Research Last 2doc.
Research Last 2doc.
Research Last 2doc.
30 May 2022G.C
Addis Abeba Ethiopia
ACKNOWLEDGMENT
First and for most we would like to thank our God for helping us accomplish this paper and
secondly we would like to express our sincere gratitude to our advisor Mr. Tewodros Tesfaye for
his help, dedication and also for his constructive comments and assistance.
ABBREVATIONS AND ACRONYMS
BioNTech- Biology and Technology
CT- computerized tomography
COVID-19- coronavirus disease
MoH- Ministry of health
SARS- Severe acute respiratory syndrome
SARSC0V-2- Severe acute respiratory syndrome coronavirus 2
WHO- World Health Organization
ETB- Ethiopian birr
CI- Confidence interval
BSc- Bachelor of science
SPSS- statistical package for social science
Table of Contents
Contents
List of Figures................................................................................................................................................4
List of Table...................................................................................................................................................4
ACKNOWLEDGMENT .................................................................................................................................... 4
ABBREVATIONS AND ACRONYMS ................................................................................................................. 5
Summary.......................................................................................................................................................6
Backgrounds ......................................................................................................................................... 8
Problem of statement.............................................................................................................................10
Significance of study ............................................................................................................................... 12
1.4. LITERATURE REVIEW ........................................................................................................................ 12
1.4.1. Socio-demographic characteristics ........................................................................................... 12
1.4.4. Knowledge of Covid-19 vaccination..........................................................................................12
1.4.5. Attitude towards the COVID-19 vaccine ................................................................................... 12
1.4.6. Acceptance of Covid-19 vaccine ............................................................................................... 12
OBJECTIVE...................................................................................................................................................12
General objectives .................................................................................................................................. 12
Specific objectives .................................................................................................................................. 12
Methodology .............................................................................................................................................. 12
Study area and period ............................................................................................................................ 12
Study design ........................................................................................................................................... 12
Study Population and source .................................................................................................................. 12
Eligibility criteria ..................................................................................................................................... 12
Inclusion Criteria ................................................................................................................................. 12
Exclusion Criteria ................................................................................................................................ 12
Variables of study ................................................................................................................................... 12
Dependent variable ............................................................................................................................ 12
Sample size and sampling procedure ..................................................................................................... 12
Sampling Technique and Procedure ....................................................................................................... 12
Operational definition ............................................................................................................................ 12
Data collection tool and procedure ........................................................................................................ 12
Pretest .................................................................................................................................................... 12
Data quality assurance ........................................................................................................................... 12
Data processing and analysis .................................................................................................................. 12
Ethical consideration .............................................................................................................................. 12
Dissemination of the result .................................................................................................................... 12
Work plan ................................................................................................................................................... 12
Budget .................................................................................................................................................... 12
Annex I Greeting ......................................................................................................................................... 12
Annex II; Consent form ............................................................................................................................... 12
Annex III-English version of questionnaire Assessment of knowledge, attitude and acceptance of
COVID-19 vaccine. ...................................................................................................................................... 12
List of Figure
Figure 1: Schematic presentation of sampling procedures ............................................................ 24
List of Table
Table 1: plan of activities for a study on the knowledge, attitude, and acceptance toward
covid-19 vaccination among students in selected higher education Addis Ababa Ethiopia 2022 27
Table 2: Budget summary..............................................................................................................29
Table 3: Socio-demographic characteristics among university students 2022G.C ....................... 36
Table 4: Questions on Vaccination status among study participants. ........................................... 38
Table 5: Assessment on general knowledge of covid-19 vaccination among higher education
students. ......................................................................................................................................... 39
Table 6: Assessment of Knowledge about covid-19 transmission and symptoms among higher
education students..........................................................................................................................40
Table 7: Questions on Attitude about COVID-19 Vaccination on higher education students. ..... 43
Table 8: Factors affecting acceptance of covid-19 vaccination.....................................................44
Summary
BACKGROUND: Coronavirus disease (COVID-19) is a deadly disease which continues to
affect many countries in the world. This is caused by the new coronavirus strain severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) which has become a serious public health
concern worldwide. The best way to protect the community from this highly contagious virus
aside from using preventive measures is introducing vaccines. Vaccines are effective
interventions that can reduce the high burden of diseases globally.
OBJECTIVES: To evaluate the knowledge, attitude and acceptance of the COVID 19 vaccines
and related factors among unity university students in Addis Ababa, Ethiopia
METHOD: An Institutional based cross-sectional survey was conducted in St.Mary's
university,St. Lideta Health science and Business collage and Rift Valley University, Addis
Ababa, Ethiopia. Data collection will be done via self-administrated questionnaire.
CONCLUSION: Acceptance of the COVID-19 vaccine is an essential determinant of vaccine
uptake and the likelihood of controlling the COVID-19 pandemic. Developing strategies to
decrease public hesitation and increase trust is vital for implementing vaccination programs.
Diagnostics can play an important role in the containment of COVID-19, enabling the rapid
implementation of control measures that limit the spread through case identification, isolation,
and contact tracing (i.e., identifying people that may have come in contact with an infected
patient). [3] Regarding the transmission, current evidence suggests that the virus spreads mainly
between people who are in close contact with each other, for example at a conversational
distance. The virus can spread from an infected person’s mouth or nose in small liquid particles
when they cough, sneeze, speak, sing or breathe. Another person can then contract the virus
when infectious particles that pass through the air are inhaled at short range (this is often called
short-range aerosol or short-range airborne transmission) or if infectious particles come into
direct contact with the eyes, nose, or mouth (droplet transmission).
The virus can also spread in poorly ventilated and/or crowded indoor settings, where people tend
to spend longer periods of time. People may also become infected when touching their eyes, nose
or mouth after touching surfaces or objects that have been contaminated by the virus. [4]
The best way to protect the community from this highly contagious virus aside from using
preventive measures is introducing vaccines. Vaccines train your immune system using a
harmless form of the virus, SARS-CoV-2, which causes COVID-19. Vaccines stimulate an
immune response without causing illness. Each type of vaccine for COVID-19 works differently
to introduce antigens, which are unique features of the SARS-CoV-2 virus, to your body. The
antigen triggers a specific immune response and this response builds immune memory, so your
body can fight off SARS-CoV-2 in future. [5] . Currently used five vaccines approved by the
EMA are: Pfizer–BioNTech, Johnsen-Johnsen, Novavax, Moderna and Oxford–AstraZeneca.
Low- and middle-income countries are at risk of vaccination delays due to several reasons: lack
of public trust, shortage of resources, and scarcity of vaccination supply as many high-income
countries secure a large amount of the new vaccines, without prioritizing other countries.[6]
Based on the latest COVID-19 vaccination dataset 65.2% of the world population has received at
least one dose of a COVID-19 vaccine. 11.56 billion doses have been administered globally, and
11.7 million are now administered each day. Only 15.3% of people in low-income countries have
received at least one dose.[7]
As for Ethiopia, On March 13, 2020, the first COVID-19 was identified. Since then, the number
of new cases in the country has been rapidly increasing. As of March 10, 2021, the country had
168,335 COVID-19 positive cases and 2451 deaths domestically. As a result, Ethiopia became
one of the five African countries with the largest COVID-19 case burden. Ethiopia’s
government, on the other hand, has been working hard to disseminate information about
COVID-19 prevention measures through television, radio, and social media, and had declared a
state of emergency.[8]
In Ethiopia, from 3 January 2020 to 28 April 2022, there have been 470,492 confirmed cases of
COVID-19 with 7,510 deaths, reported to WHO. As of 10 April 2022, only 21% (a total of
29,411,822 vaccine doses have been administered).[9]
Therefore, we chose university students for this initial study as a number of these people will
become influential in the future. Hence it is critical to evaluate university students intentions
regarding the COVID-19 vaccination, leading to more widespread knowledge distribution.
1.2. Problem of statement
Coronavirus disease (COVID-19) is a deadly disease which continues to affect many countries in
the world. This is caused by the new coronavirus strain severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) which has become a serious public health concern worldwide [10].
The virus that causes COVID-19 is mainly transmitted through droplets generated when an
infected person coughs, sneezes, or exhales [11,12]. Countries within Africa and Asia that
introduced preventative measures early appeared to have lower prevalence and morbidity rates
than countries than introduced such measures later on such as Western European countries
certainly during the early stages of the pandemic. [13-15]
The pandemic’s impact on the global economy combined with disruptions it causes in Ethiopia
represents a large, unprecedented shock to the country’s economy. Although the country took
early swift measures, our assessment of the partial lockdown measures suggests that they were
not as strict as those observed in other Africa countries. Accordingly, our estimates of the
economic costs of COVID-19 on Ethiopia are significantly lower than those reported for other
countries on the continent. We estimate that during the lockdown period Ethiopia’s GDP
suffered a 14 percent loss (43.5 billion Birr or 1.9 billion USD) compared to a no-COVID case
over the same period. Nearly two-thirds of the losses were in the services sector.. The broader
agri-food system also was affected considerably because of its linkages with the rest of the
economy. In terms of the welfare of Ethiopians, we estimate that the economic impacts during
the lockdown caused 10.1 million additional people to fall below the poverty line [16]
Healthcare professionals also suffered from insomnia, loneliness, sleep disorder, and mental
depression as a result of the workload and related stress [17]. They were experiencing anxiety
attacks as well as frustration due to a lack of knowledge, environmental changes, and fear of
infection both by themselves and by their family members [18]. The world has implemented
different COVID-19 prevention measures, like quarantine, restricted movement, nationwide
lockdowns, [19] hand washing with water and soap, keep respiratory hygiene, and use facemask
[20,21]. Despite the implementation of these measures across the world, the burden of the
pandemic is not significantly reduced [22].. The health and economic burden of the pandemic
prompted the need for timely and effective vaccine development [23]. Hence, vaccination was
considered as the best strategy for controlling the transmission of the disease [22]
Globally, 12 March 2022 there have been 452,201,564 confirmed cases of COVID-19, including
6,029,852 deaths, reported to WHO. In Africa 8,481,781 Confirmed case [20]. In Ethiopia, from
3 January 2020 to 12 March 2022, there have been 469,134 confirmed cases of COVID-19 with
7,484 deaths, reported to WHO[24]. 63.5% of the world population has received at least one
dose of a COVID-19 vaccine. 10.86 billion Doses have been administered globally, and 18.29
million are now administered each day [25].
Based on the latest COVID-19 vaccination dataset 65.2% of the world population has received at
least one dose of a COVID-19 vaccine. 11.56 billion doses have been administered globally, and
11.7 million are now administered each day. Only 15.3% of people in low-income countries have
received at least one dose.[7]
Vaccine hesitancy is complex and is influenced by multiple factors. Some of factors associated
with COVID-19 vaccine hesitancy are lack of confidence in the vaccine itself, the possible
justification might be social media such as face book and telegram might distribute
misinformation and conspiracies theories regarding the COVID-19 vaccine might cause
menstrual disturbance and infertility and lack of adequate information about the COVID-19
vaccine. The major cited reasons for COVID-19 vaccine hesitancy were due to side effects,
concerned about efficacy and might be those were found ≤ 23 year old might consider
themselves as healthy, young and have immunity that could protect them from severe COVID-19
complications. Therefore, building the public confidence in vaccines is an important starting
point towards acceptance and sufficient uptake of safe COVID-19 vaccines [26]. In this regard,
identifying and addressing possible gaps and COVID-19 vaccine related misconceptions in the
public is a key element to be taken into consideration [27].
Universities are considering high risk area for COVID-19 outbreak given the crowded
environment of campuses with the high mobility and limited space. Extensive vaccination of
college students is important in the context of vaccination safety assessment and improving
vaccination coverage and control of disease [18]. Therefore the objective of this study is to
determine the level knowledge, attitude and acceptance of COVID 19 vaccine among higher
education students.
1.3. Significance of study
University students play a critical role in all societies. They are regarded as wise, influential,
receptive, informed, and responsive to public health challenges. To ensure herd immunity and
develop effective COVID-19 vaccination programs, it is crucial to identify the factors that
influence the intention and behavior of the specialized group with possible reluctance or
hesitancy about COVID-19 vaccines. Furthermore, the majority of university students lives in
residential halls and shared housing.
Hence, it is critical to evaluate university students’ intentions regarding the COVID-19
vaccination, leading to more widespread knowledge distribution. The transmission of COVID-19
is very high among University students due to the presence of different contributing factors.
They are very active both on social media and in the community. They make an opportunity to
make judgments by their own. Furthermore, they may participate in different activities like sport
clubs, and part-time work which makes good opportunity to contract COVID-19 pandemic.
Variables of study
Dependent variable
Attitude, Knowledge and Acceptance level of other than health students toward COVID-19
vaccine.
Independent variable
Socio-demographic characteristics gender, age, marital status, educational status, social media,
residence area and chronic medical illness.
3.5. Sample size and sampling procedure
A single population proportion formula is used to calculate the sample size. we use 50% of
prevalence was used to get the maximum sample size by considering 95% confidence interval,
marginal error (d) of 5% and 10% non-response rate.
2 2
Z ×P(1-P) 1.96 ×0.5(1-0.5)
n= = = 384.16 ≈384
2 2
D 0.05
We use adjust the formula because the total population is less than 10,000
na= nr = 384 = 314.75≈315 add 10% non-respond rate the total sample size will be
1+ (nr-1) 1+(384-1)
N 1715
346.5≈347
3.6. Sampling Technique and Procedure
Simple random sampling or lottery method will be used to select higher educational institutes
and the total sample size of the study will be allocated to each institution based on the number of
students in each institution the study participants or samples will be selected by the day the data
will be collected.
Proportional for each selected institutions based on the department
Proportionate sample (n) = total sample size (nt) ×population of individual institutions(N)
total population(Nt)
Table 1: plan of activities for a study on the knowledge, attitude, and acceptance toward covid-19
vaccination among students in selected higher education Addis Ababa Ethiopia 2022
Sr.no Activity Responsib Jan Feb Mar Apr May June July Aug
le unit
1. Topic selection RER
and approval committee
2. Finalizing the Advisor,
topics of the and RER
research committee
3. Submission of RER
draft proposal to committee
RER committee and
advisors
4. Facilitating Students
student research
work to submit at
least every 2
weeks to
respective adviser
5. Training of data Students
collectors and and
pretest advisors
6. Data collection Students
and data entry
and
7. Data analysis Students
8. Reporting finding Students
9. submission of first RER
draft and research committee
defense and
advisors
10. Research project Students
writing up and
finalization
11. Defense of the RER
research project committee
and
advisors
4.1. Budget
Table 2: Budget summary
Items Cost
Transportation 500 ETB
Stationary (pen pencil) 100 ETB
Paper printing and duplicating ink 3500 ETB
Flash disk and CD 250 ETB
Card 500 ETB
Total 4850 ETB
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Annex I Greeting
Hello, I am____________. I am a student at Unity University, faculty of Health Science. I would
like to ask you few questions about knowledge, attitude and acceptance on covid-19 vaccination.
Your name will not be written in this form and will never be used in connection with any
information you tell us. All information given by you will be kept strictly confidential. Your
participation is voluntary and you are not obliged to answer any question you do not wish to
answer. If you feel discomfort with the interview please feel free to drop it any time you want.
But, your willingness to answer all of the questions would be appreciated. Your correct answer
to the questions can make the study achieve the goals. Therefore, you are kindly requested to
respond genuinely and voluntarily with patience.
Do I have your permission to continue? 1. Yes 2. No If yes, continue to the next page. If no, skip
to the next participant by writing reasons for his/ her refusal
Name and Signature of the data collector __________________________________ Date of
interview ____________Time started ___________Time completed________ Checked by
Supervisor: Name _______________signature ________ Date_______
Result of interview:
1. Completed
2. Respondent not available.
3. Refused
4. Partially completed.
Annex II; Consent form
The questionnaire must be completed at the school address. If a respondent refuses to co-operate,
make a note for the researcher. Please hand the respondent your letter of introduction or read it
out if necessary. Confirm to the respondent (owner) that the information supplied will be treated
strictly confidential. Obtain signed/verbal Consent.
Follow the instruction to the interviewers carefully to ensure that the questions are asked
according to sequence. Indicate the response by means of a tick or circle in the blocks provided
for closed ended questions or write down the exact response where applicable.
Do not try to influence respondents. Should the respondents give you wrong answers
deliberately, make a note of this next to the relevant question. Check the completed questionnaire
thoroughly to ensure that no question has been skipped and all the questions have responses.
Complete the Observation Checklist. Upon completion of the Questionnaire, thank the
respondent for agreeing to participate and remind them that they will receive feedback.
Annex III-English version of questionnaire Assessment of knowledge, attitude and acceptance of
COVID-19 vaccine.
Table 3: Socio-demographic characteristics among university students 2022G.C
Variable Category
Sex 1.Male
2.Female
Age 1.20–24
2.25–29
3.≥30
Religion 1.Orthodox
2.Muslim
3.Protestant
4.Others
Marital status 1.Single
2.Married
3.Divorced
4.Widowed
Residence 1.Urban
2.Rural
Year of university level education 1.2nd
2.3rd
3.4th
4.Above
Educational status of mother 1.Cannot read and write
2.Can read and write
3.Primary (grades 1–8)
4.Secondary (grades 9–12)
5.College or above
Educational status of father 1.Cannot read and write
2.Can read and write
3.Primary (grades 1–8)
4.Secondary (grades 9–12)
5.College or above
By our signature below, we declare and affirm that this proposal is our own work. We have
followed all ethical principles of scholarship in the preparation of this proposal. All scholarly
matter that is included in the proposal has been given recognition through citation. We affirm
that we have cited and referenced all sources used in this document. Every effort has been made
to avoid plagiarism in the preparation of this proposal.
This proposal is submitted in partial fulfillment of the requirement for a graduate degree from
Unity University. We solemnly declare that this proposal has not been submitted to any other
institution anywhere for the award of any academic degree, diploma or certificate.
STUDENT
Name: Signature: Date:
________________________________ _________ ____________
________________________________ _________ ____________
________________________________ _________ ____________
________________________________ _________ ____________
________________________________ _________ ____________
________________________________ _________ ____________
______________________________ _________ ____________
________________________________ _________ ____________
RESEARCH ADVISORS: