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    Pentose Phosphate Pathway

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    GianneCarloGomed
    The pentose phosphate pathway generates NADPH and ribose-5-phosphate through two stages. It occurs in fatty tissue, liver, mammary glands and adrenal cortex. The oxidative stage converts glucose-6-phosphate to ribulose-5-phosphate and CO2 while producing NADPH. The nonoxidative stage converts ribulose-5-phosphate to ribose-5-phosphate. NADPH is used for lipid biosynthesis and glutathione generation to maintain red blood cell health, while ribose-5-phosphate is used for nucleic acid and coenzyme synthesis. The pathway balances producing these products with shunting intermediates into glycolysis depending on cellular needs.

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    Pentose Phosphate Pathway

    Uploaded by

    GianneCarloGomed
    39 views2 pages
    The pentose phosphate pathway generates NADPH and ribose-5-phosphate through two stages. It occurs in fatty tissue, liver, mammary glands and adrenal cortex. The oxidative stage converts glucose-6-phosphate to ribulose-5-phosphate and CO2 while producing NADPH. The nonoxidative stage converts ribulose-5-phosphate to ribose-5-phosphate. NADPH is used for lipid biosynthesis and glutathione generation to maintain red blood cell health, while ribose-5-phosphate is used for nucleic acid and coenzyme synthesis. The pathway balances producing these products with shunting intermediates into glycolysis depending on cellular needs.

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    2. PENTOSE PHOSPHATE PATHWAY

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    The pentose phosphate pathway generates NADPH and ribose-5-phosphate through two stages. It occurs in fatty tissue, liver, mammary glands and adrenal cortex. The oxidative stage converts glucose-6-phosphate to ribulose-5-phosphate and CO2 while producing NADPH. The nonoxidative stage converts ribulose-5-phosphate to ribose-5-phosphate. NADPH is used for lipid biosynthesis and glutathione generation to maintain red blood cell health, while ribose-5-phosphate is used for nucleic acid and coenzyme synthesis. The pathway balances producing these products with shunting intermediates into glycolysis depending on cellular needs.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    39 views2 pages

    Pentose Phosphate Pathway

    Uploaded by

    GianneCarloGomed
    The pentose phosphate pathway generates NADPH and ribose-5-phosphate through two stages. It occurs in fatty tissue, liver, mammary glands and adrenal cortex. The oxidative stage converts glucose-6-phosphate to ribulose-5-phosphate and CO2 while producing NADPH. The nonoxidative stage converts ribulose-5-phosphate to ribose-5-phosphate. NADPH is used for lipid biosynthesis and glutathione generation to maintain red blood cell health, while ribose-5-phosphate is used for nucleic acid and coenzyme synthesis. The pathway balances producing these products with shunting intermediates into glycolysis depending on cellular needs.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 2

    PENTOSE PHOSPHATE PATHWAY Ribose

    PPP  Components of:


     Pentose Phosphate Pathway is the metabolic pathway  ATP
    by which glucose 6-phosphate is used to produce  GTP
    NADPH, ribose 5-phosphate, and numerous other  UTP
    sugars.  CoA
     PPP’s significance: fatty tissue, liver, mammary  NAD+/NADH
    glands, and the adrenal cortex.  FAD/FADH2
     RNA
    Major functions:
    1. Synthesis of coenzyme NADPH needed lipid  Further steps in the nonoxidative stage contain
    biosynthesis. provision for the conversions of ribose 5-phosphate to
    2. Production of ribose 5-phosphate needed for the numerous other sugar phosphates.
    synthesis of nucleic acids and many coenzymes.  Ultimately glyceraldehyde 3-phosphate and fructose 6-
    phosphate (glycolysis intermediates) are formed.
    NADPH
     reduced form of NADP+ 3 G6P + 6 NADP+ + 3H2O =
     Phosphorylated version of NAD+/NADH 2 Fructose 6-phosphate + 3CO2 + Glyceraldehyde 3-
     Phosphorylated and non-phosphorylated versions: phosphate + 6 NADPH + 6H+
    different functions.
     NAD+=needed in common metabolic pathway. PPP for cellular needs
     NADPH= biosynthesis of lipids and nucleic acids  When ATP demand is high, the pathway continues to
    its end products, which enter glycolysis.
    2 STAGES of PPP  When NADPH demand is high, intermediates are
    1. OXIDATIVE - recycled to glucose 6-phosphate (start of the
     involves 3 steps through which glucose 6-phosphate is pathway), and further NADPH is produced.
    converted to ribulose5-phosphate and CO2.  When ribose 5-phosphate demand is high (nucleic
    G6P + 2NADP+ + H2O= acid and coenzyme production ), nonoxidative stage is
    ribulose 6-phosphate +CO2 + 2NADPH + 2H+ non-functional, leaving ribose 5-phosphate as a major
    product.

    2. NONOXIDATIVE
     Ribulose 5-phosphate is converted to ribose 5-
    phosphate (isomerization process).
     Enzyme involved: Phosphopentose isomerase
     Use of ribose?
    Glutathione
     Main antioxidant used by the body to keep Hgb in its
    reduced form.
     NADPH is needed for the generation of the depleted
    glutathione.
     An insufficient supply of NADPH, and ensuing lack of
    glutathione, leads to the destruction of Hgb-containing
    RBC’s which can result to anemia.

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