1. SIADH causes water retention, resulting in decreased urine output, dilute urine, and hyponatremia. Diabetes insipidus causes increased urine output, concentrated urine, and hypernatremia due to decreased water retention from low ADH levels.
2. Reed-Sternberg cells are seen in Hodgkin's disease and Bence Jones proteins in urine indicate multiple myeloma. Philadelphia chromosomes are present in chronic myelogenous leukemia.
3. Common signs of cancers include painless hematuria for bladder cancer, hematochezia for colorectal cancer, and painless lymph node swelling for Hodgkin's disease.
1. SIADH causes water retention, resulting in decreased urine output, dilute urine, and hyponatremia. Diabetes insipidus causes increased urine output, concentrated urine, and hypernatremia due to decreased water retention from low ADH levels.
2. Reed-Sternberg cells are seen in Hodgkin's disease and Bence Jones proteins in urine indicate multiple myeloma. Philadelphia chromosomes are present in chronic myelogenous leukemia.
3. Common signs of cancers include painless hematuria for bladder cancer, hematochezia for colorectal cancer, and painless lymph node swelling for Hodgkin's disease.
1. SIADH causes water retention, resulting in decreased urine output, dilute urine, and hyponatremia. Diabetes insipidus causes increased urine output, concentrated urine, and hypernatremia due to decreased water retention from low ADH levels.
2. Reed-Sternberg cells are seen in Hodgkin's disease and Bence Jones proteins in urine indicate multiple myeloma. Philadelphia chromosomes are present in chronic myelogenous leukemia.
3. Common signs of cancers include painless hematuria for bladder cancer, hematochezia for colorectal cancer, and painless lymph node swelling for Hodgkin's disease.
1. SIADH causes water retention, resulting in decreased urine output, dilute urine, and hyponatremia. Diabetes insipidus causes increased urine output, concentrated urine, and hypernatremia due to decreased water retention from low ADH levels.
2. Reed-Sternberg cells are seen in Hodgkin's disease and Bence Jones proteins in urine indicate multiple myeloma. Philadelphia chromosomes are present in chronic myelogenous leukemia.
3. Common signs of cancers include painless hematuria for bladder cancer, hematochezia for colorectal cancer, and painless lymph node swelling for Hodgkin's disease.
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FINAL COACHING: MEDICAL SURGICAL NURSING
PROF. REX B. YANGCO
SPECIAL SENSES: Give the disease condition 1. Blurring of Vision/Foggy/ Cloudy/ Cataract FLUIDS AND ELECTROLYTES: Give the electrolyte imbalance Hazy Vision Torsades de pointes- Prolonged QT Hypocalcemia 2. Floaters around light Retinal Detachment interval Detachment of the retinal pigmented 4F’s Peaked T wave- Tall tented T wave Hyperkalemia epithelium layer from the sensory Flashes of lights Prolonged QT interval Hypocalcemia layer of the retina. Floaters Presence of U wave Hypokalemia SURGERY: Scleral Buckling Falling of curtain Chvostek sign- facial spasm Hypocalcemia Fainless Trousseau sign- carpo pedal spasm Hypocalcemia 3. Narrowed vision/ Tunnel/ Loss of Glaucoma Weakness of the lower extremities- Hypokalemia peripheral vision early sign - increase of IOP (10-21 mmHg) Paralytic ileus- complication of Hypokalemia OPEN- degenerative, chronic prolonged constipation/ decrease in -asymptomatic at first peristaltic movement CLOSED- acute emergency Laryngospasm- fatal- airway Hypocalcemia - Sudden severe headache obstruction: - OBSTRUCTION- BEDSIDE: iridocorneal angle Tracheostomy set DOC: Pilocarpine Calcium Gluconate - Miotic Metabolic Acidosis Hyperkalemia - Pulls the trabecular Increase H- acid meshwork – increases the H blood- cell drainage of the aqeous K cell- blood humor/ outflow- decrease Metabolic Alkalosis Hypokalemia IOP Decrease H- alkaline H cell- blood 4. Tunnel vision Glaucoma K blood- cell 5. Loss of red reflex- opacity of the Cataract “Cellular Ion Exchange lens/ deposition of the grayish Increasing ICP Hyponatremia substances in the lens due to abnormal Water Intoxication- water from the ocular metabolism blood- cell- cell swelling 6. PAIN Closed Angle Glaucoma Cerebral Edema 7. Curtain falling in the visual field Retinal Detachment Increase water, less Na 8. Loss of central vision Macular Degeneration Hemodilution MD- degeneration of the macula lutea Cushing’s Disease Hypernatremia Macula lutea- center of the retina, Increase 3 S: Salt, sugar and sex Hypokalemia contains millions of cones Aldosterone, Cortisol and Androgen (photoreceptor- color, day and central Water and Na retention vision) Inc Na, Dec K DRY/ATROPHIC- accumulation of SIADH Dilutional the debris- DRUSEN (yellow) Increase ADH- water reabsorption Hyponatremia WET/ EXUDATIVE- neovascular Inc water, less Na formation- RED Addison’s Disease Hyponatremia 9. DRUSEN- yellow Atrophic/ Dry Macular Decrease in 3S Hyperkalemia Degeneration Increasing water and Na excretion 10. Sudden severe headaches- Closed Angle Glaucoma Dec Na, Inc K mistaken as migraine Diabetes Insipidus Hypernatremia 11. Halos around light Glaucoma Decreasing ADH- water excretion- 12. Cloudy vision Cataract POLYURIA 13. Increasing IOP- aqeous humor Glaucoma Water Deficit- DHN 14. Myopia- nearsightedness Retinal Detachment Dec water, Inc Na- Most common cause of RD hemoconcentration 15. Opacity of the lens Cataract
1 |NOVEMBER 2022 PNLE REVIEW
FINAL COACHING: MEDICAL SURGICAL NURSING PROF. REX B. YANGCO appearance of the breast SIADH/ Diabetes Insipidus (D.I.) Reed Sternberg Cell- confirmatory Hodgkin’s Disease (ADH- water reabsorption in the kidney tubules) Immature lymphoid cell Signs/ Symptoms SIADH D.I. Bence Jones CHON- urine Multiple Myeloma Inc ADH Dec ADH MM- abnormal proliferation of Polyuria plasma cell in the bone marrow Concentrated urine- Oliguria/ Bone destruction- bone resorption of decrease UO Ca Urine specific gravity= 1.009- Hypercalcemia diluted (polyuria) Auer rods Acute Myelogenous Normal USG: 1.010- 1.025 Leukemia Weight loss- water loss/ excretion Philadelphia chromosomes Chronic Myelogenous Edema- water retention A piece of chromosome 9 and 22 Leukemia break off and trade places Dehydration- water deficit due to Most common leukemia in children Acute Lymphocytic water loss Leukemia Serum sodium = 120 mEq/L- Dukes classification Colorectal Ca Hyponatremia A intestinal mucosa Noraml: 135-145 mEq/L B muscle C lymph nodes Constipation- water deficit D distant metastasis Increased blood osmolarity- Tamoxifen- Anti Estrogen DOC Breast Ca Hemoconcentration- Increase Hct WOF: Endometrial Ca level Expected: bone pain- effective Increased urine specific gravity- Flourouracil- Antimetabolite Colorectal Ca concentrated urine- decreased UO Cell Cycle Specific Hemodilution- Decrease Hct level Attacks the cell- S phase- DNA Hypervolemia synthesis Diluted urine- polyuria Painless Hematuria- early sign Bladder Ca Polydipsia- compensation due to Hematochezia fresh blood in the stool Colorectal Ca water loss Most common site: sigmoid and Hypertension- Increase circulating rectum blood volume Schistomiasis Bladder Ca Pulmonary edema Painless swelling of the lymph nodes- Hodgkin’s Disease cervical lymph nodes, upper part of Decreased blood osmolarity- the body Hemodilution Abdominal enlargement- increasing Liver/ Ovarian Ca Decreased urine specific gravity- size of the tumor diluted urine- increasing urine HPV- Multiple sexual partner Cervical Ca excretion Nulliparity Breast Ca Water- like urine Multiparity Cervical Ca Growth retardation Tail of Spence- first site of metastasis, Breast Ca Pituitary Gland – hypofunctioning axillary lymph nodes located Urine sp gr = 1.040- concentrated Hepa Virus- Hepa B Hepatocellular Ca urine A- Fecal oral B- Body secretions and blood CELLULAR ABERRATION: Give the specific kind of cancer C- Post BT hepatitis 1 case for female- morbidity Breast Ca D- Post Hepa B 1 mortality for both sexes- death Lung Ca E- Fecal oral Caused primarily by smoking- 90% of Lung Ca Asbestos Lung Ca its cause is smoking Hemoptysis Lung Ca Passive smokers are 4 to 5x risker High fat diet- low fiber diet Colorectal Ca than active active smokers High nitrate diet- salt cured/ Gastric Ca SIADH- Small Cell Lung Carcinoma Lung Ca preservatives; hotdogs, bacon, ham - Ability to secrete ADH Burkitt’s Lymphoma Non-Hodgkin’s Disease Peau d orange- orange peel Breast Ca Lymphosarcoma
2 |NOVEMBER 2022 PNLE REVIEW
FINAL COACHING: MEDICAL SURGICAL NURSING PROF. REX B. YANGCO
NHD- (-) reed Sternberg cell
Right- sided CHF/ Left- sided CHF CA 125 tumor marker Ovarian Ca Signs/Symptoms RIGHT LEFT HYPERTHYROIDISM/ BRCA 1 and 2 Hyperthy Breast CaHypothyr Systemic Pulmonar HYPOTHYROIDISM CA 15-3- old roidism Breast Caoidism y Signs/ Symptoms Everything Everything CA 19-9 Pancreatic Ca Paroxysmal nocturnal dyspnea is high, fast is low, slow AFP Alpha feto CHON Liver Caand dry Dyspnea on exertion and wet CEA carcino embryonic Rales/crackles Increased appetite to eat antigen Colorectal Ca Enlarged spleen splenomegaly HeatProstate PSA intolerance specific antigen Prostate Ca Jaundice- liver – hepatomegaly Constipation- Dribbling decrease of urine in peristalsis – early sign Prostate Ca Ascites- accumulation of fluid in the Fatigue- decrease metabolism Cryptorchidism- undescended testes Testicular Ca peritoneal cavity due to third space Weight loss- hyper metabolism shifting- decrease colloid oncotic Protrusion of eyeballs- Exophthalmus pressure Obesity Polycythemia decrease perfusion- Decrease Restlessness, Nervousness compensation circulating Fine, oily hair O2 level Dry, sparse hair Hypokalemia Hypocalcemia- parathyroid hormone Decrease CO- decrease renal insufficiency perfusion- RAAS- Hypernatremia/ Hypercalcemia Hypokalemia Fine tremors early sign Leg edema Infrequent blinking of eyes- protrusion of Clubbing of fingers- decrease O2 eyeball Hypoxia Tachycardia Leg varicosities Hypertension Blood- tinged frothy sputum- Hyperlipidemia- increasing cholesterol Pulmonary Edema level- decrease metabolism Elevated CVP – measures the pressure Brittle nails at the R side of the heart Thickened, hyperpigmented skin in the Elevated PAP – Pulmonary Artery pretibial area- increase capillary fragility – Pressure blood leaks from the vessel Enlarged liver Dry, scaly skin Hypertension Diarrhea Hemolytic anemia- Splenomegaly Diaphoresis Liver cirrhosis Bradycardia Syncope- due to decrease cerebral Slow physical and mental reaction perfusion Weight loss Fatigue, weakness Elevated body temperature BMR = (-) 25 % Treated with Synthroid- thyroid hormone TYPES OF DIABETES Treated with Tapazole Signs/Symptoms Type I Type II Treated with PTU Absence of Islets of Langerhans Treated with Lugol’s solution/ SSKI Onset after age 30 years Given pre op: decrease vascularity- prevent Thin bleeding Prone to DKA- absence of insulin- fat Dull look converted into ketones Exophthalmos/ Proptosis Associated with obesity Von Graefe’s sign- lid lag Lifelong insulin therapy Jeffrey’s sign- absence of folds at the Treated with Byetta- OHA forehead Associated with autoimmune disorders- Dalyrimple’s sign- thyroid stare destruction of the beat cells in the islet in Treated with Cytomel the islet of langherhans Requires low calorie diet Treated with OHA Requires high fiber diet- constipation Occurs among children- Congenital/ High calorie diet- metabolism and energy IDDM Requires cool, quiet environment Prone to HHNK Requires warm environment during cold Presence of insulin- prevents fats to be climate converted to ketones Hyperactive Tendon of Achilles Brittle DM Reflex Non- insulin dependent – NIDDM/ Adult Onset
3 |NOVEMBER 2022 PNLE REVIEW
FINAL COACHING: MEDICAL SURGICAL NURSING PROF. REX B. YANGCO Ketosis- resistant – presence of insulin occur Onset before age 30 years/ Juvenile DM Common: N/V and abdominal pain Associated with heredity Poor wound healing Obese Muscle weakness- hypokalemia Insulin- dependent DM Depression- mental and behavioral Best managed with diet, activity, and changes exercise Buffalo hump Cell resistance Hypernatremia Increasing Aldosterone Enough insulin to carry glucose to the Hyponatremia cell Hirsutism in females elevated Androgen Cell- resistance- glucose stays in the level blood Gynecomastia in males Obesity/ Lifestyle – causes the Increased virilism in females resistance Decrease female hormone, strong male characteristics ADDISON’S DISEASE/ CUSHING’S DISEASE Signs/ Symptoms Addison’ Cushing’ s s NEUROMUSCULAR DISORDERS Decrease Increase Signs/Symptoms Disorders 3S 3S Resting tremors Parkinson’s Disease Hypotension- water and Na excretion Intentional tremors- Charcot’s Multiple Sclerosis Hyperglycemia- increase Cortisol TRIAD: SIN Gluconeogenesis- formation of new Scanning speech glucose Intentional tremors Glycogenolysis- breakdown of glycogen Nystagmus Edema- Na and water retention Ascending paralysis GBS (Aldosterone) Tiptoe walking Cerebral Palsy Hyperkalemia Ataxic gait- loss of balance and MS/ PD Decrease in Aldosterone coordination Decrease Na, Increase K Pillrolling tremors PD Delayed wound healing- CHON Treated with Levodopa PD catabolism- effect of CORTISOL Muscle weakness associated with Myasthenia Gravis Easy bruising activity Moon face- deposition of fats Treated with Mestinon- Cholinergic MG Hyponatremia (decrease aldosterone) Bradykinesia- slowed movement PD Thinning of scalp hair Cogwheel rigidity PD Dehydration loss of water and Na Treated with Cogentin- PD Hypertension water and Na retention- Anticholinergic Hypervolemia Decreased dopamine production PD Eternal tan appearance of the skin Decreased acetylcholine receptor MG Hyperpigmentation sites- autoimmune- destruction of the Bronze Colored skin acetylcholine receptor site Due to hyperstimulation of MSH- Positive tensilon test MG negative feedback mechanism Ptosis, strabismus, diplopia- PS MG Hirsutism elevated Androgen level Sticky skin- increase perspiration/ MG Osteoporosis- CHON catabolism secretion Hypoglycemia decrease cortisol level Bladder and bowel dysfunction GBS Tachycardia Scanning speech MS Compensation- decrease circulating blood Soft, monotonous voice PD volume due to water and Na excretion Treated with Comtan (Entacapone) PD Hypovolemia Treated with Baclofen- muscle MS Purple striae on the abdomen- truncal spasticity obesity Treated with cholinergic MG Obesed trunk, thin arm and legs Flattened affect- mask like face PD Weight loss Treated with Baclofen MS Loss of appetite to eat increased Na and Treated with anticholinergic PD glucose level Stooped posture PD Hypocalcemia- associated with Small, shaky handwriting PD hypoparathyroidism Associated with swine flu vaccine GBS Fatigue Shuffling gait PD Nausea, vomiting, diarrhea Charcot’s triad MS Addison’s Disease- GI symptoms Backpain on passive flexion of neck Meningitis Diarrhea- less common but may still (Brudzinski) 4 |NOVEMBER 2022 PNLE REVIEW FINAL COACHING: MEDICAL SURGICAL NURSING PROF. REX B. YANGCO Absence of arm swing when walking PD joints Morning stiffness ANTIDOTES Pain-on-use of joints Drugs/ Conditions Pain-on-nonuse of joints 1. Morphine Naloxone/ Narcan Boutouniere’s deformity- flexion in 2. Magnesium Sulfate Ca Gluconate proximal 3. Hyperkalemia- prevent Cardiac Ca Gluconate Extension at the distal arrest Swan neck- flexion at the distal 4. Beta adrenergic blockers Glucagon Extension at the proximal 5. Calcium channel blockers Glucagon Excessive dryness of eyes, mouth, and 6. Acetaminophen poisoning Acetylcysteine vagina 7. Lead Poisoning EDTA Leukopenia, splenomegaly- felty’s 8. Heparin Protamine Sulfate syndrome 9. Coumadin Vitamin K Hemolytic anemia 10. Opiate addiction Methadone Localized inflammation 11. Digitalis toxicity Digibind/ Digitalis Unilateral affectation of joints Immune Fab Ulnar drift of the hand 12. Alcohol abuse Metadoxine Cock- up toe 13. Myasthenic crisis- underdose Prostigmine/ Neostigmine 14. Cholinergic crisis-overdose Atropine SO4 15. Diazepam Flumazenil/ Romazicon 16. Hemosiderosis accumulation of Deferoxamine iron in the blood- Thalassemia Iron Chelation Therapy
DIFFERENT TYPES OF ANEMIA
Different Types of Arthritis
Signs/ Symptoms RA OA GA Autoimmune disorder Degenerative disorder Metabolic disorder Females more commonly affected Males more commonly affected Inflammation affects both side of the body Cartilage of joints wear off- degeneration Synovial membrane affected Tophi- urate crystals Obese elderly commonly affected Joints of fingers commonly affected Weight- bearing joints most commonly affected Big toe commonly affected and ankle Heberden’s nodes- distal interphalangeal joints Bouchard’s nodes- proximal interphalangeal joints Sjogren’s syndromeautoimmune d/o Dry mouth/eye Felty’s syndrome TRIAD: RA Splenomegaly Neutropenia Elevated urine and serum uric acid Crepitus- cracking or popping sound at the
5 |NOVEMBER 2022 PNLE REVIEW
FINAL COACHING: MEDICAL SURGICAL NURSING PROF. REX B. YANGCO Signs and Symptoms IDA Folate Deficiency Pernicious Aplastic Thalassemia Microcytic, Hypochromic Anemia- small and pale RBC Iron- gives color to the RBC Cause of IDA: Blood loss Malnutrition Pancytopenia decrease in all blood cells Anemia Leukopenia Thrombocytopenia Megaloblastic/ Macrocytic anemia- RBC: WOF: Neural large and dark red Tube Defect Cheilosis- crack at the side of the lips Beefy red Tongue Spoon- shaped Fingernails- Koilonychia Intrinsic factor deficiency- absence of parietal cells- produces the intrinsic factor Decrease absorption of Vit. B 12 Abnormal hgb, short lifespan of RBC Vitamin B12 Deficiency Atrophic glossitis, dysphagia, stomatitis- Vinson Plummer Syndrome Hemosiderosis