GPAT QUESTION PAPER 2014 WITH ANSWER KEY GPAT QUESTIONS 1 , system does not have orifice to release the drug (a) Elementary Osmotic Pump (b) L-oROS (0) Sandwich Osmotic Pump Tablet (d) Controlled Porosity Osmotic Pump Tablet 2. In which rearrangement reaction, Isocyanate is formed? (a) Curtious (b) Lossen (©) Both A&B (a) None 3. Chitin gets converted in to Chitosan upon: (a) Acetylation (b) Deacetylation (©) Oxidation (@) Reduction 4. Allof the following are af constants EXCEPT (a) Vein-islet number (b) Vein- termination number (0) Stomatal number (a) Leaf fiber 5. Zink chloride is added to mouth wash because it acts as (a) Fragrance (b) Astringent (c) Cooling agent (d) Antibacterial 6. The choice of route of administration plays an important role in action of directly acting cholinomimetic Adverse effect of choline esters that may be avoided by selection of an appropriate route of administration is (a) Bradycardia (b) Hypotension (© Delirium (a) Sweating 7. Sieve size 80 has opening of (a) 0.100 mm (b) 0.125 mm {c) 0.150 mm (d) 0.180 mm 8. The ideal saponification value for suppository base is (a) 50-100 (b) 100-150 (©) 150-200 (©) 200-500 9. 0, m, p- isomers can be differentiated on the basis of: (a) Chemical shift (b) Coupling constant (€)_ Extinction coefficient (d) Dipole moment 10, Which of the following drug comes under Schedule C, (a) Opium (b) Ergot {c) Fish liver oil (4) Insulin 11. Source of aml is (a) Phyllanthus inruri (b) Terminiliachebu (0). Terminalia Bacteria (@)_Embika officinalis 12. What is the unit of dielectric constant (a) Dyne (b) Debey (c) Farad/meter (a) No Unit 13. Monitoring of plasma drug concentration is required while using (a) Antihypertensive drugs (b) Levodopa (©) Lithium carbonate (a) MAO inhibitors14, Of the following antibiotics, which one would be acceptabk to use when treating penicillin resistant S, pnumoinae otitis media (a) Azithromycin (b) Clarithromycin (9) Cefuroxime (d) Cefaclor 15, Addition of which of the following to a large volume parntral product is not advised (a) Active pharmaceutical ingredient (b) Preservatives {c) Bulfering agens (d) Tonicity adjusters 16. A drug suspension decomposes by zero-order kinetics with a rate constant of 2 mg mL! month? if the initial concentration is 100 mg mL* what is the shelf life (a) 2 months (b) 3 months (o) 4months (d) 5 months 17. Sanguinarine belongs to the subgroup of (a) Morphinans (b) Benzyl isoquinolines {c)_ Phthalide isoquinolines (4) Benzophenanthrenes 18, Antidote for paracetamol overdosing is (a) Atropine (b) N-Acetly cysteine {c) Glutathione (4) Theophylline 19. Which one of the following drug combination is contraindicated (a) Glyceryl triniwate and sikenafil (b) Amoxicillin and clavulanic acid (€) Losartan and hydrochlorothiazide (a) Pycimthemaine and sulfadoxine 20, Which sugar is suitable for diabetic patient (a) Fructose {h) Lactose () Mannitol (a) Sucratose 21, Headquarter of Bureau of Indian standards is situated at (a) New dethi (b) Mumbai (0. Kolkata (@) Chennai 22, Identity the structure of barbituric acid (b) i &) d) © 3. ° 4 «d) er R wr ch SL NN ¢ XX. we NX 4 wo, Ehtics for pharmacist are put forth by fa) PCL (») cpsco (© AICTE (4) WHO 24, What is the IUPAC name of the following compound (a) 23. {a) Bicyclo[2.2.2] octane (b) Tricyclo[2.2.2] ontane (9) Bicyclo[2.2.0] ontane (4) Bicyclo [2.2.1] heptanes27. 28. 29. 30. 31 32. 33. 34. 35. Morphine does not cause: (a) Constriction of pupil (b) CNS depression (©) Respiratory depression (@) Diarrhoea Which of the following is seed gum (P) Gaur gum (Q) Locust bean gum (R) Xanthan gum (S) Gellan gum (a) PandQ (b) Rands () QandR (@) Pands ‘The cancer that derived form ectoderm of endoderm of epithelial cells is (a) Carcinoma (b) Sarcoma (©) Leukaemia (@) Myloid Which of the following is/are marine anticancer (a) Trabectadine (b) Eribulin (0) Cytarabine (a) All of the above Identity the compound which is derived form typtophan (a) Pilocarpine (b) Ephedrine (©) Muscarine (4) Quinoline Opium, cocoa, poppy straw are given in (a) Schedule H (b) Schedule X (c) Narcotic drugs and Psychotropic substances act 1998 (a) Scheduk Which of the following will be inert in NMR spectrometry (a) 13¢ (b) 31P (q 2H (a) 1H What is the retionship between keto and enol tautomers (a) Resonance forms (b) Steriosomers (c) Constituonal isomers (A) Different conformations of the same compound Which of the following is following is true for natural killer cells (a) They may phagocytose tumor cells (b)_ Killing of cel is enhanced by interleukin-2, (0) They recognize and kill some virus-infected cells (4) Killing of cells is stimulated by prostaglandin £2 Evaluation of colour is tablets is done by (a} Reflectance spectrophotometer (b) Tristimulus colorimeter (c) Microreflectance photometer (d) All of the above he disintegration time of the effervescent tablets is (a) 2 minutes (b) 2.4 minutes (©) 3.5 minutes (4) S minutes36, Identify the false statements about magmas: (P) The addition of suspending agents to magmas is always necessary (Q) Magmas differ from gels in that their suspended particks are larger (R) Magmas are two- phase systems (8) Magmas basically are gets (a) PandQ (b) QandR (c) OnlyP (a) Onlys 37. All of the following ACE inhibitors are prodrugs EXCEP*T (@) Ramipril (b) Lisinopril (©) Enalapril (a) Perindopril 38, All of the following is resistant to both true and pseudo cholinesterase enzymes (@) Carbachol (b) Acetyicholine (©) Methacholine (4) Pilocarpine 39. Globuke size of parenteral emulsion should be (a) 0.1005 um (b) 05-5 pm (o) 5-10 pm () Any of the above 40. The objective of audit is to (a) Improve the product quality (b} Find out the fault (©) Improve the product value (d) Find and process fault and to improve a is an alkaloid derived form aliphatic amino acid (a) Reserpine (b) Nicotinic acid (©) Anabasine (a) Vinbbstine 42. The drug sulphan blue is obtained from source (@) Phnt (b) Animal (6) Synthetic (@) Mineral 43. Inmammals, The major fat in adipose tissue ist hrtpy//wwrw.samstudy.com (a) Triglyceride (b) Cholesterol (©) Sphingophospholipids (a) Phospholipids 44, Dovers powder used as a diaphoretic contal (a) Ipecac & Opium (b) Ipecac, Senna & Cinchona (©) Opium, Ipecac & Cinchona (@) all 45. Biological active form of Vit D in man is: (@) Cholecaleiferol (b) Caleifediol (0) Cabiferot (a) Cakeitriot 46, Actions and clinical uses of muscarinic cholinoceptor agonists include which on of the following (a) Bronchodilation (asthama) () Improved aqueous humor drainage (gaucoma) (0) Decreased gastrointestinal motility (diarrhea) (d) Decreased neuromuscular transmission and relaxation of skeletal muscke (During surgical anesthesia)47. Regarding the rok of surfactants in pharmaceutical suspensions for oral administration which of the following statements is false (a) Surfactants decrease the water contact angk of dispersed drug partice (b) Surfactants promote flocculation (c) Surfactants with high HLB stabilize oral suspensions (d) Surfactants increase the viscosity of the continuous phase of pharmaceutical suspensions 48. Which of the following drug is NOT used in treatment of H. Pylori infeetion (a) Ampiciliin (b) Clarithromycin (0) Mosapride (d) Bismuth subgalate 49, The most suitable disinfectant for decontamination of HIV contaminated endoscope is (a) 1% Sodium hypochlorite (b) 2% Glutarakiehyde (0) 5% phenol (a) 70% ethanol 50. Which rub does provide the most accurate method to calculate the dose for chikl based on adult dose (a) Age is months (b) Age in years (©) Weight in pounds (d) Body surface area 51. Chemokine co-receptor 5 (CCR 5 ) inhibitor is {a) Enfuvirtide (b) Maraviroc (©) Raltegravir (@) Atazanavir 52. The Franz diffusion cell which is used for the evaluation of transdermal drug delivery systems consists of: (a) 1 chamber (0) 2 chamber (©) 3 chamber (a) None 53. Whick of the following plastic is transparent and flexible {a) Silicon rubber (b) PVP (©) HDPED (a) PE 54. In which method an order of a fixed number of items is placed every time an inventory kvel falls to a predetermined point (@) A-B-Cmethod (>) Maximum and minimum method (0) Open-to-buy method (@) Economie order quantity 55. Choose the option with two reducing sugars (a) Lactose and maltose (b) Trehalose and surcrose (0. Maltose and wedhalose (@) Economic order quantity 56. The Local anesthetic with highest cardiotoxicity is (a) Lingocaine (b) Bupivacaine (0) Levo- bupivacaine (A) Procaine 57. Homatropine is (a) (c) Tropine methyl bromide ester of mencelic acid (4) Tropine ester of amino formic acid vropine ester of amino acetic acid (b) Tropine ester of mendelic acid 58. Tranexamic acid is (a) Antithrombotic (hb) Antifibrinolytic (€) Fibrinolytic (a) Syptic60. 61. 62. 63. 64. 65. 66. 67. Which of the antihistaminic compound has antiadrogenic effect (2) Famotidine (b) Ranitidine (©) Nizatidine (4) Cimetidine Which of the following drug is used prefenntially as preanesthetic mediation (@) Midazolam (b) Oxazepam (0 Alprazokm (d) Nitwozepam Proton pump inhibitors are most effective when given (a) Half hour before meals (b) With meal (©) After prolonged fasting (4) Along with 112 blockers Match compounds is Group I with inhibitory activities in Group Ik Group [ Group II (P) Vancomycin (1) Folate metabolism (Q) Rifampin (2) DNA synthesis (8) Puromycin (3) Protein synthesis (S) Ciprofloxacin (4) RNA synthesis (5) Cell wall systhesis (a) P5,Q4,R3,8-2 (b) P-4,Q-3, R-4,5-2 (©) P-4,Q4,R:3,$-2 (d) P-5,Q-3, R-2,5-4 Formation of Okazaki occurs in (a) Transcription (b) Replication (c) Transktion (d) Reverse Transcription Drug used in ventricular arrhythmia ts (a) Flecainide (b) Verapamil (O Esmolol (4) Diltazem ‘The lipoprotein with the fastest electrophoretic mobility and the lowest TG content is (2) VLDL. (o) HDL. () LDL (4) Chylomicrons As per schedule 'Y’ of the drugs and cosmetics act, the animal toxicity study requirements for marketing of a drug depends upon tentative route and duration of administration in humans. In This context , which one of the following statements is incorrect (a) Singk cose human use-animal toxicity for 2 weeks in 2 species (b) Oral use for 2 weeks in humans- animal toxicity for 4 week in 2 species (0) Aerosol use by repeated use in humans- animal toxicity for 24 weeks in 2 species (4) Multiple daily ocular application for short duration-iregation test in 1 species for 3 weeks For determining the efficacy of sterilization in an autoclave, the spores of the following organism are used as test organisms (a) Bacillus cereus (b) Clostridium peftingens (©) Bacillus stearothemophilus (d) Clostridium histolyticum68. Which of the following pairs is mismatched (a) Aerobic, helical bacteria- gram negative (b) Entrics- gram negative (©) Myconbacteria ~ acid fase (d) Pseudomonas ~gram positive 69. Listof drugs whose import, manufacture and sale, labeling and packaging are governed by special provisions are included in schedule (@ x (b) K (OH (@ Gc 70. Sigma minus method is used in assessment of (a) Bioavailability (b) Absorption {c) Metabolism (d) Tissue distribuation 71. Which of the pnt family contains voltike oil in their trichome (a) Rutaceae (b) Papaveracease (Q Umbelliferare (a) Laminaceae 72. Ferritinis: (@) Coenzyme (b) The stored form of tron (¢) Non-protein moiety (d) Isoenzyme 73. Which oil is solute is alcohol (a) Arachis (0) Castor oil (@) Corn oil 74. One of the first step ofthe citric acid cyck is isomerization of citric acid to isoctiricacid this step is necessary (b) Sesame oil because (a) Oxidation of secondary alcohols is very difficult le (b) Reduction of secondary akohol is very impos (0) Reduction of tertiary akohols would require a very powerful oxidizing agent (d) Oxidation of tertiary alcohols would require o 75. Which of the following alkyl halides woukl undergo SN2 reaction most rapidly izing agents (a) CHCH,-BR (b) CH,CH,-Cl. ( cH,cH,t (a) cH,CH,, 76. Mechanism of action of Ketoconazole is: (@) Inhibits Ergosterol synthesis (b) Inhibits DNA gyrase (0) Inhibits dihydropteroate synthetase (d) Induces translation misreading 77. Allare adrenal gland over activity disorders EXCEPT (a) Addison's disease (b) Conn's syndrome (©) Cushing's syndrome (a) Cushing's disease 78, The oil used in a parenteral product cannot contain. (a) WEI (b) Parffin oil (c) Peanut oil (a) Glycerine 79, Identity the non-absorbable sature (a) Catgut suture (b) Chromic catgut suture (©) Silk suture (4) Polydioxanone suture80, The relative lowering of vapour pressure is given by {a) Raoult’s aw (b) Henry's bw () Boyk's bw (d) Charks bw 81. Identity the functional group present in meprobamate (a) Amide 82, Match the following (P) Gypsum salt (Q) Epson salt (R) Alum (S) Green vitriol (a) Pl, Q-2, Red, $-3 (6) P4,Q-3, RA, 5-2 83. Tinea capitis is ringworm infection of (a) Feet (b) Groin (b) Ester (o) Carbamie (@) Lactam (1) KAI(S0,), 12H,0 (2) FeSO, -7H,0 (3) CaS0,.2H,0 (4) MgSO, -7H,0 (b) P-3,Q-4, Rel, $-2 (d)_P-2, Q-4, R-1, $-3 (©) Head (a) Nails 84. Ranlcthe following compoundsis order of increasing reactivity in electrophilic aromatic Substitution reactions () C,H, (@) Q) CH,CH,C=CH () CHl,C=CcH, () CH,CHCH,CH, 115. In the carbon NMR, in what region of the spectrum does ane typically observe carbons which are part of the aromatic ring (a) -10-0 ppm (b) 40-60 ppm {Q) 80-100 ppm (d) 120-150 ppm 116, Meclofenamate belongs to which class of drug (a) Slicyltes (b) Oxicams () Aryl antaranillic acid (a) p-Amino phenols 117. Match the following crude with their chemical constituents (P) Aloe (1) Hesperidine (Q) Ginger (2) Palmitin (R) Lemon peel (3) Barbaloin (S) Olive oil (4) Allin (a) P-4,Q-3,R-2, $-1 (b) P-3,Q-4,R-2,S-1 (OQ P3,Q-4,. RL S-2 (d) P83, QL, RL S-4 118. Dopamine agonists with tetralene function (a) Ropinorole (b) Pirebidil (0) Pramipixok (d) Rotigotine 119. The IUPAC name of the compound-(CH,),CHCH, Cl: (a) 2-methyl-3-chloropropane () 1-chloro-3-mehtyl butane (0) 1-chloropentane (d) 2-mehtyb4-chlorobutane120. A powerful inhibitor of stomatal opening is (a) Auxin (b) Bytokinin (0) Gibberellin (d) Abscisic acid 121. Whatis the renal clearance of a substance, if its concentration in plasma is 10mg, concentration in urine is 100 mg and urine flow is 2 ml/min (a) 0.02 ml/min (b) 0.2 ml/min (9) 2ml/min (4) 20 ml/min 122. Aim of pharmacovigitance is (a) To monitor drug toxicity (b) To monitor unauthorized drug manufacture () To monitor rational use of drugs (d) To check and control drug costs 123, Phase zero studies is a/an (P) Exploratory investigational new drug study (Q) Human microdosingstudies (R) Step to speed up drug discovery/ development process (S) Mandatory by FDA (a) PandQ (b) QandR (c) PQandR (4) PQ Rands 124, Parenteral product must be: (a) Packed in bottle (b) Sterilized (c)_ Free from viable/living organism (4) Pyrogenic 125. Quinine present in highest amount in (a) C.calisaya (b) G.officinalis (0) G. edgeriana (4) ©. suecirubra ANSWER KEY GPAT 2014 id |[2ce [3b [4d [sb [eb [7d [ee (9b [ioe Vid [12d [Be [4c 1Sb 16d (17h | 18b 19a 20d 2ha22b 23a 2ha 25d | 26a | 27a | 2d Wh | 3b Bic | a2e | ake 34d 35d | 36c |37b | 38a 39a | 40d Mc 42 Ada Ada AS | 46b | A7-d [4B AT | 50d Sib (52h (53d S4d (5S-a | 56b | 57h |58b 59d | 60-a 61a (62a (6b 64a 65b | 66d | 67 | 6Bd — 69-a | 70 Thd | 72b Te Td 75¢ | 76a 77b | 7b 79-c | AO-a Blc | 82-b | Be Gha BSc | 86d | A7-d | 88-b BIb | 90-b 1a [92d (93d 94-c 95S-b 96d | 97-a_ | H-e —9F-d | 100-€ 101-a | 102-b | 103-d | 104-a | 105-b | 106-c | 107-< | 108-d 109-b | 110 Tba | i2b | 113d 114 115d | 160 | 17 | Bd 119A | 120-4 42i-d | 122-a | 123-¢ | 124-b | 125-¢Remix education (pharmacy) Vv Free study material Vv Daily pharma Quiz Vv Test series (Free) v Pharma realated Post V Full PDF books 7 Ward writen notes ~~. 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