3the Birth of The Mind by Gary Marcus

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10.10.

2018
The Birth of the Mind: How a Tiny Number of Genes Create the Complexities
of Human Thought

Gary Marcus

Alper Mert
0060708

Sophomore

In his book “The Birth of the Mind: How a Tiny Number of Genes Create the Complexities of
Human Thought”, Gary Marcus starts by explaining the protein template theory (PTT), the theory
that genes are involved in every protein synthesis in a cell body, and the discovery of DNA. Then
he continues to examine the subsequent studies about what DNA is and how it works. We see
that the first studies done on DNA was unsuccessful in revealing the nature or structure of the
substance. However, he shows that with J. Watson and F. Crick’s discovery of double helix and
the chemical properties of nucleotides, we began to understand the processes which occur within
a cell. Double helix structure allows DNA to untangle and, create RNA to govern the cell, or
copy itself to create new cells; which aligns with Mendel’s findings on heredity. Then he
proceeds to explain how the genes, the groups of at least 3 nucleodites, synthesize proteins. He
continues to examine the effect of “faulty genes” in people and emphasizes on the fact that PTT
does not account for DNA’s defense mechanisms towards those ’faulty genes’, or knowledge of
when the templates within the DNA should be used. That’s because PTT theory is one half of a
picture; the other part is the regulation or as he names it Autonomous Agent Theory (AAT),
which accounts for change in cell behavior in different circumstances. In order to explain the
PTT and, AAT he uses a simple if-then model; if there is no glucose in the environment (if-
regulatory) but there is lactose, E. choli bacteria starts secreting galactosidase, an enzyme that
breaks down lactose to glucose (then-protein template). As he talks about more complex
organisms, like humans, he points out that the if-then process is not enough. The cells use their
locations and their antecessors as a basis on what function or form they will take.

The point of this article seems to be piqueing the readers interest towards cellbiology and DNA.
However, the biologic descriptions seem to be superfacial and unbranched; the protein synthesis
procedure is described without RNA. He doesn’t give more than a sentence about the function of
RNA, furthermore that sentence is the only mention of the RNA in the text. Despite the poor
cellular explanations, the history of the subject is given in a fashion that would captivate the
reader as it does not get into too much detail. The examples used are well designed as they are
complex enough to be relevant to the subject, but not complex enough to confuse the reader; the
example of roundworm is used to explain both lineages, and the anchor cells by giving only the
necessary information. The history, given chronologically and simply, is enough to see the
collaboration and the cumulative nature of science. The if-then explanation and computer
programming methaphor used to emulate it, helps the reader understand the connection between
the regulation and the production tasks of DNA. The only two problems with the text are; the
oversimplification of cellular processes, and that the text does not explain “How a Tiny Number
of Genes Create the Complexities of Human Thought” as the title suggests. However, the fact
that this text was taken from the first chapters of a book that approached the nature vs. nurture
debate from a point of view that included the genomics, makes up for these problems.

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