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    Pathophysiology of Chronic Kidney Disease: Predisposing Factors: Precipitating Factors

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    Reina Samson
    Chronic kidney disease develops due to thickening and narrowing of blood vessels in the kidneys from risk factors like hypertension and diabetes, reducing blood flow. This activates the renin-angiotensin-aldosterone system and causes further hypertension. Over time, loss of nephrons leads to hyperfiltration in remaining nephrons and eventual glomerulosclerosis, further reducing kidney function until late stage chronic kidney disease causes waste retention and other clinical signs.

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    Pathophysiology of Chronic Kidney Disease: Predisposing Factors: Precipitating Factors

    Uploaded by

    Reina Samson
    990 views1 page
    Chronic kidney disease develops due to thickening and narrowing of blood vessels in the kidneys from risk factors like hypertension and diabetes, reducing blood flow. This activates the renin-angiotensin-aldosterone system and causes further hypertension. Over time, loss of nephrons leads to hyperfiltration in remaining nephrons and eventual glomerulosclerosis, further reducing kidney function until late stage chronic kidney disease causes waste retention and other clinical signs.

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    CKD Pathophysiology

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    Chronic kidney disease develops due to thickening and narrowing of blood vessels in the kidneys from risk factors like hypertension and diabetes, reducing blood flow. This activates the renin-angiotensin-aldosterone system and causes further hypertension. Over time, loss of nephrons leads to hyperfiltration in remaining nephrons and eventual glomerulosclerosis, further reducing kidney function until late stage chronic kidney disease causes waste retention and other clinical signs.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    990 views1 page

    Pathophysiology of Chronic Kidney Disease: Predisposing Factors: Precipitating Factors

    Uploaded by

    Reina Samson
    Chronic kidney disease develops due to thickening and narrowing of blood vessels in the kidneys from risk factors like hypertension and diabetes, reducing blood flow. This activates the renin-angiotensin-aldosterone system and causes further hypertension. Over time, loss of nephrons leads to hyperfiltration in remaining nephrons and eventual glomerulosclerosis, further reducing kidney function until late stage chronic kidney disease causes waste retention and other clinical signs.

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    © All Rights Reserved
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    Pathophysiology of Chronic Kidney Disease

    Precipitating Factors:
    Predisposing Factors:
    Hypertension
    Family History
    DM
    Older Age
    Smoking

    Unhealthy diet

    Thickening of blood vessels which leads to narrowing of the


    lumen.

    Decrease blood flow to the kidney, the nephrons.

    The afferent arterial blood vessel brings blood towards the head of the
    nephrons but with less blow flowing through the due to thickening and
    narrowing of the lumen, there is a decrease infiltration thus decrease in GFR.

    Cells affected in the area stops producing RENIN that leads to activation of
    RAAS system. Leading to increased HR and further HTN.

    The kidney thinks that by increasing BP, the kidney will receive more blood. It may
    work sometime but cycle will continue and there will be vessel thickening and
    narrowing.

    Glumerulosis (thickening and hardening of the vessels)

    Leads to ischemic injury or loss of nephrons.

    Since the loss of nephrons is irreversible, the blood flow will got he functional
    nephrons.

    More blood flow will enter the functional nephron leading to glumelular
    hyperfiltration

    Leading to increase in GFR. In early stage of this disease, this is tolerated. But
    overtime can lead to glumerosclerosis due to so much pressure and can lead to
    loss of the other functional nephrons.

    Late Stage: Loss of so much kidney functions. Decreased GFR, decreased UO, begin
    to retain waste and clinical manifestations of CKD.

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