Guidelines For Moderna Vaccine - 7401

Date: 30th June 2021
Document Code: 74-01

Version: 01
Guidelines
COVID-19 Vaccination
Moderna Vaccine Guidelines
Objective
To provide guidelines for the Moderna vaccine storage, handling, administration, and safe disposal along
with recommendations for vaccine recipients.
Rationale
Vaccines are important part of strategies to curtail the devastating Covid-19 pandemic. Moderna vaccine
needs special handling and cold chain maintenance to preserve the vaccine’s effectiveness. Safe
transportation, storage, administration, and disposal of vaccine waste must be ensured at all vaccination
facilities.
Instructions
Vaccine Storage
• Store vaccine in a freezer or refrigerator.

• First use vaccine vials stored in the refrigerator before removing vials from frozen storage.
• Check and record storage unit temperature regularly each workday.
Freezer
Frozen vials prior to use should be stored at temperatures

of -25o C to -15o C and protected from light, in the
original packaging.
Do not store on dry ice or below -40ºC.
Refrigerator
Thawed, unpunctured vials may be stored in the
refrigerator between 2° to 8°C (36° to 46°F) for up to 30
1
days or at +8o C to +25o C for up to 24 hours. During storage, vials should be protected from light, in
the original packaging.
• Do NOT refreeze thawed vaccine.

• Thawed, punctured vials should be stored between +2o C to +25o C and used within 24 hours from the
time of first puncture. During storage, vials should be protected from light.
• Monitor how long the vaccine has been in the refrigerator using beyond-use date labels.
• Remove the vaccine container boxes from frozen storage, rather than taking out vaccine vials
from the freezer/frozen storage.
• Complete/fill the information on the storage label.
• Attach the storage label it to the box holding the vaccine vials.
Preparation: Thaw each vial before use:
• Thaw in refrigerated conditions between 2°C to 8°C for 2 hours and 30 minutes. Let each vial stand
at room temperature for 15 minutes before administering.
• Alternatively, thaw at room temperature between 15°C to 25°C for 1 hour.
Who should receive the Vaccine
• People aged 18 years and older.

• Pregnant and lactating women.
• Those with comorbid conditions, e.g diabetes, hypertension, congestive cardiac failure, renal failure,
chronic liver disease, etc.
• Those who have experienced a mild episode of COVID-19 in the recent past can receive the vaccine
once the isolation period is completed.
• Those with severe COVID-19 can receive the vaccine once they become clinically stable.
• Those chronically immunosuppressed may receive the vaccine, though efficacy may be lower
1. Post organ transplantation, the patient may receive the vaccine 3 months after
transplantation procedure.
2. Post chemotherapy, the patient may receive the vaccine 28 days after chemotherapy.
Who should NOT receive Vaccine
• If you have had a severe allergic reaction (anaphylaxis) or an immediate allergic reaction, even
if it was not severe:
o to any ingredient in an mRNA COVID-19 vaccine (such as polyethylene glycol).
o or after getting the first dose of the vaccine, should not get a second dose of either of the
mRNA COVID-19 vaccines.
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• The vaccine is not recommended for persons younger than 18 years of age pending the results of
further studies.
• In general, persons with an immediate non-anaphylactic allergic reaction to the first dose should
not receive additional doses, unless recommended after review by a health professional with
specialist expertise.
Adverse Effects
Pain, redness, swelling at injection site. Fever, myalgia, headache
There have been reports of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines, including
the Moderna vaccine. Available information indicates that cases have been mild, occurring more commonly after the second
dose of vaccine and more often in male adolescents and young adults. Symptoms have been reported to start within several
days after vaccination
Vaccine Administration
• Route of Administration: Intra-muscular
• Site of Administration: Lateral Deltoid Muscle (Upper Arm), Non-dominant side
• Regimen: Two doses one month (28 days) apart
• Dose: 0.5ml/vial (5 x 1010 viral particles)
• Authorized Interval: 28 days
• Presentation: Single dose vial
• No additional booster dose required
Steps of Administration
1. Wear mask and observe COVID-19 SOPs
2. Greet the client
3. Complete verification process in the NIMS
4. Ensure consent by stating “that you are receiving this COVID-19 vaccine because you have
registered yourself into the system”
5. Expose site (deltoid of non-dominant arm) for administration
6. Explain the procedure and inform that some pain on giving injection, discomfort at the site of
injection or fever after the injection may happen
7. Swab the injection site with an alcohol swab for 30 seconds, then let the area dry for another
30 seconds so that the alcohol doesn’t enter the puncture and sting
8. Take vaccine vial out of the vaccine carrier
9. Open the vial by removing plastic cover/cap
10. Take out 22G-25G 0.5ml syringe and remove needle cap
11. Discard the cap in safety box
12. Insert the syringe needle through the top rubber pad of vaccine vial
13. Draw 0.5ml of the vaccine from the vial
3
14. Inject intra muscularly at the site of injection at an angle of 90⁰ (right angle)
15. Dispose the syringe in the safety box
16. Complete entry in the NIMS
17. Send the client to observation area for 30 minutes
18. After 30 minutes if no acute adverse event is experienced by the client, send the client home.
Also, advise the client to report to health facility /1166 helpline if any adverse event is
experienced.
Vaccine Waste Management
• Used vials and syringes must be collected safely by the vaccinator

• Syringes must be disposed through environment friendly incinerators where
available.
• In case of non-availability of incinerators, follow the under mentioned link for
proper disposal of the vaccine waste.
https://apps.who.int/iris/bitstream/handle/10665/43476/9241594284_eng.pdf?seq
uence=1&isAllowed=y
• The vaccinator under supervision of the health facility in-charge of the
concerned health facility will ensure proper disposal of COVID-19 vaccination
waste
• Daily waste generation and disposal record must be maintained by the
vaccinator
During vaccination, Do NOT
• Touch the rubber pad of vaccine vial (causes contamination and can result in an AEFI)
• Recap needle of syringes (to prevent needle stick injuries)
Please refer to “Annexure A” checklist for covid-19 vaccine administration
4
Note: The above recommendations are being regularly reviewed by the Ministry of National Health Services,
Regulations & Coordination and will be updated based on the international & national recommendations and best
practices.
The Ministry acknowledges the contribution of Mr Shamim Raza, Ms. Amina Ehsan Qazi, EPI Team and HSA/
HPSIU/ NIH team to compile these guidelines.
References
1. https://www.cdc.gov/vaccines/covid-19/info-by-product/moderna/downloads/storage-summary.pdf
2. https://www.fda.gov/media/144637/download
3. https://www.who.int/publications/i/item/interim-recommendations-for-use-of-the-moderna-mrna-1273-vaccine-
against-covid-19
4. https://www.cdc.gov/vaccines/covid-19/info-by-product/moderna/index.html
5. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/recommendations/pregnancy.html
6. https://www.health.gov.on.ca/en/pro/programs/publichealth/coronavirus/docs/vaccine/COVID-
19_Moderna_vaccine_admin.pdf
For more information, please contact:
HSA/ HPSIU/ NIH, PM National Health Complex, Islamabad

http://covid.gov.pk/
http://nhsrc.gov.pk/ https://www.facebook.com/NHSRCOfficial
http://www.hsa.edu.pk/ https://twitter.com/nhsrcofficial
https://www.nih.org.pk/ https://www.youtube.com/NHSRC-PK
5
Annex-A
CHECKLIST FOR COVID-19 VACCINE ADMINISTRATION
Client Name: Age:
ID Card: Gender:
Address:
Staff name/Signatures
1. Greet the Client
2. Make sure that you and client are wearing face mask
3. Complete the 2-step verification of client
4. Ensure consent by stating that "you are receiving this COVID-19

vaccine because you registered yourself in the system"
5. Prepare dose
6. Explain the procedure and inform that some pain on giving injection,
and discomfort or fever after the injection can occur
7. Sterilize injection site with alcohol swab
8. Administer injection
9. Properly dispose the injection waste
10. Send the client to observation section for 30 minutes
11. After 30 minutes, and with no acute AEFI, client is ready to be sent
home.
12. Respond to Qs if any, as the last step.

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Date: 30th June 2021

Document Code: 74-01

• Store vaccine in a freezer or refrigerator.

Frozen vials prior to use should be stored at temperatures

Do not store on dry ice or below -40ºC.

• Do NOT refreeze thawed vaccine.

Who should receive the Vaccine

• People aged 18 years and older.

Who should NOT receive Vaccine

Pain, redness, swelling at injection site. Fever, myalgia, headache

Vaccine Waste Management

• Used vials and syringes must be collected safely by the vaccinator

During vaccination, Do NOT

Please refer to “Annexure A” checklist for covid-19 vaccine administration

For more information, please contact:

HSA/ HPSIU/ NIH, PM National Health Complex, Islamabad

CHECKLIST FOR COVID-19 VACCINE ADMINISTRATION

Client Name: Age:

1. Greet the Client

3. Complete the 2-step verification of client

4. Ensure consent by stating that "you are receiving this COVID-19

7. Sterilize injection site with alcohol swab

9. Properly dispose the injection waste

10. Send the client to observation section for 30 minutes

12. Respond to Qs if any, as the last step.

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