SIGMA-ALDRICH sigma-aldrich.

com

SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006
Version 6.0 Revision Date 30.03.2016
Print Date 10.03.2019
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers
Product name : Benzene
Product Number : 319953
Brand : SIGALD
Index-No. : 601-020-00-8
REACH No. : 01-2119447106-44-XXXX
CAS-No. : 71-43-2
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Pte Ltd
(Co. Registration No. 199403788W)
1 Science Park Road
#02-14 The Capricorn, S'pore Sci. PkII
SINGAPORE 117528
SINGAPORE
Telephone : +65 6779-1200
Fax : +65 6779-1822
1.4 Emergency telephone number
Emergency Phone # : 1-800-262-8200

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008
Flammable liquids (Category 2), H225
Skin irritation (Category 2), H315
Eye irritation (Category 2), H319
Germ cell mutagenicity (Category 1B), H340
Carcinogenicity (Category 1A), H350
Specific target organ toxicity - repeated exposure (Category 1), H372
Aspiration hazard (Category 1), H304
Chronic aquatic toxicity (Category 3), H412
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram

Signal word Danger

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 Hazard statement(s)
H225 Highly flammable liquid and vapour.
H304 May be fatal if swallowed and enters airways.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H340 May cause genetic defects.
H350 May cause cancer.
H372 Causes damage to organs through prolonged or repeated exposure.
H412 Harmful to aquatic life with long lasting effects.
Precautionary statement(s)
P201 Obtain special instructions before use.
P210 Keep away from heat, hot surfaces, sparks, open flames and other
ignition sources. No smoking.
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
P370 + P378 In case of fire: Use dry powder or dry sand to extinguish.
P403 + P235 Store in a well-ventilated place. Keep cool.
Supplemental Hazard none
Statements
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances
Formula : C6H6
Molecular weight : 78.11 g/mol
CAS-No. : 71-43-2
EC-No. : 200-753-7
Index-No. : 601-020-00-8
Registration number : 01-2119447106-44-XXXX

Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration
Benzene
CAS-No. 71-43-2 Flam. Liq. 2; Skin Irrit. 2; Eye <= 100 %
EC-No. 200-753-7 Irrit. 2; Muta. 1B; Carc. 1A;
Index-No. 601-020-00-8 STOT RE 1; Asp. Tox. 1;
Registration number 01-2119447106-44-XXXX Aquatic Chronic 3; H225,
H315, H319, H340, H350,
H372, H304, H412
For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

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 In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Flash back possible over considerable distance., Container explosion may occur under fire conditions.
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.
Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to
form explosive concentrations. Vapours can accumulate in low areas.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
environment must be avoided.
6.3 Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
place in container for disposal according to local regulations (see section 13).
6.4 Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling
Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes. Avoid inhalation
of vapour or mist.
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
charge.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): Flammable liquids
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection
8.1 Control parameters
8.2 Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Full contact
Material: Fluorinated rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
Splash contact
Material: Fluorinated rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected],
test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
contact the supplier of the CE approved gloves. This recommendation is advisory only and must
be evaluated by an industria situation of anticipated use by our customers. It should not be
construed as offering an approval for any specific use scenario.
Body Protection
Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The
type of protective equipment must be selected according to the concentration and amount of the
dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN
14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air
respirator. Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
the environment must be avoided.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
a) Appearance Form: liquid
Colour: clear, colourless

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 b) Odour No data available
c) Odour Threshold No data available
d) pH No data available
e) Melting point/freezing Melting point/range: 5.5 °C - lit.
point
f) Initial boiling point and 80 °C - lit.
boiling range
g) Flash point -11.0 °C - closed cup
h) Evaporation rate No data available
i) Flammability (solid, gas) No data available
j) Upper/lower Upper explosion limit: 8 %(V)
flammability or Lower explosion limit: 1.3 %(V)
explosive limits
k) Vapour pressure 166.0 mmHg at 37.7 °C
74.6 mmHg at 20.0 °C
l) Vapour density No data available
m) Relative density 0.874 g/cm3 at 25 °C
n) Water solubility ca.1.88 g/l at 23.5 °C - soluble
o) Partition coefficient: n- log Pow: 2.13 at 25 °C
octanol/water
p) Auto-ignition 562.0 °C
temperature
q) Decomposition No data available
temperature
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
No data available

SECTION 10: Stability and reactivity

10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
Heat, flames and sparks.
10.5 Incompatible materials
acids, Bases, Halogens, Strong oxidizing agents, Metallic salts
10.6 Hazardous decomposition products
Other decomposition products - No data available
Hazardous decomposition products formed under fire conditions. - Carbon oxides
In the event of fire: see section 5

SIGALD - 319953 Page 5 of 8

SECTION 11: Toxicological information
11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - male - > 5,960 mg/kg(Benzene)
(OECD Test Guideline 401)
LC50 Inhalation - Rat - female - 4 h - 43.7 mg/l(Benzene)
(OECD Test Guideline 403)
LD50 Dermal - Rabbit - 8,263 mg/kg(Benzene)
Skin corrosion/irritation
Skin - Rabbit(Benzene)
Result: Skin irritation - 4 h
(OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Rabbit(Benzene)
Result: Eye irritation
Respiratory or skin sensitisation
Maximisation Test - Guinea pig(Benzene)
Result: Does not cause skin sensitisation.
Germ cell mutagenicity

Laboratory experiments have shown mutagenic effects.(Benzene)

In vivo tests showed mutagenic effects(Benzene)
Chinese hamster lung cells
Result: positive
OECD Test Guideline 475(Benzene)
Mouse - male
Result: positive
Carcinogenicity
This is or contains a component that has been reported to be carcinogenic classification.(Benzene)
Human carcinogen.(Benzene)
IARC: 1 - Group 1: Carcinogenic to humans (Benzene)
Reproductive toxicity
Specific target organ toxicity - single exposure
No data available(Benzene)
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
May be fatal if swallowed and enters airways.(Benzene)

Additional Information
Repeated dose toxicity - Rat - male and female - Oral - No observed adverse effect level - 100
mg/kg(Benzene)
RTECS: CY1400000

Nausea, Dizziness, Headache, narcosis, Inhalation of high concentrations of benzene may have an initial
stimulato exhilaration, nervous excitation and/or giddiness, depression, drowsiness chest, breathlessness,
and loss of consciousness. Tremors, convulsions, a collapse can occur in a few minutes to several hours
following severe exp causes pulmonary edema and hemorrhage of pulmonary tissue. Direct skin co
contact may result in drying, scaling dermatitis, or development of secon hematopoietic system. Bleeding
from the nose, gums, or mucous membranes a leukopenia, thrombocytopenia, aplastic anemia, and

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 leukemia may occur as normal, aplastic or hyperplastic, and may not correlate with peripheral b benzene
exposure may be delayed for many months or years after the actual, Blood disorders(Benzene)

SECTION 12: Ecological information

12.1 Toxicity
Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 15.00 - 32.00 mg/l - 96
h(Benzene)
Toxicity to daphnia and EC50 - Ceriodaphnia dubia (water flea) - 17.2 mg/l - 48 h(Benzene)
other aquatic
invertebrates
Toxicity to algae Growth inhibition EC50 - Pseudokirchneriella subcapitata (green algae) - 100
mg/l - 72 h(Benzene)
(OECD Test Guideline 201)
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 28 d(Benzene)
Result: 96 % - Readily biodegradable
(OECD Test Guideline 301F)

12.3 Bioaccumulative potential

Bioaccumulation Leuciscus idus (Golden orfe) - 3 d
- 0.05 mg/l(Benzene)

Bioconcentration factor (BCF): 10

12.4 Mobility in soil
No data available(Benzene)
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
12.6 Other adverse effects
Harmful to aquatic life with long lasting effects.

SECTION 13: Disposal considerations

13.1 Waste treatment methods
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer
surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number
ADR/RID: 1114 IMDG: 1114 IATA: 1114
14.2 UN proper shipping name
ADR/RID: BENZENE
IMDG: BENZENE
IATA: Benzene
14.3 Transport hazard class(es)
ADR/RID: 3 IMDG: 3 IATA: 3
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II

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14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.
H225 Highly flammable liquid and vapour.
H304 May be fatal if swallowed and enters airways.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H340 May cause genetic defects.
H350 May cause cancer.
H372 Causes damage to organs through prolonged or repeated exposure.
H412 Harmful to aquatic life with long lasting effects.
Further information
Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held
liable for any damage resulting from handling or from contact with the above product. See www.sigma-
aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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