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    STS Gene Cell Therapy (Sarbues, Sonza, Toledo)

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    Raef Cen R. PALOMAR
    This document discusses gene therapy and its history and process. It provides definitions that gene therapy is a medical field that focuses on delivering nucleic acids into patients' cells as a drug to treat genetic diseases. The first human gene therapy experiments took place in 1971 using recombinant DNA technology. There are two types of gene therapy - somatic, which treats cells without inheritance to offspring, and germline, which modifies heritable germ cells. The basic process involves replacing a mutated gene with a healthy copy using a virus vector to transport the gene into cells. Stem cell gene therapy is also discussed, noting the two sources of stem cells - embryonic and somatic - and their characteristics including self-renewal potential and ability to develop into different cell types.

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    STS Gene Cell Therapy (Sarbues, Sonza, Toledo)

    Uploaded by

    Raef Cen R. PALOMAR
    122 views9 pages
    This document discusses gene therapy and its history and process. It provides definitions that gene therapy is a medical field that focuses on delivering nucleic acids into patients' cells as a drug to treat genetic diseases. The first human gene therapy experiments took place in 1971 using recombinant DNA technology. There are two types of gene therapy - somatic, which treats cells without inheritance to offspring, and germline, which modifies heritable germ cells. The basic process involves replacing a mutated gene with a healthy copy using a virus vector to transport the gene into cells. Stem cell gene therapy is also discussed, noting the two sources of stem cells - embryonic and somatic - and their characteristics including self-renewal potential and ability to develop into different cell types.

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    This document discusses gene therapy and its history and process. It provides definitions that gene therapy is a medical field that focuses on delivering nucleic acids into patients' cells as a drug to treat genetic diseases. The first human gene therapy experiments took place in 1971 using recombinant DNA technology. There are two types of gene therapy - somatic, which treats cells without inheritance to offspring, and germline, which modifies heritable germ cells. The basic process involves replacing a mutated gene with a healthy copy using a virus vector to transport the gene into cells. Stem cell gene therapy is also discussed, noting the two sources of stem cells - embryonic and somatic - and their characteristics including self-renewal potential and ability to develop into different cell types.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    122 views9 pages

    STS Gene Cell Therapy (Sarbues, Sonza, Toledo)

    Uploaded by

    Raef Cen R. PALOMAR
    This document discusses gene therapy and its history and process. It provides definitions that gene therapy is a medical field that focuses on delivering nucleic acids into patients' cells as a drug to treat genetic diseases. The first human gene therapy experiments took place in 1971 using recombinant DNA technology. There are two types of gene therapy - somatic, which treats cells without inheritance to offspring, and germline, which modifies heritable germ cells. The basic process involves replacing a mutated gene with a healthy copy using a virus vector to transport the gene into cells. Stem cell gene therapy is also discussed, noting the two sources of stem cells - embryonic and somatic - and their characteristics including self-renewal potential and ability to develop into different cell types.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 9

    The Aspects of

    Gene Therapy
    Reporters:
    Sarbues, Aina Angela
    Sonza, Francy Gwyn Beatriz
    Toledo, Andre
    Gene Therapy

    It is a medical field which focuses on the


    utilization of the therapeutic delivery of
    nucleic acid into a patient’s cells as a drug to
    treat disease. Gene therapy is a potential
    method to either treat or cure genetic-related
    illness.

    2
    1
    Human Gene
    Therapy
    Human Gene Therapy was
    first realized in 1971
    It was during this year when the first recombinant DNA
    experiments were planned. Foreign DNA is inserted into a
    patient’s tissue with hopes to eradicate a targeted disease. It was
    actually inspired by the success of recombinant DNA
    technology which occurred over the last 20 years. Without a
    doubt, gene therapy is the most promising yet possibly
    unfavorable medical field being studied.

    4
    Basic Process (Fliesler, 2017)
    ⦁ Replacement of mutated In general, a gene cannot be
    gene that causes disease directly inserted into a human
    with a healthy copy of gene or cell. A gene is inserted
    into another gene using a carrier
    gene
    or a vector. At present, the most
    ⦁ Inactivation of a mutated common type of vectors are
    gene that is functioning viruses that have been genetically
    improperly changed to carry normal human
    DNA. Viruses have evolved a way
    ⦁ Introducing a new gene
    of encapsulating and transporting
    into the body to help fight their genes to human cells in a
    a disease pathogenic manner.

    5
    Two Types of Gene Therapy
    Somatic Gene Therapy involves Germ-line Gene Therapy which
    the manipulation of genes in cells involves the genetic modification
    that will be helpful to the patient of germ cells or the origin cells
    but not inherited to the next that will pass the change on to the
    generation. next generation.

    6
    2
    Stem Cell Gene
    Therapy
    Stem cells are mother cells that have the Characteristic: has the
    potential to become any type of cell in the ability to self-renew or
    multiply while maintaining
    body. the potential to develop into
    Two sources of stem cells:
    other types of cells

    ⦁ Embryonic stem cells are derived from a four- or five-day-old


    human embryo that is in the blastocyst phase of development. The
    embryos are usually extras that have been created in IVF clinics
    where several eggs are fertilized in a test tube then implanted into
    a woman.
    ⦁ Somatic stem cells are cells that exist throughout the body after
    embryonic development and are found inside of different types of
    tissue. These stem cells have been found in tissues such as the
    brain, bone marrow, blood, blood vessels, skeletal muscles, skin,
    and the liver. They remain in a non-dividing state for years until
    activated by disease or tissue injury. 8
    “
    Thank you for
    listening!

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