No : F/QCL/008 Rev.

01

MATERIAL SAFETY DATA SHEET

TOLUENE

Revision : 01 Date: 16.05.2017 MSDS Number : 251

Section 1 - Chemical Product and Company Identification

1.1 Product Name : TOLUENE

Synonyms : Toluol, Methylbenzene, Methylbenzol, Phenylmethane, Methacide.
CAS No. : 108-88-3
HS Code : 2902 30 00
Molecular Weight : 92.14 g/mol
Chemical Formula : C7H8
Product Code : A-1075
Brand : SMART-LAB
1.2 Manufacturer : PT.Smart-Lab Indonesia
Address : Ruko Boulevard TamanTekno Blok E No.10 -11BSD SektorXI
Serpong, Tangerang - Indonesia
Website : www.smartlab.co.id
Email :[email protected]
For information :Telp: +62-21- 7588 0205(Hunting) , fax:+62-21-7588 0198
1.3 Application : General Chemical reagent
Emergency Telephone: +62-21-7588 0205(Hunting)

Section 2 - Hazards Identification

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008
Flammable liquids (Category 2), H225
Skin irritation (Category 2), H315
Reproductive toxicity (Category 2), H361d
Specific target organ toxicity - single exposure (Category 3), Central nervous system, H336
Specific target organ toxicity - repeated exposure (Category 2), H373
Aspiration hazard (Category 1), H304

For the full text of the H-Statements mentioned in this Section, see Section 16

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008

Pictogram

Signal word danger

Hazard statement(s)
H225 Highly flammable liquid and vapour.
H304 May be fatal if swallowed and enters airways.
H315 Causes skin irritation.
H336 May cause drowsiness or dizziness.
H361d Suspected of damaging the unborn child.
H373 May cause damage to organs through prolonged or
repeated exposure.

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MATERIAL SAFETY DATA SHEET

TOLUENE

Revision : 01 Date: 16.05.2017 MSDS Number : 251

Precautionary statement(s)
P210 Keep away from heat, hot surfaces, sparks, open flames
and other ignition sources. No smoking.
P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P280 Wear protective gloves/ protective clothing/ eye
protection/ face protection.
P301 + P310 IF SWALLOWED: Immediately call a POISON
CENTER/doctor.
P370 + P378 In case of fire: Use dry powder or dry sand to extinguish.
P403 + P235 Store in a well-ventilated place. Keep cool.

Supplemental Hazard Statements none

2.3 Other hazards

This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Section 3 - Composition, Information on Ingredients

3.1 Substances
Synonyms : methylbenzene
Formula : C7H8
Molecular weight : 92.14 g/mol
CAS-No. : 108-88-3
EC-No. : 203-625-9
No. Index : 601-021-00-3

Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Toluene Flam. Liq. 2; Skin Irrit. 2; Repr. 2;
CAS-No. 108-88-3 STOT SE 3; STOT RE 2; Asp. Tox. 1;
<=100 %
EC-No. 203-625-9 H225, H315, H361d, H336, H373,
Index-No. 601-021-00-3 01- H304

For the full text of the H-Statements mentioned in this Section, see Section 16.

Section 4 - First Aid Measures

4.1 Description of first aid measures

General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact

Flush eyes with water as a precaution.

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MATERIAL SAFETY DATA SHEET

TOLUENE

Revision : 01 Date: 16.05.2017 MSDS Number : 251

If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water.
Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11

4.3 Indication of any immediate medical attention and special treatment needed
No data available

Section 5 - Firefighting Measures

5.1 Extinguishing media

Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture

Carbon oxides

5.3 Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information

Use water spray to cool unopened containers

Section 6 - Accidental Release Measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.
Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form
explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
environment must be avoided.

6.3 Methods and materials for containment and cleaning up

Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place
in container for disposal according to local regulations (see section 13).

6.4 Reference to other sections

For disposal see section 13.

Section 7 - Handling and Storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition -
No smoking.
Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

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MATERIAL SAFETY DATA SHEET

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7.2 Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510):
Flammable liquids

7.3 Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

Section 8 - Exposure Controls, Personal Protection

8.1 Control parameters

Derived No Effect Level (DNEL)

Application Area Exposure routes Health effect Value

Workers Inhalation Acute systemic effects 384 mg/m3
Workers Inhalation Acute local effects 384 mg/m3
Workers Skin contact Long-term systemic 384mg/kg BW/d
effects
Workers Inhalation Long-term systemic 192 mg/m3
effects
Workers Inhalation Long-term local effects 192 mg/m3
Consumers Inhalation Acute systemic effects 226 mg/m3
Consumers Inhalation Acute local effects 226 mg/m3
Consumers Skin contact Long-term systemic 226mg/kg BW/d
effects
Consumers Inhalation Long-term systemic 56.5 mg/m3
effects
Consumers Ingestion Long-term systemic 8.13mg/kg BW/d
effects

Predicted No Effect Concentration (PNEC)

Compartment Value
Soil 2.89 mg/kg
Marine water 0.68 mg/l
Fresh water 0.68 mg/l
Marine sediment 16.39 mg/kg
Fresh water sediment 16.39 mg/kg
Sewage treatment plant 13.61 mg/l
Aquatic intermittent release 0.68 mg/l

8.2 Exposure controls

Appropriat engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at
the end of workday.

Personal protective equipment

Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).

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MATERIAL SAFETY DATA SHEET

TOLUENE

Revision : 01 Date: 16.05.2017 MSDS Number : 251

Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal
technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good
laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC
and the standard EN 374 derived from it.

Full contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740, Size M)

Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740, Size M)

Body Protection
Complete suit protecting against chemicals, Flame retardant antistatic protective clothing.,
The type of protective equipment must be selected according to the concentration and amount
of the dangerous substance at the specific workplace.

Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use (EN 143)
respirator cartridges as a backup to engineering controls. If th full-face supplied air
respirator. Use respirators and components tested and approved under appropriate
government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
the environment must be avoided.

Section 9 - Physical and Chemical Properties

9.1 Information on basic physical and chemical properties

Appearance Form: liquid
Colour: colourless
Odour aromatic
Odour Threshold No data available
pH No data available
Melting point/freezingpoint Melting point/range: -93 °C
Initial boiling point and boiling range 110 - 111 °C
Flash point 4.0 °C - closed cup
Evaporation rate No data available
Flammability (solid, gas) No data available
Upper/lower flammability or Upper explosion limit: 7 %(V)
Lower explosion limit: 1.2 %(V)
explosive limits
Vapour pressure 21.8 mmHg at 20.0 °C
Vapour density No data available

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MATERIAL SAFETY DATA SHEET

TOLUENE

Revision : 01 Date: 16.05.2017 MSDS Number : 251

Relative density 0.865 g/mL at 25 °C

Water solubility 0.5 g/l at 15 °C
Partition coefficient: noctanol/water No data available
Auto-ignition temperature 535.0 °C
Decomposition temperature No data available
Viscosity No data available
Explosive properties No data available
Oxidizing properties No data available

9.2 Other safety information

No data available

Section 10 - Stability and Reactivity

10.1 Reactivity
No data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

No data available

10.4 Conditions to avoid

Heat, flames and sparks.

10.5 Incompatible materials

Strong oxidizing agents

10.6 Hazardous decomposition products

Hazardous decomposition products formed under fire conditions. - Carbon oxides
Other decomposition products - No data available
In the event of fire: see section 5

Section 11 - Toxicological Information

11.1 Information on toxicological effects

Acute toxicity
LD50 Oral - Rat - > 5,580 mg/kg(Toluene)
LC50 Inhalation - Rat - 4 h - 12,500 - 28,800 mg/m3(Toluene)
LD50 Dermal - Rabbit - 12,196 mg/kg(Toluene)

Skin corrosion/irritation
Skin - Rabbit(Toluene)
Result: Skin irritation - 24 h

Serious eye damage/eye irritation

Eyes - Rabbit(Toluene)
Result: No eye irritation
(OECD Test Guideline 405)

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Respiratory or skin sensitisation

Damage to fetus possible(Toluene) Suspected human reproductive toxicant (Toluene) Experiments have
shown reproductive toxicity effects in male and female laboratory animals.(Toluene)

Germ cell mutagenicity

Rat(Toluene) Liver
DNA damage

Carcinogenicity
IARC: 3 - Group 3: Not classifiable as to its carcinogenicity to humans (Toluene)

Reproductive toxicity
No data available(Toluene)

Specific target organ toxicity - single exposure

No data available(Toluene)

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard
No data available(Toluene)

Additional Information
RTECS: XS5250000
Lung irritation, chest pain, pulmonary edema, Inhalation studies on toluene have demonstrated the
development of inflamm scrotum in animals., Central nervous system(Toluene)

Section 12 - Ecological Information

12.1 Toxicity
Toxicity to fish
LC50 - Oncorhynchus mykiss (rainbow trout) - 7.63 mg/l - 96 h(Toluene)
NOEC - Pimephales promelas (fathead minnow) - 5.44 mg/l - 7 d(Toluene)

Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 8.00 mg/l - 24 h(Toluene)

Toxicity to algae
EC50 - Chlorella vulgaris (Fresh water algae) - 245.00 mg/l - 24 h(Toluene)
EC50 - Pseudokirchneriella subcapitata (green algae) - 10.00 mg/l - 24 h(Toluene)

12.2 Persistence and degradability

Biodegradability
Result: - Readily biodegradable.

12.3 Bioaccumulative potential

Bioaccumulation Leuciscus idus (Golden orfe) - 3 d - 0.05 mg/l(Toluene)
Bioconcentration factor (BCF): 90

12.4 Mobility in soil

No data available(Toluene)

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MATERIAL SAFETY DATA SHEET

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12.5 Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects

Toxic to aquatic life.

Section 13 – Disposal Considerations

13.1 Waste treatment methods

Product
Burn in a chemical incinerator equipped with an afterburner and scrubber b highly flammable. Offer
surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging
Dispose of as unused product.

Section 14 – Transport Information

14.1 UN number
ADR/RID: 1294 IMDG: 1294 IATA: 1294
14.2 UN proper shipping name
ADR/RID: TOLUENE
IMDG: TOLUENE
IATA: Toluene
14.3 Transport hazard class(es)
ADR/RID: 3 IMDG: 3 IATA: 3
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
No data available

Section 15 - Regulatory Information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out

Section 16 - Additional Information

Full text of H-Statements referred to under sections 2 and 3.

H225 Highly flammable liquid and vapour.
H304 May be fatal if swallowed and enters airways.
H315 Causes skin irritation.
H336 May cause drowsiness or dizziness.

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MATERIAL SAFETY DATA SHEET

TOLUENE

Revision : 01 Date: 16.05.2017 MSDS Number : 251

H361d Suspected of damaging the unborn child.

H373 May cause damage to organs through prolonged or repeated exposure.

National Fire Protection Association (U.S.A.):

Health: 2
Flammability: 3
Reactivity: 0

Further information
The above information is believed to be correct but does not purport to be all inclusive and shall be used only as
a guide. The information in this document is based on the present state of our knowledge and is applicable to
the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties
of the product. PT. Smartlab Indonesia Corporation and its Affiliates shall not be held liable for any damage
resulting from handling or from contact with the above product. See www.sigmaaldrich.com and/or the reverse
side of invoice or packing slip for additional terms and conditions of sale.

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