Environ Health Perspect

DOI: 10.1289/ehp.1509834

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Supplemental Material

Genome-Wide Analysis of DNA Methylation and Cigarette Smoking

in Chinese

Xiaoyan Zhu, Jun Li, Siyun Deng, Kuai Yu, Xuezhen Liu, Qifei Deng, Huizhen Sun, Xiaomin

Zhang, Meian He, Huan Guo, Weihong Chen, Jing Yuan, Bing Zhang, Dan Kuang, Xiaosheng

He, Yansen Bai, Xu Han, Bing Liu, Xiaoliang Li, Liangle Yang, Haijing Jiang, Yizhi Zhang, Jie

Hu, Longxian Cheng, Xiaoting Luo, Wenhua Mei, Zhiming Zhou, Shunchang Sun, Liyun Zhang,

Chuanyao Liu, Yanjun Guo, Zhihong Zhang, Frank B. Hu, Liming Liang, and Tangchun Wu

Table of Contents

Table S1. The 318 identified CpGs associated with cigarette smoking in the genome-wide
meta-analysis (FDR < 0.05).
Table S2. The effect size (s.e.) of smoking on the 318 CpGs with inverse normal transformed
methylation values calculated in different groups.
Table S3. The median methylation values (inter quartile range) of the 318 smoking-related CpGs
in never, former and current smokers.
Table S4. Methylation-gene expression correlations of the smoking-related CpGs in SY (n =
144).
Table S5. Contribution rates of smoking on urinary PAHs metabolites calculated in male
individuals from the WHZH cohort (n = 206).
Table S6. Associations between the smoking-related CpGs and urinary 2-hydroxynaphthalene
levels in males from the WHZH Cohort and the Coke Oven Cohort.
Figure S1. The flowchart of the study.
References

2
 Table S1. The 318 identified CpGs associated with cigarette smoking in the genome-wide meta-analysis (FDR < 0.05).

Our study In Europeans In African Americans

Relation to
Chr Position Gene CpG (n=596)a (n=745)b (n=972)c
gene
Effect p Effect p* Effect p#
1 1078901 - - cg19708306d 0.136 7.89E-06 - -
1 8212843 - - cg05270224d 0.196 5.70E-06 - -
1 11865352 CLCN6 TSS1500 cg05228408 -0.152 1.79E-05 -0.090 4.00E-08 -0.020 2.44E-06
1 11908164 NPPA TSS1500 cg05396397d 0.257 1.02E-07 - -
1 16301562 ZBTB17 5'UTR cg04211179 -0.145 5.11E-08 - -
1 19717337 CAPZB Body cg07573717d -0.104 1.00E-07 - -
1 19810690 CAPZB Body cg19713429 -0.175 1.05E-06 -0.172 1.46E-09 -
1 21617442 ECE1 TSS1500 cg26348226d -0.143 2.18E-06 - -
1 24867657 - - cg17094249d -0.229 6.34E-06 - -
1 25173236 - - cg02818189d -0.135 1.85E-05 - -
1 25254746 RUNX3 Body cg10951873 -0.186 1.85E-06 - -
1 25349681 - - cg27537125 -0.141 1.11E-09 -0.207 2.55E-26 -
1 28521540 PTAFR TSS1500 cg20460771d 0.133 5.47E-06 - -
1 31234437 - - cg25310233d -0.125 1.87E-05 - -
1 42367407 HIVEP3 5'UTR cg14663208d 0.193 1.63E-07 - -
1 42385662 HIVEP3 TSS1500 cg16145216d 0.197 1.12E-05 - -
1 54122060 GLIS1 5'UTR cg24741609 -0.181 1.39E-06 - -
1 54946918 - - cg04158878d 0.147 2.86E-05 - -
1 68299493 GNG12 TSS1500 cg25189904 -0.296 2.25E-11 -0.559 1.25E-32 -
1 90289611 LRRC8D 5'UTR cg20146909 -0.185 5.88E-06 - -
1 92946825 GFI1 Body cg12876356 -0.181 8.95E-06 -0.415 1.63E-17 -
1 92947588 GFI1 Body cg09935388 -0.289 1.11E-10 -0.669 9.56E-33 -
1 153746211 INTS3 3'UTR cg08129092d 0.120 2.52E-05 - -
1 154298956 ATP8B2 TSS1500 cg23924887d -0.110 2.44E-05 - -
1 154299179 ATP8B2 TSS1500 cg06811467d -0.126 1.29E-08 - -
1 154379696 IL6R Body cg09257526d -0.112 5.59E-08 - -
1 156074135 - - cg12593793 -0.110 1.32E-05 -0.120 3.28E-10 -
3
1 156710278 MRPL24 5'UTR cg01416295d -0.180 6.53E-06 - -
1 159753902 - - cg09471611d 0.144 1.84E-05 - -
1 206224334 AVPR1B 5'UTR cg08709672 -0.235 5.08E-07 -0.189 4.75E-25 -
1 228689056 - - cg11229399d 0.194 4.75E-06 - -
2 8343710 - - cg23079012 -0.278 2.07E-11 - -
2 9843525 - - cg08035323 0.261 6.31E-11 - -
2 11969958 - - cg02560388d -0.180 1.60E-06 - -
2 42071660 - - cg13711966d 0.168 6.76E-06 - -
2 65284262 CEP68 5'UTR cg05010058d -0.181 1.78E-05 - -
2 87088834 CD8B Body cg15746583d 0.094 1.59E-05 - -
2 112124380 - - cg09570614 0.139 3.57E-05 - -
2 129231478 - - cg01765406 -0.120 3.16E-05 -0.111 6.80E-11 -
2 135926634 RAB3GAP1 3'UTR cg20949306d 0.180 2.71E-05 - -
2 136577303 LCT Body cg14667406d -0.212 8.71E-06 - -
2 176987918 HOXD9 1stExon cg22674699d 0.216 7.15E-07 - -
2 231790037 GPR55 TSS200 cg16382047d -0.128 1.31E-06 - -
2 231790777 GPR55 TSS1500 cg19827923 -0.161 1.33E-06 -0.131 1.27E-11 -
2 233283329 - - cg03329539 -0.312 9.46E-18 -0.348 6.51E-35 -
2 233284112 - - cg06644428 -0.255 1.86E-09 -0.708 8.48E-28 -
2 233284402 - - cg05951221 -0.490 6.13E-33 -0.627 7.52E-69 -
2 233284661 - - cg21566642 -0.588 4.35E-38 -0.918 2.14E-79 -
2 233284934 - - cg01940273 -0.539 4.56E-33 -0.613 7.44E-74 -
2 233285289 - - cg13193840 -0.230 7.42E-06 -0.293 6.96E-16 -
2 233320593 ALPI TSS1500 cg13481776d 0.131 2.17E-05 - -
2 241140248 - - cg12756150d 0.201 6.94E-06 - -
3 24725365 - - cg13279811d -0.176 3.06E-05 - -
3 39193251 CSRNP1 5'UTR cg00501876 -0.265 8.61E-12 -0.141 1.03E-16 -
3 49394622 GPX1 3'UTR cg18642234 -0.196 2.35E-06 -0.106 6.82E-12 -
3 52812520 ITIH1 TSS200 cg19784816d 0.133 3.24E-05 - -
3 53700141 CACNA1D Body cg15417641 0.221 3.42E-06 - -
3 53700195 CACNA1D Body cg00336149 0.208 3.68E-05 - -
3 53700263 CACNA1D Body cg21188533 0.226 7.81E-06 - -
4
3 96533520 EPHA6 1stExon cg09301294d 0.159 1.96E-05 - -
3 98251294 GPR15 1stExon cg19859270 -0.279 7.50E-09 -0.340 8.57E-27 -0.021 2.45E-11
3 99792561 C3orf26 Body cg15554421d -0.159 5.94E-07 - -
3 111260756 CD96 TSS200 cg05655806 -0.196 3.71E-06 -0.224 3.84E-09 -
3 111260783 CD96 TSS200 cg04039397 -0.204 1.98E-05 - -
3 126242973 CHST13 TSS1500 cg18165852d 0.187 1.65E-05 - -
3 130236259 - - cg26958735d 0.176 1.57E-05 - -
3 188425256 LPP Body cg25853622d -0.061 2.12E-05 - -
3 194119885 GP5 5'UTR cg13185177 0.135 2.45E-05 - -
4 2460483 - - cg23867146d 0.194 1.34E-05 - -
4 5053341 STK32B TSS200 cg10351287d 0.193 1.11E-05 - -
4 26789915 - - cg19719391 0.150 2.32E-05 - -
4 56813860 CEP135 TSS1500 cg26542660d -0.150 1.57E-08 - -
4 95679705 BMPR1B 5'UTR cg09156233d 0.198 3.15E-06 - -
5 321320 AHRR Body cg11554391 -0.217 4.03E-07 -0.201 5.91E-12 -
5 323794 AHRR Body cg17924476 0.173 7.64E-07 - -
5 344057 AHRR Body cg09338136 -0.150 1.07E-05 - -
5 368394 AHRR Body cg12806681 -0.275 3.16E-08 -0.365 4.36E-13 -
5 368447 AHRR Body cg03991871 -0.289 1.02E-09 -0.477 1.63E-21 -
5 368804 AHRR Body cg23916896 -0.300 2.18E-09 -0.505 2.93E-19 -
5 368843 AHRR Body cg11902777 -0.256 4.06E-08 -0.320 4.04E-14 -
5 373299 AHRR Body cg23576855 -0.586 2.62E-44 -0.900 1.08E-14 -
5 373378 AHRR Body cg05575921 -0.617 2.71E-48 -1.445 3.05E-106 -
5 377358 AHRR Body cg26703534 -0.382 1.17E-27 -0.323 9.82E-59 -
5 392920 AHRR Body cg14817490 -0.294 1.92E-12 -0.419 4.22E-37 -
5 393347 AHRR Body cg17287155 -0.196 1.36E-07 -0.321 9.67E-17 -
5 393366 AHRR Body cg04551776 -0.225 4.68E-08 -0.213 4.30E-20 -
5 395444 AHRR Body cg25648203 -0.312 1.00E-15 -0.350 5.14E-37 -
5 399360 AHRR Body cg21161138 -0.397 2.08E-17 -0.463 8.51E-57 -
5 400732 AHRR Body cg24090911 -0.186 1.82E-06 -0.279 1.70E-19 -
5 429559 AHRR Body cg26850624 0.166 5.16E-06 - -
5 14147618 TRIO Body cg10179300 -0.218 2.38E-05 -0.192 5.82E-09 -
5
5 32018601 PDZD2 Body cg13039251 0.192 4.60E-06 - -
5 52096811 ITGA1 Body cg16619991d -0.157 1.42E-05 - -
5 75878300 IQGAP2 Body cg08595501 -0.219 2.02E-06 - -
5 138861241 TMEM173 Body cg04232128d -0.094 2.24E-05 - -
5 146614298 STK32A TSS1500 cg09088988d 0.177 5.57E-07 - -
5 149756966 TCOF1 Body cg24032269d 0.121 1.59E-05 - -
5 150161299 C5orf62 Body cg14580211 -0.177 2.33E-06 -0.273 2.33E-23 -
5 174178256 - - cg24996482d 0.189 2.06E-05 - -
6 30720080 - - cg06126421 -0.359 8.65E-17 -0.761 2.00E-60 -
6 30720108 - - cg14753356 -0.196 2.48E-09 -0.274 3.55E-34 -
6 30720203 - - cg24859433 -0.240 1.85E-07 -0.329 4.43E-35 -
6 30720209 - - cg15342087 -0.241 3.31E-08 -0.273 2.09E-32 -
6 30881112 VARS2 TSS1500 cg08617970d -0.215 5.62E-06 - -
6 30921592 DPCR1 3'UTR cg11485823d 0.169 9.12E-06 - -
6 35696870 FKBP5 TSS1500 cg25114611d -0.124 4.69E-06 - -
6 36645812 CDKN1A TSS1500 cg15474579 -0.147 5.60E-07 -0.162 7.78E-14 -
6 36650733 CDKN1A 5'UTR cg01955533d -0.106 8.25E-06 - -
6 41121920 TREML1 Body cg01564343d 0.184 7.89E-06 - -
6 46702983 PLA2G7 1stExon cg18630040d 0.196 6.68E-07 - -
7 1102177 C7orf50 Body cg15693483d -0.161 3.33E-09 - -
7 1102226 C7orf50 Body cg06009448d -0.105 2.97E-05 - -
7 2847517 GNA12 Body cg09658497 -0.234 4.38E-06 -0.432 1.78E-09 -
7 2847554 GNA12 Body cg19717773 -0.228 3.69E-06 -0.384 1.14E-10 -
7 2847575 GNA12 Body cg18446336 -0.162 1.73E-05 -0.260 6.45E-11 -
7 5457225 TNRC18 Body cg09022230 -0.229 3.51E-08 -0.159 3.13E-10 -
7 26578098 KIAA0087 Body cg02451831 -0.203 2.75E-05 -0.217 1.37E-27 -
7 29606349 PRR15 3'UTR cg06868100d -0.222 5.71E-06 - -
7 38370874 - - cg01726890d 0.152 3.35E-05 - -
7 45002287 MYO1G 3'UTR cg19089201 0.263 2.08E-08 - -
7 45002486 MYO1G Body cg22132788 0.396 5.14E-16 1.070 3.57E-18 -
7 45002736 MYO1G Body cg04180046 0.224 1.56E-06 - -
7 45002919 MYO1G Body cg12803068 0.358 1.10E-13 0.595 2.53E-15 -
6
7 45023329 C7orf40 Body cg03440944 -0.175 1.31E-08 -0.115 1.32E-08 -
7 51384528 COBL TSS200 cg09613161d 0.190 3.60E-05 - -
7 51384609 COBL TSS200 cg04016086d 0.204 1.10E-05 - -
7 56147257 SUMF2 Body cg19956914 0.233 1.51E-06 - -
7 63642083 - - cg20164601d -0.192 1.87E-05 - -
7 98246001 NPTX2 TSS1500 cg13314145d 0.189 1.27E-05 - -
7 100465833 TRIP6 Body cg22851200 -0.186 2.19E-06 -0.181 1.40E-10 -
7 101556588 CUX1 Body cg09762515 0.152 1.84E-05 - -
7 116786606 ST7 Body cg22619824d -0.173 1.49E-05 - -
7 130795028 FLJ43663 TSS1500 cg13990486d -0.194 2.26E-05 - -
7 145812842 CNTNAP2 TSS1500 cg21322436 -0.214 4.94E-06 -0.239 1.49E-24 -
7 145814306 CNTNAP2 Body cg25949550 -0.168 8.19E-09 -0.242 3.09E-18 -
7 146904205 CNTNAP2 Body cg11207515 0.204 1.64E-07 0.293 2.74E-16 -
7 147065665 MIR548I4 Body cg15700587d 0.181 1.81E-07 - -
7 156814480 - - cg09858188d 0.165 1.36E-05 - -
7 158937969 VIPR2 TSS1500 cg23572908d 0.239 1.16E-06 - -
8 11422167 - - cg05635807d 0.240 3.34E-06 - -
8 17658543 MTUS1 TSS200 cg00778858d 0.193 1.05E-05 - -
8 28258603 - - cg24540678 -0.203 8.80E-10 -0.168 4.63E-11 -
8 31496644 NRG1 TSS1500 cg18387156d 0.120 1.28E-05 - -
8 41895100 MYST3 Body cg14316231 -0.152 2.96E-05 -0.125 8.47E-12 -
8 65282185 - - cg25260137d 0.167 1.69E-05 - -
8 93103361 RUNX1T1 5'UTR cg03760919d 0.130 2.66E-05 - -
8 105478855 DPYS Body cg16783744d 0.181 4.26E-06 - -
8 126446923 TRIB1 Body cg22644321d -0.149 1.15E-05 - -
8 128378218 - - cg25305703 -0.165 5.35E-07 -0.330 4.52E-20 -
8 142402728 - - cg12873476 -0.197 6.73E-06 -0.194 1.26E-08 -
8 144576604 ZC3H3 Body cg26361535 -0.228 2.99E-07 -0.269 4.62E-16 -
8 145012644 PLEC1 Body cg13389508d -0.165 1.15E-05 - -
8 145012748 PLEC1 Body cg25325005 -0.146 1.00E-06 - -
9 108005349 - - cg01692968 -0.250 3.01E-10 -0.293 1.36E-26 -
9 126105738 - - cg13418576 -0.195 9.78E-06 - -
7
 9 127054428 NEK6 TSS1500 cg14556677d -0.111 7.99E-09 - -
9 132803508 FNBP1 Body cg06901890 -0.176 3.54E-05 - -
10 8101566 GATA3 Body cg17489908d -0.154 4.80E-06 - -
10 18429661 CACNB2 TSS200 cg20185017d 0.176 2.49E-05 - -
10 21462441 NEBL Body cg17426273d 0.155 1.58E-05 - -
10 43892075 HNRNPF 5'UTR cg00326958 -0.169 2.46E-05 - -
10 46970625 SYT15 TSS200 cg09373037d 0.203 8.44E-06 - -
10 49892930 WDFY4 TSS1500 cg15164194d -0.091 1.81E-06 - -
10 73497514 CDH23 Body cg10750182 -0.213 3.67E-11 -0.118 3.54E-19 -
10 99790170 CRTAC1 Body cg04105282d 0.169 3.53E-05 - -
10 112838983 ADRA2A 1stExon cg05329352 -0.235 3.25E-07 -0.188 1.65E-08 -
10 116298339 ABLIM1 Body cg07978738d -0.145 3.62E-07 - -
10 128994432 DOCK1 Body cg03242819d 0.229 3.41E-07 - -
10 128994644 FAM196A TSS1500 cg03129384d 0.132 8.60E-06 - -
11 2722391 KCNQ1OT1 TSS1500 cg07123182 -0.220 1.51E-05 -0.529 4.85E-15 -
11 2722401 KCNQ1OT1 TSS1500 cg16556677 -0.194 7.36E-06 -0.189 1.71E-13 -
11 2722407 KCNQ1OT1 TSS1500 cg26963277 -0.243 7.39E-07 -0.395 9.93E-18 -
11 5830030 - - cg12884422d -0.213 1.91E-05 - -
11 35161900 CD44 Body cg23186333 -0.180 9.53E-06 - -
11 58870075 - - cg16611234 -0.193 1.29E-05 -0.238 3.60E-13 -
11 60623782 GPR44 TSS1500 cg19254163 -0.176 1.92E-07 -0.142 2.31E-13 -
11 64379586 NRXN2 Body cg27122888d -0.195 4.48E-06 - -
11 65196622 - - cg20889322 -0.204 4.77E-07 - -
11 65201834 - - cg10416861d 0.216 8.67E-07 - -
11 65550444 - - cg09419102d -0.141 1.60E-06 - -
11 68138269 LRP5 Body cg21611682 -0.331 3.80E-14 -0.201 5.51E-33 -
11 68138505 LRP5 Body cg10420527 -0.208 7.06E-08 -0.105 1.05E-14 -
11 68141470 LRP5 Body cg09578155 -0.181 4.44E-07 -0.086 7.02E-10 -
11 68142198 LRP5 Body cg14624207 -0.165 8.62E-07 -0.134 6.54E-14 -
11 71927938 FOLR2 1stExon cg11295113d 0.124 1.18E-05 - -
11 86510915 PRSS23 TSS1500 cg11660018 -0.256 1.36E-12 -0.261 6.89E-30 -
11 86510998 PRSS23 TSS1500 cg23771366 -0.185 1.42E-07 -0.230 1.09E-21 -
8
11 86512100 PRSS23 5'UTR cg23351584 -0.179 1.26E-05 - -
11 116661388 APOA5 Body cg09044186d 0.198 3.66E-05 - -
11 121322456 SORL1 TSS1500 cg10908953 -0.097 3.48E-05 - -
11 122709551 CRTAM Body cg22512531d 0.138 4.70E-07 - -
11 134095863 VPS26B Body cg09084200 -0.187 7.40E-09 -0.118 9.10E-11 -0.015 6.39E-06
12 4384888 CCND2 Body cg07066369d -0.206 1.27E-05 - -
12 4488800 FGF23 5'UTR cg07178945* 0.223 7.62E-09 - -
12 7055657 PTPN6 TSS200 cg23193870d -0.204 1.84E-06 - -
12 11898284 ETV6 Body cg07986378 -0.185 1.08E-05 -0.307 2.57E-18 -
12 25055967 BCAT1 Body cg20399616d 0.228 1.02E-05 - -
12 54677008 HNRNPA1 Body cg02583484 -0.147 5.76E-06 -0.164 3.13E-15 -
12 56403172 - - cg21752525d -0.192 1.83E-05 - -
12 66223718 HMGA2 Body cg01598741d -0.204 3.83E-06 - -
12 109025846 SELPLG 5'UTR cg25165932d 0.197 1.30E-05 - -
12 113914222 - - cg02801786d 0.146 1.20E-05 - -
12 122518517 MLXIP Body cg03844971d -0.178 1.62E-05 - -
12 124016861 RILPL1 Body cg21618017d -0.135 1.28E-05 - -
12 124726864 - - cg02869235d 0.135 2.57E-05 - -
12 124950720 NCOR2 Body cg25922751d -0.179 2.02E-05 - -
12 129337910 GLT1D1 TSS200 cg06419750d 0.180 2.98E-05 - -
13 29068987 FLT1 1stExon cg22574825d 0.202 5.09E-06 - -
13 32889023 BRCA2 TSS1500 cg12836863 0.110 2.02E-05 - -
13 46964186 - - cg02985540 -0.112 1.88E-05 - -
13 48987165 LPAR6 5'UTR cg03646329 -0.196 8.65E-07 - -
13 50702707 - - cg04214430d -0.156 2.05E-05 - -
13 50702719 - - cg02003272 -0.173 3.87E-06 -0.263 6.32E-10 -
13 50702795 - - cg13774342 -0.203 6.73E-07 - -
13 100632250 - - cg18656829d 0.207 1.45E-05 - -
13 111357885 CARS2 Body cg20124610 -0.160 1.03E-06 -0.133 4.35E-12 -
13 114172890 TMCO3 Body cg00619505d 0.147 1.33E-05 - -
14 23450238 JUB Body cg06959340d -0.214 3.06E-05 - -
14 24037169 AP1G2 5'UTR cg02945646d -0.095 3.43E-05 - -
9
14 25079357 GZMH TSS1500 cg02150910d 0.136 2.71E-05 - -
14 74214183 C14orf43 5'UTR cg22851561 -0.146 3.90E-06 -0.160 5.81E-12 -
14 74223355 C14orf43 5'UTR cg24996979 -0.172 2.20E-06 -0.129 1.03E-08 -
14 78051204 SPTLC2 Body cg14544289d -0.199 3.06E-06 - -
14 89933549 FOXN3 5'UTR cg13679772d 0.149 1.94E-06 - -
14 91818668 CCDC88C Body cg01055824d -0.169 8.47E-06 - -
14 91881497 CCDC88C Body cg20303561 -0.150 2.31E-05 -0.164 3.14E-09 -
14 93552128 ITPK1 Body cg05284742 -0.181 1.40E-07 -0.208 1.03E-29 -
14 104190678 ZFYVE21 Body cg26242531 0.146 4.99E-07 - -
14 104190829 ZFYVE21 Body cg14977938 0.196 9.06E-06 - -
14 104196038 ZFYVE21 Body cg19838043 0.185 1.63E-05 - -
14 105857250 PACS2 Body cg12158535d 0.205 8.21E-06 - -
14 106329158 - - cg01513913 -0.347 3.08E-14 -0.119 4.15E-09 -
14 106329206 - - cg13074055 -0.322 7.33E-11 - -
14 106329607 - - cg23594345 -0.326 5.65E-12 - -
14 106329652 - - cg01208318 -0.320 1.04E-12 -0.241 6.19E-09 -
14 106331803 - - cg14387626d -0.142 4.34E-08 - -
14 106354912 - - cg27113548d -0.284 4.60E-09 - -
14 106366503 - - cg00980649 -0.281 2.91E-10 - -
15 38857474 RASGRP1 TSS1500 cg03603381 -0.186 2.58E-05 - -
15 40076065 FSIP1 TSS1500 cg14428590d -0.162 3.25E-05 - -
15 55513621 RAB27A Body cg24687805* 0.158 5.69E-06 - -
15 60296425 FOXB1 5'UTR cg22777952d 0.171 2.01E-05 - -
15 60959637 RORA Body cg15451980 0.129 3.48E-05 - -
15 70387217 TLE3 Body cg26971042 -0.189 1.29E-05 - -
15 70387268 TLE3 Body cg09747445d -0.141 1.13E-05 - -
15 74862662 ARID3B Body cg02384859d 0.142 4.45E-06 - -
15 78384840 SH2D7 TSS200 cg18946533d 0.157 2.30E-05 - -
15 84322591 ADAMTSL3 TSS1500 cg14096889d 0.184 2.15E-05 - -
15 88798877 NTRK3 Body cg20664238d 0.161 2.17E-05 - -
15 90357202 ANPEP 5'UTR cg23161492 -0.310 5.14E-12 -0.303 8.68E-19 -
15 96874050 NR2F2 TSS200 cg14858469d 0.199 2.00E-05 - -
10
15 99194021 IGF1R Body cg07779120d 0.251 2.35E-07 - -
16 3029641 PKMYT1 Body cg04755561d -0.146 1.52E-05 - -
16 17562960 XYLT1 Body cg06321596 -0.210 1.43E-07 -0.178 1.24E-09 -
16 28913517 ATP2A1 Body cg02304156d 0.139 3.16E-05 - -
16 30671749 - - cg07069636 -0.141 9.85E-07 -0.124 2.08E-13 -
16 83962037 - - cg04528720d 0.133 7.86E-06 - -
16 84746995 USP10 Body cg08126789d 0.179 3.04E-05 - -
16 85721561 GINS2 Body cg01383486d -0.135 1.82E-05 - -
16 89041793 CBFA2T3 Body cg04887172d -0.135 1.12E-05 - -
16 89408248 ANKRD11 5'UTR cg01107178d 0.118 1.83E-05 - -
17 1104805 - - cg02352716d 0.128 3.64E-05 - -
17 1553341 RILP 5'UTR cg15380836d -0.092 7.81E-06 - -
17 4923126 KIF1C Body cg03877174d 0.154 7.12E-07 - -
17 8804279 PIK3R5 Body cg05460226 -0.156 9.32E-06 -0.203 5.37E-16 -
17 9921982 GAS7 Body cg02018337d -0.122 4.43E-07 - -
17 27050723 RPL23A Body cg18150958d -0.229 8.85E-07 - -
17 27401793 TIAF1 5'UTR cg18960216d 0.181 1.97E-07 - -
17 38476024 RARA 5'UTR cg19572487 -0.304 4.90E-14 -0.319 4.82E-29 -
17 45785206 TBKBP1 Body cg23673974d 0.122 1.86E-05 - -
17 46622522 HOXB2 TSS200 cg22807449d -0.183 8.42E-06 - -
17 53167407 STXBP4 Body cg07465627 -0.172 1.33E-08 -0.106 9.09E-10 -
17 56082867 SFRS1 3'UTR cg08591265d -0.152 1.42E-06 - -
17 58227267 CA4 TSS200 cg05248618d 0.211 1.31E-05 - -
17 75371764 SEPT9 5'UTR cg07827420d -0.218 2.06E-05 - -
17 75445905 SEPT9 Body cg07324245 -0.108 1.07E-06 - -
18 76739409 SALL3 TSS1500 cg05080154d 0.212 4.87E-08 - -
19 1265879 - - cg00073090 -0.169 7.26E-08 -0.170 2.08E-21 -
19 2093896 MOBKL2A 5'UTR cg15187398 -0.202 8.51E-07 -0.192 3.96E-11 -
19 2094327 MOBKL2A 5'UTR cg07381806 -0.190 3.58E-05 -0.296 8.24E-12 -
19 2291020 LINGO3 Body cg00378510d -0.193 1.46E-05 - -
19 2291373 LINGO3 Body cg01294327 -0.236 4.65E-07 - -
19 7986206 SNAPC2 Body cg14074174 -0.158 1.94E-05 -0.093 5.91E-09 -
11
19 8677774 - - cg03172931d 0.184 4.56E-06 -
19 12776725 MORG1 TSS1500 cg11621113 -0.125 1.53E-06 -0.135 5.08E-09 -
19 13951168 - - cg05339037 -0.171 1.78E-05 -0.086 2.25E-08 -
19 15528530 AKAP8L Body cg14588779d -0.119 1.06E-05 - -
19 16284242 CIB3 1stExon cg09686308d 0.173 1.16E-05 - -
19 17000585 F2RL3 Body cg03636183 -0.471 2.78E-29 -0.660 5.37E-82 -0.096 6.21E-42
19 17003890 CPAMD8 3'UTR cg15159987 -0.162 8.94E-06 -0.146 8.38E-15 -
19 17534351 FAM125A Body cg22678402d -0.093 1.80E-05 - -
19 18873222 CRTC1 Body cg23973524 0.190 4.87E-07 0.195 9.15E-12 -
19 18873268 CRTC1 Body cg21473814 0.198 7.28E-06 - -
19 40919465 PRX TSS200 cg01447828d 0.233 1.54E-07 - -
19 40919485 PRX TSS1500 cg15393221 0.185 1.16E-07 - -
19 41768075 HNRNPUL1 TSS1500 cg13668129 -0.099 8.24E-06 - -0.013 1.06E-07
19 51875451 NKG7 Body cg10126923 0.114 1.77E-06 - -
19 51876788 NKG7 TSS1500 cg12916723d 0.179 2.01E-05 - -
19 51890586 LIM2 Body cg01500140 0.106 2.72E-06 - 0.022 8.10E-07
19 53758055 ZNF677 5'UTR cg03217253d 0.216 3.10E-07 - -
19 56701254 ZSCAN5B Body cg21733502d -0.197 3.44E-05 - -
20 1310884 SDCBP2 TSS1500 cg05007126d -0.137 3.17E-05 - -
20 6748730 BMP2 TSS200 cg13724496d 0.189 1.15E-05 - -
20 43438809 RIMS4 Body cg15207742d 0.212 1.40E-06 - -
20 44069038 - - cg20344344d -0.159 8.93E-06 - -
20 45985741 ZMYND8 TSS1500 cg12303084 -0.109 2.60E-05 -0.170 4.09E-12 -
20 50312490 ATP9A Body cg07339236 -0.256 8.39E-10 -0.296 6.76E-13 -
20 55204986 TFAP2C Body cg26736540d 0.169 3.19E-05 - -
20 61637856 BHLHE23 1stExon cg06135139d 0.222 4.80E-06 - -
21 40180000 ETS2 5'UTR cg15892280 -0.103 8.40E-06 - -
21 40182073 ETS2 Body cg23110422 -0.255 9.38E-08 -0.258 5.45E-15 -
21 47319304 PCBP3 Body cg10204884d -0.164 2.81E-05 - -
22 20792535 SCARF2 TSS1500 cg14785479d 0.123 1.10E-06 - -
22 31686097 PIK3IP1 Body cg08548559 -0.154 2.62E-05 - -
22 37257404 NCF4 Body cg02532700 -0.217 2.02E-06 -0.251 2.22E-11 -
12
22 41633219 CHADL Body cg26364091 -0.197 1.86E-05 - -
d
22 45403507 PHF21B Body cg06008724 0.172 1.22E-05 - -
22 48971959 FAM19A5 Body cg04198308d 0.195 1.15E-05 - -
Abbreviations: Chr, Chromosome; UTR, untranslated regions; Body, gene body; 1stExon, the first exon; TSS200, within 200 bps from
transcription start site; TSS1500, within 1500 bps from transcription start site.
a
Fixed effect meta-analysis, with sample size-weighted method to get p values, and an inverse-variance weighted method to get
estimates of effect size. b Linear models with DNA methylation levels as the dependent variable, smoking status as the dependent
variable, adjusting for micro-array, position of the sample on the micro-array and blood cell composition (Guida et al. 2015). c Linear
mixed models with methylation beta values as the dependent variable, current smoker and pack-years as the primary independent
variables, adjusting for age and sex (Sun et al. 2013). d CpGs that have not been reported to be significantly associated with smoking in
previous genome-wide studies of methylation and smoking in Europeans (Guida et al. 2015; Shenker et al. 2013; Zeilinger et al. 2013)
or in African Americans (Dogan et al 2014; Philibert et al. 2013; Sun et al. 2013).
*
Bonferroni p < 0.05. # Bonferroni p < 0.05 or FDR <0.05

13
 Table S2. The effect size (s.e.) of smoking on the 318 CpGs with inverse normal transformed methylation values calculated in
different groups.

Datasets of ACS patients Datasets of healthy individuals

Individuals in Wuhan Individuals in Guangdong
ACS in Wuhan ACS in Guangdong
CpG Gene (COW-1&Wuhan residents (Zhuhai residents of
(ACS-1, n = 101) (ACS-2, n = 97)
of WHZH, n = 299) WHZH, n = 99)
Effect (s.e.) p Effect (s.e.) p Effect (s.e.) p Effect (s.e.) p
cg19708306 - 0.117 (0.061) 0.060 0.028 (0.089) 0.756 0.182 (0.042) 1.60E-05 0.092 (0.073) 0.210
cg05270224 - 0.254 (0.115) 0.030 0.139 (0.094) 0.142 0.193 (0.064) 0.003 0.219 (0.093) 0.021
cg05228408 CLCN6 -0.202 (0.087) 0.023 -0.211 (0.080) 0.010 -0.102 (0.049) 0.038 -0.189 (0.090) 0.038
cg05396397 NPPA 0.302 (0.121) 0.014 0.278 (0.104) 0.009 0.249 (0.070) 4.35E-04 0.214 (0.112) 0.059
cg04211179 ZBTB17 -0.120 (0.064) 0.065 -0.162 (0.059) 0.007 -0.138 (0.038) 3.69E-04 -0.169 (0.062) 0.008
cg07573717 CAPZB -0.172 (0.044) 1.99E-04 -0.035 (0.039) 0.369 -0.138 (0.031) 1.03E-05 -0.039 (0.051) 0.449
cg19713429 CAPZB -0.225 (0.100) 0.028 -0.254 (0.079) 0.002 -0.129 (0.048) 0.008 -0.196 (0.094) 0.040
cg26348226 ECE1 -0.143 (0.078) 0.069 -0.243 (0.079) 0.003 -0.133 (0.043) 0.002 -0.100 (0.063) 0.118
cg17094249 - -0.136 (0.122) 0.268 -0.254 (0.114) 0.029 -0.295 (0.075) 1.00E-04 -0.123 (0.119) 0.302
cg02818189 - -0.048 (0.078) 0.541 -0.100 (0.068) 0.146 -0.143 (0.046) 0.002 -0.219 (0.068) 0.002
cg10951873 RUNX3 -0.191 (0.095) 0.048 -0.153 (0.086) 0.081 -0.140 (0.055) 0.012 -0.345 (0.091) 3.02E-04
cg27537125 - -0.180 (0.057) 0.002 -0.071 (0.052) 0.173 -0.120 (0.033) 2.70E-04 -0.252 (0.057) 2.74E-05
cg20460771 PTAFR 0.202 (0.076) 0.009 0.096 (0.085) 0.266 0.114 (0.038) 0.003 0.161 (0.068) 0.020
cg25310233 - -0.111 (0.074) 0.138 -0.129 (0.071) 0.072 -0.132 (0.039) 7.51E-04 -0.105 (0.076) 0.172
cg14663208 HIVEP3 0.197 (0.095) 0.042 0.031 (0.117) 0.795 0.200 (0.046) 1.78E-05 0.241 (0.076) 0.002
cg16145216 HIVEP3 0.260 (0.109) 0.020 0.169 (0.096) 0.083 0.136 (0.065) 0.037 0.308 (0.097) 0.002
cg24741609 GLIS1 -0.074 (0.097) 0.453 -0.195 (0.080) 0.017 -0.181 (0.052) 5.84E-04 -0.260 (0.093) 0.006
cg04158878 - 0.280 (0.109) 0.012 0.175 (0.092) 0.060 0.141 (0.047) 0.003 0.059 (0.087) 0.497
cg25189904 GNG12 -0.299 (0.086) 7.59E-04 -0.134 (0.105) 0.206 -0.255 (0.064) 9.25E-05 -0.518 (0.096) 6.90E-07
cg20146909 LRRC8D -0.313 (0.096) 0.002 -0.105 (0.098) 0.287 -0.150 (0.057) 0.009 -0.238 (0.098) 0.017
14
cg12876356 GFI1 -0.202 (0.101) 0.050 -0.177 (0.102) 0.088 -0.188 (0.058) 0.001 -0.150 (0.092) 0.108
cg09935388 GFI1 -0.267 (0.113) 0.020 -0.340 (0.100) 0.001 -0.268 (0.064) 3.97E-05 -0.303 (0.095) 0.002
cg08129092 INTS3 0.088 (0.066) 0.184 0.011 (0.069) 0.870 0.157 (0.041) 1.69E-04 0.162 (0.069) 0.022
cg23924887 ATP8B2 -0.149 (0.071) 0.040 -0.153 (0.057) 0.009 -0.148 (0.039) 1.69E-04 0.050 (0.059) 0.398
cg06811467 ATP8B2 -0.170 (0.050) 9.80E-04 -0.105 (0.058) 0.076 -0.139 (0.028) 1.62E-06 -0.032 (0.059) 0.595
cg09257526 IL6R -0.129 (0.053) 0.017 -0.049 (0.046) 0.287 -0.119 (0.030) 7.39E-05 -0.151 (0.049) 0.003
cg12593793 - -0.231 (0.058) 1.60E-04 -0.046 (0.059) 0.437 -0.070 (0.036) 0.051 -0.155 (0.056) 0.007
cg01416295 MRPL24 -0.118 (0.096) 0.226 -0.151 (0.095) 0.114 -0.111 (0.053) 0.038 -0.410 (0.082) 3.03E-06
cg09471611 - 0.239 (0.086) 0.007 0.094 (0.109) 0.393 0.157 (0.040) 1.29E-04 0.024 (0.085) 0.782
cg08709672 AVPR1B -0.145 (0.102) 0.157 -0.395 (0.094) 7.34E-05 -0.140 (0.067) 0.036 -0.399 (0.115) 8.68E-04
cg11229399 - 0.262 (0.108) 0.018 0.099 (0.101) 0.331 0.227 (0.059) 1.70E-04 0.136 (0.101) 0.184
cg23079012 - -0.399 (0.113) 7.05E-04 -0.276 (0.099) 0.007 -0.239 (0.057) 3.87E-05 -0.299 (0.091) 0.001
cg08035323 - 0.389 (0.108) 5.48E-04 0.316 (0.107) 0.004 0.177 (0.053) 0.001 0.356 (0.084) 5.66E-05
cg02560388 - -0.185 (0.092) 0.047 -0.085 (0.089) 0.345 -0.226 (0.053) 2.96E-05 -0.142 (0.089) 0.116
cg13711966 - 0.322 (0.091) 6.70E-04 0.132 (0.086) 0.127 0.130 (0.054) 0.017 0.163 (0.083) 0.051
cg05010058 CEP68 -0.045 (0.101) 0.659 -0.100 (0.098) 0.308 -0.264 (0.063) 4.31E-05 -0.194 (0.097) 0.049
cg15746583 CD8B 0.079 (0.058) 0.180 0.122 (0.048) 0.012 0.100 (0.030) 0.001 0.055 (0.051) 0.277
cg09570614 - 0.252 (0.074) 0.001 0.032 (0.081) 0.691 0.101 (0.047) 0.033 0.224 (0.080) 0.006
cg01765406 - -0.100 (0.072) 0.166 0.048 (0.068) 0.480 -0.143 (0.041) 5.19E-04 -0.207 (0.057) 5.00E-04
cg20949306 RAB3GAP1 0.414 (0.109) 2.85E-04 0.151 (0.112) 0.183 0.148 (0.060) 0.015 0.102 (0.095) 0.284
cg14667406 LCT -0.090 (0.122) 0.460 -0.319 (0.112) 0.005 -0.210 (0.066) 0.002 -0.215 (0.111) 0.057
cg22674699 HOXD9 0.284 (0.103) 0.007 0.154 (0.117) 0.191 0.213 (0.059) 3.70E-04 0.204 (0.102) 0.049
cg16382047 GPR55 -0.157 (0.079) 0.049 -0.063 (0.059) 0.285 -0.132 (0.037) 4.25E-04 -0.170 (0.062) 0.007
cg19827923 GPR55 -0.189 (0.087) 0.033 -0.216 (0.066) 0.002 -0.101 (0.048) 0.036 -0.207 (0.068) 0.003
cg03329539 - -0.314 (0.075) 7.00E-05 -0.402 (0.091) 3.11E-05 -0.272 (0.050) 1.01E-07 -0.350 (0.091) 2.53E-04
cg06644428 - -0.309 (0.096) 0.002 -0.332 (0.107) 0.003 -0.179 (0.061) 0.004 -0.309 (0.082) 3.09E-04
cg05951221 - -0.502 (0.081) 2.29E-08 -0.480 (0.088) 5.15E-07 -0.493 (0.058) 1.44E-15 -0.479 (0.092) 1.25E-06
cg21566642 - -0.683 (0.100) 1.21E-09 -0.658 (0.093) 4.84E-10 -0.516 (0.061) 1.47E-15 -0.607 (0.100) 4.02E-08
15
cg01940273 - -0.608 (0.102) 5.95E-08 -0.718 (0.096) 6.74E-11 -0.436 (0.06) 5.77E-12 -0.555 (0.092) 3.97E-08
cg13193840 - -0.309 (0.116) 0.009 -0.344 (0.120) 0.005 -0.121 (0.073) 0.098 -0.322 (0.115) 0.006
cg13481776 ALPI 0.231 (0.079) 0.004 0.082 (0.084) 0.331 0.099 (0.042) 0.018 0.169 (0.067) 0.014
cg12756150 - 0.140 (0.114) 0.222 0.128 (0.106) 0.233 0.219 (0.062) 4.77E-04 0.275 (0.106) 0.011
cg13279811 - -0.282 (0.096) 0.004 -0.089 (0.100) 0.380 -0.168 (0.060) 0.006 -0.167 (0.101) 0.102
cg00501876 CSRNP1 -0.243 (0.105) 0.023 -0.214 (0.082) 0.010 -0.302 (0.053) 3.98E-08 -0.232 (0.096) 0.018
cg18642234 GPX1 -0.211 (0.113) 0.066 -0.235 (0.095) 0.016 -0.183 (0.060) 0.002 -0.183 (0.087) 0.038
cg19784816 ITIH1 0.159 (0.073) 0.031 0.168 (0.067) 0.014 0.079 (0.046) 0.085 0.233 (0.088) 0.010
cg15417641 CACNA1D 0.196 (0.120) 0.106 0.249 (0.118) 0.038 0.215 (0.067) 0.001 0.233 (0.105) 0.029
cg00336149 CACNA1D 0.230 (0.124) 0.069 0.126 (0.124) 0.312 0.181 (0.070) 0.011 0.319 (0.109) 0.004
cg21188533 CACNA1D 0.248 (0.126) 0.053 0.185 (0.118) 0.121 0.227 (0.074) 0.002 0.242 (0.110) 0.030
cg09301294 EPHA6 0.113 (0.094) 0.234 0.167 (0.096) 0.087 0.139 (0.051) 0.006 0.242 (0.083) 0.005
cg19859270 GPR15 -0.439 (0.117) 3.32E-04 -0.214 (0.110) 0.056 -0.269 (0.069) 1.09E-04 -0.224 (0.114) 0.053
cg15554421 C3orf26 -0.143 (0.084) 0.092 -0.169 (0.066) 0.013 -0.134 (0.046) 0.004 -0.219 (0.070) 0.002
cg05655806 CD96 -0.233 (0.112) 0.041 -0.140 (0.088) 0.113 -0.184 (0.063) 0.004 -0.269 (0.099) 0.008
cg04039397 CD96 -0.026 (0.116) 0.823 -0.128 (0.106) 0.231 -0.231 (0.069) 9.73E-04 -0.383 (0.111) 8.78E-04
cg18165852 CHST13 0.080 (0.106) 0.452 0.085 (0.104) 0.415 0.230 (0.060) 1.64E-04 0.263 (0.105) 0.014
cg26958735 - 0.106 (0.098) 0.284 0.089 (0.097) 0.365 0.190 (0.057) 0.001 0.294 (0.098) 0.004
cg25853622 LPP -0.112 (0.038) 0.004 -0.042 (0.034) 0.219 -0.079 (0.023) 5.75E-04 -0.010 (0.030) 0.733
cg13185177 GP5 0.278 (0.082) 0.001 0.159 (0.076) 0.040 0.090 (0.046) 0.055 0.114 (0.067) 0.092
cg23867146 - 0.333 (0.110) 0.003 0.259 (0.094) 0.007 0.137 (0.067) 0.041 0.140 (0.093) 0.136
cg10351287 STK32B 0.107 (0.105) 0.314 0.102 (0.104) 0.328 0.261 (0.065) 8.44E-05 0.194 (0.097) 0.049
cg19719391 - 0.183 (0.102) 0.076 0.079 (0.085) 0.359 0.198 (0.050) 9.21E-05 0.071 (0.080) 0.375
cg26542660 CEP135 -0.199 (0.062) 0.002 -0.108 (0.062) 0.083 -0.161 (0.037) 2.34E-05 -0.110 (0.065) 0.094
cg09156233 BMPR1B 0.151 (0.099) 0.133 0.231 (0.104) 0.029 0.239 (0.062) 1.34E-04 0.112 (0.099) 0.264
cg11554391 AHRR -0.058 (0.110) 0.596 -0.173 (0.098) 0.080 -0.272 (0.060) 9.93E-06 -0.244 (0.096) 0.013
cg17924476 AHRR 0.164 (0.103) 0.114 0.144 (0.086) 0.096 0.149 (0.045) 0.001 0.297 (0.089) 0.001
cg09338136 AHRR -0.207 (0.076) 0.008 -0.037 (0.087) 0.672 -0.158 (0.048) 0.001 -0.157 (0.075) 0.039
16
cg12806681 AHRR -0.477 (0.117) 9.68E-05 -0.284 (0.120) 0.020 -0.243 (0.069) 4.50E-04 -0.150 (0.120) 0.214
cg03991871 AHRR -0.433 (0.113) 2.50E-04 -0.268 (0.111) 0.018 -0.281 (0.068) 4.93E-05 -0.202 (0.106) 0.060
cg23916896 AHRR -0.467 (0.102) 1.57E-05 -0.279 (0.117) 0.019 -0.238 (0.071) 8.77E-04 -0.269 (0.119) 0.026
cg11902777 AHRR -0.383 (0.099) 2.23E-04 -0.119 (0.104) 0.255 -0.223 (0.068) 0.001 -0.338 (0.110) 0.003
cg23576855 AHRR -0.695 (0.103) 1.74E-09 -0.517 (0.100) 1.56E-06 -0.575 (0.053) 8.02E-23 -0.591 (0.082) 2.41E-10
cg05575921 AHRR -0.648 (0.089) 1.52E-10 -0.481 (0.094) 2.12E-06 -0.582 (0.055) 2.89E-22 -0.768 (0.081) 6.06E-15
cg26703534 AHRR -0.497 (0.093) 6.92E-07 -0.321 (0.079) 1.17E-04 -0.372 (0.046) 3.45E-14 -0.389 (0.076) 2.11E-06
cg14817490 AHRR -0.351 (0.087) 1.19E-04 -0.190 (0.091) 0.041 -0.286 (0.062) 5.32E-06 -0.367 (0.102) 5.57E-04
cg17287155 AHRR -0.106 (0.094) 0.259 -0.286 (0.072) 1.42E-04 -0.127 (0.051) 0.013 -0.353 (0.090) 1.91E-04
cg04551776 AHRR -0.215 (0.108) 0.048 -0.130 (0.088) 0.145 -0.221 (0.059) 2.18E-04 -0.353 (0.096) 3.97E-04
cg25648203 AHRR -0.387 (0.101) 2.48E-04 -0.195 (0.089) 0.032 -0.346 (0.054) 6.23E-10 -0.279 (0.087) 0.002
cg21161138 AHRR -0.481 (0.112) 4.82E-05 -0.287 (0.102) 0.006 -0.370 (0.066) 4.64E-08 -0.513 (0.107) 6.39E-06
cg24090911 AHRR -0.127 (0.087) 0.146 -0.135 (0.092) 0.147 -0.222 (0.057) 1.34E-04 -0.212 (0.096) 0.030
cg26850624 AHRR 0.293 (0.081) 4.92E-04 0.078 (0.089) 0.385 0.180 (0.048) 2.28E-04 0.038 (0.094) 0.690
cg10179300 TRIO -0.055 (0.126) 0.664 -0.141 (0.119) 0.237 -0.280 (0.076) 3.01E-04 -0.286 (0.113) 0.013
cg13039251 PDZD2 0.145 (0.103) 0.162 0.231 (0.095) 0.017 0.138 (0.059) 0.020 0.340 (0.096) 6.67E-04
cg16619991 ITGA1 -0.234 (0.091) 0.012 -0.234 (0.075) 0.003 -0.193 (0.050) 1.59E-04 0.128 (0.088) 0.150
cg08595501 IQGAP2 -0.124 (0.105) 0.242 -0.003 (0.114) 0.979 -0.320 (0.066) 1.95E-06 -0.238 (0.107) 0.029
cg04232128 TMEM173 -0.190 (0.045) 6.49E-05 -0.007 (0.047) 0.886 -0.111 (0.031) 4.28E-04 -0.006 (0.059) 0.917
cg09088988 STK32A 0.118 (0.076) 0.123 0.129 (0.081) 0.113 0.267 (0.054) 1.35E-06 0.068 (0.090) 0.449
cg24032269 TCOF1 0.141 (0.068) 0.042 0.048 (0.067) 0.480 0.123 (0.040) 0.002 0.160 (0.061) 0.011
cg14580211 C5orf62 -0.048 (0.093) 0.609 -0.267 (0.078) 9.61E-04 -0.158 (0.053) 0.003 -0.225 (0.083) 0.009
cg24996482 - 0.061 (0.109) 0.579 0.227 (0.103) 0.030 0.225 (0.062) 3.24E-04 0.161 (0.107) 0.134
cg06126421 - -0.369 (0.096) 2.35E-04 -0.335 (0.103) 0.002 -0.325 (0.060) 1.66E-07 -0.452 (0.094) 7.11E-06
cg14753356 - -0.222 (0.079) 0.006 -0.140 (0.074) 0.061 -0.194 (0.049) 1.13E-04 -0.227 (0.067) 0.001
cg24859433 - -0.193 (0.110) 0.084 -0.301 (0.112) 0.009 -0.229 (0.064) 4.34E-04 -0.257 (0.108) 0.020
cg15342087 - -0.202 (0.111) 0.072 -0.250 (0.099) 0.014 -0.199 (0.060) 0.001 -0.403 (0.107) 3.16E-04
cg08617970 VARS2 -0.321 (0.108) 0.004 -0.195 (0.114) 0.091 -0.205 (0.068) 0.003 -0.148 (0.110) 0.181
17
cg11485823 DPCR1 0.210 (0.092) 0.025 0.147 (0.093) 0.117 0.136 (0.052) 0.010 0.259 (0.097) 0.009
cg25114611 FKBP5 -0.159 (0.073) 0.033 -0.079 (0.062) 0.206 -0.141 (0.037) 1.98E-04 -0.094 (0.068) 0.173
cg15474579 CDKN1A -0.224 (0.062) 4.99E-04 -0.092 (0.070) 0.193 -0.117 (0.041) 0.005 -0.197 (0.075) 0.010
cg01955533 CDKN1A -0.189 (0.056) 0.001 0.004 (0.058) 0.945 -0.098 (0.034) 0.005 -0.137 (0.048) 0.005
cg01564343 TREML1 0.221 (0.099) 0.028 0.347 (0.101) 9.28E-04 0.109 (0.057) 0.057 0.212 (0.097) 0.031
cg18630040 PLA2G7 0.094 (0.107) 0.381 0.165 (0.092) 0.075 0.210 (0.055) 1.51E-04 0.246 (0.080) 0.003
cg15693483 C7orf50 -0.200 (0.075) 0.010 -0.156 (0.057) 0.008 -0.157 (0.039) 8.82E-05 -0.150 (0.060) 0.015
cg06009448 C7orf50 -0.191 (0.066) 0.005 -0.185 (0.057) 0.002 -0.048 (0.035) 0.175 -0.111 (0.056) 0.051
cg09658497 GNA12 -0.271 (0.125) 0.033 -0.313 (0.108) 0.005 -0.213 (0.074) 0.004 -0.160 (0.117) 0.177
cg19717773 GNA12 -0.231 (0.125) 0.067 -0.302 (0.106) 0.005 -0.218 (0.071) 0.003 -0.167 (0.110) 0.133
cg18446336 GNA12 -0.238 (0.089) 0.009 -0.153 (0.076) 0.048 -0.166 (0.058) 0.004 -0.091 (0.089) 0.308
cg09022230 TNRC18 -0.320 (0.099) 0.002 -0.279 (0.098) 0.006 -0.169 (0.058) 0.004 -0.261 (0.099) 0.010
cg02451831 KIAA0087 -0.379 (0.104) 4.73E-04 -0.100 (0.116) 0.395 -0.190 (0.068) 0.006 -0.129 (0.113) 0.255
cg06868100 PRR15 -0.071 (0.114) 0.537 -0.368 (0.117) 0.002 -0.211 (0.070) 0.003 -0.259 (0.111) 0.022
cg01726890 - 0.165 (0.088) 0.064 0.210 (0.093) 0.026 0.129 (0.051) 0.013 0.155 (0.086) 0.075
cg19089201 MYO1G 0.075 (0.111) 0.504 0.249 (0.109) 0.025 0.371 (0.063) 1.11E-08 0.110 (0.117) 0.352
cg22132788 MYO1G 0.276 (0.122) 0.026 0.421 (0.113) 3.71E-04 0.447 (0.065) 5.58E-11 0.321 (0.115) 0.006
cg04180046 MYO1G 0.141 (0.113) 0.214 0.245 (0.117) 0.039 0.261 (0.065) 7.91E-05 0.181 (0.110) 0.104
cg12803068 MYO1G 0.285 (0.120) 0.020 0.441 (0.111) 1.41E-04 0.378 (0.065) 2.16E-08 0.275 (0.113) 0.017
cg03440944 C7orf40 -0.204 (0.061) 0.001 -0.017 (0.076) 0.825 -0.189 (0.044) 2.43E-05 -0.252 (0.078) 0.002
cg09613161 COBL 0.244 (0.116) 0.038 0.052 (0.126) 0.680 0.231 (0.064) 3.56E-04 0.140 (0.097) 0.154
cg04016086 COBL 0.194 (0.115) 0.096 0.087 (0.114) 0.447 0.303 (0.064) 3.29E-06 0.029 (0.109) 0.787
cg19956914 SUMF2 0.203 (0.125) 0.109 0.249 (0.100) 0.014 0.181 (0.070) 0.010 0.343 (0.101) 0.001
cg20164601 - -0.133 (0.114) 0.246 -0.102 (0.097) 0.298 -0.267 (0.066) 6.18E-05 -0.150 (0.111) 0.182
cg13314145 NPTX2 0.262 (0.096) 0.008 0.271 (0.109) 0.015 0.150 (0.062) 0.017 0.145 (0.099) 0.147
cg22851200 TRIP6 -0.201 (0.092) 0.032 -0.201 (0.094) 0.035 -0.143 (0.056) 0.011 -0.273 (0.091) 0.003
cg09762515 CUX1 0.247 (0.083) 0.004 0.193 (0.088) 0.032 0.087 (0.049) 0.077 0.207 (0.084) 0.016
cg22619824 ST7 -0.110 (0.090) 0.226 -0.139 (0.098) 0.159 -0.210 (0.060) 5.92E-04 -0.181 (0.087) 0.042
18
cg13990486 FLJ43663 -0.147 (0.109) 0.181 -0.161 (0.099) 0.110 -0.243 (0.069) 5.20E-04 -0.157 (0.109) 0.153
cg21322436 CNTNAP2 -0.198 (0.121) 0.106 -0.286 (0.104) 0.007 -0.187 (0.067) 0.006 -0.217 (0.099) 0.032
cg25949550 CNTNAP2 -0.153 (0.064) 0.019 -0.199 (0.070) 0.005 -0.153 (0.044) 6.11E-04 -0.187 (0.059) 0.002
cg11207515 CNTNAP2 0.206 (0.093) 0.030 0.185 (0.087) 0.036 0.203 (0.056) 3.64E-04 0.225 (0.092) 0.017
cg15700587 MIR548I4 0.102 (0.091) 0.268 0.119 (0.086) 0.171 0.189 (0.046) 4.66E-05 0.275 (0.082) 0.001
cg09858188 - 0.091 (0.088) 0.304 0.006 (0.093) 0.947 0.219 (0.055) 8.31E-05 0.235 (0.084) 0.006
cg23572908 VIPR2 0.267 (0.122) 0.032 0.106 (0.130) 0.418 0.254 (0.066) 1.46E-04 0.274 (0.114) 0.019
cg05635807 - 0.173 (0.123) 0.162 0.176 (0.124) 0.158 0.194 (0.071) 0.007 0.451 (0.110) 9.69E-05
cg00778858 MTUS1 0.245 (0.114) 0.035 0.120 (0.106) 0.260 0.226 (0.064) 4.51E-04 0.142 (0.096) 0.143
cg24540678 - -0.293 (0.068) 4.82E-05 -0.049 (0.073) 0.506 -0.211 (0.048) 1.59E-05 -0.250 (0.088) 0.006
cg18387156 NRG1 0.032 (0.071) 0.653 0.195 (0.054) 5.64E-04 0.099 (0.039) 0.012 0.141 (0.056) 0.014
cg14316231 MYST3 -0.136 (0.091) 0.142 -0.133 (0.081) 0.104 -0.194 (0.051) 1.78E-04 -0.059 (0.091) 0.522
cg25260137 - 0.158 (0.096) 0.104 0.246 (0.108) 0.025 0.135 (0.054) 0.014 0.198 (0.081) 0.016
cg03760919 RUNX1T1 0.158 (0.071) 0.028 0.147 (0.075) 0.055 0.079 (0.043) 0.071 0.223 (0.071) 0.002
cg16783744 DPYS 0.140 (0.095) 0.143 0.145 (0.102) 0.161 0.222 (0.055) 7.63E-05 0.138 (0.089) 0.124
cg22644321 TRIB1 -0.365 (0.082) 2.40E-05 0.010 (0.096) 0.917 -0.131 (0.044) 0.003 -0.114 (0.078) 0.146
cg25305703 - -0.229 (0.060) 2.71E-04 -0.068 (0.069) 0.328 -0.175 (0.051) 7.23E-04 -0.157 (0.087) 0.075
cg12873476 - -0.255 (0.104) 0.016 -0.168 (0.107) 0.122 -0.139 (0.061) 0.024 -0.307 (0.093) 0.002
cg26361535 ZC3H3 -0.281 (0.094) 0.004 -0.412 (0.099) 7.60E-05 -0.131 (0.063) 0.039 -0.222 (0.103) 0.034
cg13389508 PLEC1 -0.188 (0.083) 0.026 -0.200 (0.084) 0.020 -0.116 (0.053) 0.030 -0.261 (0.105) 0.015
cg25325005 PLEC1 -0.175 (0.073) 0.018 -0.040 (0.061) 0.515 -0.188 (0.048) 1.20E-04 -0.181 (0.078) 0.022
cg01692968 - -0.188 (0.097) 0.056 -0.234 (0.096) 0.017 -0.251 (0.055) 7.78E-06 -0.315 (0.089) 6.88E-04
cg13418576 - -0.119 (0.100) 0.238 -0.185 (0.111) 0.099 -0.227 (0.064) 4.74E-04 -0.203 (0.103) 0.051
cg14556677 NEK6 -0.090 (0.052) 0.088 -0.099 (0.040) 0.015 -0.123 (0.027) 6.83E-06 -0.105 (0.047) 0.028
cg06901890 FNBP1 -0.218 (0.089) 0.016 -0.181 (0.085) 0.036 -0.112 (0.064) 0.082 -0.275 (0.102) 0.009
cg17489908 GATA3 -0.168 (0.095) 0.081 -0.162 (0.083) 0.055 -0.159 (0.047) 9.52E-04 -0.131 (0.071) 0.070
cg20185017 CACNB2 0.069 (0.097) 0.476 0.305 (0.110) 0.007 0.131 (0.060) 0.030 0.252 (0.077) 0.002
cg17426273 NEBL 0.078 (0.080) 0.333 0.166 (0.097) 0.091 0.237 (0.050) 2.94E-06 -0.016 (0.088) 0.857
19
cg00326958 HNRNPF -0.048 (0.092) 0.603 -0.238 (0.100) 0.019 -0.221 (0.060) 3.00E-04 -0.114 (0.092) 0.220
cg09373037 SYT15 0.157 (0.097) 0.111 0.015 (0.116) 0.900 0.258 (0.067) 1.49E-04 0.268 (0.101) 0.009
cg15164194 WDFY4 -0.145 (0.047) 0.003 0.025 (0.042) 0.556 -0.124 (0.029) 2.01E-05 -0.096 (0.050) 0.060
cg10750182 CDH23 -0.138 (0.085) 0.108 -0.260 (0.084) 0.003 -0.211 (0.044) 2.82E-06 -0.234 (0.064) 4.48E-04
cg04105282 CRTAC1 0.103 (0.098) 0.296 0.288 (0.093) 0.003 0.139 (0.057) 0.015 0.194 (0.100) 0.057
cg05329352 ADRA2A -0.206 (0.113) 0.073 -0.177 (0.105) 0.096 -0.247 (0.067) 3.07E-04 -0.285 (0.099) 0.005
cg07978738 ABLIM1 -0.215 (0.070) 0.003 -0.077 (0.070) 0.275 -0.174 (0.041) 2.86E-05 -0.073 (0.064) 0.258
cg03242819 DOCK1 0.200 (0.107) 0.064 0.252 (0.101) 0.014 0.217 (0.065) 0.001 0.258 (0.101) 0.012
cg03129384 FAM196A 0.081 (0.068) 0.236 0.176 (0.081) 0.033 0.163 (0.043) 2.19E-04 0.079 (0.066) 0.235
cg07123182 KCNQ1OT1 -0.186 (0.114) 0.106 -0.302 (0.115) 0.010 -0.139 (0.074) 0.060 -0.348 (0.106) 0.002
cg16556677 KCNQ1OT1 -0.254 (0.097) 0.010 -0.325 (0.097) 0.001 -0.092 (0.061) 0.133 -0.253 (0.095) 0.009
cg26963277 KCNQ1OT1 -0.221 (0.115) 0.057 -0.242 (0.119) 0.045 -0.230 (0.070) 0.001 -0.300 (0.114) 0.011
cg12884422 - -0.213 (0.127) 0.097 -0.095 (0.116) 0.416 -0.197 (0.070) 0.005 -0.358 (0.109) 0.001
cg23186333 CD44 -0.155 (0.102) 0.130 -0.042 (0.091) 0.645 -0.274 (0.058) 3.41E-06 -0.083 (0.103) 0.420
cg16611234 - -0.100 (0.099) 0.319 -0.210 (0.112) 0.065 -0.208 (0.065) 0.001 -0.236 (0.099) 0.020
cg19254163 GPR44 -0.191 (0.081) 0.020 -0.187 (0.093) 0.049 -0.175 (0.045) 1.15E-04 -0.155 (0.086) 0.076
cg27122888 NRXN2 -0.206 (0.101) 0.045 -0.054 (0.106) 0.614 -0.241 (0.060) 7.13E-05 -0.179 (0.097) 0.068
cg20889322 - -0.247 (0.096) 0.012 -0.139 (0.087) 0.116 -0.181 (0.060) 0.003 -0.283 (0.089) 0.002
cg10416861 - 0.116 (0.101) 0.252 0.328 (0.103) 0.002 0.219 (0.064) 7.42E-04 0.204 (0.101) 0.047
cg09419102 - -0.110 (0.068) 0.109 -0.124 (0.065) 0.060 -0.151 (0.043) 4.95E-04 -0.175 (0.077) 0.025
cg21611682 LRP5 -0.384 (0.096) 1.38E-04 -0.228 (0.099) 0.024 -0.307 (0.064) 2.77E-06 -0.418 (0.091) 1.42E-05
cg10420527 LRP5 -0.241 (0.102) 0.021 -0.145 (0.074) 0.054 -0.182 (0.059) 0.002 -0.322 (0.084) 2.40E-04
cg09578155 LRP5 -0.272 (0.081) 0.001 -0.002 (0.078) 0.979 -0.205 (0.055) 2.27E-04 -0.239 (0.087) 0.007
cg14624207 LRP5 -0.227 (0.078) 0.005 -0.124 (0.070) 0.079 -0.148 (0.051) 0.004 -0.194 (0.077) 0.013
cg11295113 FOLR2 0.157 (0.068) 0.022 0.059 (0.056) 0.294 0.124 (0.045) 0.006 0.200 (0.074) 0.008
cg11660018 PRSS23 -0.213 (0.079) 0.008 -0.336 (0.087) 2.37E-04 -0.248 (0.052) 3.86E-06 -0.255 (0.081) 0.002
cg23771366 PRSS23 -0.157 (0.068) 0.024 -0.140 (0.092) 0.131 -0.230 (0.052) 1.15E-05 -0.138 (0.090) 0.130
cg23351584 PRSS23 -0.140 (0.092) 0.132 -0.161 (0.086) 0.065 -0.163 (0.062) 0.010 -0.286 (0.097) 0.004
20
cg09044186 APOA5 0.263 (0.117) 0.028 0.042 (0.117) 0.719 0.264 (0.066) 7.65E-05 0.079 (0.117) 0.500
cg10908953 SORL1 -0.116 (0.049) 0.021 -0.126 (0.062) 0.045 -0.073 (0.034) 0.031 -0.120 (0.057) 0.038
cg22512531 CRTAM 0.164 (0.071) 0.023 0.124 (0.066) 0.066 0.168 (0.035) 2.92E-06 0.008 (0.070) 0.909
cg09084200 VPS26B -0.267 (0.065) 9.50E-05 -0.201 (0.068) 0.004 -0.149 (0.045) 0.001 -0.159 (0.089) 0.076
cg07066369 CCND2 -0.237 (0.114) 0.041 -0.419 (0.110) 2.55E-04 -0.079 (0.064) 0.224 -0.335 (0.112) 0.004
cg07178945 FGF23 0.290 (0.108) 0.009 0.209 (0.099) 0.039 0.179 (0.051) 5.12E-04 0.333 (0.093) 5.62E-04
cg23193870 PTPN6 -0.276 (0.100) 0.007 -0.224 (0.097) 0.024 -0.172 (0.061) 0.005 -0.197 (0.104) 0.062
cg07986378 ETV6 -0.207 (0.100) 0.041 -0.128 (0.097) 0.192 -0.155 (0.061) 0.012 -0.274 (0.087) 0.002
cg20399616 BCAT1 0.286 (0.117) 0.017 0.146 (0.125) 0.244 0.222 (0.074) 0.003 0.261 (0.124) 0.039
cg02583484 HNRNPA1 -0.191 (0.082) 0.022 -0.103 (0.070) 0.149 -0.143 (0.046) 0.002 -0.176 (0.084) 0.039
cg21752525 - -0.213 (0.106) 0.048 -0.177 (0.108) 0.103 -0.181 (0.064) 0.005 -0.211 (0.100) 0.039
cg01598741 HMGA2 -0.182 (0.111) 0.103 -0.320 (0.102) 0.002 -0.110 (0.061) 0.072 -0.338 (0.091) 3.88E-04
cg25165932 SELPLG 0.221 (0.103) 0.035 0.033 (0.109) 0.765 0.211 (0.064) 0.001 0.298 (0.112) 0.010
cg02801786 - -0.021 (0.078) 0.792 0.062 (0.082) 0.454 0.246 (0.046) 2.54E-07 0.108 (0.082) 0.191
cg03844971 MLXIP -0.205 (0.085) 0.019 -0.191 (0.094) 0.046 -0.172 (0.062) 0.006 -0.143 (0.098) 0.147
cg21618017 RILPL1 -0.140 (0.079) 0.080 -0.101 (0.071) 0.159 -0.145 (0.043) 9.49E-04 -0.137 (0.075) 0.072
cg02869235 - -0.132 (0.090) 0.145 0.103 (0.071) 0.149 0.203 (0.042) 2.97E-06 0.145 (0.063) 0.025
cg25922751 NCOR2 -0.154 (0.105) 0.148 -0.316 (0.098) 0.002 -0.092 (0.057) 0.110 -0.327 (0.101) 0.002
cg06419750 GLT1D1 0.118 (0.096) 0.220 0.294 (0.100) 0.004 0.187 (0.064) 0.004 0.115 (0.100) 0.256
cg22574825 FLT1 0.062 (0.112) 0.582 0.347 (0.102) 0.001 0.219 (0.062) 4.59E-04 0.131 (0.099) 0.192
cg12836863 BRCA2 0.056 (0.062) 0.367 0.059 (0.056) 0.301 0.149 (0.039) 1.57E-04 0.132 (0.066) 0.050
cg02985540 - -0.094 (0.069) 0.175 -0.122 (0.066) 0.070 -0.094 (0.036) 0.009 -0.161 (0.056) 0.005
cg03646329 LPAR6 -0.081 (0.095) 0.396 -0.212 (0.085) 0.014 -0.208 (0.059) 5.17E-04 -0.247 (0.087) 0.006
cg04214430 - -0.233 (0.098) 0.020 0.008 (0.077) 0.921 -0.228 (0.063) 3.26E-04 -0.167 (0.084) 0.051
cg02003272 - -0.119 (0.099) 0.234 -0.133 (0.084) 0.118 -0.211 (0.054) 1.28E-04 -0.161 (0.083) 0.055
cg13774342 - -0.068 (0.102) 0.509 -0.185 (0.091) 0.047 -0.223 (0.058) 1.32E-04 -0.280 (0.093) 0.004
cg18656829 - 0.154 (0.111) 0.170 0.279 (0.113) 0.016 0.261 (0.068) 1.35E-04 0.027 (0.116) 0.815
cg20124610 CARS2 -0.123 (0.078) 0.116 -0.121 (0.074) 0.106 -0.192 (0.048) 8.82E-05 -0.156 (0.077) 0.047
21
cg00619505 TMCO3 0.306 (0.086) 6.17E-04 0.145 (0.076) 0.061 0.105 (0.047) 0.027 0.131 (0.084) 0.126
cg06959340 JUB -0.114 (0.127) 0.372 -0.112 (0.122) 0.362 -0.297 (0.076) 1.07E-04 -0.192 (0.112) 0.091
cg02945646 AP1G2 -0.081 (0.064) 0.207 -0.106 (0.053) 0.047 -0.120 (0.030) 8.94E-05 -0.007 (0.057) 0.907
cg02150910 GZMH 0.247 (0.077) 0.002 0.098 (0.088) 0.271 0.106 (0.044) 0.017 0.147 (0.076) 0.057
cg22851561 C14orf43 -0.029 (0.068) 0.669 -0.102 (0.070) 0.148 -0.234 (0.051) 7.43E-06 -0.149 (0.088) 0.094
cg24996979 C14orf43 -0.127 (0.087) 0.150 -0.135 (0.081) 0.102 -0.163 (0.052) 0.002 -0.303 (0.095) 0.002
cg14544289 SPTLC2 -0.404 (0.098) 8.30E-05 -0.243 (0.094) 0.012 -0.110 (0.059) 0.064 -0.187 (0.105) 0.077
cg13679772 FOXN3 0.123 (0.081) 0.134 0.072 (0.075) 0.343 0.175 (0.042) 4.74E-05 0.172 (0.078) 0.031
cg01055824 CCDC88C -0.215 (0.098) 0.032 -0.097 (0.084) 0.247 -0.250 (0.063) 8.82E-05 -0.066 (0.083) 0.426
cg20303561 CCDC88C -0.048 (0.084) 0.570 -0.151 (0.072) 0.039 -0.152 (0.054) 0.005 -0.222 (0.074) 0.004
cg05284742 ITPK1 -0.214 (0.080) 0.009 -0.228 (0.081) 0.006 -0.104 (0.048) 0.033 -0.286 (0.070) 1.12E-04
cg26242531 ZFYVE21 0.188 (0.063) 0.004 0.162 (0.073) 0.030 0.106 (0.041) 0.011 0.191 (0.065) 0.004
cg14977938 ZFYVE21 0.325 (0.095) 9.42E-04 0.119 (0.100) 0.239 0.160 (0.064) 0.014 0.214 (0.101) 0.036
cg19838043 ZFYVE21 0.239 (0.106) 0.027 0.292 (0.093) 0.002 0.096 (0.062) 0.123 0.224 (0.082) 0.008
cg12158535 PACS2 0.146 (0.112) 0.196 0.308 (0.105) 0.004 0.198 (0.067) 0.003 0.172 (0.100) 0.091
cg01513913 - -0.365 (0.121) 0.003 -0.354 (0.100) 6.47E-04 -0.365 (0.068) 1.46E-07 -0.298 (0.091) 0.002
cg13074055 - -0.244 (0.121) 0.047 -0.334 (0.110) 0.003 -0.362 (0.072) 8.74E-07 -0.282 (0.109) 0.012
cg23594345 - -0.288 (0.111) 0.011 -0.303 (0.108) 0.006 -0.367 (0.069) 2.23E-07 -0.286 (0.106) 0.009
cg01208318 - -0.276 (0.108) 0.012 -0.280 (0.107) 0.010 -0.362 (0.066) 1.04E-07 -0.300 (0.092) 0.002
cg14387626 - -0.145 (0.068) 0.035 -0.137 (0.051) 0.009 -0.227 (0.042) 1.43E-07 0.025 (0.060) 0.674
cg27113548 - -0.205 (0.126) 0.107 -0.096 (0.116) 0.412 -0.354 (0.069) 4.89E-07 -0.321 (0.097) 0.001
cg00980649 - -0.143 (0.112) 0.204 -0.181 (0.114) 0.115 -0.340 (0.061) 5.20E-08 -0.306 (0.094) 0.002
cg03603381 RASGRP1 -0.268 (0.090) 0.004 -0.145 (0.119) 0.228 -0.163 (0.062) 0.009 -0.176 (0.106) 0.099
cg14428590 FSIP1 -0.057 (0.098) 0.560 -0.193 (0.084) 0.024 -0.160 (0.056) 0.004 -0.213 (0.086) 0.016
cg24687805 RAB27A 0.129 (0.085) 0.134 0.109 (0.065) 0.099 0.182 (0.057) 0.002 0.218 (0.085) 0.012
cg22777952 FOXB1 0.093 (0.089) 0.302 0.183 (0.101) 0.074 0.174 (0.057) 0.003 0.252 (0.102) 0.016
cg15451980 RORA 0.138 (0.076) 0.073 0.092 (0.091) 0.311 0.125 (0.043) 0.004 0.152 (0.064) 0.020
cg26971042 TLE3 -0.154 (0.113) 0.176 -0.223 (0.109) 0.043 -0.153 (0.059) 0.010 -0.286 (0.097) 0.004
22
cg09747445 TLE3 -0.131 (0.081) 0.108 -0.142 (0.068) 0.038 -0.139 (0.047) 0.004 -0.153 (0.073) 0.041
cg02384859 ARID3B 0.156 (0.067) 0.023 0.151 (0.093) 0.111 0.152 (0.044) 5.79E-04 0.099 (0.070) 0.161
cg18946533 SH2D7 0.309 (0.097) 0.002 0.021 (0.077) 0.788 0.217 (0.053) 5.56E-05 0.001 (0.106) 0.991
cg14096889 ADAMTSL3 0.140 (0.097) 0.151 0.170 (0.105) 0.110 0.167 (0.063) 0.008 0.281 (0.098) 0.005
cg20664238 NTRK3 0.162 (0.084) 0.057 0.164 (0.091) 0.075 0.173 (0.053) 0.001 0.112 (0.100) 0.265
cg23161492 ANPEP -0.393 (0.100) 1.66E-04 -0.213 (0.105) 0.046 -0.271 (0.064) 3.34E-05 -0.404 (0.097) 8.01E-05
cg14858469 NR2F2 0.142 (0.119) 0.236 0.056 (0.112) 0.619 0.297 (0.066) 9.53E-06 0.117 (0.107) 0.278
cg07779120 IGF1R 0.254 (0.105) 0.018 0.063 (0.119) 0.600 0.210 (0.067) 0.002 0.499 (0.107) 1.08E-05
cg04755561 PKMYT1 -0.045 (0.079) 0.570 -0.245 (0.062) 1.50E-04 -0.140 (0.051) 0.006 -0.107 (0.070) 0.132
cg06321596 XYLT1 -0.211 (0.103) 0.044 -0.131 (0.089) 0.142 -0.252 (0.060) 3.57E-05 -0.199 (0.087) 0.025
cg02304156 ATP2A1 0.127 (0.095) 0.182 0.029 (0.069) 0.671 0.214 (0.047) 8.72E-06 0.065 (0.090) 0.474
cg07069636 - -0.102 (0.072) 0.160 -0.207 (0.072) 0.005 -0.113 (0.038) 0.003 -0.228 (0.081) 0.006
cg04528720 - 0.181 (0.075) 0.018 0.174 (0.083) 0.038 0.132 (0.041) 0.001 0.064 (0.070) 0.359
cg08126789 USP10 0.205 (0.119) 0.088 0.117 (0.105) 0.267 0.185 (0.059) 0.002 0.198 (0.099) 0.048
cg01383486 GINS2 -0.281 (0.088) 0.002 -0.146 (0.082) 0.079 -0.128 (0.045) 0.004 -0.050 (0.071) 0.481
cg04887172 CBFA2T3 -0.141 (0.064) 0.032 -0.190 (0.058) 0.002 -0.150 (0.042) 3.99E-04 0.057 (0.086) 0.509
cg01107178 ANKRD11 0.092 (0.067) 0.171 0.100 (0.060) 0.098 0.098 (0.040) 0.015 0.200 (0.059) 0.001
cg02352716 - 0.213 (0.079) 0.008 0.153 (0.089) 0.091 0.102 (0.044) 0.020 0.115 (0.065) 0.081
cg15380836 RILP -0.203 (0.054) 3.24E-04 -0.061 (0.051) 0.230 -0.043 (0.028) 0.124 -0.196 (0.054) 5.04E-04
cg03877174 KIF1C 0.177 (0.072) 0.016 0.182 (0.072) 0.013 0.095 (0.044) 0.033 0.244 (0.065) 3.36E-04
cg05460226 PIK3R5 -0.096 (0.090) 0.290 -0.159 (0.081) 0.052 -0.128 (0.049) 0.010 -0.244 (0.069) 7.07E-04
cg02018337 GAS7 -0.185 (0.061) 0.003 -0.015 (0.057) 0.791 -0.179 (0.036) 9.79E-07 -0.034 (0.054) 0.529
cg18150958 RPL23A -0.172 (0.116) 0.143 -0.213 (0.098) 0.034 -0.234 (0.069) 7.94E-04 -0.285 (0.105) 0.008
cg18960216 TIAF1 0.255 (0.092) 0.007 -0.019 (0.092) 0.840 0.201 (0.045) 1.34E-05 0.213 (0.078) 0.008
cg19572487 RARA -0.233 (0.092) 0.013 -0.264 (0.087) 0.003 -0.265 (0.057) 6.09E-06 -0.499 (0.088) 1.86E-07
cg23673974 TBKBP1 0.132 (0.065) 0.045 0.095 (0.078) 0.229 0.132 (0.038) 5.11E-04 0.094 (0.075) 0.210
cg22807449 HOXB2 -0.007 (0.097) 0.940 -0.274 (0.081) 0.001 -0.238 (0.057) 4.56E-05 -0.055 (0.104) 0.599
cg07465627 STXBP4 -0.138 (0.074) 0.066 -0.202 (0.068) 0.004 -0.184 (0.041) 1.25E-05 -0.128 (0.078) 0.105
23
cg08591265 SFRS1 -0.179 (0.087) 0.044 -0.205 (0.087) 0.021 -0.163 (0.043) 1.99E-04 -0.074 (0.070) 0.297
cg05248618 CA4 0.335 (0.112) 0.004 0.189 (0.121) 0.123 0.166 (0.068) 0.016 0.227 (0.110) 0.042
cg07827420 SEPT9 -0.164 (0.123) 0.186 -0.165 (0.114) 0.151 -0.182 (0.073) 0.014 -0.405 (0.114) 6.63E-04
cg07324245 SEPT9 -0.130 (0.053) 0.017 -0.081 (0.046) 0.079 -0.113 (0.031) 3.49E-04 -0.105 (0.065) 0.110
cg05080154 SALL3 0.229 (0.082) 0.007 0.132 (0.098) 0.181 0.254 (0.059) 2.57E-05 0.170 (0.084) 0.045
cg00073090 - -0.104 (0.070) 0.142 -0.135 (0.069) 0.054 -0.185 (0.048) 1.34E-04 -0.232 (0.071) 0.001
cg15187398 MOBKL2A -0.269 (0.077) 7.91E-04 -0.191 (0.107) 0.079 -0.114 (0.058) 0.049 -0.355 (0.097) 4.16E-04
cg07381806 MOBKL2A -0.232 (0.114) 0.045 -0.068 (0.112) 0.544 -0.192 (0.064) 0.003 -0.256 (0.105) 0.017
cg00378510 LINGO3 -0.294 (0.098) 0.004 -0.342 (0.107) 0.002 -0.078 (0.063) 0.213 -0.248 (0.099) 0.014
cg01294327 LINGO3 -0.368 (0.107) 8.82E-04 -0.472 (0.104) 2.01E-05 -0.109 (0.064) 0.090 -0.207 (0.111) 0.065
cg14074174 SNAPC2 -0.246 (0.078) 0.002 -0.216 (0.090) 0.019 -0.108 (0.053) 0.044 -0.129 (0.082) 0.119
cg03172931 - 0.192 (0.109) 0.082 0.206 (0.097) 0.037 0.161 (0.055) 0.004 0.221 (0.090) 0.016
cg11621113 MORG1 -0.184 (0.075) 0.017 -0.114 (0.052) 0.032 -0.087 (0.037) 0.018 -0.238 (0.073) 0.002
cg05339037 - -0.213 (0.101) 0.038 -0.086 (0.100) 0.396 -0.183 (0.055) 9.09E-04 -0.173 (0.094) 0.068
cg14588779 AKAP8L 0.002 (0.070) 0.972 -0.268 (0.062) 3.87E-05 -0.112 (0.034) 0.001 -0.078 (0.067) 0.249
cg09686308 CIB3 0.223 (0.087) 0.013 0.262 (0.097) 0.008 0.139 (0.054) 0.011 0.126 (0.103) 0.225
cg03636183 F2RL3 -0.538 (0.103) 1.23E-06 -0.376 (0.101) 3.83E-04 -0.445 (0.055) 2.93E-14 -0.549 (0.083) 2.89E-09
cg15159987 CPAMD8 -0.123 (0.083) 0.144 -0.037 (0.085) 0.668 -0.199 (0.055) 3.65E-04 -0.233 (0.081) 0.005
cg22678402 FAM125A -0.180 (0.064) 0.006 -0.036 (0.054) 0.515 -0.087 (0.028) 0.002 -0.125 (0.069) 0.076
cg23973524 CRTC1 0.408 (0.098) 7.96E-05 0.121 (0.078) 0.126 0.178 (0.058) 0.002 0.135 (0.085) 0.118
cg21473814 CRTC1 0.435 (0.109) 1.32E-04 0.122 (0.100) 0.227 0.128 (0.065) 0.048 0.232 (0.090) 0.012
cg01447828 PRX 0.174 (0.106) 0.107 0.135 (0.101) 0.185 0.285 (0.065) 1.51E-05 0.259 (0.105) 0.016
cg15393221 PRX 0.102 (0.087) 0.243 0.050 (0.082) 0.545 0.214 (0.048) 1.37E-05 0.289 (0.075) 2.45E-04
HNRNPUL
cg13668129 -0.044 (0.060) 0.472 -0.101 (0.044) 0.024 -0.116 (0.029) 1.00E-04 -0.076 (0.062) 0.221
1
cg10126923 NKG7 0.003 (0.057) 0.960 0.107 (0.060) 0.078 0.120 (0.033) 2.68E-04 0.231 (0.062) 3.30E-04
cg12916723 NKG7 0.243 (0.117) 0.040 0.188 (0.109) 0.088 0.134 (0.056) 0.018 0.272 (0.103) 0.010
cg01500140 LIM2 0.091 (0.055) 0.099 0.083 (0.061) 0.177 0.095 (0.030) 0.002 0.171 (0.053) 0.002

24
cg03217253 ZNF677 0.213 (0.092) 0.023 0.172 (0.106) 0.107 0.253 (0.060) 3.10E-05 0.150 (0.105) 0.155
cg21733502 ZSCAN5B -0.268 (0.104) 0.012 -0.166 (0.103) 0.110 -0.155 (0.071) 0.030 -0.256 (0.111) 0.024
cg05007126 SDCBP2 -0.062 (0.083) 0.456 -0.100 (0.074) 0.184 -0.164 (0.047) 5.15E-04 -0.169 (0.079) 0.035
cg13724496 BMP2 0.048 (0.107) 0.655 0.248 (0.102) 0.017 0.240 (0.059) 6.04E-05 0.102 (0.103) 0.324
cg15207742 RIMS4 -0.055 (0.106) 0.602 0.310 (0.095) 0.002 0.275 (0.066) 4.17E-05 0.199 (0.092) 0.033
cg20344344 - -0.232 (0.090) 0.012 -0.024 (0.085) 0.783 -0.161 (0.051) 0.002 -0.216 (0.081) 0.009
cg12303084 ZMYND8 -0.103 (0.070) 0.144 -0.085 (0.056) 0.135 -0.110 (0.035) 0.002 -0.146 (0.072) 0.046
cg07339236 ATP9A -0.274 (0.086) 0.002 -0.270 (0.100) 0.009 -0.248 (0.060) 5.20E-05 -0.240 (0.101) 0.021
cg26736540 TFAP2C 0.012 (0.088) 0.894 0.136 (0.106) 0.203 0.187 (0.059) 0.002 0.367 (0.104) 6.65E-04
cg06135139 BHLHE23 0.152 (0.108) 0.162 -0.079 (0.122) 0.516 0.315 (0.068) 5.41E-06 0.305 (0.117) 0.011
cg15892280 ETS2 -0.117 (0.058) 0.049 -0.071 (0.042) 0.097 -0.142 (0.040) 4.38E-04 -0.068 (0.057) 0.236
cg23110422 ETS2 -0.357 (0.101) 7.04E-04 -0.164 (0.112) 0.147 -0.229 (0.071) 0.001 -0.282 (0.102) 0.007
cg10204884 PCBP3 -0.201 (0.095) 0.037 -0.223 (0.081) 0.007 -0.139 (0.058) 0.017 -0.122 (0.089) 0.176
cg14785479 SCARF2 0.159 (0.067) 0.020 0.094 (0.051) 0.071 0.121 (0.039) 0.002 0.135 (0.052) 0.012
cg08548559 PIK3IP1 -0.231 (0.083) 0.007 -0.197 (0.079) 0.014 -0.077 (0.052) 0.144 -0.234 (0.087) 0.009
cg02532700 NCF4 -0.251 (0.109) 0.024 -0.210 (0.112) 0.063 -0.182 (0.063) 0.004 -0.299 (0.114) 0.010
cg26364091 CHADL -0.180 (0.108) 0.099 -0.266 (0.113) 0.021 -0.180 (0.065) 0.006 -0.195 (0.108) 0.075
cg06008724 PHF21B 0.040 (0.105) 0.706 0.226 (0.100) 0.027 0.220 (0.056) 1.04E-04 0.115 (0.080) 0.156
cg04198308 FAM19A5 0.270 (0.098) 0.007 0.221 (0.112) 0.052 0.223 (0.064) 6.09E-04 0.018 (0.103) 0.862

25
 Table S3. The median methylation values (inter quartile range) of the 318 smoking-related CpGs in never, former and current
smokers.

Methylation values Former vs. never Current vs. never

CpG Gene Current smoker Former smoker Never smoker
Effect (s.e.)a P Effect (s.e.)a P
(n = 273) (n = 64) (n = 259)
cg05575921 AHRR 0.641 (0.143) 0.729 (0.104) 0.795 (0.062) -0.778 1.33E-12 -1.342 3.83E-67
cg23576855 AHRR 0.515 (0.134) 0.591 (0.091) 0.663 (0.065) -0.685 6.75E-10 -1.302 1.61E-62
cg21566642 - 0.352 (0.093) 0.398 (0.076) 0.442 (0.069) -0.581 2.00E-06 -1.103 1.09E-40
cg05951221 - 0.286 (0.074) 0.291 (0.062) 0.351 (0.057) -0.827 1.33E-11 -1.044 1.09E-37
cg26703534 AHRR 0.551 (0.060) 0.575 (0.077) 0.592 (0.059) -0.369 2.52E-03 -0.793 4.22E-23
cg03636183 F2RL3 0.534 (0.101) 0.553 (0.089) 0.605 (0.070) -0.628 3.36E-07 -1.000 3.69E-34
cg01940273 - 0.468 (0.064) 0.491 (0.076) 0.539 (0.060) -0.567 2.08E-06 -1.134 3.68E-44
cg25648203 AHRR 0.690 (0.063) 0.709 (0.049) 0.718 (0.059) -0.229 0.077 -0.693 1.66E-16
cg22132788 MYO1G 0.913 (0.062) 0.889 (0.051) 0.876 (0.068) 0.184 0.174 0.676 1.14E-14
cg21161138 AHRR 0.629 (0.065) 0.657 (0.055) 0.669 (0.048) -0.261 0.043 -0.814 9.00E-22
cg03329539 - 0.329 (0.068) 0.339 (0.070) 0.363 (0.077) -0.333 0.010 -0.603 4.83E-13
cg06126421 - 0.629 (0.120) 0.602 (0.108) 0.692 (0.084) -0.758 1.39E-10 -0.835 2.68E-27
cg01513913 - 0.371 (0.064) 0.381 (0.056) 0.391 (0.064) -0.082 0.522 -0.509 5.97E-10
cg12803068 MYO1G 0.768 (0.096) 0.752 (0.093) 0.718 (0.106) 0.291 0.032 0.657 6.57E-14
cg21611682 LRP5 0.501 (0.041) 0.504 (0.055) 0.532 (0.036) -0.705 5.32E-08 -0.843 1.74E-23
cg00501876 CSRNP1 0.545 (0.045) 0.553 (0.039) 0.562 (0.042) -0.175 0.188 -0.506 2.91E-09
cg14817490 AHRR 0.200 (0.066) 0.236 (0.086) 0.236 (0.066) -0.033 0.803 -0.591 3.38E-12
cg01208318 - 0.426 (0.114) 0.478 (0.177) 0.460 (0.108) -0.018 0.890 -0.501 4.88E-09
cg06811467 ATP8B2 0.284 (0.079) 0.284 (0.078) 0.294 (0.079) -0.345 4.51E-03 -0.319 3.39E-05
cg24540678 - 0.200 (0.058) 0.217 (0.081) 0.222 (0.071) -0.216 0.103 -0.406 1.46E-06
cg23594345 - 0.442 (0.115) 0.481 (0.148) 0.484 (0.107) 0.041 0.758 -0.519 1.30E-09
cg02018337 GAS7 0.251 (0.081) 0.234 (0.063) 0.263 (0.095) -0.296 8.40E-03 -0.228 0.001
cg07573717 CAPZB 0.321 (0.068) 0.311 (0.064) 0.328 (0.065) -0.221 0.066 -0.288 1.58E-04
cg14387626 - 0.345 (0.052) 0.334 (0.040) 0.356 (0.048) -0.459 2.25E-04 -0.368 3.07E-06
cg23161492 ANPEP 0.263 (0.059) 0.280 (0.066) 0.290 (0.047) -0.252 0.057 -0.647 4.17E-14
26
cg03991871 AHRR 0.783 (0.047) 0.797 (0.056) 0.815 (0.037) -0.294 0.026 -0.717 6.00E-17
cg00980649 - 0.332 (0.084) 0.342 (0.124) 0.342 (0.106) 0.029 0.830 -0.312 2.09E-04
cg11660018 PRSS23 0.448 (0.058) 0.450 (0.070) 0.488 (0.061) -0.721 1.27E-09 -0.816 6.32E-26
cg03440944 C7orf40 0.643 (0.056) 0.660 (0.063) 0.655 (0.058) 0.034 0.776 -0.284 2.04E-04
cg19089201 MYO1G 0.832 (0.060) 0.830 (0.056) 0.812 (0.060) 0.221 0.117 0.378 2.48E-05
cg23079012 - 0.894 (0.036) 0.898 (0.031) 0.904 (0.031) -0.219 0.104 -0.525 1.25E-09
cg13074055 - 0.545 (0.103) 0.553 (0.120) 0.571 (0.104) -0.021 0.879 -0.377 1.65E-05
cg26542660 CEP135 0.157 (0.067) 0.154 (0.060) 0.161 (0.064) -0.231 0.055 -0.291 1.48E-04
cg22512531 CRTAM 0.704 (0.077) 0.722 (0.076) 0.688 (0.083) 0.322 3.65E-03 0.219 0.002
cg15164194 WDFY4 0.262 (0.083) 0.240 (0.068) 0.265 (0.075) -0.318 6.54E-03 -0.192 0.009
cg27113548 - 0.641 (0.076) 0.647 (0.083) 0.667 (0.072) -0.115 0.381 -0.361 1.48E-05
cg19572487 RARA 0.468 (0.082) 0.488 (0.096) 0.503 (0.067) -0.152 0.240 -0.588 1.58E-12
cg19859270 GPR15 0.816 (0.031) 0.820 (0.029) 0.831 (0.026) -0.345 0.012 -0.568 1.07E-10
cg18960216 TIAF1 0.668 (0.061) 0.670 (0.046) 0.658 (0.057) 0.186 0.104 0.266 2.41E-04
cg07978738 ABLIM1 0.213 (0.061) 0.214 (0.057) 0.221 (0.067) -0.043 0.728 -0.320 4.17E-05
cg25189904 GNG12 0.387 (0.093) 0.420 (0.138) 0.434 (0.096) -0.509 1.21E-04 -0.616 4.27E-13
cg04232128 TMEM173 0.222 (0.076) 0.208 (0.061) 0.224 (0.079) -0.183 0.118 -0.231 0.002
cg23916896 AHRR 0.218 (0.051) 0.225 (0.062) 0.247 (0.058) -0.355 8.88E-03 -0.624 6.54E-13
cg07339236 ATP9A 0.167 (0.055) 0.165 (0.048) 0.189 (0.049) -0.491 4.99E-05 -0.578 1.04E-13
cg18946533 SH2D7 0.565 (0.048) 0.554 (0.052) 0.555 (0.047) -0.065 0.634 0.227 0.009
cg05080154 SALL3 0.117 (0.104) 0.110 (0.066) 0.093 (0.078) 0.135 0.283 0.381 2.02E-06
cg12806681 AHRR 0.818 (0.033) 0.827 (0.033) 0.836 (0.030) -0.298 0.027 -0.593 7.80E-12
cg09088988 STK32A 0.128 (0.062) 0.101 (0.069) 0.110 (0.060) 0.020 0.873 0.330 5.09E-05
cg26850624 AHRR 0.757 (0.052) 0.748 (0.056) 0.745 (0.051) 0.310 0.013 0.407 3.15E-07
cg23771366 PRSS23 0.385 (0.070) 0.384 (0.068) 0.419 (0.058) -0.469 1.83E-04 -0.622 1.34E-14
cg04016086 COBL 0.077 (0.038) 0.066 (0.024) 0.069 (0.029) -0.131 0.339 0.353 4.89E-05
cg10750182 CDH23 0.522 (0.048) 0.515 (0.043) 0.543 (0.056) -0.533 1.87E-05 -0.478 1.74E-09
cg01692968 - 0.287 (0.064) 0.271 (0.042) 0.324 (0.068) -0.796 6.17E-11 -0.671 4.44E-18
cg09578155 LRP5 0.392 (0.051) 0.386 (0.052) 0.408 (0.043) -0.417 9.60E-04 -0.414 2.46E-07
cg23186333 CD44 0.319 (0.066) 0.316 (0.066) 0.332 (0.072) -0.092 0.472 -0.325 4.50E-05
cg09084200 VPS26B 0.281 (0.065) 0.286 (0.074) 0.295 (0.063) 0.020 0.877 -0.337 4.73E-05
cg25305703 - 0.556 (0.100) 0.555 (0.120) 0.589 (0.077) -0.453 6.47E-04 -0.441 1.71E-07
27
cg14556677 NEK6 0.253 (0.078) 0.245 (0.074) 0.263 (0.073) -0.283 0.018 -0.242 0.001
cg03217253 ZNF677 0.107 (0.058) 0.090 (0.061) 0.094 (0.058) 0.058 0.665 0.351 3.43E-05
cg14663208 HIVEP3 0.728 (0.060) 0.734 (0.057) 0.713 (0.063) 0.229 0.038 0.318 5.59E-06
cg14753356 - 0.352 (0.093) 0.327 (0.075) 0.390 (0.105) -0.620 1.30E-07 -0.535 9.26E-13
cg09935388 GFI1 0.700 (0.070) 0.711 (0.067) 0.732 (0.061) -0.451 7.00E-04 -0.628 2.12E-13
cg08595501 IQGAP2 0.568 (0.076) 0.579 (0.065) 0.599 (0.075) -0.218 0.116 -0.432 1.05E-06
cg07465627 STXBP4 0.302 (0.063) 0.312 (0.066) 0.316 (0.072) -0.166 0.215 -0.306 3.31E-04
cg15693483 C7orf50 0.432 (0.056) 0.418 (0.059) 0.450 (0.061) -0.481 4.12E-05 -0.441 3.45E-09
cg22644321 TRIB1 0.157 (0.054) 0.155 (0.054) 0.165 (0.061) -0.208 0.059 -0.321 4.90E-06
cg27537125 - 0.168 (0.057) 0.180 (0.086) 0.180 (0.069) 0.013 0.922 -0.278 7.31E-04
cg19708306 - 0.824 (0.061) 0.822 (0.056) 0.812 (0.075) 0.272 0.024 0.247 0.001
cg09471611 - 0.648 (0.051) 0.647 (0.054) 0.637 (0.057) 0.077 0.523 0.230 0.003
cg11902777 AHRR 0.067 (0.021) 0.072 (0.023) 0.075 (0.027) -0.107 0.436 -0.429 9.84E-07
cg06135139 BHLHE23 0.180 (0.034) 0.173 (0.037) 0.169 (0.030) 0.238 0.086 0.466 1.38E-07
cg09257526 IL6R 0.267 (0.062) 0.260 (0.061) 0.274 (0.065) -0.281 0.018 -0.257 6.41E-04
cg23973524 CRTC1 0.597 (0.076) 0.560 (0.101) 0.566 (0.081) 0.081 0.540 0.498 4.45E-09
cg02560388 - 0.190 (0.055) 0.175 (0.058) 0.197 (0.055) -0.279 0.014 -0.303 2.48E-05
cg06321596 XYLT1 0.339 (0.072) 0.324 (0.059) 0.354 (0.078) -0.397 2.88E-03 -0.412 1.15E-06
cg08035323 - 0.258 (0.080) 0.235 (0.086) 0.252 (0.095) -0.290 0.031 0.066 0.438
cg01447828 PRX 0.522 (0.051) 0.496 (0.051) 0.513 (0.053) -0.348 9.70E-03 0.301 4.00E-04
cg16619991 ITGA1 0.490 (0.085) 0.495 (0.087) 0.491 (0.078) 0.066 0.625 -0.091 0.287
cg17426273 NEBL 0.122 (0.054) 0.112 (0.054) 0.111 (0.058) -0.024 0.849 0.277 5.73E-04
cg09044186 APOA5 0.931 (0.027) 0.931 (0.020) 0.931 (0.025) -0.064 0.644 0.133 0.133
cg02304156 ATP2A1 0.707 (0.056) 0.710 (0.053) 0.702 (0.064) 0.149 0.241 0.288 3.49E-04
cg25325005 PLEC1 0.715 (0.075) 0.740 (0.069) 0.723 (0.070) 0.308 0.020 -0.131 0.117
cg19254163 GPR44 0.571 (0.059) 0.569 (0.071) 0.595 (0.054) -0.544 5.28E-06 -0.495 8.01E-11
cg01055824 CCDC88C 0.843 (0.047) 0.833 (0.058) 0.848 (0.046) -0.211 0.122 -0.230 0.008
cg23110422 ETS2 0.767 (0.032) 0.771 (0.041) 0.781 (0.032) -0.399 2.58E-03 -0.601 1.69E-12
cg11229399 - 0.104 (0.045) 0.099 (0.046) 0.097 (0.043) 0.034 0.803 0.286 8.19E-04
cg27122888 NRXN2 0.126 (0.035) 0.131 (0.044) 0.138 (0.033) -0.054 0.648 -0.339 6.85E-06
cg22674699 HOXD9 0.166 (0.113) 0.129 (0.115) 0.140 (0.094) 0.040 0.766 0.417 1.22E-06
cg14858469 NR2F2 0.102 (0.019) 0.096 (0.019) 0.097 (0.022) -0.042 0.760 0.273 0.002
28
cg25853622 LPP 0.352 (0.113) 0.317 (0.090) 0.361 (0.115) -0.396 3.38E-04 -0.192 0.006
cg23572908 VIPR2 0.147 (0.039) 0.136 (0.026) 0.135 (0.036) 0.077 0.572 0.444 2.90E-07
cg15393221 PRX 0.355 (0.055) 0.319 (0.061) 0.343 (0.055) -0.401 3.12E-03 0.153 0.074
cg02801786 - 0.161 (0.064) 0.146 (0.057) 0.147 (0.072) -0.043 0.724 0.320 3.48E-05
cg07178945 FGF23 0.370 (0.058) 0.368 (0.082) 0.350 (0.064) 0.248 0.070 0.383 1.06E-05
cg04198308 FAM19A5 0.057 (0.027) 0.051 (0.026) 0.051 (0.022) -0.031 0.816 0.361 2.22E-05
cg07324245 SEPT9 0.659 (0.075) 0.678 (0.073) 0.665 (0.075) 0.314 0.010 -0.079 0.306
cg25114611 FKBP5 0.310 (0.076) 0.306 (0.073) 0.320 (0.068) -0.199 0.092 -0.279 2.00E-04
cg23924887 ATP8B2 0.079 (0.028) 0.076 (0.034) 0.087 (0.031) -0.216 0.113 -0.260 0.003
cg04214430 - 0.855 (0.031) 0.861 (0.028) 0.859 (0.027) 0.120 0.373 -0.175 0.041
cg19719391 - 0.546 (0.068) 0.519 (0.082) 0.532 (0.06) -0.153 0.241 0.163 0.048
cg05396397 NPPA 0.508 (0.063) 0.480 (0.072) 0.485 (0.061) -0.162 0.238 0.441 4.48E-07
cg13679772 FOXN3 0.468 (0.075) 0.463 (0.086) 0.458 (0.075) -0.012 0.927 0.235 0.004
cg08591265 SFRS1 0.624 (0.089) 0.643 (0.096) 0.626 (0.088) 0.291 0.018 -0.028 0.714
cg15474579 CDKN1A 0.549 (0.094) 0.538 (0.091) 0.568 (0.095) -0.365 2.12E-03 -0.406 8.23E-08
cg04551776 AHRR 0.705 (0.051) 0.733 (0.042) 0.722 (0.049) 0.070 0.598 -0.416 9.86E-07
cg20124610 CARS2 0.481 (0.082) 0.492 (0.104) 0.494 (0.079) 0.072 0.585 -0.232 0.006
cg11207515 CNTNAP2 0.389 (0.079) 0.391 (0.096) 0.349 (0.078) 0.536 5.63E-05 0.638 8.54E-14
cg16783744 DPYS 0.192 (0.071) 0.185 (0.060) 0.183 (0.069) 0.054 0.673 0.319 7.73E-05
cg04887172 CBFA2T3 0.285 (0.089) 0.263 (0.108) 0.289 (0.083) -0.124 0.290 -0.089 0.228
cg25949550 CNTNAP2 0.122 (0.046) 0.130 (0.064) 0.134 (0.048) -0.188 0.164 -0.340 7.41E-05
cg09338136 AHRR 0.218 (0.053) 0.224 (0.062) 0.225 (0.055) -0.231 0.081 -0.337 6.24E-05
cg02451831 KIAA0087 0.679 (0.038) 0.678 (0.038) 0.687 (0.035) -0.265 0.058 -0.306 5.57E-04
cg09613161 COBL 0.084 (0.040) 0.078 (0.029) 0.078 (0.038) 0.079 0.558 0.301 4.68E-04
cg02384859 ARID3B 0.743 (0.076) 0.758 (0.074) 0.728 (0.077) 0.386 3.16E-04 0.277 4.29E-05
cg00778858 MTUS1 0.057 (0.018) 0.055 (0.017) 0.054 (0.017) 0.124 0.354 0.269 0.002
cg22851561 C14orf43 0.483 (0.085) 0.510 (0.095) 0.508 (0.088) -0.023 0.862 -0.329 8.09E-05
cg09022230 TNRC18 0.670 (0.058) 0.669 (0.071) 0.699 (0.065) -0.589 3.75E-06 -0.648 2.36E-15
cg11554391 AHRR 0.156 (0.043) 0.167 (0.038) 0.170 (0.042) -0.211 0.112 -0.475 2.03E-08
cg09373037 SYT15 0.121 (0.059) 0.111 (0.047) 0.109 (0.052) 0.106 0.430 0.398 3.54E-06
cg01955533 CDKN1A 0.238 (0.079) 0.218 (0.067) 0.242 (0.081) -0.262 0.020 -0.230 0.001
cg15700587 MIR548I4 0.690 (0.046) 0.694 (0.046) 0.681 (0.049) 0.342 4.78E-03 0.340 9.85E-06
29
cg06644428 - 0.101 (0.052) 0.104 (0.053) 0.122 (0.058) -0.596 4.10E-06 -0.523 2.15E-10
cg09156233 BMPR1B 0.073 (0.042) 0.057 (0.035) 0.062 (0.033) -0.037 0.778 0.396 2.28E-06
cg20164601 - 0.514 (0.069) 0.528 (0.087) 0.513 (0.087) 0.122 0.393 -0.079 0.380
cg08617970 VARS2 0.889 (0.017) 0.888 (0.017) 0.892 (0.015) -0.235 0.094 -0.257 0.004
cg00073090 - 0.316 (0.054) 0.315 (0.059) 0.338 (0.063) -0.506 5.89E-05 -0.588 3.56E-13
cg16382047 GPR55 0.306 (0.079) 0.294 (0.057) 0.320 (0.088) -0.427 1.87E-04 -0.318 1.07E-05
cg04180046 MYO1G 0.506 (0.078) 0.508 (0.074) 0.480 (0.069) 0.185 0.174 0.370 1.89E-05
cg24090911 AHRR 0.671 (0.053) 0.681 (0.064) 0.690 (0.042) -0.176 0.174 -0.543 7.37E-11
cg22678402 FAM125A 0.709 (0.094) 0.697 (0.105) 0.702 (0.09) -0.050 0.694 -0.066 0.410
cg15892280 ETS2 0.375 (0.064) 0.364 (0.048) 0.389 (0.056) -0.424 3.30E-04 -0.352 2.63E-06
cg05329352 ADRA2A 0.518 (0.089) 0.546 (0.095) 0.563 (0.095) -0.221 0.096 -0.486 1.07E-08
cg02945646 AP1G2 0.116 (0.046) 0.117 (0.045) 0.121 (0.049) -0.072 0.584 -0.141 0.088
cg01383486 GINS2 0.748 (0.085) 0.744 (0.092) 0.749 (0.083) -0.134 0.312 -0.075 0.372
cg23673974 TBKBP1 0.531 (0.074) 0.536 (0.093) 0.521 (0.08) 0.035 0.790 0.211 0.012
cg04211179 ZBTB17 0.484 (0.076) 0.513 (0.108) 0.492 (0.081) 0.248 0.048 -0.152 0.056
cg20344344 - 0.810 (0.032) 0.815 (0.038) 0.816 (0.035) -0.031 0.822 -0.171 0.048
cg18656829 - 0.076 (0.021) 0.072 (0.021) 0.071 (0.019) -0.129 0.355 0.307 5.16E-04
cg14316231 MYST3 0.434 (0.053) 0.432 (0.067) 0.450 (0.048) -0.363 7.64E-03 -0.409 2.21E-06
cg04528720 - 0.679 (0.061) 0.689 (0.069) 0.667 (0.065) 0.314 4.07E-03 0.247 3.62E-04
cg20949306 RAB3GAP1 0.910 (0.026) 0.907 (0.024) 0.903 (0.027) 0.146 0.227 0.417 7.54E-08
cg17094249 - 0.212 (0.045) 0.217 (0.051) 0.221 (0.046) -0.052 0.710 -0.309 4.84E-04
cg08129092 INTS3 0.178 (0.080) 0.153 (0.051) 0.169 (0.078) -0.256 0.049 0.085 0.302
cg09858188 - 0.171 (0.074) 0.148 (0.063) 0.156 (0.07) -0.067 0.612 0.311 1.89E-04
cg05339037 - 0.385 (0.042) 0.391 (0.042) 0.397 (0.039) -0.251 0.069 -0.444 4.27E-07
cg24859433 - 0.754 (0.045) 0.751 (0.053) 0.772 (0.037) -0.526 7.06E-05 -0.493 5.01E-09
cg02003272 - 0.828 (0.043) 0.838 (0.036) 0.829 (0.049) 0.310 0.019 -0.090 0.280
cg14624207 LRP5 0.483 (0.056) 0.481 (0.069) 0.503 (0.056) -0.349 5.14E-03 -0.487 9.90E-10
cg10351287 STK32B 0.083 (0.033) 0.073 (0.031) 0.077 (0.033) -0.007 0.956 0.310 3.23E-04
cg25165932 SELPLG 0.051 (0.011) 0.049 (0.012) 0.048 (0.012) 0.180 0.204 0.276 0.002
cg07779120 IGF1R 0.056 (0.026) 0.048 (0.018) 0.049 (0.019) -0.093 0.500 0.419 1.72E-06
cg20460771 PTAFR 0.673 (0.076) 0.693 (0.074) 0.654 (0.076) 0.299 6.54E-03 0.327 2.71E-06
cg04158878 - 0.613 (0.048) 0.619 (0.048) 0.601 (0.047) 0.345 7.18E-03 0.359 1.05E-05
30
cg13279811 - 0.196 (0.055) 0.193 (0.054) 0.211 (0.051) -0.236 0.060 -0.359 6.68E-06
cg20889322 - 0.255 (0.051) 0.256 (0.061) 0.258 (0.054) 0.066 0.628 -0.184 0.034
cg20146909 LRRC8D 0.669 (0.044) 0.668 (0.037) 0.679 (0.039) -0.318 0.016 -0.303 2.90E-04
cg09419102 - 0.586 (0.053) 0.591 (0.056) 0.587 (0.057) 0.021 0.876 -0.149 0.077
cg15159987 CPAMD8 0.586 (0.051) 0.618 (0.051) 0.602 (0.055) 0.102 0.413 -0.305 1.21E-04
cg14785479 SCARF2 0.133 (0.054) 0.128 (0.048) 0.128 (0.055) 0.035 0.793 0.149 0.076
cg10420527 LRP5 0.471 (0.048) 0.462 (0.052) 0.487 (0.051) -0.535 2.64E-05 -0.460 1.28E-08
cg06959340 JUB 0.061 (0.014) 0.062 (0.018) 0.065 (0.015) -0.107 0.447 -0.246 0.006
cg14977938 ZFYVE21 0.641 (0.054) 0.615 (0.058) 0.623 (0.051) 0.011 0.936 0.405 1.56E-06
cg02583484 HNRNPA1 0.281 (0.055) 0.300 (0.061) 0.297 (0.058) 0.104 0.433 -0.308 2.49E-04
cg03129384 FAM196A 0.211 (0.077) 0.185 (0.079) 0.203 (0.087) -0.109 0.380 0.153 0.052
cg20399616 BCAT1 0.065 (0.023) 0.061 (0.015) 0.060 (0.016) 0.151 0.281 0.414 3.37E-06
cg26963277 KCNQ1OT1 0.858 (0.038) 0.864 (0.035) 0.873 (0.032) -0.254 0.062 -0.473 5.32E-08
cg23193870 PTPN6 0.078 (0.024) 0.080 (0.027) 0.085 (0.031) -0.051 0.690 -0.394 1.22E-06
cg12876356 GFI1 0.760 (0.061) 0.763 (0.047) 0.772 (0.050) -0.224 0.102 -0.355 4.34E-05
cg13711966 - 0.582 (0.063) 0.560 (0.077) 0.578 (0.075) -0.241 0.071 0.111 0.186
cg03242819 DOCK1 0.155 (0.084) 0.117 (0.057) 0.125 (0.081) -0.111 0.394 0.398 1.70E-06
cg18446336 GNA12 0.489 (0.136) 0.509 (0.127) 0.528 (0.130) -0.189 0.127 -0.403 3.57E-07
cg05010058 CEP68 0.108 (0.024) 0.104 (0.022) 0.118 (0.028) -0.410 1.31E-03 -0.410 4.21E-07
cg20664238 NTRK3 0.104 (0.035) 0.099 (0.035) 0.097 (0.033) 0.094 0.469 0.342 3.20E-05
cg15342087 - 0.752 (0.043) 0.755 (0.046) 0.768 (0.034) -0.395 3.76E-03 -0.510 4.71E-09
cg21618017 RILPL1 0.078 (0.026) 0.075 (0.024) 0.084 (0.033) -0.347 5.38E-03 -0.342 1.52E-05
cg17489908 GATA3 0.292 (0.062) 0.295 (0.075) 0.305 (0.071) -0.281 0.030 -0.385 3.11E-06
cg13668129 HNRNPUL1 0.212 (0.066) 0.226 (0.077) 0.222 (0.067) -0.091 0.485 -0.220 0.008
cg12836863 BRCA2 0.387 (0.138) 0.337 (0.131) 0.373 (0.129) -0.379 2.96E-03 0.047 0.563
cg03603381 RASGRP1 0.453 (0.032) 0.454 (0.033) 0.467 (0.037) -0.342 0.013 -0.354 5.11E-05
cg18630040 PLA2G7 0.068 (0.037) 0.059 (0.028) 0.061 (0.033) -0.028 0.825 0.317 6.94E-05
cg01765406 - 0.423 (0.071) 0.395 (0.057) 0.427 (0.072) -0.493 6.83E-05 -0.305 9.71E-05
cg13724496 BMP2 0.072 (0.028) 0.063 (0.031) 0.066 (0.025) -0.048 0.708 0.300 2.26E-04
cg13990486 FLJ43663 0.099 (0.014) 0.102 (0.013) 0.104 (0.018) -0.158 0.260 -0.358 5.94E-05
cg05270224 - 0.398 (0.074) 0.378 (0.097) 0.379 (0.084) 0.100 0.443 0.264 0.001
cg25310233 - 0.386 (0.075) 0.385 (0.072) 0.401 (0.074) -0.204 0.099 -0.316 5.42E-05
31
cg24032269 TCOF1 0.665 (0.076) 0.671 (0.079) 0.644 (0.086) 0.319 4.44E-03 0.339 2.05E-06
cg13774342 - 0.778 (0.048) 0.802 (0.046) 0.788 (0.052) 0.241 0.079 -0.148 0.085
cg18150958 RPL23A 0.781 (0.040) 0.790 (0.047) 0.789 (0.049) 0.004 0.975 -0.200 0.022
cg18165852 CHST13 0.085 (0.034) 0.077 (0.024) 0.078 (0.030) -0.084 0.525 0.321 1.33E-04
cg26242531 ZFYVE21 0.367 (0.088) 0.331 (0.070) 0.357 (0.088) -0.152 0.199 0.177 0.018
cg12756150 - 0.760 (0.056) 0.749 (0.079) 0.738 (0.073) 0.151 0.234 0.432 9.37E-08
cg02150910 GZMH 0.724 (0.065) 0.734 (0.066) 0.707 (0.058) 0.266 0.024 0.340 6.33E-06
cg21473814 CRTC1 0.643 (0.062) 0.616 (0.067) 0.622 (0.066) -0.093 0.485 0.326 1.22E-04
cg00619505 TMCO3 0.793 (0.045) 0.788 (0.060) 0.789 (0.050) -0.010 0.937 0.296 2.15E-04
cg21188533 CACNA1D 0.587 (0.126) 0.541 (0.138) 0.557 (0.138) -0.075 0.590 0.348 7.81E-05
cg13418576 - 0.404 (0.060) 0.408 (0.071) 0.422 (0.057) -0.428 1.62E-03 -0.401 3.31E-06
cg17924476 AHRR 0.458 (0.115) 0.467 (0.123) 0.438 (0.111) 0.073 0.568 0.262 0.001
cg02532700 NCF4 0.181 (0.053) 0.183 (0.074) 0.197 (0.059) -0.279 0.039 -0.417 1.32E-06
cg12593793 - 0.253 (0.070) 0.250 (0.059) 0.263 (0.070) -0.291 0.019 -0.331 2.74E-05
cg14544289 SPTLC2 0.754 (0.045) 0.743 (0.045) 0.768 (0.049) -0.616 5.38E-06 -0.488 1.36E-08
cg22619824 ST7 0.506 (0.073) 0.508 (0.081) 0.524 (0.078) -0.260 0.042 -0.470 9.17E-09
cg22807449 HOXB2 0.355 (0.049) 0.340 (0.050) 0.357 (0.055) -0.398 2.86E-03 -0.209 0.013
cg15417641 CACNA1D 0.621 (0.103) 0.587 (0.110) 0.593 (0.115) -0.023 0.864 0.363 2.88E-05
cg07381806 MOBKL2A 0.419 (0.077) 0.423 (0.081) 0.437 (0.072) -0.126 0.373 -0.348 1.04E-04
cg08126789 USP10 0.765 (0.044) 0.766 (0.050) 0.760 (0.044) 0.222 0.083 0.337 3.51E-05
cg03844971 MLXIP 0.113 (0.028) 0.117 (0.030) 0.119 (0.028) -0.021 0.868 -0.229 0.004
cg05248618 CA4 0.063 (0.017) 0.063 (0.013) 0.058 (0.015) 0.422 2.16E-03 0.403 3.92E-06
cg05655806 CD96 0.432 (0.077) 0.447 (0.071) 0.448 (0.084) -0.059 0.657 -0.232 0.005
cg09658497 GNA12 0.686 (0.124) 0.694 (0.129) 0.731 (0.113) -0.150 0.268 -0.391 6.09E-06
cg06008724 PHF21B 0.175 (0.091) 0.166 (0.082) 0.156 (0.085) 0.086 0.492 0.388 1.14E-06
cg26348226 ECE1 0.221 (0.079) 0.208 (0.056) 0.234 (0.077) -0.331 2.94E-03 -0.320 5.68E-06
cg18642234 GPX1 0.464 (0.055) 0.462 (0.046) 0.477 (0.049) -0.297 0.021 -0.378 4.12E-06
cg19717773 GNA12 0.604 (0.119) 0.626 (0.118) 0.639 (0.114) -0.125 0.359 -0.380 1.20E-05
cg11295113 FOLR2 0.784 (0.046) 0.782 (0.066) 0.775 (0.050) 0.190 0.158 0.273 0.001
cg01500140 LIM2 0.674 (0.089) 0.671 (0.092) 0.662 (0.093) 0.141 0.196 0.279 5.48E-05
cg15746583 CD8B 0.136 (0.060) 0.137 (0.065) 0.135 (0.061) 0.043 0.743 0.061 0.462
cg10416861 - 0.747 (0.043) 0.746 (0.050) 0.736 (0.049) 0.038 0.771 0.300 2.94E-04
32
cg09570614 - 0.430 (0.059) 0.400 (0.056) 0.416 (0.060) -0.143 0.254 0.222 0.005
cg24687805 RAB27A 0.107 (0.030) 0.098 (0.022) 0.097 (0.028) -0.092 0.482 0.317 1.31E-04
cg13481776 ALPI 0.713 (0.070) 0.721 (0.058) 0.693 (0.074) 0.301 8.09E-03 0.308 1.93E-05
cg09686308 CIB3 0.579 (0.068) 0.576 (0.065) 0.570 (0.066) 0.028 0.827 0.236 0.004
cg24996979 C14orf43 0.191 (0.043) 0.199 (0.052) 0.198 (0.055) 0.061 0.635 -0.313 1.25E-04
cg03646329 LPAR6 0.667 (0.074) 0.707 (0.067) 0.672 (0.091) 0.384 3.75E-03 -0.034 0.685
cg13314145 NPTX2 0.109 (0.045) 0.102 (0.030) 0.098 (0.034) 0.032 0.810 0.312 2.18E-04
cg19713429 CAPZB 0.241 (0.055) 0.250 (0.068) 0.253 (0.063) 0.166 0.205 -0.255 0.002
cg12303084 ZMYND8 0.179 (0.066) 0.181 (0.084) 0.186 (0.068) 0.028 0.828 -0.129 0.119
cg21752525 - 0.776 (0.047) 0.782 (0.048) 0.781 (0.043) -0.026 0.846 -0.155 0.071
cg15451980 RORA 0.787 (0.063) 0.787 (0.066) 0.770 (0.069) 0.318 5.40E-03 0.305 2.64E-05
cg15187398 MOBKL2A 0.430 (0.079) 0.431 (0.083) 0.468 (0.070) -0.615 3.14E-06 -0.600 1.13E-12
cg00326958 HNRNPF 0.120 (0.034) 0.137 (0.059) 0.122 (0.043) 0.276 0.041 0.006 0.940
cg24996482 - 0.072 (0.040) 0.064 (0.042) 0.066 (0.036) 0.124 0.352 0.303 3.35E-04
cg05007126 SDCBP2 0.710 (0.046) 0.728 (0.039) 0.721 (0.043) 0.074 0.569 -0.214 0.009
cg26958735 - 0.087 (0.021) 0.085 (0.021) 0.083 (0.020) 0.122 0.361 0.241 0.004
cg03172931 - 0.694 (0.046) 0.688 (0.047) 0.678 (0.055) 0.318 0.011 0.442 2.68E-08
cg15554421 C3orf26 0.186 (0.047) 0.179 (0.055) 0.192 (0.053) -0.302 0.012 -0.234 0.002
cg11485823 DPCR1 0.693 (0.053) 0.682 (0.063) 0.683 (0.055) 0.024 0.856 0.243 0.004
cg24741609 GLIS1 0.338 (0.059) 0.358 (0.075) 0.357 (0.067) -0.072 0.593 -0.361 2.37E-05
cg10179300 TRIO 0.783 (0.042) 0.788 (0.041) 0.794 (0.036) -0.013 0.925 -0.338 1.35E-04
cg02352716 - 0.706 (0.081) 0.712 (0.065) 0.689 (0.080) 0.156 0.158 0.249 3.76E-04
cg09747445 TLE3 0.552 (0.089) 0.556 (0.072) 0.572 (0.076) -0.202 0.106 -0.345 1.39E-05
cg02869235 - 0.469 (0.088) 0.455 (0.066) 0.467 (0.087) -0.134 0.298 0.070 0.390
cg22574825 FLT1 0.094 (0.042) 0.083 (0.038) 0.080 (0.034) 0.171 0.200 0.464 4.60E-08
cg13185177 GP5 0.497 (0.101) 0.460 (0.093) 0.472 (0.097) 0.014 0.906 0.337 1.04E-05
cg22851200 TRIP6 0.573 (0.067) 0.561 (0.086) 0.591 (0.072) -0.392 2.93E-03 -0.333 6.79E-05
cg15207742 RIMS4 0.092 (0.043) 0.081 (0.033) 0.080 (0.041) -0.117 0.367 0.357 1.50E-05
cg14074174 SNAPC2 0.360 (0.047) 0.354 (0.047) 0.369 (0.041) -0.291 0.016 -0.400 1.93E-07
cg16611234 - 0.326 (0.075) 0.332 (0.093) 0.343 (0.070) -0.291 0.034 -0.439 4.91E-07
cg26361535 ZC3H3 0.653 (0.076) 0.659 (0.088) 0.680 (0.062) -0.520 1.27E-04 -0.455 1.32E-07
cg23867146 - 0.594 (0.033) 0.581 (0.039) 0.588 (0.046) -0.063 0.625 0.095 0.240
33
cg11621113 MORG1 0.314 (0.085) 0.327 (0.097) 0.331 (0.094) -0.011 0.934 -0.265 0.001
cg07069636 - 0.430 (0.071) 0.439 (0.074) 0.436 (0.069) 0.121 0.312 -0.174 0.021
cg12884422 - 0.291 (0.117) 0.317 (0.101) 0.303 (0.100) -0.024 0.867 -0.275 0.002
cg07986378 ETV6 0.537 (0.087) 0.543 (0.078) 0.563 (0.089) -0.259 0.044 -0.411 4.46E-07
cg26364091 CHADL 0.635 (0.026) 0.636 (0.030) 0.647 (0.027) -0.317 0.018 -0.546 2.09E-10
cg12158535 PACS2 0.627 (0.038) 0.611 (0.030) 0.615 (0.037) 0.089 0.518 0.312 3.75E-04
cg21322436 CNTNAP2 0.272 (0.052) 0.287 (0.058) 0.284 (0.047) 0.010 0.940 -0.277 0.001
cg10126923 NKG7 0.294 (0.084) 0.269 (0.075) 0.285 (0.075) -0.181 0.160 0.160 0.050
cg10951873 RUNX3 0.109 (0.027) 0.120 (0.036) 0.111 (0.032) 0.278 0.036 -0.115 0.166
cg05284742 ITPK1 0.655 (0.049) 0.658 (0.051) 0.669 (0.052) -0.387 2.57E-03 -0.481 4.44E-09
cg12873476 - 0.611 (0.064) 0.616 (0.068) 0.641 (0.067) -0.281 0.027 -0.537 4.33E-11
cg21733502 ZSCAN5B 0.824 (0.035) 0.828 (0.043) 0.827 (0.032) -0.054 0.695 -0.193 0.026
cg01294327 LINGO3 0.621 (0.109) 0.612 (0.146) 0.629 (0.106) -0.221 0.114 -0.200 0.024
cg15380836 RILP 0.132 (0.062) 0.137 (0.065) 0.144 (0.067) -0.138 0.268 -0.240 0.002
cg06419750 GLT1D1 0.138 (0.071) 0.121 (0.054) 0.127 (0.064) -0.003 0.984 0.266 0.001
cg00336149 CACNA1D 0.367 (0.078) 0.334 (0.081) 0.346 (0.084) -0.071 0.607 0.315 3.21E-04
cg22777952 FOXB1 0.089 (0.019) 0.085 (0.016) 0.086 (0.024) -0.242 0.070 0.166 0.048
cg14667406 LCT 0.841 (0.028) 0.843 (0.029) 0.848 (0.029) -0.038 0.781 -0.283 0.001
cg10204884 PCBP3 0.742 (0.043) 0.751 (0.041) 0.747 (0.037) 0.103 0.426 -0.128 0.119
cg12916723 NKG7 0.606 (0.045) 0.603 (0.045) 0.591 (0.047) 0.083 0.501 0.412 1.56E-07
cg01726890 - 0.699 (0.049) 0.703 (0.057) 0.685 (0.062) 0.163 0.162 0.372 6.02E-07
cg03877174 KIF1C 0.223 (0.069) 0.218 (0.064) 0.215 (0.062) 0.001 0.995 0.190 0.022
cg05635807 - 0.063 (0.023) 0.056 (0.017) 0.054 (0.017) 0.199 0.153 0.459 2.44E-07
cg19956914 SUMF2 0.473 (0.092) 0.427 (0.086) 0.453 (0.069) -0.208 0.124 0.297 5.25E-04
cg10908953 SORL1 0.190 (0.069) 0.190 (0.062) 0.199 (0.070) -0.145 0.253 -0.231 0.004
cg14096889 ADAMTSL3 0.101 (0.040) 0.094 (0.046) 0.095 (0.033) 0.166 0.200 0.393 1.91E-06
cg23351584 PRSS23 0.140 (0.032) 0.136 (0.032) 0.148 (0.031) -0.399 1.95E-03 -0.438 8.84E-08
cg13389508 PLEC1 0.424 (0.039) 0.437 (0.031) 0.431 (0.044) 0.129 0.322 -0.257 0.002
cg09762515 CUX1 0.605 (0.081) 0.592 (0.078) 0.599 (0.08) -0.074 0.569 0.152 0.063
cg16145216 HIVEP3 0.364 (0.080) 0.365 (0.074) 0.326 (0.082) 0.472 3.75E-04 0.626 2.25E-13
cg04039397 CD96 0.296 (0.065) 0.315 (0.074) 0.314 (0.061) 0.020 0.881 -0.372 1.71E-05
cg02818189 - 0.550 (0.093) 0.513 (0.085) 0.569 (0.093) -0.455 1.48E-04 -0.365 1.51E-06
34
cg09301294 EPHA6 0.111 (0.029) 0.102 (0.036) 0.107 (0.032) -0.067 0.594 0.222 0.005
cg25260137 - 0.124 (0.051) 0.115 (0.056) 0.114 (0.047) 0.023 0.859 0.312 1.53E-04
cg05228408 CLCN6 0.359 (0.057) 0.355 (0.056) 0.367 (0.054) -0.224 0.065 -0.317 4.14E-05
cg02985540 - 0.278 (0.066) 0.271 (0.074) 0.287 (0.067) -0.217 0.083 -0.249 0.002
cg26971042 TLE3 0.214 (0.039) 0.215 (0.040) 0.223 (0.045) -0.103 0.410 -0.379 1.75E-06
cg06868100 PRR15 0.239 (0.080) 0.257 (0.077) 0.246 (0.100) 0.043 0.759 -0.113 0.202
cg19827923 GPR55 0.747 (0.045) 0.753 (0.041) 0.753 (0.044) 0.112 0.406 -0.155 0.069
cg14580211 C5orf62 0.602 (0.087) 0.598 (0.079) 0.622 (0.068) -0.414 5.75E-04 -0.434 1.45E-08
cg07827420 SEPT9 0.435 (0.030) 0.438 (0.040) 0.443 (0.032) -0.105 0.455 -0.340 1.38E-04
cg01107178 ANKRD11 0.647 (0.072) 0.661 (0.076) 0.631 (0.077) 0.392 5.32E-04 0.286 6.48E-05
cg14588779 AKAP8L 0.170 (0.053) 0.170 (0.057) 0.174 (0.057) -0.086 0.519 -0.165 0.050
cg05460226 PIK3R5 0.390 (0.101) 0.401 (0.114) 0.432 (0.115) -0.403 1.59E-03 -0.481 3.52E-09
cg14428590 FSIP1 0.404 (0.066) 0.393 (0.052) 0.415 (0.062) -0.198 0.119 -0.381 2.29E-06
cg26736540 TFAP2C 0.068 (0.023) 0.064 (0.016) 0.065 (0.020) -0.017 0.900 0.265 0.002
cg01564343 TREML1 0.670 (0.046) 0.665 (0.041) 0.657 (0.045) 0.238 0.069 0.353 2.14E-05
cg13193840 - 0.144 (0.033) 0.148 (0.030) 0.154 (0.036) -0.204 0.144 -0.357 5.63E-05
cg13039251 PDZD2 0.727 (0.068) 0.687 (0.089) 0.704 (0.076) -0.182 0.139 0.195 0.012
cg06901890 FNBP1 0.187 (0.039) 0.200 (0.055) 0.195 (0.046) 0.122 0.368 -0.158 0.065
cg17287155 AHRR 0.831 (0.032) 0.841 (0.038) 0.838 (0.038) 0.117 0.379 -0.240 0.005
cg20303561 CCDC88C 0.652 (0.063) 0.666 (0.083) 0.671 (0.056) -0.039 0.765 -0.241 0.004
cg03760919 RUNX1T1 0.701 (0.053) 0.706 (0.069) 0.691 (0.055) 0.374 2.68E-03 0.215 0.006
cg04755561 PKMYT1 0.655 (0.057) 0.674 (0.059) 0.659 (0.047) 0.252 0.032 -0.161 0.030
cg04105282 CRTAC1 0.115 (0.051) 0.109 (0.040) 0.101 (0.043) 0.208 0.114 0.417 6.92E-07
cg08548559 PIK3IP1 0.287 (0.084) 0.296 (0.113) 0.310 (0.095) 0.030 0.820 -0.285 6.17E-04
cg16556677 KCNQ1OT1 0.734 (0.044) 0.739 (0.053) 0.746 (0.056) -0.319 0.017 -0.337 7.38E-05
cg06009448 C7orf50 0.365 (0.058) 0.364 (0.060) 0.379 (0.050) -0.311 0.011 -0.343 9.08E-06
cg19784816 ITIH1 0.697 (0.061) 0.694 (0.060) 0.683 (0.065) 0.165 0.205 0.309 1.86E-04
cg00378510 LINGO3 0.447 (0.105) 0.457 (0.094) 0.459 (0.112) -0.065 0.627 -0.123 0.150
cg08709672 AVPR1B 0.569 (0.047) 0.572 (0.046) 0.595 (0.048) -0.446 8.18E-04 -0.642 7.37E-14
cg19838043 ZFYVE21 0.611 (0.068) 0.581 (0.077) 0.596 (0.072) -0.093 0.477 0.215 0.009
cg07123182 KCNQ1OT1 0.907 (0.026) 0.908 (0.020) 0.915 (0.019) -0.218 0.112 -0.412 2.49E-06
cg18387156 NRG1 0.155 (0.054) 0.152 (0.053) 0.149 (0.055) 0.005 0.969 0.147 0.082
35
cg01416295 MRPL24 0.314 (0.069) 0.312 (0.073) 0.318 (0.088) -0.086 0.525 -0.179 0.036
cg01598741 HMGA2 0.695 (0.070) 0.692 (0.072) 0.704 (0.069) -0.099 0.485 -0.115 0.195
cg20185017 CACNB2 0.084 (0.029) 0.082 (0.021) 0.078 (0.026) 0.184 0.167 0.332 8.39E-05
cg25922751 NCOR2 0.067 (0.017) 0.073 (0.020) 0.069 (0.015) 0.273 0.026 -0.154 0.047
cg07066369 CCND2 0.067 (0.012) 0.064 (0.015) 0.070 (0.015) -0.436 1.70E-03 -0.356 5.29E-05
a
Estimates were calculated by linear regression models adjusting for age, drinking status, BMI, disease status, geographical regions,
differential leukocyte proportions and beadchip operation date.

36
 Table S4. Methylation-gene expression correlations of the smoking-related CpGs in SY (n = 144).

CpG information
Transcripts information
CpG-expression probe association
Chr Position CpG Gene Relation to Gene
Probe Gene
Effect s.e. p
1 11865352 cg05228408 MTHFR TSS1500
ILMN_1734830 MTHFR
7.733 2.148 4.41E-04
1 11865352 cg05228408 CLCN6 TSS1500
ILMN_1763036 CLCN6
7.137 2.156 0.001
1 16301562 cg04211179 ZBTB17 5'UTR
ILMN_1711048 ZBTB17
7.856 1.711 9.73E-06
1 21617442 cg26348226 ECE1 TSS1500
ILMN_1672174 ECE1
-14.337 1.926 9.11E-12
1 25254746 cg10951873 RUNX3 Body
ILMN_1787461 RUNX3
-26.344 4.769 1.57E-07
1 28521540 cg20460771 PTAFR TSS1500
ILMN_1746836 PTAFR
13.025 1.395 2.07E-16
1 90289611 cg20146909 LRRC8D 5'UTR
ILMN_1763409 LRRC8D
6.287 2.812 0.027
1 153746211 cg08129092 INTS3 3'UTR
ILMN_1756086 INTS3
-16.351 2.352 1.27E-10
1 154299179 cg06811467 ATP8B2 TSS1500
ILMN_1782057 ATP8B2
11.790 2.625 1.47E-05
1 154379696 cg09257526 IL6R Body
ILMN_1696394 IL6R
-16.010 2.494 1.98E-09
1 154379696 cg09257526 IL6R Body
ILMN_1754753 IL6R
-12.405 2.627 5.61E-06
2 231790037 cg16382047 GPR55 TSS200
ILMN_1723274 GPR55
7.689 1.974 1.52E-04
2 231790777 cg19827923 GPR55 TSS1500
ILMN_1723274 GPR55
-17.588 3.253 2.70E-07
3 49394622 cg18642234 GPX1 3'UTR
ILMN_1749662 GPX1
4.120 1.963 0.038
3 111260756 cg05655806 CD96 TSS200
ILMN_2415786 CD96
-7.176 1.715 5.05E-05
3 111260756 cg05655806 CD96 TSS200
ILMN_1711573 CD96
-9.435 1.646 5.89E-08
3 111260783 cg04039397 CD96 TSS200
ILMN_2415786 CD96
-6.825 1.525 1.57E-05
3 111260783 cg04039397 CD96 TSS200
ILMN_1711573 CD96
-9.026 1.449 5.36E-09
3 126242973 cg18165852 CHST13 TSS1500
ILMN_1734707 CHST13
-8.940 2.845 0.002
3 188425256 cg25853622 LPP Body
ILMN_1651254 LPP
-5.155 1.120 9.25E-06
3 194119885 cg13185177 GP5 5'UTR
ILMN_1780622 GP5
3.062 1.533 0.048
4 56813860 cg26542660 CEP135 TSS1500
ILMN_1693766 CEP135
-7.353 3.078 0.018
5 138861241 cg04232128 TMEM173 Body
ILMN_2145116 TMEM173
17.222 1.732 5.84E-18
6 35696870 cg25114611 FKBP5 TSS1500
ILMN_1778444 FKBP5
-6.479 2.793 0.022
37
 6 36650733 cg01955533 CDKN1A 5'UTR
ILMN_1784602 CDKN1A
5.044 1.837 0.007
7 2847575 cg18446336 GNA12 Body
ILMN_2216157 GNA12
3.496 1.181 0.004
7 5457225 cg09022230 TNRC18 Body
ILMN_1678329 TNRC18
-9.621 1.664 4.61E-08
7 45002736 cg04180046 MYO1G Body
ILMN_1692295 MYO1G
5.040 1.758 0.005
7 51384528 cg09613161 COBL TSS200
ILMN_1711888 COBL
-2.977 0.990 0.003
7 51384609 cg04016086 COBL TSS200
ILMN_1711888 COBL
-3.274 1.548 0.036
7 56147257 cg19956914 SUMF2 Body
ILMN_1685371 SUMF2
2.725 1.084 0.013
7 100465833 cg22851200 TRIP6 Body
ILMN_1713990 TRIP6
-5.725 1.636 6.24E-04
7 116786606 cg22619824 ST7 Body
ILMN_1702175 ST7
7.387 1.314 9.94E-08
7 116786606 cg22619824 ST7 Body
ILMN_1707763 ST7
5.346 1.376 1.57E-04
8 31496644 cg18387156 NRG1 TSS1500
ILMN_1737252 NRG1
6.519 2.535 0.011
8 126446923 cg22644321 TRIB1 Body
ILMN_1803811 TRIB1
-18.246 2.262 2.93E-13
8 144576604 cg26361535 ZC3H3 Body
ILMN_1702389 ZC3H3
-3.217 1.597 0.046
8 145012748 cg25325005 PLEC1 Body
ILMN_1744268 PLEC1
-5.925 1.567 2.30E-04
8 145012748 cg25325005 PLEC1 Body
ILMN_1736792 PLEC1
7.896 1.510 6.06E-07
10 49892930 cg15164194 WDFY4 TSS1500
ILMN_3236551 WDFY4
-11.274 1.524 1.17E-11
10 73497514 cg10750182 CDH23 Body
ILMN_1779934 CDH23
-4.980 1.893 0.009
11 2722391 cg07123182 KCNQ1 Body
ILMN_2409520 KCNQ1
9.891 3.372 0.004
11 2722407 cg26963277 KCNQ1OT1 TSS1500
ILMN_3248707 KCNQ1OT1
5.587 2.563 0.031
11 86510915 cg11660018 PRSS23 TSS1500
ILMN_1797776 PRSS23
7.850 1.692 7.94E-06
11 86510998 cg23771366 PRSS23 TSS1500
ILMN_1797776 PRSS23
8.629 2.068 5.25E-05
11 86512100 cg23351584 PRSS23 5'UTR
ILMN_1797776 PRSS23
20.719 4.950 5.00E-05
11 121322456 cg10908953 SORL1 TSS1500
ILMN_1759818 SORL1
-18.779 2.766 2.95E-10
11 121322456 cg10908953 SORL1 TSS1500
ILMN_2060115 SORL1
-21.510 2.635 1.70E-13
12 4384888 cg07066369 CCND2 Body
ILMN_2067656 CCND2
28.294 6.613 3.47E-05
12 4384888 cg07066369 CCND2 Body
ILMN_1667081 CCND2
24.758 6.752 3.48E-04
12 7055657 cg23193870 PTPN6 TSS200
ILMN_1738675 PTPN6
-23.094 6.997 0.001
12 7055657 cg23193870 PTPN6 TSS200
ILMN_1716578 PTPN6
-21.788 7.095 0.003
38
12 11898284 cg07986378 ETV6 Body
ILMN_1789596 ETV6
-6.905 1.419 3.04E-06
12 124016861 cg21618017 RILPL1 Body
ILMN_1805643 RILPL1
-23.846 7.746 0.003
12 129337910 cg06419750 GLT1D1 TSS200
ILMN_1656327 GLT1D1
-4.899 1.281 1.96E-04
13 48987165 cg03646329 RB1 5'UTR
ILMN_1696591 RB1
3.697 1.372 0.008
13 114172890 cg00619505 TMCO3 Body
ILMN_2220739 TMCO3
11.309 2.788 8.24E-05
14 25079357 cg02150910 GZMH TSS1500
ILMN_1731233 GZMH
-14.102 1.462 3.38E-17
14 91818668 cg01055824 CCDC88C Body
ILMN_3248352 CCDC88C
-14.824 3.736 1.15E-04
14 91881497 cg20303561 CCDC88C Body
ILMN_3248352 CCDC88C
-10.949 1.963 1.21E-07
14 93552128 cg05284742 ITPK1 Body
ILMN_1715674 ITPK1
-9.874 2.247 2.18E-05
14 104190678 cg26242531 ZFYVE21 Body
ILMN_2197030 ZFYVE21
-5.361 1.477 3.97E-04
15 38857474 cg03603381 RASGRP1 TSS1500
ILMN_1768958 RASGRP1
5.513 2.317 0.019
15 55513621 cg24687805 RAB27A Body
ILMN_1665859 RAB27A
-20.736 4.910 4.31E-05
15 55513621 cg24687805 RAB27A Body
ILMN_1699878 RAB27A
-27.973 4.637 1.36E-08
15 55513621 cg24687805 RAB27A Body
ILMN_2329773 RAB27A
-25.988 4.564 7.01E-08
15 60959637 cg15451980 RORA Body
ILMN_2322499 RORA
-10.094 1.355 8.70E-12
15 60959637 cg15451980 RORA Body
ILMN_2322498 RORA
-10.437 1.349 1.81E-12
15 60959637 cg15451980 RORA Body
ILMN_1813134 RORA
-8.499 1.430 2.12E-08
15 70387217 cg26971042 TLE3 Body
ILMN_2234412 TLE3
-8.926 2.702 0.001
15 74862662 cg02384859 ARID3B Body
ILMN_1696956 ARID3B
9.939 1.669 2.01E-08
15 90357202 cg23161492 ANPEP 5'UTR
ILMN_1763837 ANPEP
-5.939 2.097 0.005
16 17562960 cg06321596 XYLT1 Body
ILMN_1830462 XYLT1
8.401 2.067 7.97E-05
16 84746995 cg08126789 USP10 Body
ILMN_1721116 USP10
6.098 2.780 0.030
16 89041793 cg04887172 CBFA2T3 Body
ILMN_1657627 CBFA2T3
-6.106 1.268 3.78E-06
16 89408248 cg01107178 ANKRD11 5'UTR
ILMN_2108709 ANKRD11
8.837 1.451 1.03E-08
17 8804279 cg05460226 PIK3R5 Body
ILMN_1681067 PIK3R5
-6.339 1.955 0.001
17 9921982 cg02018337 GAS7 Body
ILMN_1745994 GAS7
-3.668 1.795 0.043
17 27050723 cg18150958 RPL23A Body
ILMN_1788607 RPL23A
-7.159 1.797 1.09E-04
17 27401793 cg18960216 TIAF1 5'UTR
ILMN_2055634 TIAF1
-8.108 2.458 0.001
39
17 46622522 cg22807449 HOXB2 TSS200
ILMN_1810274 HOXB2
8.546 1.931 1.92E-05
17 56082867 cg08591265 SFRS1 3'UTR;Body
ILMN_1795341 SFRS1
-4.897 1.302 2.47E-04
17 58227267 cg05248618 CA4 TSS200
ILMN_1695157 CA4
-11.653 2.872 8.22E-05
17 75371764 cg07827420 SEPT9 5'UTR
ILMN_1769118 SEPT9
-8.857 3.586 0.015
17 75445905 cg07324245 SEPT9 Body
ILMN_1769118 SEPT9
-8.944 1.384 1.58E-09
19 51875451 cg10126923 NKG7 Body
ILMN_1682993 NKG7
9.290 1.462 2.75E-09
19 51876788 cg12916723 NKG7 TSS1500
ILMN_1682993 NKG7
-12.113 2.207 1.84E-07
20 1310884 cg05007126 SDCBP2 TSS1500
ILMN_1705107 SDCBP2
7.264 2.590 0.006
21 40180000 cg15892280 ETS2 5'UTR
ILMN_1720158 ETS2
-13.054 1.607 2.15E-13
22 31686097 cg08548559 PIK3IP1 Body
ILMN_1719986 PIK3IP1
-4.952 1.593 0.002
22 37257404 cg02532700 NCF4 Body
ILMN_2335704 NCF4
-8.136 2.809 0.004
22 37257404 cg02532700 NCF4 Body
ILMN_1757361 NCF4
-6.751 2.766 0.016
22 37257404 cg02532700 NCF4 Body
ILMN_1785005 NCF4
-8.782 2.835 0.002
Abbreviations: Chr, Chromosome; Body, gene body; TSS200, within 200 bps from transcription start site; TSS1500, within 1500 bps
from transcription start site; UTR, untranslated regions.

For each CpG, the significance threshold was defined as 0.05/number of expression probes of the corresponding gene.

40
 Table S5. Contribution rates of smoking on urinary PAHs metabolites calculated in male individuals from the WHZH cohort (n =
206).

Model 1a Model 2b Variance of OH-PAHs

Concentrations of OH-PAHs
OH-PAHs explained by smokingc
(×10-2) R2 p R2 p ΔR2 (%)
1-hydroxynaphthalene 0.32 (0.22, 0.52) 0.152 9.30E-04 0.059 0.277 9.307
2-hydroxynaphthalene 0.58 (0.38, 1.00) 0.258 4.72E-08 0.079 0.095 17.979
2-hydroxyfluorene 0.12 (0.08, 0.17) 0.080 0.131 0.065 0.204 1.497
9-hydroxyfluorene 0.27 (0.18, 0.44) 0.070 0.214 0.064 0.205 0.548
1-hydroxyphenanthrene 0.08 (0.06, 0.14) 0.198 1.71E-05 0.198 7.46E-06 0.020
2-hydroxyphenanthrene 0.06 (0.04, 0.08) 0.119 0.012 0.117 0.007 0.133
3-hydroxyphenanthrene 0.11 (0,07, 0.14) 0.252 1.07E-07 0.250 4.74E-08 0.170
4-hydroxyphenanthrene 0.10 (0.07, 0.15) 0.126 0.007 0.121 0.006 0.500
9-hydroxyphenanthrene 0.22 (0.15, 0.30) 0.093 0.064 0.093 0.041 0.000
1-hydroxypyrene 0.24 (0.17, 0.36) 0.102 0.034 0.096 0.031 0.591
ΣOH-PAHs 2.41 (1.82, 3.09) 0.169 2.34E-04 0.122 0.005 4.608
The OH-PAHs levels were calibrated by urinary creatinine and presented as micromoles per millimole creatinine. Concentrations of
OH-PAHs (×10-2) are median (25th, 75th).

a
Model 1: Linear regression models with urinary metabolite as dependent variables, age, drinking, BMI, occupation, geographical
regions beadchip and operation date included as independent variables. Concentrations of urinary PAHs metabolites were
ln-transformed. b Model 2: additionally included smoking in Model 1.cThe variance of each urinary OH-PAH metabolite explained by
smoking, calculated as the variance explained by Model 2 minus the variance explained by Model 1.

41
Table S6. Associations between the smoking-related CpGs and urinary 2-hydroxynaphthalene levels in males from the WHZH Cohort
and the Coke Oven Cohorta.

WHZH nonsmoker COW nonsmoker

WHZH (n = 206) COW (n = 107)
CpG Gene (n = 72) (n = 20)
Effectb p Effectb p Effectc p Effectc p
cg05575921 AHRR -0.664 1.94E-09 -0.223 0.284 -0.679 1.40E-05 -0.062 0.907
cg23576855 AHRR -0.581 1.01E-07 -0.161 0.477 -0.587 1.57E-04 0.130 0.790
cg21566642 - -0.574 2.59E-07 0.065 0.766 -0.531 4.88E-04 -0.413 0.311
cg05951221 - -0.435 7.14E-05 -0.047 0.833 -0.573 3.39E-04 -0.719 0.077
cg26703534 AHRR -0.529 6.58E-07 -0.463 0.028 -0.319 0.020 0.055 0.884
cg03636183 F2RL3 -0.462 2.70E-05 -0.252 0.226 -0.311 0.056 0.327 0.563
cg01940273 - -0.592 2.88E-08 -0.248 0.250 -0.470 0.002 0.264 0.613
cg25648203 AHRR -0.475 1.26E-05 -0.545 0.015 -0.377 0.017 0.346 0.348
cg22132788 MYO1G 0.334 0.004 0.138 0.599 0.426 0.006 0.266 0.673
cg21161138 AHRR -0.562 3.78E-07 -0.321 0.180 -0.503 0.002 -0.715 0.201
cg03329539 - -0.407 1.64E-04 0.095 0.667 -0.394 0.014 -0.234 0.621
cg06126421 - -0.393 1.61E-04 0.172 0.423 -0.346 0.010 -0.026 0.944
cg01513913 - -0.328 0.003 -0.176 0.482 -0.355 0.021 0.388 0.372
cg12803068 MYO1G 0.242 0.039 0.255 0.296 0.429 0.007 -0.125 0.832
cg21611682 LRP5 -0.362 0.001 -0.473 0.052 -0.373 0.024 0.571 0.206
cg00501876 CSRNP1 -0.302 0.007 -0.113 0.654 -0.133 0.382 -0.414 0.370
cg14817490 AHRR -0.378 6.26E-04 -0.165 0.485 -0.450 0.006 -1.025 0.013
cg01208318 - -0.331 0.003 0.002 0.994 -0.479 0.003 0.224 0.630
cg06811467 ATP8B2 -0.112 0.269 0.160 0.462 -0.186 0.202 -0.249 0.576
cg24540678 - -0.210 0.061 0.050 0.825 -0.393 0.017 -0.334 0.524
cg23594345 - -0.338 0.003 -0.228 0.349 -0.353 0.034 0.520 0.274
cg02018337 GAS7 -0.103 0.302 -0.087 0.697 -0.301 0.015 -0.246 0.511
42
cg07573717 CAPZB -0.071 0.493 -0.228 0.272 -0.288 0.041 -0.569 0.207
cg14387626 - -0.182 0.088 -0.246 0.263 -0.212 0.141 0.265 0.556
cg23161492 ANPEP -0.417 2.87E-04 -0.112 0.637 -0.297 0.069 0.453 0.347
cg03991871 AHRR -0.320 0.004 -0.300 0.206 -0.377 0.018 -8.351 0.999
cg00980649 - -0.095 0.402 0.092 0.703 -0.382 0.017 0.396 0.388
cg11660018 PRSS23 -0.364 3.77E-04 -0.405 0.054 -0.382 0.005 0.362 0.440
cg03440944 C7orf40 -0.002 0.989 0.503 0.027 -0.286 0.019 -0.224 0.501
cg19089201 MYO1G 0.292 0.014 0.508 0.046 0.295 0.062 0.254 0.654
cg23079012 - -0.354 0.001 -0.506 0.014 -0.097 0.556 0.711 0.109
cg13074055 - -0.153 0.172 0.207 0.363 -0.318 0.060 0.876 0.064
cg26542660 CEP135 -0.073 0.461 0.122 0.575 -0.136 0.343 -0.324 0.449
cg22512531 CRTAM 0.190 0.076 0.290 0.187 0.212 0.073 -0.248 0.379
cg15164194 WDFY4 -0.144 0.163 -0.153 0.506 -0.145 0.301 -0.088 0.845
cg27113548 - -0.281 0.014 -0.293 0.225 -0.361 0.017 0.453 0.391
cg19572487 RARA -0.332 0.004 0.357 0.122 -0.306 0.034 -0.195 0.610
cg19859270 GPR15 -0.350 0.002 -0.141 0.547 -0.605 1.77E-04 -0.614 0.150
cg18960216 TIAF1 0.106 0.291 0.102 0.644 0.359 0.011 0.601 0.238
cg07978738 ABLIM1 -0.112 0.285 0.066 0.755 -0.349 0.023 -0.155 0.766
cg25189904 GNG12 -0.374 9.39E-04 0.364 0.132 -0.342 0.037 -0.214 0.581
cg04232128 TMEM173 -0.060 0.549 0.186 0.416 -0.270 0.056 -0.170 0.694
cg23916896 AHRR -0.458 5.18E-05 -0.594 0.012 -0.100 0.536 -0.018 0.962
cg07339236 ATP9A -0.291 0.007 -0.263 0.221 -0.178 0.265 0.379 0.517
cg18946533 SH2D7 -0.048 0.679 -0.168 0.475 0.408 0.014 0.625 0.201
cg05080154 SALL3 0.167 0.111 -0.279 0.197 0.375 0.016 0.387 0.175
cg12806681 AHRR -0.247 0.026 0.078 0.737 -0.414 0.011 -0.312 0.477
cg09088988 STK32A -0.090 0.407 -0.244 0.255 0.118 0.473 0.226 0.690
cg26850624 AHRR 0.135 0.202 0.285 0.172 0.186 0.221 0.753 0.187
cg23771366 PRSS23 -0.310 0.004 -0.277 0.195 -0.428 0.005 0.005 0.993
43
cg04016086 COBL 0.050 0.664 -0.388 0.112 0.320 0.035 0.479 0.257
cg10750182 CDH23 -0.309 0.004 -0.541 0.014 -0.254 0.068 -0.170 0.617
cg01692968 - -0.363 7.14E-04 -0.210 0.286 -0.224 0.106 0.490 0.197
cg09578155 LRP5 -0.148 0.166 0.004 0.986 -0.098 0.515 0.011 0.984
cg23186333 CD44 -0.002 0.987 0.074 0.732 -0.199 0.183 0.060 0.917
cg09084200 VPS26B -0.107 0.329 0.153 0.484 -0.242 0.134 -0.119 0.802
cg25305703 - -0.159 0.143 0.142 0.499 -0.131 0.401 -0.047 0.927
cg14556677 NEK6 -0.103 0.307 -0.044 0.843 -0.149 0.315 -0.448 0.358
cg03217253 ZNF677 -0.028 0.810 -0.421 0.065 0.232 0.138 0.530 0.177
cg14663208 HIVEP3 0.198 0.070 0.078 0.754 0.272 0.034 0.147 0.588
cg14753356 - -0.303 0.003 0.008 0.968 -0.375 0.003 -0.538 0.141
cg09935388 GFI1 -0.425 8.82E-05 0.109 0.627 -0.279 0.095 0.312 0.551
cg08595501 IQGAP2 -0.299 0.011 -0.134 0.577 -0.214 0.199 0.660 0.238
cg07465627 STXBP4 -0.100 0.369 0.269 0.271 -0.197 0.211 -0.492 0.197
cg15693483 C7orf50 -0.308 0.002 -0.501 0.031 -0.143 0.284 0.716 0.059
cg22644321 TRIB1 -0.219 0.028 -0.227 0.285 -0.153 0.270 -0.539 0.112
cg27537125 - -0.118 0.285 0.288 0.199 -0.177 0.236 -0.410 0.311
cg19708306 - 0.072 0.485 -0.020 0.930 0.178 0.171 0.274 0.465
cg09471611 - 0.163 0.131 0.358 0.138 0.240 0.061 0.180 0.643
cg11902777 AHRR -0.129 0.265 -0.189 0.437 -0.208 0.207 -0.370 0.171
cg06135139 BHLHE23 0.179 0.130 -0.186 0.464 0.176 0.273 0.245 0.677
cg09257526 IL6R -0.159 0.129 -0.273 0.208 -0.286 0.044 -0.447 0.245
cg23973524 CRTC1 0.133 0.229 -0.392 0.076 0.414 0.013 0.627 0.093
cg02560388 - -0.303 0.004 -0.048 0.831 -0.210 0.123 -0.253 0.471
cg06321596 XYLT1 -0.325 0.005 -0.243 0.297 -0.013 0.933 0.310 0.452
cg08035323 - 0.146 0.200 -0.177 0.496 0.177 0.214 -0.411 0.402
cg01447828 PRX 0.000 0.997 -0.437 0.100 0.448 0.006 -0.478 0.274
cg16619991 ITGA1 0.054 0.628 0.291 0.192 -0.058 0.714 -0.487 0.333
44
cg17426273 NEBL -0.004 0.970 -0.516 0.024 0.120 0.425 0.678 0.118
cg09044186 APOA5 0.073 0.544 -0.103 0.701 0.150 0.335 0.343 0.569
cg02304156 ATP2A1 0.035 0.745 -0.044 0.852 0.172 0.282 -0.091 0.840
cg25325005 PLEC1 0.013 0.912 0.487 0.040 -0.390 0.014 -0.355 0.416
cg19254163 GPR44 -0.196 0.059 -0.121 0.572 -0.231 0.064 0.153 0.718
cg01055824 CCDC88C 0.000 0.997 0.275 0.246 -0.328 0.037 -0.431 0.388
cg23110422 ETS2 -0.188 0.101 0.281 0.257 -0.320 0.052 -0.164 0.777
cg11229399 - 0.050 0.641 0.049 0.831 0.112 0.483 -0.641 0.159
cg27122888 NRXN2 -0.229 0.035 -0.150 0.500 -0.211 0.162 0.085 0.852
cg22674699 HOXD9 -0.011 0.923 -0.299 0.160 0.210 0.200 0.149 0.774
cg14858469 NR2F2 0.072 0.540 -0.402 0.113 -0.030 0.853 -0.280 0.533
cg25853622 LPP -0.096 0.297 -0.218 0.311 -0.146 0.210 -0.129 0.665
cg23572908 VIPR2 0.257 0.021 -0.229 0.365 0.269 0.089 0.246 0.644
cg15393221 PRX 0.139 0.209 -0.437 0.065 0.288 0.079 0.116 0.840
cg02801786 - 0.084 0.380 -0.134 0.464 0.194 0.195 0.519 0.174
cg07178945 FGF23 0.184 0.107 0.236 0.310 0.018 0.909 -0.449 0.246
cg04198308 FAM19A5 -0.023 0.836 -0.159 0.464 0.404 0.008 0.229 0.576
cg07324245 SEPT9 -0.140 0.151 -0.026 0.906 0.075 0.557 0.344 0.404
cg25114611 FKBP5 -0.164 0.109 -0.034 0.870 -0.259 0.072 -0.688 0.199
cg23924887 ATP8B2 0.022 0.845 0.178 0.470 -0.253 0.111 0.005 0.991
cg04214430 - 0.043 0.700 0.144 0.562 0.148 0.362 1.155 0.022
cg19719391 - -0.034 0.743 -0.192 0.371 0.190 0.229 1.072 0.010
cg05396397 NPPA 0.126 0.275 -0.377 0.159 0.374 0.026 -0.052 0.876
cg13679772 FOXN3 0.099 0.341 0.097 0.672 0.144 0.312 0.370 0.323
cg08591265 SFRS1 -0.018 0.868 0.319 0.156 -0.093 0.511 -0.624 0.140
cg15474579 CDKN1A -0.199 0.052 -0.078 0.729 -0.190 0.133 0.036 0.905
cg04551776 AHRR -0.345 0.002 -0.163 0.487 -0.479 0.003 -0.302 0.515
cg20124610 CARS2 -0.132 0.238 0.069 0.786 -0.253 0.104 -0.565 0.289
45
cg11207515 CNTNAP2 0.196 0.100 -0.116 0.650 -0.028 0.869 -0.765 0.061
cg16783744 DPYS 0.000 0.997 -0.419 0.054 0.140 0.350 0.476 0.311
cg04887172 CBFA2T3 -0.147 0.188 -0.285 0.221 -0.047 0.705 -0.005 0.988
cg25949550 CNTNAP2 -0.125 0.248 -0.073 0.733 -0.443 0.006 -0.615 0.169
cg09338136 AHRR -0.142 0.203 -0.175 0.449 -0.357 0.026 -0.806 0.053
cg02451831 KIAA0087 -0.215 0.056 -0.309 0.183 -0.224 0.172 -0.002 0.996
cg09613161 COBL -0.011 0.917 -0.218 0.314 0.187 0.235 -0.076 0.885
cg02384859 ARID3B 0.134 0.212 0.200 0.402 0.242 0.076 0.121 0.762
cg00778858 MTUS1 0.093 0.418 -0.009 0.973 0.218 0.129 0.217 0.620
cg22851561 C14orf43 -0.127 0.272 -0.148 0.556 -0.063 0.706 -0.068 0.897
cg09022230 TNRC18 -0.463 2.68E-05 -0.546 0.013 -0.198 0.166 -0.108 0.707
cg11554391 AHRR -0.255 0.026 -0.150 0.526 -0.408 0.013 -0.410 0.282
cg09373037 SYT15 0.165 0.158 -0.249 0.321 0.347 0.034 -0.040 0.939
cg01955533 CDKN1A -0.122 0.215 -0.095 0.672 -0.328 0.019 -0.544 0.179
cg15700587 MIR548I4 0.140 0.176 0.034 0.879 0.062 0.652 -0.887 0.030
cg06644428 - -0.285 0.010 -0.052 0.808 -0.354 0.029 -0.678 0.150
cg09156233 BMPR1B 0.267 0.017 -0.131 0.530 0.215 0.176 0.158 0.781
cg20164601 - -0.126 0.277 0.368 0.136 -0.024 0.890 0.784 0.036
cg08617970 VARS2 -0.098 0.410 0.006 0.979 -0.140 0.398 0.565 0.288
cg00073090 - -0.227 0.028 -0.091 0.653 -0.311 0.040 -0.404 0.334
cg16382047 GPR55 -0.184 0.061 -0.110 0.592 -0.354 0.009 0.074 0.825
cg04180046 MYO1G 0.010 0.931 -0.144 0.548 0.322 0.045 0.025 0.959
cg24090911 AHRR -0.465 1.81E-05 -0.228 0.293 -0.369 0.013 -0.431 0.352
cg22678402 FAM125A -0.066 0.542 -0.262 0.209 0.104 0.463 0.362 0.411
cg15892280 ETS2 -0.134 0.187 -0.150 0.483 -0.102 0.446 0.309 0.486
cg05329352 ADRA2A -0.095 0.377 0.305 0.168 -0.270 0.089 0.676 0.165
cg02945646 AP1G2 -0.010 0.920 0.232 0.280 -0.142 0.349 -0.539 0.180
cg01383486 GINS2 -0.041 0.714 -0.091 0.699 0.003 0.983 0.009 0.986
46
cg23673974 TBKBP1 0.083 0.463 0.029 0.907 0.060 0.680 -0.259 0.497
cg04211179 ZBTB17 0.038 0.723 0.513 0.018 -0.277 0.044 -0.564 0.055
cg20344344 - -0.032 0.776 0.098 0.684 0.097 0.537 -0.034 0.951
cg18656829 - -0.104 0.381 -0.557 0.018 -0.080 0.612 -0.203 0.697
cg14316231 MYST3 -0.157 0.153 -0.112 0.631 -0.180 0.266 -0.097 0.835
cg04528720 - 0.228 0.032 0.329 0.133 0.242 0.059 0.015 0.953
cg20949306 RAB3GAP1 0.073 0.503 -0.050 0.836 0.376 0.005 0.377 0.362
cg17094249 - -0.074 0.527 -0.059 0.827 -0.137 0.418 -0.208 0.710
cg08129092 INTS3 -0.026 0.807 -0.080 0.735 0.160 0.281 -0.245 0.544
cg09858188 - 0.125 0.248 -0.243 0.252 0.035 0.833 0.753 0.104
cg05339037 - -0.069 0.519 0.098 0.675 -0.226 0.175 -0.199 0.659
cg24859433 - -0.168 0.139 0.035 0.881 -0.065 0.691 -0.139 0.804
cg02003272 - 0.003 0.976 0.295 0.172 -0.007 0.965 0.081 0.851
cg14624207 LRP5 -0.355 7.74E-04 -0.402 0.080 -0.269 0.064 0.312 0.524
cg10351287 STK32B 0.070 0.527 -0.308 0.189 0.290 0.051 0.048 0.911
cg25165932 SELPLG 0.224 0.059 0.071 0.787 0.250 0.146 0.886 0.070
cg07779120 IGF1R 0.244 0.038 -0.123 0.601 0.338 0.035 0.214 0.675
cg20460771 PTAFR 0.233 0.021 0.280 0.210 0.336 0.014 0.270 0.438
cg04158878 - 0.101 0.355 0.054 0.824 0.164 0.256 -0.438 0.395
cg13279811 - -0.205 0.069 -0.028 0.914 -0.097 0.534 0.655 0.154
cg20889322 - -0.209 0.057 -0.223 0.328 -0.375 0.022 -0.534 0.176
cg20146909 LRRC8D -0.193 0.075 -0.334 0.173 0.014 0.929 0.156 0.773
cg09419102 - -0.087 0.407 0.107 0.632 -0.084 0.601 0.633 0.200
cg15159987 CPAMD8 -0.075 0.499 0.306 0.185 -0.375 0.011 -0.055 0.891
cg14785479 SCARF2 0.049 0.636 -0.017 0.930 -0.052 0.747 -0.223 0.616
cg10420527 LRP5 -0.306 0.005 -0.319 0.179 -0.292 0.061 0.247 0.563
cg06959340 JUB -0.262 0.024 -0.030 0.900 -0.165 0.328 0.475 0.404
cg14977938 ZFYVE21 0.111 0.316 0.063 0.771 0.270 0.103 0.292 0.572
47
cg02583484 HNRNPA1 -0.166 0.123 0.101 0.670 -0.174 0.226 -0.023 0.955
cg03129384 FAM196A 0.053 0.605 -0.262 0.198 -0.052 0.744 -0.255 0.514
cg20399616 BCAT1 0.348 0.004 -0.137 0.604 0.368 0.028 -0.640 0.105
cg26963277 KCNQ1OT1 -0.220 0.054 0.088 0.723 -0.372 0.024 -0.579 0.256
cg23193870 PTPN6 -0.170 0.129 0.057 0.818 -0.244 0.120 -0.150 0.778
cg12876356 GFI1 -0.254 0.022 -0.370 0.071 -0.229 0.168 0.177 0.707
cg13711966 - 0.078 0.469 -0.048 0.838 0.165 0.279 0.478 0.324
cg03242819 DOCK1 0.075 0.503 -0.326 0.129 -0.022 0.894 0.034 0.942
cg18446336 GNA12 -0.230 0.030 -0.396 0.086 -0.225 0.124 0.360 0.486
cg05010058 CEP68 -0.076 0.500 0.005 0.984 -0.223 0.175 0.791 0.106
cg20664238 NTRK3 -0.088 0.446 -0.288 0.212 0.137 0.347 0.209 0.568
cg15342087 - -0.311 0.008 -0.057 0.813 -0.097 0.558 -0.481 0.367
cg21618017 RILPL1 -0.059 0.571 0.083 0.694 -0.238 0.124 -0.180 0.720
cg17489908 GATA3 -0.217 0.053 -0.081 0.699 -0.191 0.228 -0.169 0.765
cg13668129 HNRNPUL1 -0.113 0.277 0.109 0.612 -0.194 0.194 -0.753 0.044
cg12836863 BRCA2 0.097 0.366 -0.104 0.665 0.038 0.789 0.152 0.688
cg03603381 RASGRP1 -0.204 0.073 -0.171 0.461 -0.215 0.179 0.221 0.661
cg18630040 PLA2G7 0.024 0.816 -0.510 0.011 0.182 0.227 0.207 0.588
cg01765406 - -0.243 0.020 -0.275 0.216 -0.144 0.294 0.328 0.366
cg13724496 BMP2 0.133 0.241 -0.265 0.240 0.193 0.193 -0.099 0.823
cg13990486 FLJ43663 0.036 0.749 0.008 0.974 -0.129 0.421 -0.246 0.506
cg05270224 - 0.102 0.348 -0.264 0.218 0.499 0.002 0.493 0.352
cg25310233 - -0.113 0.293 -0.029 0.897 -0.332 0.037 0.131 0.806
cg24032269 TCOF1 0.228 0.023 0.314 0.163 0.146 0.268 -0.131 0.728
cg13774342 - -0.078 0.503 0.150 0.551 -0.044 0.774 -0.142 0.761
cg18150958 RPL23A -0.085 0.470 0.040 0.863 -0.230 0.164 -0.120 0.838
cg18165852 CHST13 0.056 0.631 -0.590 0.022 -0.137 0.393 -0.690 0.105
cg26242531 ZFYVE21 0.122 0.226 -0.122 0.584 0.179 0.161 -0.100 0.841
48
cg12756150 - 0.142 0.208 -0.003 0.990 0.307 0.053 0.198 0.638
cg02150910 GZMH 0.137 0.193 0.270 0.239 0.282 0.038 -0.630 0.123
cg21473814 CRTC1 -0.029 0.798 -0.397 0.101 0.229 0.135 0.616 0.236
cg00619505 TMCO3 0.081 0.451 -0.384 0.101 0.222 0.139 0.817 0.033
cg21188533 CACNA1D 0.116 0.302 -0.223 0.334 0.091 0.587 -0.433 0.251
cg13418576 - -0.138 0.226 0.269 0.282 -0.028 0.863 -0.327 0.464
cg17924476 AHRR 0.245 0.022 0.325 0.141 -0.128 0.373 -0.337 0.457
cg02532700 NCF4 -0.313 0.006 0.082 0.742 -0.210 0.205 -0.244 0.489
cg12593793 - -0.224 0.026 0.138 0.540 -0.129 0.402 0.087 0.863
cg14544289 SPTLC2 -0.085 0.450 -0.108 0.652 -0.016 0.917 0.215 0.630
cg22619824 ST7 -0.345 0.002 -0.319 0.137 -0.092 0.560 0.033 0.947
cg22807449 HOXB2 -0.193 0.090 -0.154 0.486 0.028 0.845 0.699 0.154
cg15417641 CACNA1D 0.161 0.140 -0.046 0.832 0.109 0.515 -0.808 0.035
cg07381806 MOBKL2A -0.364 0.002 -0.130 0.626 -0.230 0.154 1.342 0.008
cg08126789 USP10 0.278 0.011 0.013 0.953 0.215 0.189 0.240 0.667
cg03844971 MLXIP -0.302 0.005 -0.340 0.146 -0.161 0.296 -0.345 0.545
cg05248618 CA4 -0.085 0.458 -0.644 0.010 0.139 0.383 0.092 0.799
cg05655806 CD96 0.014 0.896 0.378 0.111 0.055 0.720 0.030 0.941
cg09658497 GNA12 -0.124 0.275 -0.615 0.011 -0.344 0.033 0.089 0.859
cg06008724 PHF21B 0.036 0.724 -0.254 0.239 0.130 0.413 1.028 0.022
cg26348226 ECE1 -0.167 0.110 -0.089 0.692 -0.294 0.029 -0.150 0.639
cg18642234 GPX1 -0.177 0.098 -0.088 0.698 -0.236 0.128 0.316 0.402
cg19717773 GNA12 -0.263 0.024 -0.562 0.026 -0.352 0.030 -0.099 0.847
cg11295113 FOLR2 0.109 0.340 -0.026 0.915 0.116 0.459 0.362 0.470
cg01500140 LIM2 0.161 0.078 0.016 0.935 0.311 0.025 0.736 0.133
cg15746583 CD8B 0.043 0.679 -0.052 0.799 0.006 0.969 -0.532 0.182
cg10416861 - 0.170 0.128 0.240 0.302 0.402 0.011 0.240 0.674
cg09570614 - 0.047 0.650 -0.186 0.394 0.107 0.443 0.031 0.929
49
cg24687805 RAB27A 0.087 0.442 -0.330 0.199 0.235 0.132 0.998 0.013
cg13481776 ALPI 0.194 0.060 0.295 0.179 0.233 0.077 0.115 0.665
cg09686308 CIB3 0.088 0.443 0.148 0.533 0.217 0.130 -0.381 0.375
cg24996979 C14orf43 -0.337 0.001 0.166 0.458 -0.100 0.544 -0.113 0.825
cg03646329 LPAR6 -0.077 0.488 0.394 0.072 -0.141 0.369 -0.390 0.373
cg13314145 NPTX2 -0.125 0.276 -0.494 0.046 0.108 0.488 0.533 0.249
cg19713429 CAPZB -0.019 0.866 0.254 0.244 -0.105 0.484 0.202 0.605
cg12303084 ZMYND8 0.046 0.664 0.457 0.030 -0.163 0.252 -0.024 0.943
cg21752525 - -0.134 0.223 0.324 0.126 -0.049 0.759 -0.314 0.380
cg15451980 RORA 0.200 0.054 0.297 0.217 0.171 0.196 -0.126 0.635
cg15187398 MOBKL2A -0.262 0.012 0.016 0.930 -0.183 0.272 0.664 0.248
cg00326958 HNRNPF -0.075 0.522 0.484 0.049 -0.214 0.165 -0.294 0.479
cg24996482 - 0.137 0.215 -0.319 0.139 0.239 0.128 0.226 0.624
cg05007126 SDCBP2 -0.026 0.811 0.225 0.386 -0.323 0.022 0.421 0.304
cg26958735 - 0.141 0.194 -0.232 0.306 0.079 0.620 -0.275 0.547
cg03172931 - 0.243 0.023 0.192 0.410 0.213 0.148 0.229 0.586
cg15554421 C3orf26 -0.204 0.055 -0.369 0.101 -0.292 0.049 -0.004 0.993
cg11485823 DPCR1 -0.015 0.890 0.164 0.497 0.153 0.321 -0.181 0.640
cg24741609 GLIS1 -0.098 0.398 0.124 0.581 -0.218 0.172 -0.503 0.281
cg10179300 TRIO -0.231 0.034 0.149 0.556 -0.272 0.100 0.087 0.860
cg02352716 - 0.226 0.032 0.250 0.277 0.186 0.156 0.275 0.177
cg09747445 TLE3 -0.190 0.086 -0.149 0.491 -0.371 0.012 -0.152 0.698
cg02869235 - 0.006 0.957 -0.093 0.693 -0.055 0.706 -0.388 0.349
cg22574825 FLT1 0.114 0.304 -0.114 0.605 -0.073 0.665 0.167 0.644
cg13185177 GP5 -0.162 0.115 -0.330 0.137 0.211 0.143 0.333 0.407
cg22851200 TRIP6 -0.192 0.078 -0.324 0.166 0.012 0.943 0.731 0.100
cg15207742 RIMS4 -0.045 0.675 -0.428 0.049 0.163 0.323 -0.093 0.850
cg14074174 SNAPC2 -0.147 0.152 -0.138 0.446 -0.222 0.110 -0.794 0.064
50
cg16611234 - -0.266 0.025 -0.195 0.455 -0.400 0.016 0.001 0.997
cg26361535 ZC3H3 -0.089 0.416 -0.008 0.972 -0.209 0.194 0.209 0.625
cg23867146 - 0.038 0.727 0.103 0.657 -0.134 0.403 1.004 0.004
cg11621113 MORG1 -0.060 0.585 0.510 0.019 -0.119 0.417 0.221 0.444
cg07069636 - -0.048 0.640 0.272 0.200 -0.202 0.091 -0.453 0.155
cg12884422 - -0.199 0.093 -0.030 0.909 -0.090 0.597 0.497 0.299
cg07986378 ETV6 -0.347 8.64E-04 -0.002 0.994 -0.011 0.943 0.180 0.715
cg26364091 CHADL -0.320 0.004 -0.177 0.429 -0.199 0.239 0.530 0.298
cg12158535 PACS2 0.084 0.465 -0.152 0.509 0.156 0.335 0.553 0.273
cg21322436 CNTNAP2 -0.460 2.81E-05 -0.555 0.009 -0.358 0.025 -0.124 0.810
cg10126923 NKG7 0.066 0.523 -0.209 0.378 0.285 0.054 -0.207 0.616
cg10951873 RUNX3 -0.078 0.498 0.321 0.147 -0.137 0.376 0.068 0.869
cg05284742 ITPK1 -0.406 1.33E-04 -0.456 0.032 -0.089 0.554 0.370 0.266
cg12873476 - -0.263 0.010 -0.228 0.262 -0.346 0.036 -0.498 0.340
cg21733502 ZSCAN5B -0.307 0.005 -0.022 0.928 -0.131 0.425 0.226 0.665
cg01294327 LINGO3 -0.319 0.006 0.079 0.754 0.006 0.972 0.650 0.055
cg15380836 RILP -0.135 0.173 0.190 0.364 -0.140 0.352 -0.414 0.410
cg06419750 GLT1D1 0.025 0.822 -0.134 0.556 -0.004 0.982 -0.438 0.154
cg00336149 CACNA1D 0.138 0.221 -0.229 0.331 0.194 0.253 -0.931 0.004
cg22777952 FOXB1 0.011 0.923 -0.637 0.004 0.044 0.777 0.032 0.946
cg14667406 LCT -0.303 0.009 -0.690 0.008 -0.014 0.929 -0.334 0.512
cg10204884 PCBP3 -0.120 0.244 -0.116 0.594 -0.203 0.210 -0.385 0.507
cg12916723 NKG7 0.197 0.083 -0.038 0.877 0.245 0.088 0.279 0.427
cg01726890 - 0.214 0.051 0.121 0.605 0.150 0.277 -0.194 0.580
cg03877174 KIF1C 0.150 0.138 0.011 0.961 0.065 0.682 -0.286 0.513
cg05635807 - 0.135 0.253 -0.680 0.007 0.313 0.050 -0.043 0.937
cg19956914 SUMF2 0.078 0.491 0.016 0.950 0.394 0.015 0.499 0.251
cg10908953 SORL1 -0.178 0.085 -0.151 0.481 -0.170 0.262 -0.687 0.167
51
cg14096889 ADAMTSL3 0.112 0.331 -0.553 0.013 0.214 0.165 0.470 0.180
cg23351584 PRSS23 -0.203 0.081 -0.166 0.505 -0.442 0.005 -0.351 0.354
cg13389508 PLEC1 -0.164 0.132 -0.136 0.532 -0.337 0.037 -0.645 0.203
cg09762515 CUX1 0.083 0.432 0.307 0.177 0.223 0.137 0.527 0.172
cg16145216 HIVEP3 0.280 0.014 0.309 0.193 0.178 0.242 0.125 0.579
cg04039397 CD96 -0.196 0.081 0.320 0.164 0.061 0.695 -0.268 0.416
cg02818189 - -0.132 0.163 -0.019 0.927 -0.164 0.239 -0.037 0.937
cg09301294 EPHA6 0.011 0.913 -0.428 0.026 0.069 0.666 0.559 0.307
cg25260137 - -0.029 0.799 -0.630 0.006 0.067 0.668 0.162 0.701
cg05228408 CLCN6 -0.103 0.332 0.012 0.952 -0.120 0.391 -0.175 0.737
cg02985540 - -0.146 0.159 0.002 0.993 -0.230 0.123 -0.273 0.482
cg26971042 TLE3 -0.288 0.010 -0.319 0.181 -0.220 0.179 -0.502 0.252
cg06868100 PRR15 -0.120 0.291 0.428 0.082 0.037 0.828 0.874 0.088
cg19827923 GPR55 -0.114 0.302 -0.247 0.298 -0.380 0.013 -0.436 0.362
cg14580211 C5orf62 -0.348 5.12E-04 -0.221 0.352 -0.214 0.128 0.382 0.429
cg07827420 SEPT9 -0.135 0.251 0.180 0.480 -0.113 0.492 0.549 0.308
cg01107178 ANKRD11 0.195 0.069 0.376 0.114 0.172 0.212 -0.468 0.125
cg14588779 AKAP8L -0.088 0.425 0.129 0.571 -0.185 0.239 -0.167 0.619
cg05460226 PIK3R5 -0.251 0.023 -0.035 0.869 -0.169 0.285 0.486 0.349
cg14428590 FSIP1 -0.230 0.034 -0.078 0.751 0.024 0.869 -0.254 0.454
cg26736540 TFAP2C 0.030 0.794 -0.397 0.128 0.004 0.981 -0.540 0.172
cg01564343 TREML1 -0.046 0.668 -0.253 0.273 0.111 0.480 -0.127 0.767
cg13193840 - -0.144 0.221 0.345 0.155 -0.156 0.349 0.488 0.398
cg13039251 PDZD2 0.208 0.053 -0.381 0.092 -0.134 0.357 -0.151 0.563
cg06901890 FNBP1 -0.129 0.271 0.283 0.233 -0.138 0.410 0.433 0.360
cg17287155 AHRR -0.194 0.091 0.103 0.623 -0.329 0.037 -0.315 0.424
cg20303561 CCDC88C -0.005 0.961 0.422 0.051 0.017 0.916 -0.041 0.925
cg03760919 RUNX1T1 0.184 0.089 0.501 0.025 -0.020 0.877 -0.497 0.181
52
 cg04755561 PKMYT1 0.048 0.643 0.022 0.921 -0.071 0.607 0.729 0.063
cg04105282 CRTAC1 0.082 0.460 -0.372 0.107 0.197 0.238 0.415 0.451
cg08548559 PIK3IP1 0.018 0.874 0.227 0.346 -0.391 0.012 -0.288 0.506
cg16556677 KCNQ1OT1 -0.179 0.113 0.115 0.652 -0.241 0.138 -0.180 0.712
cg06009448 C7orf50 -0.167 0.095 -0.071 0.746 -0.120 0.381 -0.095 0.827
cg19784816 ITIH1 0.054 0.598 -0.221 0.317 0.280 0.081 0.543 0.180
cg00378510 LINGO3 -0.197 0.073 0.279 0.202 0.121 0.452 0.949 0.021
cg08709672 AVPR1B -0.270 0.022 -0.059 0.815 -0.291 0.066 -0.587 0.230
cg19838043 ZFYVE21 0.028 0.796 -0.299 0.208 0.327 0.043 0.978 0.038
cg07123182 KCNQ1OT1 -0.358 0.002 -0.132 0.592 -0.439 0.009 -0.111 0.840
cg18387156 NRG1 0.024 0.825 -0.285 0.203 -0.069 0.672 -0.210 0.711
cg01416295 MRPL24 -0.084 0.446 0.284 0.245 0.106 0.495 -0.749 0.062
cg01598741 HMGA2 -0.203 0.070 -0.273 0.274 0.164 0.319 0.176 0.683
cg20185017 CACNB2 0.002 0.984 -0.122 0.526 0.008 0.958 -0.115 0.841
cg25922751 NCOR2 -0.205 0.060 0.121 0.606 0.141 0.303 -0.017 0.965
cg07066369 CCND2 -0.226 0.050 -0.263 0.276 -0.353 0.033 -0.037 0.933
a
Estimates were calculated by linear regression models. Methylation values were inverse-normal transformed and concentrations of
urinary 2-hydroxynaphthalene and 1-hydroxypyrene were ln-transformed. b Adjusting for age, drinking status, BMI, occupation,
beadchip operation date, differential leukocyte proportions and geographical regions. c Adjusting for 1-hydroxypyrene, age, drinking
status, BMI, beadchip operation date, differential leukocyte proportions.

53
Figure S1. The flowchart of the study.

54
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