SDE MGMT Snake-Bite
SDE MGMT Snake-Bite
SDE MGMT Snake-Bite
Common Krait
New Delhi
2005
© World Health Organization 2005
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Preface ............................................................................................... v
1. Introduction .................................................................................. 1
1.1 Venomous snakes of South-East Asia ..................................................... 1
1.2 Snake venoms ...................................................................................... 8
1.3 How common are snake bites? ............................................................. 9
1.4 How do snake bites happen? .............................................................. 11
1.5 How can snake bites be avoided? ....................................................... 11
Annex
1. Algorithm: Antivenom treatment of snakebite cases .................................... 61
2. Algorithm: Differentiating major asian snake
species by clincal symdrome ....................................................................... 62
3. Antivenoms for treatment of bites by South-East Asian snakes ...................... 63
4. Measurement of Central Venous Pressure ................................................... 66
5. Measurement of intracompartmental pressure in
tensely swollen snake-bitten limbs .............................................................. 67
The geographical area specifically covered by this publication extends from Pakistan
and the rest of the Indian subcontinent in the west through to the Philippines and
Indonesia in the east, excluding Tibet, China, Taiwan, Korea, Japan, the eastern islands
of Indonesia and New Guinea and Australia (Figure 1, inside of front cover).
Figure 1: Map of Asia showing the area specifically covered by the guidelines
I acknowledge the exellent help provided by Miss Eunice Berry (Centre for Tropical
Medicine, University of Oxford), who typed the several drafts of the manuscript, and
by Ms Vimolsri Panichyanon (Assistant Programme Coordinator, SEAMEOTROPMED
Network) and Drs Suvanee Supavej and Parnpen Viriyavejakul (Deputy Assistant
Deans for International Relations, Faculty of Tropical Medicine, Mahidol University)
who, under the overall direction of Professor Sornchai Looareesuwan, were
responsible for organising the meeting of the international panel of experts in Bangkok
on 29/30 November 1998.
David A Warrell
Oxford, December 1998
Introduction
Compressor
glandulae muscle Venom gland
Accessory
venom gland
Secondary
venom duct
Figure 3: Short, permanently erect, fangs of a Figure 5: North Indian or Oxus cobra (Naja
typical elapid (Thai monocellate cobra – Naja oxiana) (Copyright DA Warrell) Viperdae
kaouthia) (Copyright DA Warrell) have long fangs
Figure 7: Chinese cobra (Naja atra) Figure 8(a): Indo-Chinese spitting cobra (Naja Saimensis)
(Copyright DA Warrell) (Copyright DA Warrell)
Figure 9: Sumatran spitting cobra Figure 10: King cobra or hamadryad (Ophiophagus
(Naja sumatrana) (a) black phase hannah). The famous king cobra dance in Yangon,
(b) golden phase (Copyright DA Myanmar (Copyright DA Warrell)
Warrell)
Figure 11: Common krait (Bungarus caeruleus) Figure 12: Malayan krait (Bungarus candidus)
(Copyright DA Warrell) (Copyright DA Warrell)
Figure 15: Blue spotted sea snake (Hydrophis cyanocinctus) (Copyright DA Warrell)
Viperidae have long fangs which are normally folded up against the upper jaw
but, when the snake strikes, are erected (Fig 2). There are two subgroups, the typical
vipers (Viperinae) and the pit vipers (Crotalinae). The Crotalinae have a special sense
organ, the pit organ, to detect their warm-blooded prey. This is situated between the
nostril and the eye (Fig 16).
Figure 16: Head of a typical pit viper – white-lipped green pit viper (Trimeresurus albolabris)
showing the pit organ situated between the nostril and the eye (arrow head) (Copyright DA Warrell)
Figure 17(a): Russell’s vipers (Copyright DA Figure 17(b): Russell’s vipers (Copyright DA Warrell)
Warrell) Eastern subspecies (Daboia russelii specimen from India
siamensis); specimen from Myanmar
Figure 17(c): Russell’s vipers Figure 17(d): Russell’s vipers (Copyright DA Warrell)
(Copyright DA Warrell) Eastern specimen from Burma
subspecies (Daboia russelii
siamensis); specimen from Thailand
Figure 19: Northern saw-scaled viper (Echis Figure 20: Northern saw-scaled viper (Echis
sochureki) (Copyright DA Warrell) sochureki) (Copyright DA Warrell)
Figure 21: Hump-nosed viper (Hynpale hypnale). Figure 22: White-lipped green pit viper
Specimen from Sri Lanka (Copyright DA Warrell) (Trimeresurus albolabris) (Copyright DA
Warrell)
Although large snakes tend to inject more venom than smaller specimens of the
same species, the venom of smaller, younger vipers may be richer in some dangerous
components, such as those affecting haemostasis.
Bites by small snakes should not be ignored or dismissed. They should be taken
just as seriously as bites by large snakes of the same species.
Bangladesh – a survey of 10% of the country in 1988-9 revealed 764 bites with
168 deaths in one year. Cobra bites (34% of all bites) caused a case fatality of 40%.
India – estimates in the region of 200,000 bites and 15-20,000 snake bite deaths
per year, originally made in the last century, are still quoted. No reliable national
statistics are available. In 1981, a thousand deaths were reported in Maharashtra
State. In the Burdwan district of West Bengal 29,489 people were bitten in one year
with 1,301 deaths. It is estimated that between 35,000 and 50,000 people die of
snake bite each year among India’s population of 980 million.
Indonesia – no reliable data are available from this vast archipelago. Snake bites
and deaths are reported from some islands, eg Komodo, but fewer than 20 deaths
are registered each year.
Myanmar (Burma) – snake bites and snake bite deaths have been reliably reported
from colonial times. Russell’s vipers are responsible for 90% of cases. In 1991, there
were 14,000 bites with 1,000 deaths and in 1997, 8,000 bites with 500 deaths.
Under-reporting is estimated at 12%. There are peaks of incidence in May and June
in urban areas and during the rice harvest in October to December in rural areas.
Nepal – there are estimated to be at least 20,000 snake bites with about 200
deaths in hospitals each year, mainly in the Terai region. One survey suggested as
many as 1,000 deaths per year. Among 16 fatalities recorded at one rural clinic
during a monsoon season, 15 had died on their way to seek medical care.
Pakistan – there are an estimated 20,000 snake bite deaths each year
Philippines – there are no reliable estimates of mortality among the many islands
of thearchipelago. Figures of 200-300 deaths each year have been suggested. Only
cobras cause fatal envenoming, their usual victims being rice farmers.
Thailand – between 1985 and 1989, the number of reported snake bite cases
increased from 3,377 to 6,038 per year, reflecting increased diligence in reporting
rather than a true increase in snake bites; the number of deaths ranged from 81 to
183 (average 141) per year. In 1991 there were 1,469 reported bites with five deaths,
in 1992, 6,733 bites with 19 deaths and, in 1994, 8,486 bites with eight deaths.
Deaths reported in hospital returns were only 11% of the number recorded by the
Public Health Authorities. In a national survey of dead snakes brought to hospital by
the people they had bitten, 70% of the snakes were venomous species, the most
commonly brought species being Malayan pit viper (Calloselasma rhodostoma) 38%,
white-lipped green pit viper (Trimeresurus albolabris) 27%, Russell’s viper (Daboia
russelii siamensis) 14%, Indo-Chinese spitting cobra (Naja siamensis) 10% and
monocellate cobra (N kaouthia) 7%. In an analysis of 46 fatal cases in which the
snake had been reliably identified, Malayan kraits (Bungarus candidus) and Malayan
pit vipers were each responsible for 13 cases, monocellate cobras for 12 and Russell’s
vipers for seven deaths.
Viet Nam – there are an estimated 30,000 bites per year. Among 430 rubber
plantation workers bitten by Malayan pit vipers between 1993 and 1998, the case
fatality was 22%, but only a minority had received antivenom treatment. Fishermen
are still occasionally killed by sea snakes but rarely reach hospitals.
• Education! Know your local snakes, know the sort of places where they like
to live and hide, know at what times of year, at what times of day/night or
in what kinds of weather they are most likely to be active.
Farmers (rice)
Plantation workers (rubber, coffee)
Herdsmen
Hunters
Snake handlers (snake charmers and in snake restaurants and
traditional Chinese
pharmacies)
Fishermen and fish farmers
Sea snake catchers (for sea snake skins, leather)
• Be specially vigilant about snake bites after rains, during flooding, at harvest
time and at night.
• Try to wear proper shoes or boots and long trousers, especially when walking
in the dark or in undergrowth.
• Use a light (torch, flashlight or lamp) when walking at night.
• Avoid snakes as far as possible, including snakes performing for snake
charmers. Never handle, threaten or attack a snake and never intentionally
trap or corner a snake in an enclosed space.
• If at all possible, try to avoid sleeping on the ground.
• Keep young children away from areas known to be snake-infested.
• Avoid or take great care handling dead snakes, or snakes that appear to be
dead.
• Avoid having rubble, rubbish, termite mounds or domestic animals close to
human dwellings, as all of these attract snakes.
• Frequently check houses for snakes and, if possible, avoid types of house
construction that will provide snakes with hiding places (e.g. thatched rooves
with open eaves, mud and straw walls with large cracks and cavities, large
unsealed spaces beneath floorboards).
• To prevent sea snake bites, fishermen should avoid touching sea snakes
caught in nets and on lines. The head and tail are not easily distinguishable.
There is a risk of bites to bathers and those washing clothes in muddy water
of estuaries, river mouths and some coastlines.
Symptoms and
Signs of Snake Bite
Figure 25: Fang marks made by Russell’s viper Figure 26: Local bleeding from
(Copyright DA Warrell) fang marks made by Malayan pit
viper (Copyright DA Warrell)
Figure 28: Tissue necrosis following a bite by a Malayan pit viper (Copyright DA Warrell)
Figure 28(a): Tissue necrosis following a bite by an Indochinese spitting cobra (Naja siamensis)
(Copyright Sornchai Looareesuwan)
Cardiovascular (Viperidae)
Visual disturbances, dizziness, faintness, collapse, shock, hypotension, cardiac
arrhythmias, pulmonary oedema, conjunctival oedema (Fig 29)
Figure 29: Bilateral conjunctival oedema (chemosis) after a bite by a Burmese Russell’s viper
(Copyright DA Warrell)
Figure 32: Bilateral ptosis (a) in a patient bitten by a common krait (Copyright DA Warrell),
Bilateral ptosis (b) in a patient bitten by a Sri Lankan Russell’s viper (Copyright DA Warrell)
Figure 35: (a) Haemorrhagic infarction of the anterior pituitary (Sheehan’s-like syndrome) after a
bite by a Burmese Russell’s viper, (b) Patient bitten by a Burmese Russell’s viper three years
previously, showing clinical signs of panhypopituitarism: loss of secondary sexual hair and
testicular atrophy (Copyright DA Warrell)
Syndrome 1
Local envenoming (swelling etc) with bleeding/clotting disturbances = Viperidae
(all species)
Syndrome 2
Local envenoming (swelling etc) with bleeding/clotting disturbances, shock or renal
failure = Russell’s viper (and possibly saw-scaled viper – Echis species – in some
areas)
with conjunctival oedema (chemosis) and acute pituitary insufficiency = Russell’s
viper, Burma
with ptosis, external ophthalmoplegia, facial paralysis etc and dark brown urine =
Russell’s viper, Sri Lanka and South India
Syndrome 3
Local envenoming (swelling etc) with paralysis = cobra or king cobra
Syndrome 4
Paralysis with minimal or no local envenoming
Bite on land while sleeping, outside the Philippines = krait
in the Philippines = cobra (Naja philippinensis)
Bite in the sea = sea snake
Syndrome 5
Paralysis with dark brown urine and renal failure:
Bite on land (with bleeding/clotting disturbance) = Russell’s viper, Sri Lanka/South
India
Bite in the sea (no bleeding/clotting disturbances) = sea snake
If the “spat” venom enters the eyes, there is immediate and persistent intense burning,
stinging pain, followed by profuse watering of the eyes with production of whitish
discharge, congested conjunctivae, spasm and swelling of the eyelids, photophobia
and clouding of vision. Corneal ulceration, permanent corneal scarring and secondary
endophthalmitis are recognised complications of African spitting cobra venom but
have not been described in Asia.
Figure 38: Bilateral conjunctivitis in a patient who had venom spat into both eyes by an Indo-
Chinese spitting cobra (Naja siamensis) (Copyright DA Warrell)
Management of Snake
Bites in South-East Asia
Unfortunately, most of the traditional, popular, available and affordable first aid
methods have proved to be useless or even frankly dangerous. These methods include:
making local incisions or pricks/punctures (“tattooing”) at the site of the bite or in the
bitten limb, attempts to suck the venom out of the wound, use of (black) snake
stones, tying tight bands (tourniquets) around the limb, electric shock, topical
instillation or application of chemicals, herbs or ice packs.
Local people may have great confidence in traditional (herbal) treatments, but
they must not be allowed to delay medical treatment or to do harm.
As far as the snake is concerned – do not attempt to kill it as this may be dangerous.
However, if the snake has already been killed, it should be taken to the dispensary or
hospital with the patient in case it can be identified. However, do not handle the
snake with your bare hands as even a severed head can bite!
Figure 39: Pressure immobilisation method. Recommended first-aid for bites by neurotoxic
elapid snakes (by courtesy of the Australian Venom Research Unit, University of Melbourne)
Ideally, compression bandages should not be released until the patient is under
medical care in hospital, resuscitation facilities are available and antivenom treatment
has been started (see Caution below).
Pressure bandaging is not recommended for bites by vipers and cobras whose
venoms cause local necrosis.
The use of a local compression pad applied over the wound, without pressure
bandaging of the entire bitten limb, has produced promising results in Myanmar and
deserves further study.
The following are examples of clinical situations in which snake bite victims
might require urgent resuscitation:
The patient should be asked how much urine has been passed since the bite and
whether it was a normal colour.
Physical examination
This should start with careful assessment of the site of the bite and signs of local
envenoming.
A bitten limb may be tensely oedematous, cold, immobile and with impalpable
arterial pulses. These appearances may suggest intravascular thrombosis, which is
exceptionally rare after snake bite, or a compartmental syndrome, which is
uncommon. If possible, intracompartmental pressure should be measured (see
Annex 5) and the blood flow and patency of arteries and veins assessed (eg by doppler
ultrasound).
General examination
Measure the blood pressure (sitting up and lying to detect a postural drop indicative
of hypovolaemia) and heart rate. Examine the skin and mucous membranes for
evidence of petechiae, purpura, ecchymoses and, in the conjunctivae, chemosis.
Thoroughly examine the gingival sulci, using a torch and tongue depressor, as these
may show the earliest evidence of spontaneous systemic bleeding. Examine the nose
for epistaxis. Abdominal tenderness may suggest gastrointestinal or retroperitoneal
bleeding. Loin (low back) pain and tenderness suggests acute renal ischaemia (Russell’s
viper bites). Intracranial haemorrhage is suggested by lateralising neurological signs,
asymmetrical pupils, convulsions or impaired consciousness (in the absence of
respiratory or circulatory failure).
Neurotoxic envenoming
To exclude early neurotoxic envenoming, ask the patient to look up and observe
whether the upper lids retract fully (Fig 40). Test eye movements for evidence of
early external ophthalmoplegia (Fig 33). Check the size and reaction of the pupils.
Ask the patient to open their mouth wide and protrude their tongue; early restriction
in mouth opening may indicate trismus (sea snake envenoming) or more often paralysis
of pterygoid muscles (Fig 41). Check other muscles innervated by the cranial nerves
(facial muscles, tongue, gag reflex etc). The muscles flexing the neck may be paralysed,
giving the “broken neck sign” (Fig 42).
Figure 40: Examination for ptosis, Figure 41: Inability to open the mouth and protrude the
usually the earliest sign of neurotoxic tongue in a patient with neurotoxic envenoming from
envenoming (Copyright DA Warrell) the Malayan krait (Copyright DA Warrell)
Figure 42: Broken neck sign in a child envenomed by a cobra in Malaysia (Copyright the late
HA Reid)
Generalised rhabdomyolysis
In victims of envenoming by sea snakes and Russell’s vipers in Sri Lanka and South
India, muscles, especially of the neck, trunk and proximal part of the limbs, may
become tender and painful on active or passive movement and later may become
paralysed. In sea snake bite there is pseudotrismus that can be overcome by sustained
pressure on the lower jaw. Myoglobinuria may be evident 3 hours after the bite.
Species diagnosis
If the dead snake has been brought, it can be identified. Otherwise, the species
responsible can be inferred indirectly form the patient’s description of the snake and
the clinical syndrome of symptoms and signs (see above and Annex 1 & 2). This is
specially important in Thailand where only monospecific antivenoms are available.
• Place a few mls of freshly sampled venous blood in a small glass vessel
• Leave undisturbed for 20 minutes at ambient temperature
• Tip the vessel once
• If the blood is still liquid (unclotted) and runs out, the patient has hypo-
fibrinogenaemia (“incoagulable blood”) as a result of venom-induced
consumption coagulopathy
• In the South East Asian region, incoagulable blood is diagnostic of a viper bite
and rules out an elapid bite
• Warning! If the vessel used for the test is not made of ordinary glass, or if it
has been used before and cleaned with detergent, its wall may not stimulate
clotting of the blood sample in the usual way and test will be invalid
• If there is any doubt, repeat the test in duplicate, including a “control” (blood
from a healthy person)
Blood film: fragmented red cells (“helmet cell”, schistocytes) are seen when
there is microangiopathic haemolysis.
Arterial blood gases and pH may show evidence of respiratory failure (neurotoxic
envenoming) and acidaemia (respiratory or metabolic acidosis).
Antivenom is the only specific antidote to snake venom. A most important decision
in the management of a snake bite victim is whether or not to give antivenom.
What is antivenom?
Antivenom is immunoglobulin (usually the enzyme refined F(ab)2 fragment of IgG)
purified from the serum or plasma of a horse or sheep that has been immunised with
the venoms of one or more species of snake. “Specific” antivenom, implies that the
antivenom has been raised against the venom of the snake that has bitten the patient
and that it can therefore be expected to contain specific antibody that will neutralise
that particular venom. Monovalent or monospecific antivenom neutralises the venom
of only one species of snake. Polyvalent or polyspecific antivenom neutralises the
venoms of several different species of snakes, usually the most important species,
from a medical point of view, in a particular geographical area. For example, Haffkine,
Kasauli, Serum Institute of India and Bengal “polyvalent anti-snake venom serum” is
raised in horses using the venoms of t he four most important venomous snakes in
India (Indian cobra, Naja naja; Indian krait, Bungarus caeruleus; Russell’s viper, Daboia
russelii; saw-scaled viper, Echis carinatus). Antibodies raised against the venom ofone
species may have cross-neutralising activity against other venoms, usually from closely
related species. This is known as paraspecific activity. For example, the manufacturers
of Haffkine polyvalent anti-snake venom serum claim that this antivenom also
neutralises venoms of two Trimeresurus species.
Antivenom treatment carries a risk of severe adverse reactions and in most countries
it is costly and may be in limited supply. It should therefore be used only in patients
in whom the benefits of antivenom treatment are considered to exceed the risks.
Systemic envenoming
• Haemostatic abnormalities: spontaneous systemic bleeding (clinical),
coagulopathy (20WBCT or other laboratory) or thrombocytopenia (<100 x
109/litre) (laboratory)
• Neurotoxic signs: ptosis, external ophthalmoplegia, paralysis etc (clinical)
• Cardiovascular abnormalities: hypotension, shock, cardiac arrhythmia (clinical),
abnormal ECG
• Acute renal failure: oliguria/anuria (clinical), rising blood creatinine/ urea
(laboratory)
• (Haemoglobin-/myoglobin-uria:) dark brown urine (clinical), urine dipsticks, other
evidence of intravascular haemolysis or generalised rhabdomyolysis (muscle
aches and pains, hyperkalaemia) (clinical, laboratory)
• Supporting laboratory evidence of systemic envenoming (see 4.5, page 30)
Local envenoming
• Local swelling involving more than half of the bitten limb (in the absence of a
tourniquet) Swelling after bites on the digits (toes and especially fingers)
• Rapid extension of swelling (for example beyond the wrist or ankle within a
few hours of bites on the hands or feet)
• Development of an enlarged tender lymph node draining the bitten limb
Skin and conjunctival “hypersensitivity” tests may reveal IgE mediated Type I
hypersensitivity to horse or sheep proteins but do not predict the large majority of
early (anaphylactic) or late (serum sickness type) antivenom reactions. Since they
may delay treatment and can in themselves be sensitizing, these tests should not
be used.
Selection of antivenom
Antivenom should be given only if its stated range of specificity includes the species
known or thought to have been responsible for the bite. Liquid antivenoms that have
become opaque should not be used as precipitation of protein indicates loss of
activity and an increased risk of reactions.
Expiry dates quoted by manufacturers are often very conservative. Provided that
antivenom has been properly stored, it can be expected to retain useful activity for
many months after the stated “expiry date”.
Administration of antivenom
Although the risk of antivenom reactions is less with intramuscular than intravenous
administration, epinephrine (adrenaline) must be readily available. Patients must be
closely observed for at least one hour after starting intravenous antivenom
administration, so that early anaphylactic antivenom reactions can be detected and
treated early with epinephrine (adrenaline).
Antivenom should never be injected into the gluteal region (upper outer quadrant
of the buttock) as absorption is exceptionally slow and unreliable and there is
always the danger of sciatic nerve damage when the injection is given by an
inexperienced operator.
Dose of antivenom
Snakes inject the same dose of venom into children and adults. Children must
therefore be given exactly the same dose of antivenom as adults.
Since the neutralising power of antivenoms varies from batch to batch, the results
of a particular clinical trial may soon become obsolete if the manufacturers change
the strength of the antivenom.
Antivenom reactions
A proportion of patients, usually more than 20%, develop a reaction either early
(within a few hours) or late (5 days or more) after being given antivenom.
In most cases, these reactions are not truly “allergic”. They are not IgE-mediated
type I hypersensitivity reactions to horse or sheep proteins as there is no evidence of
specific IgE, either by skin testing or radioallergosorbent tests (RAST). Complement
activation by IgG aggregates or residual Fc fragments or direct stimulation of mast
cells or basophils by antivenom protein are more likely mechanisms for these reactions.
Late (serum sickness type) reactions develop 1-12 (mean 7) days after treatment.
Clinical features include fever, nausea, vomiting, diarrhoea, itching, recurrent urticaria,
arthralgia, myalgia, lymphadenopathy, periarticular swellings, mononeuritis multiplex,
proteinuria with immune complex nephritis and rarely encephalopathy. Patients who
suffer early reactions and are treated with antihistamines and corticosteroid are less
likely to develop late reactions.
Additional treatment
After epinephrine (adrenaline), an anti H1 antihistamine such as chlorpheniramine
maleate (adults 10 mg, children 0.2 mg/kg by intravenous injection over a few minutes)
should be given followed by intravenous hydrocortisone (adults 100 mg, children
2 mg/kg body weight). The corticosteroid is unlikely to act for several hours, but may
prevent recurrent anaphylaxis.
In pyrogenic reactions the patient must also be cooled physically and with
antipyretics (for example paracetamol by mouth or suppository). Intravenous fluids
should be given to correct hypovolaemia.
Prednisolone: adults 5 mg six hourly, children 0.7 mg/kg/day in divided doses for
5-7 days
Recurrent neurotoxic envenoming after treatment of cobra bite has also been
described.
If the blood remains incoagulable (as measured by 20WBCT) six hours after the
initial dose of antivenom, the same dose should be repeated. This is based on the
observation that, if a large dose of antivenom (more than enough to neutralise the
venom procoagulant enzymes) is given initially, the time taken for the liver to restore
coagulable levels of fibrinogen and other clotting factors is 3-9 hours.
Renal failure: conservative treatment or dialysis (see Oliguria and renal failure,
page 42).
Neurotoxic envenoming
Antivenom treatment alone cannot be relied upon to save the life of a patient with
bulbar and respiratory paralysis.
Although artificial ventilation was first suggested for neurotoxic envenoming 125
years ago, patients continue to die of asphyxiation because some doctors believe
that antivenom is sufficient treatment.
Trial of anticholinesterase
• Baseline observations
• Give atropine intravenously
• Give anticholinesterase drug
• Observe effect
• If positive, institute regular atropine and (long acting) anticholinesterase
This is usually the result of hypovolaemia (from loss of circulating volume into the
swollen limb, or internal/external haemorrhage), venom-induced vasodilatation or
direct myocardial effects with or without arrhythmias. Ideally, treatment with plasma
expanders (colloids or crystalloid) should be controlled by observation of the central
venous pressure (jugular venous pressure or direct measurement of pressure in the
superior vena cava via a catheter connected to a saline manometer, see Annex 4).
Excessive volume replacement may cause pulmonaryoedema when plasma
extravasated in the bitten limb and elsewhere is reabsorbed into the circulation.
In victims of Russell’s viper bites in Myanmar and South India, acute pituitary
adrenal insufficiency resulting from haemorrhagic infarction of the anterior pituitary
may contribute to shock. Hydrocortisone is effective in these cases.
(9) Dialysis
• correct hypovolaemia (see above) and maintain saline diuresis (if possible)
• correct severe acidosis with bicarbonate (see above)
• give a single infusion of mannitol (200 ml of 20% solution over 20 minutes)
Haemostatic disturbances
Bleeding and clotting disturbances usually respond satisfactorily to treatment with
specific antivenom, but the dose may need to be repeated several times, at six hourly
intervals, before blood coagulability (assessed by the 20WBCT) is finally and
permanently restored.
Antifibrinolytic agents are not effective and should not be used in victims of
snake bite.
Bacterial infections
Infection at the time of the bite with organisms from the snake’s venom and buccal
cavity is a problem with some species such as the Malayan pit viper. In this case, a
prophylactic course of penicillin (or erythromycin for penicillin-hypersensitive patients)
and a single dose of gentamicin or a course of chloramphenicol, together with a
booster dose of tetanus toxoid is recommended. Interference with the wound
(incisions made with an unsterilised razor blade/knife etc) creates a risk of secondary
bacterial infection and justifies the use of broad spectrum antibiotics (eg amoxycillin
or a cephalosporin plus a single dose of gentamicin plus metronidazole).
4.9 Rehabilitation
Restoration of normal function in the bitten part after the patient has been discharged
from hospital is not usually supervised. Conventional physiotherapy may well
accelerate this process. In patients with severe local envenoming, the limb should be
maintained in a functional position. For example, in the leg, equinus deformity of
the ankle should be prevented by application of a back slab.
Management of Cobra
Spit Ophthalmia
First aid consists of irrigating the affected eyes and other mucous membranes with
liberal quantities of water or any other available bland liquid. Instillation of 0.5%
adrenaline drops relieves pain and inflammation. In view of the risk of corneal abrasion,
fluorescein staining or slit lamp examination is essential. Otherwise, topical
antimicrobials (tetracycline or chloramphenicol) should be applied to prevent
endophthalmitis or blinding corneal opacities. Some ophthalmologists recommend
the use of a dressing pad to close the eye.
The instillation of diluted antivenom may cause local irritation and is of uncertain
benefit. It is not recommended.
1. It is clear that in many parts of the South East Asian region, snake bite is an
important medical emergency and cause of hospital admission. It results in the
death or chronic disability of many active younger people, especially those
involved in farming and plantation work. However, the true scale of mortality
and acute and chronic morbidity from snake bite remains uncertain because of
inadequate reporting in almost every part of the region.
3. Despite its importance, there have been fewer proper clinical studies of snake
bite than of almost any other tropical disease. Snake bites probably cause more
deaths in the region than do Entamoeba histolytica infections but only a small
fraction of the research investment in amoebiasis has been devoted to the study
of snake bite.
6. Most of the familiar methods for first-aid treatment of snake bite, both western
and “traditional/herbal”, have been found to result in more harm (risk) than
good (benefit). Their use should be discouraged and they should never be allowed
to delay the movement of the patient to medical care at the hospital or dispensary.
7. Diagnosis of the species of snake responsible for the bite is important for optimal
clinical management. This may be achieved by identifying the dead snake or by
inference from the “clinical syndrome” of envenoming.
8. Antivenom is the only effective antidote for snake venom. However, it is usually
expensive and in short supply and its use carries the risk of potentially dangerous
reactions.
9.
10.
11.
12.
Fasciotomy should not be carried out in snake bite patients unless or until
haemostatic abnormalities have been corrected, clinical features of an
intracompartmental syndrome are present and a high intracompartmental pressure
has been confirmed by direct measurement.
Further Reading
Bhat RN (1974). Viperine snake bite poisoning in Jammu. J Indian Med Assoc 63:
383-392.
Bhetwal BB, O’Shea M, Warrell DA (1998). Snakes and snake bite in Nepal. Tropical
Doctor 28: 193-5.
Bücherl W, Buckley EE & Deulofeu V (eds) (1968, 1971). Venomous animals and
their venoms. Vols 1 and 2. Academic Press, New York.
Gans C & Gans KA (eds) (1978). Biology of the reptilia. Vol 8. Academic Press, London.
Lee C-Y (ed) (1979). Snake venoms. Handbook of experimental pharmacology. Vol
52. Springer-Verlag, Berlin.
Matsen FA (1980). Compartmental syndromes. New York: Grune & Stratton. May
Mya Win (1996). Snake bite control for primary health care providers. 1st edition.
WHO Snake Bite control Project, Myanmar.
Reid HA, Thean PC, Chan KE, Baharom AR (1963). Clinical effects of bites by Malayan
viper (Ancistrodon rhodostoma). Lancet i: 617-21.
Reid HA (1975). Epidemiology of sea snake bites. J Trop Med Hyg 78: 106-113.
Reid HA, Chan KE & Thean PC (1963). Prolonged coagulation defect (defibrination
syndrome) in Malayan viper bite. Lancet i: 621-626.
Reid HA & Lim KJ (1957). Sea snake bite. A survey of fishing villages in northwest
Malaya. BMJ 2: 1266-1272.
Reid HA, Thean PC & Martin WJ (1963). Specific antivenene and prednisone in
viper bite poisoning: controlled trial. BMJ 2: 1378-1380.
Sitprija V, Boonpucknavig V (1979). Snake venoms and nephrotoxicity. In: Lee C-Y
(ed). Snake venoms. Handbook of Experimental Pharmacology 52: 997-1018.
Swaroop S & Grab B (1954). Snake bite mortality in the world. Bull World Health
Org 10: 35-76.
Theakston RDG et al (1990). Bacteriological studies of the venom and mouth cavities
of wild Malayan pit vipers (Calloselasma rhodostoma) in southern Thailand. Trans
Roy Soc Trop Med Hyg 84: 875-879.
Thorpe RS, Wüster W, Malhotra A (eds) (1997). Venomous snakes. Ecology, evolution
and snake bite. Symposia of the Zoological Society of London No 70, Clarendon
Press, Oxford.
Tin-Nu-Swe et al (1993). Renal ischaemia, transient glomerular leak and acute renal
tubular damage in patients envenomed by Russell’s vipers (Daboia russelii siamensis)
in Myanmar. Trans Roy Soc Trop Med Hyg 87: 678-681.
Tun-Pe et al (1987). Acute and chronic pituitary failure resembling Sheehan’s syndrome
following bites by Russell’s viper in Burma. Lancet ii: 763-7.
Tun-Pe et al (1995). Local compression pads as a first-aid measure for victims of bites
by Russell’s viper (Daboia russelii siamensis) in Myanmar. Trans Roy Soc Trop Med
Hyg 89: 293-295.
Warrell DA, Arnett C (1976). The importance of bites by the saw-scaled or carpet
viper (Echis carinatus). Epidemiological studies in Nigeria and a review of the world
literature. Acta Tropica Basel 33: 307-341.
Warrell DA (1986). Tropical snake bite: clinical studies in South-East Asia. In: Harris
JB (ed). Natural Toxins. Animal, plant and microbial. Clarendon Press, Oxford pp 25-
45.
Warrell DA (1989). Russell’s viper: biology, venom and treatment of bites. Trans Roy
Soc Trop Med Hyg 83: 732-40.
Warrell DA (1992). The global problem of snake bite: its prevention and treatment.
In: Recent Advances in Toxinology Research [Gopalakrishnakone P, Tan CK (eds)],
National University of Singapore, Vol 1, pp 121-153.
Watt G et al (1988). Tourniquet application after cobra bite: delay in the onset of
neurotoxicity and the dangers of sudden release. American J Trop Med & Hyg 38:
618-622.
Algorithm: Antivenom
Treatment of Snakebite Cases
Patient presents with
history of snakebite
No Yes
Treatment*
observe in hospital Yes Snake defintely
for 24 hours non-venomous
No Yes
Treatment
Signs diagnostic of
envenoming by a Signs of Reassure, give
envenoming tetanus toxoid
particular species present then discharge
found in this
geographical area Yes No
(see algorithm 2) Treatment*
Signs meet criteria No Observe in hospital
Yes
for antivenom
No treatment for 24 hours
Yes
Signs meet criteria Appropriate
for antivenom monospecific or
treatment polyspecific
antivenom available No
No Yes
Yes
Treatment* Treatment* Treatment* Treatment*
Give polyspecific Give appropriate Treat conservatively
Observe in hospital
antivenom covering monospecific or (refer to section
for 24 hours
medically important polyspecific 5.6.16)
species in this antivenom
geographical area
Check response
Treatment* Treatment*
No Yes Yes No
Treatment*
Non-clotting Observe in
In Sri Lanka or Bitten on
blood (20WBCT) hospital for
South India the land
or spontaneous 24 hours
systemic bleeding
Yes No Yes
No Yes No
1. China
Shanghai Institute of Biological Products, Ministry of Health, 1262 Yan An Road (W),
Shanghai 200052, China (Tel ++ 8621-62803189; Fax ++ 8621-62801807).
Contact: Ms Minzhi Lu, Manager, International Affairs & Trade Department
(Tel ++ 8621-62805234)
2. Germany
Knoll AG, Postfach 21 08 05, 67008 Ludwigshafen, Germany (Tel ++ 49621-
5892688; Fax ++ 49621-5893707). Contact: Mr Lok, Managing Director
(liquid antivenom, 10 ml/ampoule)
• Cobra monospecific antivenom (Naja naja sputatrix = Malaysian N sumatrana)
3. India
(a) Bengal Chemicals & Pharmaceuticals, 6 Ganesh Chunder Avenue, Calcutta
(Fax ++91 33 2257697)
(liquid antivenom)
• Polyvalent (Bungarus caeruleus, Naja naja, Vipera russelli, Echis carinatus)
(c) Haffkine Biopharmaceutical Company Ltd, Acharya Donde Marg, Parel, Bombay
400012 (Tel ++ 91-224129320 and 234129224; Fax ++ 91 41 68578; Telex
11.71427 HBPC IN)
(lyopholised antivenoms, 10 ml/ampoule)
• Polyvalent anti-snake venom serum (B caeruleus, E carinatus, N naja, V russelli)
(e) Serum Institute of India Ltd, 212/2 Hadapsar, Pune-411 028 (Tel ++ 91-
212672016; Fax ++ 91-212672040; Telex 145-7317 SERA IN, 145-7216 SEAL
IN) Contact: Dr SS Jadhav, Executive Director (QA)
(lyopholized antivenoms)
• Polyvalent (B caeruleus, N naja, V russelli, E carinatus)
• Bivalent (E carinatus, V russelli)
4. Indonesia
Perum Bio Farma (Pasteur Institute), Jl Pasteur 28, Post Box 1136, Bandung 40161
(Tel ++ 6222-83755; Fax ++ 6222-210299; Telex 28432 BIOFAR IA)
(liquid antivenom, 5 ml/ampoule)
• Polyvalent antivenom serum (Calloselasma rhodostoma, B fasciatus, N
sputatrix)
5. Iran
State Serum & Vaccine Institute, Razi Hessarek, bP 656, Teheran
(Tel ++ 98 2221 2005)
(liquid antivenoms, 10 ml/ampoule)
• Polyvalent snake antivenom (equine) (said to neutralise the venoms of two
South-East Asian species – Naja oxiana and Echis carinatus (probably E sochureki),
Vipera lebetina (= Macrovipera lebetina) and Pseudocerastes persicus
6. Myanmar (Burma)
Myanmar Pharmaceutical Factory, Yangon
(lyophilized and liquid antivenoms, 10 ml/ampoule)
• Viper antivenom (V russelli)
• Cobra antivenom (N kaouthia)
8. Philippines
Biologicals Production Service, Dept of Health, Los Baños, Laguna
(liquid antivenom)
• Philippine cobra antivenin (Naja philippinensis)
9. Taiwan
National Institute of Preventive Medicine, 161 Kun-Yang Street, Nan-Kang, Taipei,
ROC 11513 (Tel ++ 8862-7859215; Fax ++ 8862-7853944). Contact: Dr Gong-
Ren Wang, Director
(lyophilised antivenoms, 10 ml/ampoule)
• Bungarus multicinctus and N atra bivalent antivenom
• Trimeresurus muquosquamatus and Trimeresurus grammineus (= T stejnegeri)
bivalent antivenom
• Agkistrodon acutus (= Deinagkistrodon acutus) antivenom
10. Thailand
The Thai Red Cross Society, Queen Saovabha Memorial Institute, 1871 Rama VI
Road, Bangkok 10330 (Tel ++ 662-2520161-4; Fax ++ 662-2540212; Telex 82535
THRESCO TH)
(freeze dried monovalent antivenoms, 10 ml/ampoule)
• Cobra antivenom
• King cobra antivenin
• Banded krait antivenin
• Russell’s viper antivenin
• Malayan pit viper antivenin
• Green pit viper antivenin
Measurement of
Central Venous Pressure
In seriously ill patients with shock or renal failure in whom clinical assessment of the
jugular venous pressure is difficult or considered inaccurate, a central venous catheter
should be inserted percutaneously. In those with no haemostatic problems, a catheter
may be inserted into the jugular or subclavian vein provided adequate facilities for a
sterile procedure and subsequent nursing are available. However, patients who have
been bitten by vipers may have obvious haemostatic problems or may develop
coagulopathy. In these cases, the antecubital approach is by far the safest as
haemostasis can be achieved by local pressure. A long catheter (at least 50-70 cm for
an adult) is required (Fig 45). The catheter is connected via a three-way tap and
pressure tubing to a manometer. The whole system is filled with sterile isotonic saline.
Before readings can be taken, the zero on the manometer must be aligned as
accurately as possible with the horizontal plane of the left atrium. A simple spiritlevel
(eg a 20 ml glass ampoule with bubble, taped to a ruler) can be used to locate the
manometer zero at the same height as an appropriate chest-wall landmark, such as
the midaxillary line, in the supine patient (Fig 46) or the sternal angle in a patient
sitting up at 45o. There should be strict attention to asepsis. Infection and thrombosis
are potential complications; especially if the catheter remains in place for a long time.
Figure 45: Central venous pressure Figure 46: Adjusting the zero point of the central
monitoring in a patient with shock after venous pressure manometer to the mid-axillary
Russell’s viper bite, in a township hospital line, using a home-made ruler-plus-glass-ampoule
in rural Myanmar. A 70 cm long catheter “spirit level” (Copyright DA Warrell)
was inserted into an antecubital vein
(Seldinger percutaneous guidewire
technique) and advanced until its tip was
in the superior vena cava. An extension
tube connects with a simple saline
manometer whose zero point is at the
level of the mid-axillary line (Copyright
DA Warrell)
Alternatively, the simple but expensive Stryker pressure monitor can be used (Fig
48). Whatever system is employed, the zero point in the pressure measuring device
must be aligned to the level at which the cannula enters the fascial compartment.
Figure 47: Infusion pump, saline manometer Figure 48: Stryker pressure monitor in use
system in use for measuring the tissue pressure for measurement of intracompartmental
inside the anterior tibial compartment (Copyright pressure (Copyright DA Warrell)
DA Warrell)
Common Krait
Russells Viper