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    c3 - Dezvoltarea Creierului

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    Elena-Andreea Mut
    The document summarizes key aspects of brain development from birth to 2 years of age. It notes that brain volume increases 101% in the first year and an additional 15% in the second year. This growth is largely due to gray matter expansion, while white matter shows more prolonged development. Specific areas of the brain, like the splenium of the corpus callosum, are associated with language development at 24 months. White matter develops in a posterior-anterior and inferior-superior manner, with sensory pathways myelinating before motor and association areas. Synaptic plasticity and pruning also play important roles in brain maturation.

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    c3 - Dezvoltarea Creierului

    Uploaded by

    Elena-Andreea Mut
    40 views17 pages
    The document summarizes key aspects of brain development from birth to 2 years of age. It notes that brain volume increases 101% in the first year and an additional 15% in the second year. This growth is largely due to gray matter expansion, while white matter shows more prolonged development. Specific areas of the brain, like the splenium of the corpus callosum, are associated with language development at 24 months. White matter develops in a posterior-anterior and inferior-superior manner, with sensory pathways myelinating before motor and association areas. Synaptic plasticity and pruning also play important roles in brain maturation.

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    c3 - dezvoltarea creierului

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    The document summarizes key aspects of brain development from birth to 2 years of age. It notes that brain volume increases 101% in the first year and an additional 15% in the second year. This growth is largely due to gray matter expansion, while white matter shows more prolonged development. Specific areas of the brain, like the splenium of the corpus callosum, are associated with language development at 24 months. White matter develops in a posterior-anterior and inferior-superior manner, with sensory pathways myelinating before motor and association areas. Synaptic plasticity and pruning also play important roles in brain maturation.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    40 views17 pages

    c3 - Dezvoltarea Creierului

    Uploaded by

    Elena-Andreea Mut
    The document summarizes key aspects of brain development from birth to 2 years of age. It notes that brain volume increases 101% in the first year and an additional 15% in the second year. This growth is largely due to gray matter expansion, while white matter shows more prolonged development. Specific areas of the brain, like the splenium of the corpus callosum, are associated with language development at 24 months. White matter develops in a posterior-anterior and inferior-superior manner, with sensory pathways myelinating before motor and association areas. Synaptic plasticity and pruning also play important roles in brain maturation.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 17

    Curs neurostiinte clinice -

    dezvoltarea creierului

    Miralena I. Tomescu, PhD, sem I 2020


    Brain development

    from birth to 1-year


    brain volume increases 101%. Brain
    volume growth
    slows down in the second year with
    volume increasing
    an additional 15%

    This dynamic growth across the


    first 2 years of life is largely a result of
    gray matter growth. In comparison,
    white matter shows a more
    prolonged developmental trajectory

    Swanson et al, 2019


    Brain Development

    Neurogeneza si migrare neuronala

    https://www.youtube.com/watch?v=WmqvOUBh2cc

    Sinaptogeneza

    https://www.youtube.com/watch?v=1fnm1vGGRYI
    Brain development

    infants with the greatest change


    over time in the development of the
    splenium of the corpus
    callosum across 6–24 months had
    superior language at 24
    months

    white matter in typically developing


    infants is associated with
    general cognition, visual orienting, and
    working memory.

    Swanson et al, 2019


    Brain development

    Anatomically, white matter develops


    in a posterior to anterior, and inferior to superior
    manner.

    The brain stem and internal capsule fiber tracts


    undergo myelination first and temporal
    association tracts undergo myelination last

    Sensory pathways myelinate first, followed


    by motor pathways, and then association areas
    Brain development
    Brain development
    Brain development

    Synaptic plasticity refers to a set of mechanisms that


    mediate the activity-dependent strengthening or weakening
    of neuronal connections at the level of the synapse.
    between neurons

    https://www.youtube.com/watch?v=hb7tjqhfDus
    Brain development
    T2 LTD T1
    Pre 20 ms
    Post
    Hebb’s postulate: Synaptic synaptic

    Cells that fire together =>> wire together T1 T2


    Pre Post
    Synaptic 20 ms synaptic
    LTP
    Cells that fire apart =>> wire apart

    TIME is Important - window of 20 ms


    What is Synaptic pruning?

    https://www.youtube.com/watch?v=0S0jKbh6R1I
    Maturation from “local” organization
    Segregarea intra lobi
    to “distributed” organization, as
    measured by functional graph
    theoretical measures. Frontal regions
    are highlighted in blue in A; notice
    they are closely connected in children
    and less so in adults. The DMN, a
    collection of anatomically distributed
    regions, is highlighted in red in B.
    Notice they are segregated in children
    and highly integrated in adults. Integrarea retelelor

    Fair et al. (2009)


    Brain development

    Swanson et al, 2019


    Brain Development
    Brain Development

    Rylaarsdam et al., 2019


    Recunoasterea obiectelor,
    fetelor, citire, procesare lexicala,
    Brain Development semantica, identificarea emotiilor,
    Memorie vizuala

    Swanson et al., 2020

    Fasciculul longitudinal inferior stang


    WM biomarker of neurodevelopment

    More about DTI

     https://www.youtube.com/watch?v=twsV81UFFcE
     Multumesc pentru atentie!!!

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