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SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006
Version 6.0 Revision Date 30.03.2016
Print Date 10.03.2019
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers
Product name : 2-Mercaptoethanol
Product Number : 97622
Brand : Sigma-Aldrich
REACH No. : A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later
registration deadline.
CAS-No. : 60-24-2
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Pte Ltd
(Co. Registration No. 199403788W)
1 Science Park Road
#02-14 The Capricorn, S'pore Sci. PkII
SINGAPORE 117528
SINGAPORE
Telephone : +65 6779-1200
Fax : +65 6779-1822
1.4 Emergency telephone number
Emergency Phone # : 1-800-262-8200

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 3), H301
Acute toxicity, Inhalation (Category 3), H331
Acute toxicity, Dermal (Category 2), H310
Skin irritation (Category 2), H315
Serious eye damage (Category 1), H318
Skin sensitisation (Category 1), H317
Specific target organ toxicity - repeated exposure, Oral (Category 2), Liver, Heart, H373
Acute aquatic toxicity (Category 1), H400
Chronic aquatic toxicity (Category 1), H410
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008

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 Pictogram

Signal word Danger

Hazard statement(s)
H301 + H331 Toxic if swallowed or if inhaled
H310 Fatal in contact with skin.
H315 Causes skin irritation.
H317 May cause an allergic skin reaction.
H318 Causes serious eye damage.
H373 May cause damage to organs (Liver, Heart) through prolonged or
repeated exposure if swallowed.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s)
P261 Avoid breathing vapours.
P273 Avoid release to the environment.
P280 Wear protective gloves/ eye protection/ face protection.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor.
P302 + P350 IF ON SKIN: Gently wash with plenty of soap and water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Supplemental Hazard none
Statements
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Stench.

SECTION 3: Composition/information on ingredients

3.1 Substances
Formula : C2H6OS
Molecular weight : 78.13 g/mol
CAS-No. : 60-24-2
EC-No. : 200-464-6

Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration
2-Mercaptoethanol
CAS-No. 60-24-2 Acute Tox. 3; Acute Tox. 2; <= 100 %
EC-No. 200-464-6 Skin Irrit. 2; Eye Dam. 1; Skin
Sens. 1; STOT RE 2; Aquatic
Acute 1; Aquatic Chronic 1;
H301, H331, H310, H315,
H318, H317, H373, H400,
H410
M-Factor - Aquatic Acute: 1
For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
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 In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides, Sulphur oxides
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove
all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form
explosive concentrations. Vapours can accumulate in low areas.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
environment must be avoided.
6.3 Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
place in container for disposal according to local regulations (see section 13). Keep in suitable, closed
containers for disposal.
6.4 Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
charge.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Recommended storage temperature 2 - 8 °C
Stench.
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 Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters
8.2 Exposure controls
Appropriate engineering controls
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling
the product.
Personal protective equipment
Eye/face protection
Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection
tested and approved under appropriate government standards such as NIOSH (US) or EN
166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN
14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air
respirator. Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
the environment must be avoided.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
a) Appearance Form: liquid
Colour: colourlessyellow
b) Odour Stench.
c) Odour Threshold No data available
d) pH 4.5 - 6 at 500 g/l at 20 °C

e) Melting point/freezing < -49.99 °C

point
f) Initial boiling point and 154 - 161 °C
boiling range
g) Flash point 74 °C - closed cup
h) Evaporation rate No data available
i) Flammability (solid, gas) No data available
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 j) Upper/lower Upper explosion limit: 18 %(V)
flammability or Lower explosion limit: 2.3 %(V)
explosive limits
k) Vapour pressure 0.76 mbar at 20 °C
4.67 mbar at 40 °C
l) Vapour density 2.70 - (Air = 1.0)
m) Relative density 1.1150 g/cm31.1140 g/cm31.12 g/cm3 at 20 °C
n) Water solubility soluble
o) Partition coefficient: n- log Pow: -0.326log Pow: -0.056 at 25 °C
octanol/water
p) Auto-ignition No data available
temperature
q) Decomposition No data available
temperature
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
Relative vapour density 2.70 - (Air = 1.0)

SECTION 10: Stability and reactivity

10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
Heat, flames and sparks.
10.5 Incompatible materials
Metals, Oxidizing agents
10.6 Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, Sulphur oxides
Other decomposition products - No data available
In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - 98 - 162 mg/kg(2-Mercaptoethanol)
(OECD Test Guideline 401)
LC50 Inhalation - Rat - 4 h - 2 mg/l(2-Mercaptoethanol)
LC50 Inhalation - Rat - 4 h - 625 ppm(2-Mercaptoethanol)
LD50 Dermal - Rabbit - 112 mg/kg(2-Mercaptoethanol)
Skin corrosion/irritation
Skin - Rabbit(2-Mercaptoethanol)
Result: Irritating to skin.

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 (Draize Test)
Serious eye damage/eye irritation
Eyes - Rabbit(2-Mercaptoethanol)
Result: Risk of serious damage to eyes.
Respiratory or skin sensitisation
Maximisation Test - Guinea pig(2-Mercaptoethanol)
May cause sensitisation by skin contact.
(OECD Test Guideline 406)
Germ cell mutagenicity

Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
No data available(2-Mercaptoethanol)
Specific target organ toxicity - single exposure
No data available(2-Mercaptoethanol)
Specific target organ toxicity - repeated exposure
Ingestion - May cause damage to organs through prolonged or repeated exposure. - Liver, Heart
Aspiration hazard
No data available(2-Mercaptoethanol)

Additional Information
RTECS: KL5600000

burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Nausea, Vomiting,
Weakness, Unconsciousness, Material is extremely destructive to tissue of the mucous membranes and
upper respiratory tract, eyes, and skin., spasm, inflammation and edema of the larynx, spasm,
inflammation and edema of the bronchi, pneumonitis, pulmonary edema(2-Mercaptoethanol)
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.(2-Mercaptoethanol)

SECTION 12: Ecological information

12.1 Toxicity
Toxicity to fish LC50 - Leuciscus idus (Golden orfe) - 46 - 100 mg/l - 96.0 h(2-
Mercaptoethanol)
Toxicity to daphnia and EC50 - Daphnia (water flea) - 0.89 mg/l - 48 h(2-Mercaptoethanol)
other aquatic (OECD Test Guideline 202)
invertebrates
Toxicity to algae EC50 - Desmodesmus subspicatus (green algae) - 12 mg/l - 72 h(2-
Mercaptoethanol)
Toxicity to bacteria LC50 - Bacteria - 125 mg/l - 17 h(2-Mercaptoethanol)
12.2 Persistence and degradability
Biodegradability Result: < 30.0 % - Not readily biodegradable.
Result: 6 % - Not readily biodegradable.
aerobic - Exposure time 28 d(2-Mercaptoethanol)
Result: < 10 % - Not readily biodegradable.

Biochemical Oxygen 105 mg/g(2-Mercaptoethanol)

Demand (BOD)
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 Chemical Oxygen 1.894 mg/g(2-Mercaptoethanol)
Demand (COD)
12.3 Bioaccumulative potential
Does not accumulate in organisms.
12.4 Mobility in soil
No data available(2-Mercaptoethanol)
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
12.6 Other adverse effects
Very toxic to aquatic life with long lasting effects.

SECTION 13: Disposal considerations

13.1 Waste treatment methods
Product
This combustible material may be burned in a chemical incinerator equipped with an afterburner and
scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number
ADR/RID: 2966 IMDG: 2966 IATA: 2966
14.2 UN proper shipping name
ADR/RID: THIOGLYCOL
IMDG: THIOGLYCOL
IATA: Thioglycol
14.3 Transport hazard class(es)
ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.
H301 Toxic if swallowed.
H301 + H331 Toxic if swallowed or if inhaled
H310 Fatal in contact with skin.
H315 Causes skin irritation.
H317 May cause an allergic skin reaction.
H318 Causes serious eye damage.
H331 Toxic if inhaled.
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 H373 May cause damage to organs through prolonged or repeated exposure if swallowed.
H400 Very toxic to aquatic life.
H410 Very toxic to aquatic life with long lasting effects.
Further information
Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held
liable for any damage resulting from handling or from contact with the above product. See www.sigma-
aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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