Effects of Chloroform in The Human Boddy When Inhaled

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EFFECTS OF CHLOROFORM TO THE HUMAN BODY WHEN INHALED

A Research Study Presented to the Faculty of Alabel National Science High School Regional
Science High School for Region XII Maribulan, Alabel Sarangani Province

In Partial Fulfillment of the Requirements in Research Grade 8

MARIANNNE ALEIAH P. MALCONTENTO


8 – VANDA

December 15, 2022


INTRODUCTION

Chloroform (CHCI3) is a colorless liquid that turns into gas. It can damage the neurological system,
liver, kidneys, eyes, and certain parts of the skin. Exposure to Chloroform may also cause cancer.
Inhaling or ingesting the substance might have harmful effects. Chloroform inhalation can cause
throat and nasal discomfort as well as shortness of breath. Systemic symptoms from acute
inhalation include excitation, nausea, and vomiting, which are followed by ataxia, vertigo, and
sleepiness.
High exposure levels have the potential to result in unconsciousness, convulsions, and even death
from cardiac arrhythmias or respiratory failure. Those who survive an initial chloroform exposure
may experience hepatic dysfunction and kidney impairment days later. Chloroform exposure over a
long period of time may harm the liver. Chloroform is a man-made byproduct formed when chlorine
is used to disinfect water. In industrial operations, chloroform is also employed. It tastes a little bit
sweet and has no offensive odor.
Its toxicity in general focuses on the central nervous system, otherwise known as NCR, and the
liver.
LITERATURE REVIEW

Inhaling intense chloroform vapor irritates exposed mucosal membranes, particularly the nose and
throat, and can result in severe acute poisoning. Additionally, breathlessness could happen.
Additionally, it may be absorbed through the skin, and long-term exposure may cause systemic
toxicity. Exposure to the skin irritates and reddens the region of touch, especially delicate areas like
the neck and eyelids. Burns and rashes could arise from prolonged contact.

Molecular dynamics computer simulation has been used to examine three alternative chloroform
models. In-depth research was done on the thermodynamic, structural, and dynamic
characteristics of the various models. Each model's generated potential energies, diffusion
coefficients, and rotational correlation periods are compared to those from experiments. It is
discovered that the rotating diffusion of chloroform cannot be adequately explained by the
hypothesis of rotational Brownian motion. It was discovered that the force field of Dietz and
Heinzinger had excellent overall agreement with experiment. A thorough analysis of this chloroform
model has been done. The isothermal compressibility, thermal expansion coefficient, and constant
volume heat capacity are all given values. The values and experiment accord quite well.
RESEARCH METHOD

This researcher searched on the internet about how chloroform effects some parts of the human
body. She also read books in her school library, though there weren’t sufficient references. She
performed secondary data analysis, otherwise known as archival study.
REFERENCES

Agency for Toxic Substances and Disease Registry (ATSDR). (1997) Toxicological Profile for
Chloroform. US Department of Health and Human Services: Atlanta, US

Foxall, K. (2007). Chloroform Toxicological overview. CHAPD HQ, HPA, Version 1


https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/
file/338535/Chloroform_Toxicological_Overview.pdf

Tironi, I. & Van Gunsteren, W. (2006). A molecular dynamics simulation of chloroform. Pages
381-403 https://link.springer.com/article/10.1023/A:1019887505651

U.S. Environmental Protection Agency (U.S. EPA). (2001). Toxicological Review of Chloroform.

WHO: Geneva. (2004). International Programme on Chemical Safety (IPCS). Chloroform.


Concise International Chemical Assessment Document 58.
BUDGETARY REQUIREMENTS

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MATERIAL QUANTITY PRICE


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