Peerj 6630
Peerj 6630
Peerj 6630
ABSTRACT
Background. Epidemiological data on malocclusion among Chinese children are
scant. The aim of this study was to provide detailed information on the prevalence
of malocclusion in early mixed dentition children in Shanghai, China.
Methods. A cross-sectional survey was conducted from September 2016 to April 2017,
and 2,810 children aged 7- to 9- years were selected from 10 primary schools by cluster
random sampling. Several occlusal parameters, including Angle molar relationship,
overjet, overbite, open bite, anterior and posterior crossbite, midline displacement,
scissors bite, and teeth crowding and spacing, were clinically registered by five calibrated
orthodontic dentists.
Results. We found that 79.4% children presented one or more occlusal anomalies.
Angle Class I, Class II and Class III molar relationship were recorded in 42.3%, 50.9%
and 5.9% of the sample, respectively. The proportion of Class III increased from 5.0%
at age 7 to 7.8% at age 9. In the sagittal plane, increased overjet >3 mm was observed
in 40.8% subjects, while the prevalence of severe overjet (>8 mm), anterior edge-to-
Submitted 31 July 2018 edge (zero overjet) and anterior crossbite were 5.2%, 8.1% and 10.5%, respectively.
Accepted 15 February 2019 Vertically, deep overbite >2/3 overlap was found in 6.2% of the children and open bite
Published 2 April 2019
in 4.3%. Boys exhibited a higher rate of overbite than girls. For the transversal occlusal
Corresponding author anomalies, 36.1% of the children had a midline displacement, which was followed by
Li Chen, [email protected]
posterior crossbite (2.6%) and scissors bite (1.0%). Teeth space discrepancies were also
Academic editor common anomalies and anterior crowding (>2 mm) affecting 28.4% of the children,
Anne Marie Kuijpers-Jagtman
while anterior spacing (>4 mm) affecting 9.5%. Girls showed a higher prevalence of
Additional Information and anterior crowding and a lower frequency of teeth spacing than boys.
Declarations can be found on
page 10
Conclusions. Our study demonstrated that malocclusion is prevalent among children
in the early mixed dentition, and more health resources should be warranted to meet
DOI 10.7717/peerj.6630
the challenge of prevention or early intervention of malocclusion.
Copyright
2019 Yu et al.
Subjects Dentistry, Epidemiology, Pediatrics
Distributed under
Creative Commons CC-BY 4.0 Keywords Malocclusion, Early mixed dentition, Prevalence, Angle classification, Overjet, Open
bite, Crossbite, Crowding, Spacing
OPEN ACCESS
How to cite this article Yu X, Zhang H, Sun L, Pan J, Liu Y, Chen L. 2019. Prevalence of malocclusion and occlusal traits in the early
mixed dentition in Shanghai, China. PeerJ 7:e6630 http://doi.org/10.7717/peerj.6630
INTRODUCTION
Malocclusion is one of the most common oral disorders among children, and it affects
not only the oral masticatory function but also the craniofacial development and facial
appearance. Children with certain malocclusion traits appear to have more problems
related to psychology and social interactions, and even their quality of life suffers when
they reach adulthood (Martins-Junior, Marques & Ramos-Jorge, 2012; Nguyen et al., 1999;
Stenvik, Espeland & Berg, 2011). For this reason, malocclusion is regarded as an emerging
public health issue.
The mixed dentition is an important developmental stage to the undisturbed occlusal
relationship. The eruption of the first permanent molar plays a critical role in maintaining
the interarch space and the sagittal occlusal relationship. Several longitudinal observations
have revealed that a substantial number of malocclusions occur during this period
(Dimberg et al., 2015; Dimberg et al., 2013; Gois et al., 2012), and the accumulated evidence
has indicated that early intervention starting from the mixed dentition would benefit
the youngsters with Class III malocclusion, crossbite, crowding and posterior crossbite
(Gianelly, 2002; Keski-Nisula et al., 2008; Lippold et al., 2013; Mitani, 2002).
Epidemiological information is essential for developing strategies and plans to promote
oral health. In China, national or local surveys on dental caries and periodontitis have
been carried out regularly (Li & Wang, 2014; Zhou et al., 2018). However, there is still
insufficient information on the prevalence of malocclusions. Recently, we made an effort to
investigate the malocclusion status of Shanghai preschool children and an extraordinarily
high prevalence, 83.9%, was found (Zhou et al., 2017). In the current study, another
cross-sectional survey was carried out to assess the prevalence of malocclusion and the
distribution of occlusal traits among school children at the stage of early mixed dentition
in Shanghai.
Oral examination
The oral examination was carried out by five calibrated orthodontic dentists. The children
were examined at schools, using portable lighting and disposable mouth mirrors. Sagittal
molar relationships by Angle classification, degree of overjet and overbite, anterior and
posterior crossbite, and teeth crowding and spacing were recorded (Table 1).
The children who presented one or more of the following indications were registered
as malocclusion: Angle Class III, increased overjet (>3 mm), anterior crossbite, anterior
edge-to-edge, deep overbite (>2/3 overlap), open bite, midline displacement, posterior
crossbite, posterior edge-to-edge, scissors bite, anterior or posterior crowding (>2 mm),
and anterior spacing (>4 mm).
Reliability of examinations
Twenty subjects were evaluated by the five examiners independently of each other. One of
the examiners was an orthodontist with more than fifteen years’ clinic experience, and the
other four examiners compared their results to the senior orthodontist’s data respectively.
Inter-examiner reliability was determined by calculating Cohen’s kappa coefficient, and
the values were >0.68.
Statistical analysis
The rates of occlusal characteristics and malocclusion were reported by age and gender.
The chi-squared test and Fisher’s exact probability method were applied to determine the
statistical associations between the independent variables and the malocclusion variable.
Cohen’s kappa value was used to measure the agreement among examiners. The data were
input using the Epidata software and analyzed using SPSS Statistics 22 (IBM, Armonk, NY,
USA). The level of significance was set at p < .05.
RESULTS
The overall prevalence of malocclusion among school children aged 7–9 years in Shanghai
was 79.4% (2231/2810), and only 20.6% of them had normal occlusion (Table 2). The boys
had a very similar rate of malocclusion to that of the girls. No significant difference was
observed between age groups (p > .05).
The distribution of the sagittal occlusal features among the children in Shanghai is
shown in Table 3. The relationship of the first molars was classified according to the Angle
classification; 42.3% children showed a Class I relationship, 50.9% children were Class II,
and 5.9% were Class III. An increasing trend in the rate of Angle Class III with age was
observed, from 5.0% at age 7 to 7.8% at age 9. The increased overjet was prevalent (40.8%),
and most of the cases were mild or moderate, but 5.2% of the children were found to have
a severe overjet. Approximately one-tenth of the children had an anterior crossbite.
Table 4 depicts the vertical and transversal occlusal anomalies. The probability of the
deep overbite of the anterior teeth was 43.8% and that of severe overbite was 6.2%. Boys
were more prone to deep overbite than girls (p = .003). The rate of open bite of anterior
teeth was 4.24%; it decreased with age, from 4.9% at age 7 to 2.7% at age 9. With respect to
transversal anomalies, 36.1% of the children were found to have a midline displacement,
and 2.6% had posterior crossbite. The prevalence of a scissors bite was relatively low (0.9%),
but it increased with age.
Teeth crowding and spacing were prevalent among the children (Table 5). The prevalence
of anterior crowding of >2 mm of the maxillary or mandibular teeth was 13.3% and 22.5%,
respectively. In all, 28.4% of the children presented anterior crowding. Posterior crowding
was less common, and only 0.2% of the subjects were found to have maxillary posterior
crowding of >2 mm, and 1.0% was mandibular posterior. The rate of anterior spacing of
>4 mm of the maxillary teeth was 8.0%, and that of the mandibular teeth was 3.0%. An
increasing trend with age was observed for the rate of crowding of the upper anterior teeth,
and the boys’ probability of anterior crowding, either of the maxillary or of the mandibular
teeth, was lower than that of the girls’ (p < .001).
DISCUSSION
The prevalence of malocclusion in different populations ranges from 21% to 90%
(Grippaudo et al., 2013; Perillo et al., 2010; Perinetti et al., 2008; Shalish et al., 2013;
Thilander et al., 2001), and this huge variation may largely be attributed to the discrepancies
in the definitions of malocclusion and the methodologies applied. We found that the
prevalence of malocclusion in early mixed dentition in Shanghai was as high as 79.4%, which
was considerably higher than the rate of 71.2% among children with mixed dentition in a
national survey in 2000 (Fu et al., 2002). This result was similar to the rate of malocclusion
in the deciduous dentition, i.e., 83.9%, in the Shanghai area (Zhou et al., 2017). Our
findings confirmed that malocclusion was one of the most common health problems in
children and adolescents.
Deep overbite (>1/3 overlap, prevalence 43.8%) and increased overjet (>3 mm,
prevalence 40.8%) were the two most common types of occlusion abnormalities in
Shanghai schoolchildren. The high rates of overbite and overjet were also reported in
Nigeria (deep overbite: 31.7% and increased overjet: 44.6%) (DaCosta et al., 2016) and in
China’s western city Xi’an (deep overbite 37.6% and increased overjet 35.0%) (Zhou et al.,
2016). Nevertheless, compared to the fact that 63.7% of the preschool children were found
to have deep overbite in Shanghai (Zhou et al., 2017), it was less frequent in the age group
considered in this study. This decline could be partly explained by the self-correction of
deep overbite during dental development (Dimberg et al., 2015). The increased overjet (>3
mm) occurred more frequently in the early mixed dentition (43.8%) than in the primary
stage (33.9%) (Zhou et al., 2017). However, in terms of severe increased overjet (>8 mm),
the change was substantial: 0.9% for primary and 5.2% for mixed dentition. This change
may increase the risk of oral trauma (Nguyen et al., 1999).
Anterior crowding and anterior crossbite were another two high-incidence
malocclusions observed in this study. In contrast to deep overbite, crowding and crossbite
are less likely to be self-corrected without any intervention or treatment. Anterior crowding
of >2 mm was recorded in 28.4% of the subjects, considerably more frequent than the
proportion in primary dentition in the city (Zhou et al., 2017). Moreover, the crowding
problem might be worse in the permanent dentition stage, as the arch length decreased
during the transition from the mixed to the permanent dentition (Gianelly, 2002). It was
noteworthy that anterior crowding was more prevalent in the mandible (22.5%) than
maxilla (13.3%) in Shanghai children, which was consistent in what was found among
children in the early mixed dentition in Germany (Tausche, Luck & Harzer, 2004) and
adolescents in the permanent dentition in Japan (Komazaki et al., 2012). However, in Iran
and Turkey, adolescents had more crowding in the maxilla than mandible (Borzabadi-
Farahani, Borzabadi-Farahani & Eslamipour, 2009; Gelgor, Karaman & Ercan, 2007).
The prevalence of anterior crossbite in Shanghai children was comparable to that in
Israeli (9.5%) (Shalish et al., 2013), German (7.7%) (Tausche, Luck & Harzer, 2004), and
CONCLUSIONS
Our cross-sectional study demonstrated that 79.4% of the children in the stage of mixed
dentition had one or more malocclusion traits. For the prevention and intervention of
malocclusion, substantial resources and efforts are warranted from orthodontists, health
policy makers, communities, and, of course, families.
ACKNOWLEDGEMENTS
The authors would like to express their sincere gratitude to all the workers of the
five Preventive Dental Clinics in the Hongkou, Putuo, Jing’an, Pudong, and Minhang
districts for supporting this study. We thank LetPub for its linguistic assistance during the
preparation of this manuscript.
Funding
This study was supported by Projects of Development and Application of Suitable Health
Technology of Shanghai Hospital Development Center (SHDC) (No. SHDC12014226),
Grant Disclosures
The following grant information was disclosed by the authors:
Projects of Development and Application of Suitable Health Technology of Shanghai
Hospital Development Center (SHDC): SHDC12014226.
Strengthening Public Health System in Shanghai: GWIV-12.
Projects of Shanghai Municipal Commission of Health and Family Planning: 2016ZB0102-
01.
Project of Characteristic Medical Specialty in Minhang Shanghai: 2017MWTZ20.
Competing Interests
The authors declare there are no competing interests.
Author Contributions
• Xin Yu performed the experiments, prepared figures and/or tables, authored or reviewed
drafts of the paper, approved the final draft.
• Hao Zhang performed the experiments, analyzed the data, prepared figures and/or
tables, authored or reviewed drafts of the paper, approved the final draft.
• Liangyan Sun and Jie Pan performed the experiments, approved the final draft.
• Yuehua Liu conceived and designed the experiments, authored or reviewed drafts of the
paper, approved the final draft.
• Li Chen conceived and designed the experiments, performed the experiments, authored
or reviewed drafts of the paper, approved the final draft.
Human Ethics
The following information was supplied relating to ethical approvals (i.e., approving body
and any reference numbers):
This study was approved by the Ethics Committee of Shanghai Stomatological Hospital,
Fudan University (2015-0012).
Data Availability
The following information was supplied regarding data availability:
The raw data is available in the Supplemental Files.
Supplemental Information
Supplemental information for this article can be found online at http://dx.doi.org/10.7717/
peerj.6630#supplemental-information.