GC/MS Varian

Saturn 2200
 The Best Choice for Today...
The Best Choice for Tomorrow!

The affordability of benchtop GC/MS has improved dramatically in the last decade, yet careful
evaluation is still key in making the best purchase decision. The system you choose must meet
your immediate needs for sensitivity, precision, and sample throughput. And, the system must
meet these requirements for 7 or even 10 years more, when the demands on your laboratory
have changed significantly.

So, how do you secure that future?

How do you guarantee continued success?
How do you stay ahead of technology obsolescence?

The Saturn® 2200 answers these questions

with the CP-3800 GC and the 2000 Series
Ion Trap MS! These components create a
platform for the world’s most versatile GC
and flexible MS. Both deliver unequaled
performance—a Saturn tradition. And, both
components support a remarkable array of
highly productive, easy-to-use options.

Under Saturn Workstation control, complex

configurations become very simple to
operate. The Saturn 2200 is the platform
that easily expands and evolves to support
your continued success.

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 Saturn 2200 = Maximum GC + Maximum MS
Flexible, reliable AutoSamplers
• CP-8400 handles up to 100 samples in liquid or ambient headspace mode
• CP-8410 provides flexibility with a fixed sample tray supporting multiple vial sizes
• Combi PAL offers maximum robotic flexibility with liquid, heated headspace, and SPME modes
• ArchonTM with Tekmar 3100 Purge and Trap

Superb flow control, injectors and column oven

• Electronic Flow Control (EFC) of all gases with gas saver mode
• CP-1177 Split/Splitless Injector with optimized flow profiles for precise vaporization and
sample transfer
• 1079 PTV Temperature Programmable Injector for maximum control and sample compatibility
• Rapid-MSTM column technology for faster analyses
• Spacious oven for multiple columns and valves
GC detectors to complement MS applications
• ECD for ultra-high sensitivity halogen selective detection
• PFPD for selective detection of sulfur, phosphorus, nitrogen and 25 additional elements
• TSD for selective detection of nitrogen/phosphorus with Varian’s reliable ceramic bead
• FID with a patented, inert tip for universal detection of organic compounds
• Simultaneous operation with the MS using single column/split effluent or parallel columns

Saturn MS – the performance standard for benchtop mass spectrometry

• Highest Electron Ionization (EI) sensitivity at installation and after years of routine use
• Most consistent quantitative response
• Library searches with commercial databases: NIST, Wiley, PMW
• SIS (Selected Ion Storage) for library searches of trace components in complex matrices
• “No tools” removal of the analyzer—the benchmark for MS hardware simplicity
• Varian V-70 Turbomolecular Pump for clean, rapid pumpdown

Powerful and easy-to-use MS options

• MS/MS for selectivity beyond full scan or SIM operation, and applications beyond NCI
• MSn delivered only through ion trap technology
• PCI (Positive Chemical Ionization) with the sensitivity and convenience of EI
• Multi-reagent CI for automated selection of up to three CI reagents (liquids or gases)
• SilChrom Inert Analyzer for sensitivity and ideal peak shape of polar analytes
• ChromatoProbe combines the advantages of a GC separation with the benefits of a
probe for solids, liquids, and slurries

A truly complete workstation

• Single point control of the system and peripherals for GLP compliance
• Flexible automation sequences and batch reprocessing
• Quantitative analysis covering the full range of calibration and peak
processing for all GC and GC/MS applications
• Choice of search algorithms: INCOS or optional NIST
• Standard reports with user-defined formats
• Custom reports for environmental and toxicological analyses
• Automated switching from EI to CI and between all MS modes (full-scan, SIS,
MS/MS) within the same analysis

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 A Saturn 2200 for Any Application
The versatile platform with a guaranteed future

Pesticide Residue Analysis Flavor Analysis

CP-8400 AutoSampler (duplicate injection), Solid Phase Microextraction (SPME), 1079 PTV, EI-MS,
dual injectors (CP-1177 and 1079 PTV), EI-MS/MS, acetonitrile PCI-MS, and PFPD
and second detector (ECD, TSD, or PFPD)

Aromatics and VOCs in Soil Drug Analysis

Headspace, CP-1177, EI-MS, and FID Dual injectors (CP-1177 and 1079 PTV),
ChromatoProbe, EI and CI, MS, and MS/MS

Soil/Drinking Water Analysis

Archon, Tekmar 3100, CP-1177, and EI-MS. Just add the CP-8400 AutoSampler for semi-volatiles.
5

Add options, any or all, as you need them!

 The Perfect GC
Expand your creativity and productivity

Get the most from the Saturn 2200 by thinking beyond

single purpose GC/MS solutions. Begin your thought
process with autosamplers and injectors. Consider the
modes you use now and the modes you may need later:
headspace/split, large volume/PTV, SPME/splitless. The
CP-3800 GC accommodates three injectors with
maximum performance always assured. All Varian
autosamplers support multiple injector operation.
And, remember detectors such as an ECD or powerful
technologies like MS/MS can be added at any time.

Take full advantage of switching between injectors,

columns, and detectors for immediate results and
increased productivity. Easily expand 38 inches/95 cm of
precious bench space into a multi-purpose platform
from a simple GC/ECD to a GC/MS, or to the ultimate
selectivity of GC/MS/MS.
Combi PAL for more sampling modes
and maximum capacity. Syringe
options: left, liquids; center, heated
headspace; right, SPME.

Small and flexible with special

features. Varian’s CP-8400
AutoSampler delivers matchless
performance with dual or duplicate
mode and internal standard addition.

Column Phase: CP-Sil 8

Detector: MS 1. Dihydrocodeine
2. Codeine
8 3. Hydrocodone
4 7 4. Morphine
5. Hydromorphone
1 2 6. Oxycodone
7. 6-Monoacetylmorphine
8. Oxymorphone
3 5
6

Column Phase: CP-Sil 24

Detector: MS 4
7
1
2
8
5
3

6 More columns, more solutions. The CP-3800 supports many

combinations of injectors and columns to ensure that extra
selectivity you need to characterize difficult mixtures.
Room to Work
For GC ovens, performance certainly matters, and so
does size. The CP-3800’s larger oven means better
access to multiple columns, injectors, and detectors.
There is even room for valves and other custom
chromatography configurations. Add the convenience
of Varian’s Chrompack columns with EZ-GRIPTM and
words like “perfect” come to mind.

Varian columns with EZ-GRIP. Patented EZ-GRIP

bar simplifies installation and supports a vacuum-
tight union to the MS transfer line.

EI/MS

PFPD in Sulfur Mode

Two detectors are better than one. Combine the specificity of a

Varian PFPD or the sensitivity of an ECD with your Saturn MS for
complementary information. Add an FID for quick screens before MS
confirmation.

Saturn 2200 in a Multi-Channel Configuration

AutoSamplers and AutoInjectors Columns Valve Detectors Saturn Workstation

ChromatoProbe MS

ECD
CP-8400 or Combi PAL
PFPD

Immediate Choices. In this example, the Saturn’s CP-3800 GC is configured with three injectors and detectors
plus a simple, inert valve for column and detector selection. Immediately, five different problem-solving tools are 7
available without downtime. These choices give you the freedom to explore new solutions and gain unequaled
efficiency—all in one GC/MS platform.
 Saturn MS Technology
Electron Ionization for unequaled detection limits

Quadrupole ion trap mass spectrometers offer Superior Signal-to-Noise

performance advantages which begin with the most for Trace Analysis
basic EI applications. The ionization and storage process
occurs simultaneously at the center of the ion trap
electrodes. This process translates into outstanding 1 pg OFN
Ion 272
analytical value: S/N 67:1

• consistent response across the full mass range

• highly efficient ion storage for maximum sensitivity
• durable, rugged performance

Since Saturn 2200 does not have the lenses and other
components of an external ion source, frequent
cleaning is just not required. Also, Saturn’s RF-only
trapping field assures stable mass calibrations for weeks
or even months. You enjoy high quality, high sensitivity
spectra at installation and for the life of your system.

Searchable spectra at picogram levels. Superb

signal-to-noise is equally essential for
qualitative analysis.

Selected Ion Storage for Improved Library Searches in Complex Matrices

Full Scan
Arochlor 1260 in Transformer Oil

Ion 430
S/N 9:1

SIS Scan SIS, a standard feature for

Saturn 2200, extends
library search performance
Ion 430 beyond full scan mode.
S/N 34:1
When transmission
quadrupoles default to two
or three ions to maintain
NIST98 sensitivity, SIS continues to
8 generate library searchable
spectra—even near the
limits of detection.
Positive CI, the easily accessible complement to Saturn EI

The advantage of the 2200’s internal ionization analyzer

is further established by the remarkable performance of
its unique, low pressure PCI process.

• If you think CI means low sensitivity, you haven’t used

Saturn PCI

• If you consider CI to be troublesome or complex, you

haven’t tried Saturn PCI using liquid reagents

If you have never applied the many benefits of PCI

to your samples, take a careful look at PCI on the
Saturn 2200. The PCI option gives you performance,
convenience, and is always available as an upgrade for
MS or MS/MS systems.

Liquid CI Reagents PCI - EI’

s Partner
• No hardware changes from EI to PCI
• No loss of calibration from EI to PCI to EI
Simple ≤ 5 mL/week
• Rapid equilibration of reagent pressure
• Contamination-free operation using low
Selective
pressure reagents
Low cost
• Superb sensitivity in either mode

Convenient
• Routine EI and routine PCI with trouble-
Safe
free performance
Actual Size

Methanol PCI Acetonitrile PCI

1 pg benzophenone
Ion 183 CH3CN Reagent
S/N 40:1

CH3CN and CD3CN Reagents

The PCI sensitivity benchmark. Saturn is the Better than low intensity adduct ions! A mixture
sensitivity standard for all benchtop systems, and of acetonitrile and its inexpensive, deuterated 9
only Saturn delivers this performance with gases or analogue generate an intense doublet (M+1 and
safe, inexpensive liquids. M+2) to confirm the molecular ion of vanillin.
 MS/MS — for more selectivity
when full scan, SIM, and SIS are not enough

In 1994, Varian introduced the first benchtop GC/MS/MS I. Ionization — EI Spectrum with Matrix Ions
and changed the image of MS/MS. Originally, MS/MS
was a tool used only by research labs. Today, thousands
of labs routinely rely on the performance of this low
cost, easy-to-use technology.

MS/MS delivers enhanced selectivity and improved

detection limits for every application. For especially
complex, “dirty” samples, Saturn 2200 MS/MS
completes an accurate analysis where other GC/MS
systems fail. The success of Saturn users repeatedly
proves that MS/MS is the logical step toward better II. Isolation — Precursor Ion
GC/MS analyses.

6-Monoacetylmorphine in Urine

Matrix ions eliminated!

III. Dissociation — Product Ion Spectrum

Drug Analysis. Saturn MS/MS meets and Varian MS/MS—the simple path to enhanced
exceeds the stringent specificity and low selectivity. Coeluting sample matrix can obscure
detection limits essential to trace analysis. an analyte’s spectrum even after background
correction. Matrix also contributes chemical
noise that limits trace detection.

I. MS begins with the ionization process.

II. In MS/MS, the isolation step clears all
background ions from the analyzer.
III. Product ions from the Collision-Induced
Dissociation (CID) are measured against a
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noise-free background. The unique product ions
yield better quantitative data and matrix-free
spectra for qualitative decisions.
MSn = (Solutions)n

MS/MS is often considered along with Negative Ion

Chemical Ionization as the “ultimate” analytical solution
in GC trace analysis. While both techniques have utility,
MS/MS is clearly easier to use and more widely
applicable as shown in the table below.

EI MS/MS Benefits
EI MS/MS Negative Ion CI/MS

Halogenated compounds Yes Yes “The major advantage of the ion

trap MS/MS over the existing
Non-halogenated compounds Yes No
methods, electron capture
Reagent gas needed Never Always negative ionization mass
spectrometer or electron capture
Source change Never System Dependent detector, is its excellent selectivity.
Interference from other
Mode selection automated Yes System Dependent
organochlorines can virtually be
Multi-ion spectrum for Often Seldom eliminated. Therefore, the
structural confirmation developed MS/MS method may be
used as a reliable alternative to
high resolution mass spectrometry for measurement of toxaphene in environmental samples with relatively low-cost
instrumentation.” H.M. Chan, J. Zhu, and F. Yeboah. Chemosphere 36 (1998) 2135-2148.

A Single Run with All The Technologies to Meet Your Requirements

Varian’s GC/MS
Workstation control
is truly unique!
With just the PC, SIS
move easily and CI/MS
automatically EI/MS
between standard CI/MS
and optional MS
technologies within
a single run. Every
Saturn technology CI/MS/MS EI/MS/MS
is accessed,
optimized, and
time-programmed
from the PC. Start
with the simplest
mode, EI full-scan. 11
Then, to improve selectivity or sensitivity, program MS/MS, SIS, or CI into the same method—even for
one peak at a time. Every MS technology is routine with Saturn Workstation control.
 EI to CI, MS to MSn . . . Satisfaction Guaranteed

The power and performance of Saturn technology is a

well established fact. Satisfied users take advantage of
Saturn’s technologies every day as they work on a wide
range of applications. Saturn 2200 runs all standard MS
methods. More importantly, Saturn 2200 gives you a
comprehensive set of additional MS tools to apply
better solutions for your ever-changing application
needs. With Saturn 2200, satisfaction is guaranteed—
year after year, application after application!

Chemical Warfare Agents, CI/MS Fire Debris, EI/MS/MS

“ ... the correlation [using GC/MS/MS] is much better
than that obtained using GC/MS ... (time programmed
MS/MS) allows us to choose certain key compounds
such as the alkylbenzenes and alkyl substituted PAH’s
... and exclude all other matrix ions.” M. Froneman and
B-J Visser. Council for Scientific and Industrial Research,
Pretoria, S.A. Varian GC/MS Application Note No. 62.

Essential Oils, EI/SIS, ChromatoProbe

Leaves

“Methanol CI ... is an excellent technique for

the detection and identification of VX
degradation products .... Reduced fragmen-
tation was observed relative to the use of
methane or ammonia as CI reagent gases .... Anthers
Methanol ... offers potential logistical
advantages for environmental analysis by
being cheaper, easier to transport and safer to
use ....” D.K. Rohrbaugh. Journal of Chromatog-
raphy A 893 (2000) 393-400.

“ ... small pieces of a selected part of the plant

material can be placed into the sample holder ....
This approach is capable of detection and
identification of essential oils in a single anther (of
12 Verticordia n. and r.).” S. Wilkinson, Chemistry Centre,
and P. Ladd. Murdoch University, Western Australia.
Varian GC/MS Application Note No. 65.
Comments from Saturn Users

Dioxins in Soil, EI/MS vs EI/MS/MS

EI/MS Pesticides in Serum, ECD, EI-MS/MS

“Two GC methods, using ECD or MS/MS
detection mode, have been developed and
validated for the analysis of endosulfan, a
and b, and three metabolites, sulphate, ether
and lactone, in human sera samples. ... better
EI/MS/MS selectivity required for the analysis of
biological samples was achieved with the
GC/MS/MS method. The tandem capabilities
“Results for the CID MS/MS technique were of the ion trap allow the elimination of
reproducible, with very little reduction in interference peaks that make difficult the
sensitivity or spectral quality during the quantitation of pesticide traces ....“
analyses of all test samples. MS/MS data J.L. Martinez Vidal, M. Moreno Frias, A. Garrido
acquisition was initiated after calibration Frenich, F. Olea-Serrano, and N. Olea. Rapid
using 2-1500 pg standards and three to four Communications in Mass Spectrometry 14
selected ions in each MS/MS spectrum. The (2000) 939-946.
responses were linear for all ions calibrated.”
D.J. Hayward. Organohalogen Compounds 23
(1995) 119-124.

Steroids in Urine, EI/MS/MS

Full Scan
Ion 358

1,4-Dioxane in Water, CI/MS/MS

“Methanol CI-MS-MS offered the potential

of detection limits three orders of magnitude MS/MS
Ion 301
lower than the electron ionization MS.”
W.M. Draper, J.S. Dhoot, J.W. Remoy, and
S.K. Perera. Analyst 125 (2000) 1403-1408.

“The analytical method used is highly

sensitive, accurate and reliable, easy to
optimize, specific in confirming the anabolic
substances and makes it possible to save
time in routine analysis.” J. Munoz-Guerra,
D. Carreras, C. Soriano, C. Rodriguez, and
A.F. Rodriguez. Journal of Chromatography B
704 (1997) 129-141.
Air Analysis, EI/MS
“We have extended our target list of compounds that can be analyzed hourly by our field-deployable autoGC-MS
system to 100 compounds, including biogenic and anthropogenic ozone precursors and oxygenated VOCs.” 13
E.H. Daughtrey Jr., J.R. Adams, K.D. Oliver, K.G. Kronmiller, and W.A. McClenny. Journal of Geophysical Research 103
(1998) 22375-22386.
 A Complete Workstation —
That Works Full-Time for You

The Saturn 2200 fully exploits advances in high

performance PCs and Windows®-based software. Every
function is under Workstation control. In fact, if it were
not for adjustment of the calibration gas and CI reagent
flows, you might forget the hardware even exists.

The 2200 Workstation is intuitive, comfortable, and

efficient. It has to be to satisfy both new users and
high throughput laboratories. Within a few days from
installation, Varian’s GC/MS Workstation will become System Control/Automation
your favorite lab assistant. This screen links to system setup functions
and allows real-time monitoring of analysis.
See our Saturn CD Brochure for detailed software
tutorials. Better yet, ask for a demonstration of our
software today.

Complete Workstation Control

• Easy setup of all autosampler, GC, and
MS components
• Streamlined automation for a single
sample or large batches
• Superior qualitative and quantitative
analyses Review/Process MS Data
Versatile, intuitive icons within this window
• Extensive standard and custom reporting facilitate initial evaluation of ion chromato-
grams or spectra and links to additional
qualitative and quantitative tools.

Saturn CD Brochure

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Reports, Reports, and More Reports

Information-rich detectors like the 2200 MS generate

vast amounts of data. Reports address qualitative,
quantitative, QC/QA, and GLP issues. A great MS
workstation helps run your samples and analyze your
data, and puts you in full control of report formats. The
Saturn Workstation, with its wide array of reports, lets
you focus quickly on the critical aspects of your data.
Use ‘standard’ or ‘custom’ reports to tailor the
presentation of results for your customers. All reporting
is completely automated so you can spend time on
other tasks.

Standard Reports. Reports and control Custom Reports. For applications with specific
charts may be printed in a variety of reporting requirements, Custom Reports such as
formats or archived as ASCII files. EnviroPro and ToxPro meet your needs with
minimal effort.

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 Options That Make the Difference —
In performance and productivity

Along with all of the GC and MS technology delivered

by the Saturn 2200, a number of affordable add-ons
can be very valuable for selected applications. Your
Varian Representative is ready to describe the benefits
that these enhancements can bring to your laboratory.

SilChrom Analyzer. Optimal peak

shapes and maximum response for
polar analytes like drugs and pesticides
are guaranteed with this inert surface.

ChromatoProbe. This
unique and rugged device
combines the benefits of a
probe with a GC column for
superior MS analysis of
solids, liquids, and slurries.

Multi-Reagent CI. Extend the convenience of

the world’s most sensitive PCI technology.
Automatically select methanol or deuterated
acetonitrile and generate information not
Custom configurations and application possible with other MS detectors.
testing. Consult with us on your special
application needs. Varian saves you time
16
and cost by assembling and testing your
customized system in our ISO-Certified
manufacturing process.
Varian Chromatography and Spectroscopy Supplies
Performance, Selection, and Value
Varian’s 50-plus years of continuous innovation in
analytical instrumentation assures you the best in high
performance products. Varian is committed to providing
analytical products and supplies at affordable prices
supported by superior customer service.

To maximize Saturn 2200 performance, select the best

value in analytical supplies ranging from sample vials
and sample preparation products to CP-Sil Low-Bleed/MS
capillary columns. Call today to request your free Varian
Chromatography and Spectroscopy Supplies catalog.

Varian injector septa and liners. Products proven

to meet the exacting performance the Saturn 2200
delivers.

Autosampler and autoinjector vials. Vials with septa

manufactured from materials specifically designed to
eliminate GC/MS system contamination.

CP-Sil Low-Bleed/MS capillary columns. These

columns are available in all the popular polarities.
Low column bleed means higher precision, especially
for trace analysis.

CP-Gas Clean Filters. Extremely efficient filters

remove moisture and oxygen to extend column life
and improve system performance.
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Varian Analytical Instruments
serving worldwide markets in:
Agriculture
Basic Chemical
Biotechnology
Clinical
Electronics
Environmental
Photonics
Toxicology
Pharmaceutical
Food and Beverage
Metals and Mining
Petroleum and Petrochemical

Varian is committed to a
process of continuous
improvement which
demands that we
understand and then meet
or exceed the needs and
expectations of our
customers — both inside
and outside the company —
in everything we do.

• Varian Sales and Dealer Offices

Varian Analytical Instruments • www.varianinc.com

• North America 800.926.3000, 925.939.2400
• Europe The Netherlands: 31.118.67.1000
• Asia Pacific Australia: 613.9560.7133
• Latin America Brazil: 55.11.3845.0444
• Other sales offices and dealers throughout the world

GC • GC/MS • HPLC • AAS • ICP • ICP-MS • UV-Vis-NIR • Fluorescence • NMR • Analytical Supplies

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