive metabolite assessment Expired air collection

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