Investigaciones científicas que respaldan el tratamiento de La Planta de la Vida 

 
Existen diversos estudios serios que avalan las características de los compuestos de la 
Synadenium Grantii, entre ellos el Phorbol. Invitamos a nuestros pacientes y lectores a visitar 
los sitios que señalamos a continuación, donde encontrarán este respaldo. 

 
 
Efecto antitumoral del látex de Synadenium grantii Hook f. (Euphorbiaceae) 

TL de Oliveira, ACM Munhoz, BM Lemes… - Journal of …, 2013 - Elsevier 

Abstract Ethnopharmacological relevance ​Synadenium grantii Hook ​f. has traditionally 

been used to treat various neoplastic diseases in southern Brazil. Aim of study Evaluation of 
the antitumoural potential of ​Synadenium grantii ​latex against B16F10 melanoma cell line. 

Citado por 31​ ​Artículos relacionados​ L

​ as 11 versiones 

[HTML]​ sagepub.com 

Antiproliferative Effect of ​Synadenium grantii​ H

​ ook ​f. stems (Euphorbiaceae) and a Rare 
Phorbol Diterpene Ester 

A Campos, ​DB Vendramini-Costa​… - … journal of toxicology, 2016 - journals.sagepub.com 

Antiproliferative Effect of ​Synadenium​ ​grantii​ ​Hook​ f. stems (Euphorbiaceae) and a Rare 

Phorbol Diterpene Ester. Adriana Campos, Débora Barbosa Vendramini-Costa, Giovanna 
Barbarini Longato, Tailyn Zermiani, Ana Lúcia Tasca Gois Ruiz, João Ernesto de Carvalho 

Citado por 8​ ​Artículos relacionados​ ​Las 5 versiones 

Isolation and characterization of proteolytic enzymes from the latex of ​Synadenium grantii 
Hook​,'f' 

M Menon, PJ Vithayathil, SM Raju, CS Ramadoss - Plant Science, 2002 - Elsevier 

Two fractions showing proteolytic enzymes have been obtained from the latex of 
Synadenium grantii Hook​,'f', using gel-filtration and anion-exchange chromatographic 
techniques. Both these proteases have the same molecular mass of 76±2 kDa each. 

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​ as 10 versiones 

Antitumoural effect of ​Synadenium grantii Hook ​f.(Euphorbiaceae) latex 

TL de Oliveira, ACM Munhoz, BM Lemes… - Journal of …, 2013 - Elsevier 

Abstract Ethnopharmacological relevance ​Synadenium grantii Hook ​f. has traditionally 

been used to treat various neoplastic diseases in southern Brazil. Aim of study Evaluation of 
the antitumoural potential of ​Synadenium grantii ​latex against B16F10 melanoma cell. 

Citado por 31​ ​Artículos relacionados​ L

​ as 11 versiones 

[PDF]​ acgpubs.org 

[PDF]​ T
​ wo New Phorbol-Type Diterpene Esters from ​Synadenium grantii Hook ​F. Leaves. 
EM Hassan, ​M Mohammed​… - Records of Natural …, 2012 - acgpubs.org 

Two new phorbol-type diterpene esters have been isolated from the chloroform extract of 
the leaves of ​Synadenium grantii Hook ​F. and identified as 3, 4, 12, 13-tetraacetylphorbol-20- 
phenylacetate and 4-deoxyphorbol-12, 13-ditiglate for which the trivial names Synagrantol 

Citado por 22​ ​Artículos relacionados​ L

​ as 12 versiones​  

Major skin‐irritant principle from ​synadenium grantii 

AD Kinghorn​ - Journal of pharmaceutical sciences, 1980 - Wiley Online Library 

EXPERIMENTAL Plant Material-​Synadenium​ ​grantii​ ​Hook​. f. (Euphorbiaceae), propagated 

from a cutting', was used as the source of latex2. Extraction and Fractionation-Dried latex 
(19.9 g) was extracted at room temperature with six 100-ml portions of acetone 

Citado por 25​ ​Artículos relacionados​ ​Las 7 versiones 

Anti-ulcer activity ​scielo.br 

Anti-ulcer activity of ​Synadenium grantii ​latex 

LLG Costa, VC David, R Pinto, BR Minozzo… - Revista Brasileira de …, 2012 - SciELO Brasil 

ABSTRACT. ​Synadenium​ g ​ rantii​ ​Hook​ f., Euphorbiaceae, is popularly known as 

leitosinha or janaúba. The diluted … ​Synadenium​ ​grantii​ ​Hook​ f. is a medicinal plant 
popularly known in southern Brazil as leitosinha and janaúba. In folk … 

Citado por 24​ A

​ rtículos relacionados​ ​Las 6 versiones​  

Purification and characterization of acetylcholinesterase isozymes from the latex 

of ​Synadenium grantii Hook​,'f' 

T Govindappa, L Govardhan… - Indian journal of …, 1987 - eprints-bangaloreuniversity.in 

Three acetylcholinesterase isoenzymes were purified from S. ​grantii ​latex by a combination 

of acetone fractionation, CM-​ Sephadex C-​ 50 chromatog., Sephadex G-​ 200 gel 
filtration, and PE-​ Cellulose chromatog. 

Citado por 12​ ​Artículos relacionados​ ​Las 5 versiones​  

[PDF]​ researchgate.net 

[PDF]​ C
​ hemical and pharmacological investigation of the stem bark of ​Synadenium grantii 

ACM Munhoz, BR Minozzo, LS Cruz, TL Oliveira… - Planta …, 2014 - researchgate.net 

Several inflammatory in- juries [4]. Previous pharmacological investiga- tions have 
described 
the potential of some Syna- denium species such as antitumoral and antian- giogenic [5], 
antiparasitic [6], anti-inflammatory, and antiasthmatic [2, 7]. 

Citado por 23​ ​Artículos relacionados​ ​Las 6 versiones 

[PDF]​ mak.ac.ug 

Anthocyanins with unusual furanose sugar (apiose) from leaves of ​Synadenium 

grantii ​(Euphorbiaceae) 

ØM Andersen, ​M Jordheim​, R Byamukama, A Mbabazi… - Phytochemistry, 2010 - Elsevier 

… β-xylopyranoside), cyanidin 3-O-(2″-(5‴-(E-caffeoyl)-β-apiofuranosyl)-β-xylopyranoside) 

and 
cyanidin 3-O-(2″-(5‴-(E-feroyl)-β-apiofuranosyl)-β-xylopyranoside) were isolated from leaves 
of African milk bush, (​Synadenium​ g
​ rantii​ ​Hook​, Euphorbiaceae) together with the … 

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​ as 10 versiones 

[HTML]​ sagepub.com​Full View 

Antiproliferative Effect of ​Synadenium grantii​ H

​ ook ​f. stems (Euphorbiaceae) and a Rare 
Phorbol Diterpene Ester 

A Campos, ​DB Vendramini-Costa​… - … journal of toxicology, 2016 - journals.sagepub.com 

Synadenium grantii ​is frequently used for the treatment of various diseases such as 
allergies, gastric disorders, and especially cancer. The aim of this study was to evaluate the 
possible antiproliferative potential of the methanol extract, fractions, and pure compounds. 

Citado por 8​ ​Artículos relacionados​ ​Las 5 versiones 

Purification and characterization of a 34-kDa, heat stable glycoprotein from ​Synadenium 

grantii ​latex: action on human fibrinogen and fibrin clot 

R Rajesh​, ​A Nataraju​, ​CDR Gowda​, BM Frey, FJ Frey… - Biochimie, 2006 - Elsevier 

Purification and characterization of a 34-kDa, heat stable glycoprotein from ​Synadenium 

grantii​ latex: action on human fibrinogen and fibrin clot … We report purification and 
characterization of a glycoprotein from ​Synadenium​ ​grantii​ latex with human 
fibrino(geno)lytic activity. 

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​ as 9 versiones 

Extraction of ​Synadenium grantii Hook ​f. using conventional solvents and supercritical CO2+ 
ethanol 

AR Guedes, ARC de Souza, RCT Barbi… - The Journal of …, 2020 - Elsevier 

Synadenium grantii ​extracts were obtained by employing two different extraction 

techniques: supercritical CO 2 with ethanol as solvent (scCO 2+ EtOH) and Soxhlet with 
different solvents. Extractions were evaluated according to antioxidant capacity, extract 
compositions. 

Citado por 2​ A

​ rtículos relacionados​ ​Las 2 versiones 

[PDF]​ ias.ac.in 

Purification and characterisation of a carboxylesterase from the latex of​Synadenium 

grantii​ H
​ ook​, 'f' 

T Govindappa, L Govardhan, PS Jyothy… - Journal of …, 1987 - Springer 

Printed in India. Purification and characterisation of a carboxylesterase from the latex of 
Synadenium​ ​grantii​ ​Hook​,'f' … The plant ​Synadenium​ g
​ rantii​ H
​ ook​ 'f'; belongs to the family 
of Euphorbiaceae. It secretes a milky-white latex on breaking the twigs, which is highly toxic 

Citado por 11​ ​Artículos relacionados​ ​Las 9 versiones 

Tigliane-Type Diterpene Esters from ​Synadenium ​grantii1, 5 

R Bagavathi, B Sorg, E Hecker - Planta medica, 1988 - thieme-connect.com 

Abstract; From the latex of ​Synadenium​ g

​ rantii​ ​Hook​ F. (Euphor- biaceae) were isolated by 
chromatographic methods five diterpene 12,13-diesters of the tigliane-type parent alcohols 
4-deoxyphorbol (la), 4,20-dideoxy-5u-hydroxyphorbol (2a) and 20-.deoxy-5u-hy- 
droxyphorbol. 

Citado por 27​ ​Artículos relacionados​ ​Las 6 versiones 

African milkbush (​Synadenium grantii Hook​. f.): ethnopharmacological, chemical and 

morpho-anatomical aspects. 

MR Duarte, I Jurgensen - Drug plants I, 2010 - cabdirect.org 

see more details, also known as the spurge family, include members widely distributed in 
tropical and subtropical areas, with diversified vegetative features, laticiferous or non- 
laticiferous, and especially rich in alkaloid and terpenoid compounds. These metabolites are … 

Citado por 2​ A

​ rtículos relacionados​  

Effect of ​Synadenium grantii​ and its isolated compound on dysmenorrhea behavior model 

in mice 

FW da Rocha Jesuíno, JP Reis, JCP Whitaker… - …, 2019 - Springer 

Abstract. Objective. This study aimed to evaluate the effects of the methanol extract of 
Synadenium​ ​grantii​ ​Hook​ f. stems and its main isolated compound Query3,4,12,13- 
tetraacetylforbol-20-phenylacetate (1) on experimental dysmenorrhea in mice. 

Citado por 3​ ​Artículos relacionados​ L

​ as 3 versiones 

[PDF]​ nih.gov 

Differential erythrocyte agglutination pattern in normal and cancer patients 

with ​Synadenium grantii ​root (​Hook ​f) lectin 

PP Durgawale​, PS Shukla, SD Sontakke… - Indian Journal of Clinical …, 2001 - Springer 

In the present study the property of lectin agglutination in blood on normal and different 
cancer patients has been observed. The purified ​Synadenium grantii ​root lectin was non 
blood group specific and its utility as a diagnostic tool in malignancy was studied. 

Citado por 4​ ​Artículos relacionados​ L

​ as 6 versiones 

[PDF]​ unipar.br 

Letalidade do extrato de ​Synadenium grantii Hook​. F.(Euphorbiaceae) frente a caramujos 

Biomphalaria glabrata Say, 1818 (Gastropoda, Planorbidae) 
DB Hartmann, RA Marim, YL da Silva… - Arquivos de Ciências …, 2011 - revistas.unipar.br 

Resumo No Brasil, o caramujo Biomphalaria glabrata Say, 1818 (Gastropoda, Planorbidae) 

atua como principal vetor hospedeiro intermediário do helminto trematódeo Schistosoma 
mansoni (Schistosomatidae), agente etiológico da esquistossomose. O combate deste … 

Citado por 5​ ​Artículos relacionados​ L

​ as 6 versiones​  

[HTML]​ imedicalpublisher.com 

[HTML]​ I​ dentification of macroelements and microelements in the leaves of the ​Synadenium 

grantii Hook ​used as medicinal plant in the Brazil 

ID de Souza, ALA de Arruda… - International …, 2017 - imedicalpublisher.com 

Abstract Introduction: The ​Synadenium grantii Hook ​species is a medicinal plant of the 

Euphorbiaceae family and is popularly known in the Midwest regions of Brazil as leitosinha 
or janaúba. All the parts of ​Synadenium grantii Hook ​as stem, latex, leaves and flowers are … 

Citado por 1​ ​Artículos relacionados​ ​Las 5 versiones​  

Evidence of fibrinolytic protease in the latex of ​Synadenium grantii Hook​'f' 

CD Dayanand, NK Murthy - International Journal of Biotechnology & …, 2010 - go.gale.com 

Enzymes catalyze the process of proteolysis are proteases, they are wide 
spread in nature, distributed in plant lattices, microorganisms, animals and humans. They 
perform various biological functions. 

Citado por 1​ ​Artículos relacionados 

[PDF]​ researchgate.net 

[PDF]​ G
​ C/MS analysis of sesquiterpenes in ​Synadenium grantii 

AAM Dawidar, ​EM Keshk​, HH Saad… - Mansoura J. Chem …, 2011 - researchgate.net 

When the stems of many members including ​Synadenium​ g ​ rantii​ ​Hook​. f. are cut, exude a 
milky sap (white latex) which has an unpleasant taste and is toxic when ingested in 
significant quantities [Judd et al., (1999)] … Plant material: ​Synadenium​ ​grantii​ H ​ ook​ … 

Citado por 3​ ​Artículos relacionados​ L

​ as 2 versiones​  

ntitumoral and antiangiogenic activity of ​Synadenium ​umbellatum Pax 

IAL Nogueira, ABB Leão, ​MS Vieira​, PL Benfica… - Journal of …, 2008 - Elsevier 

Synadenium​ umbellatum (SU) Pax (synonyms: Euphorbia umbellata and ​Synadenium 

grantii​ H
​ ook​), a traditional medicinal plant in the Midwestern region of Brazil, is used 
to treat several diseases, mainly cancer (Ortêncio, 1997) 

Citado por 41​ A

​ rtículos relacionados​ ​Las 12 versiones 

[HTML]​ scielo.br 

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​ ngiogenic activity of ​Synadenium ​umbellatum Pax latex 
PR Melo-Reis​, ​LS Andrade​, ​CB Silva​… - Brazilian Journal of …, 2010 - SciELO Brasil 

Studies carried out with ​Synadenium​ g ​ rantii​ ​Hook​ showed the presence 

of toxic substances and proteolytic enzymes in its latex (Govindappa et al., 1987, 
Jäger et al., 1996; Menonn et al., 2002) 

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​ as 18 versiones​  

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​ ssessment of the mutagenic and antimutagenic activity 
of ​Synadenium ​umbellatum Pax latex by micronucleus test in mice 

PR Melo-Reis​, LSA Bezerra, M Vale… - Brazilian Journal of …, 2011 - SciELO Brasil 

Synadenium​ umbellatum Pax (Euphobiaceae) (synonyms: Euphorbia umbellata 

and ​Synadenium​ ​grantii​ ​Hook​), popularly known as "cola-nota", "avelós", "milagrosa", and 
"cancerola", is a medicinal plant that grows in tropical regions, both in the American and 
African continents 

Citado por 25​ ​Artículos relacionados​ ​Las 10 versiones​  

[PDF]​ semanticscholar.org 

[PDF]​ E
​ ritrodermia secundaria a planta productora de látex (​Synadenium grantii​) 

PC Docampo, S Cabrerizo… - Archivos …, 2010 - pdfs.semanticscholar.org 

Citado por 4​ ​Artículos relacionados​ L

​ as 3 versiones​  

[PDF]​ scielo.br 

[PDF]​ R
​ ole of ​Synadenium grantii ​latex proteases in nematicidal activity on Meloidogyne 
incognita and Panagrellus redivivus 

EH Gomes​, ​FEF Soares​, ​DC Souza​, ​LT Lima​… - Brazilian Journal of …, 2019 - SciELO Brasil 

Citado por 6​ ​Artículos relacionados​ L

​ as 11 versiones​  

[PDF]​ iec.gov.br 

Avaliação do potencial citotóxico e mutagênico/genotóxico do látex de janaúba 

(​Synadenium grantii Hook​. f., Euphorbiaceae) 

JF do Nascimento Fernandes​… - … Pan-Amazônica de …, 2018 - revista.iec.gov.br 

OBJETIVO: Avaliar a mutagenicidade/genotoxicidade e citotoxicidade in vivo do látex de 

janaúba (​Synadenium grantii Hook​. f., Euphorbiaceae). MATERIAIS E MÉTODOS: O látex foi 
diluído em água destilada e, utilizando o teste de Allium cepa (cebola), foi feita a medição … 

Citado por 1​ ​Artículos relacionados​ ​Las 4 versiones​  

[PDF]​ uepg.br 

Screening fitoquímico e estudo biológico de ​Synadenium grantii Hook​. f.(Euphorbiaceae) 

LLG Costa - 2011 - tede2.uepg.br 

RESUMO A espécie ​Synadenium grantii Hook​. f. é uma planta da família Euphorbiaceae, 
sendo conhecida popularmente como cega-olho, leitosinha, janaúba, cola-nota e outros. Há 
muitos anos é utilizada sob a forma de preparado do látex diluído (18 gotas/1 litro de água) … 

Citado por 1​ ​Artículos relacionados​  

Lethality of ​Synadenium grantii Hook​. f.(Euphorbiaceae) extract to snails Biomphalaria 

glabrata Say, 1818 (Gastropoda, Planorbidae). 

DB Hartmann, RA Marim, YL da Silva… - Arquivos de Ciências …, 2011 - cabdirect.org 

A way of reducing transmission risk of schistosomiasis is the combat of this 

host with molluscicide substances. In the search for new natural products to control this 
vector, the present study tested the extracts of some exotic plant species considered toxic … 

[PDF]​ 189.125.155.35 

Synadenium grantii ​eo câncer de mama/​Synadenium grantii ​and Breast cancer 

MM Martins, AP Lucarelli, JS Oliveira… - Arquivos Médicos dos …, 2017 - 189.125.155.35 

… species.. 2014 J Ethnopharmacol; 151(1):733-9. 7. Oliveira TL, Munhoz AC, Lemes 

BM, Minozzo BR, Nepel A, Barison A, et al. Antitumoural effect of ​Synadenium​ ​grantii 
Hook​ f. (Euphorbiaceae) látex. J Ethnopharmacol. 2013 … 

Citado por 1​ ​Artículos relacionados​ ​Las 2 versiones​  

[PDF]​ uepg.br 

ESTUDO FITOQUÍMICO E AVALIAÇÃO ANTITUMORAL DO LÁTEX DE ​Synadenium grantii 

Hook​. f.(Euphorbiaceae) 

TL Oliveira - 2013 - tede2.uepg.br 

RESUMO A espécie ​Synadenium grantii Hook​. f. é uma planta pertencente a família 

Euphorbiaceae, sendo conhecida popularmente como cega-olho, leitosinha, janaúba, cola- 
nota e outros. Seu látex tem sido usado tradicionalmente na região dos Campos Gerais na … 

Citado por 1​ ​Artículos relacionados​