RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES

KARNATAKA, BANGALORE.
PROFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION FOR
AYURVEDA VACHASPATHI (M.D) IN DRAVYAGUNA VIJNANA

PHARMACOGNOSTICAL AND CLINICAL EVALUATION OF

TECTONA GRANDIS LINN. IN DARUNAKA (DANDRUFF)
-A FOLKLORE CLAIM
BY
Dr.APARNA.G

1ST Year MD.(Ayu) Scholar,

Department of PG studies in DravyagunaVijnana,

Alva’s Ayurveda Medical College & Hospital ,Moodbidri.

Guide
Dr.SUBRAHMANYA.P, M.D, (Ayu) Ph.D

Prof: and HOD, Dept of PG Studies in DravyagunaVijnana,

Alva’s Ayurveda Medical College& Hospital, Moodbidri.

CO-Guide
Dr. MAHESH.T.S, MD., (Ayu) Ph.D, M.B.A

Asst.prof,Dept of PG Studies in DravyagunaVijnana,

Alva’s Ayurveda Medical College& Hospital,Moodbidri.

2012-2013

ALVA’S AYURVEDA MEDICAL COLLEGE & HOSPITAL,

MOODBIDRI.
From,
Dr. APARNA.G
1styearMD. (Ayu) scholar
Dept.of P.G Studies in DravyagunaVijnana,
Alva’s Ayurveda Medical College & Hospital, Moodbidri.

To,
THE REGISTRAR,
Rajiv Gandhi University of Health Sciences,
Bangalore, Karnataka.

Through,
THE PRINCIPAL
Alva’s Ayurveda Medical College & Hospital – Moodbidri.

Sub- submission of completed Proforma for registration of synopsis for dissertation work
in MD.(Ayu).
Respected sir,

I request you to register the below mentioned subject in my name for submission of
dissertation to Rajiv Gandhi University of Health Sciences, Bangalore as the partial
fulfillment for the award of the degree MD.(Ayu) in DRAVYAGUNA VIJNANA.

TITLE OF DISSERTATION

PHARMACOGNOSTICAL AND CLINICAL EVALUATION OF TECTONA

GRANDIS LINN. IN DARUNAKA (DANDRUFF) - A FOLKLORE CLAIM

Here with i am enclosing the completed Proforma for registration for dissertation subject.

Thanking you,

Place: Moodbidri yours sincerely

Date: (Dr.Aparna.G)
 Rajiv Gandhi University of Health Sciences,Karnataka,Bangalore.
ANNEXURE II

PROFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION

1) Name of the Candidate : Dr. APARNA.G

Address (In block letters) : 1ST YEAR, MD. SCHOLAR,

DEPT OF P.G STUDIES IN
DRAVYA GUNA VIJNANA,
ALVA’S AYURVEDA MEDICAL
COLLEGE, MOODBIDRI.
Permanent address : D/o N.K GOPINATH
KAZHUNGIL VALAPPIL (H)
THALAMUNDA EDAPPAL
MALAPPURAM DIST
KERALA.PIN – 679576
2) Name of the institution : ALVA’S AYURVEDA MEDICAL
COLLEGE, MOODBIDRI- 574227
3) Course of the study & Subject : MD. (AYU) IN DRAVYA GUNA

4) Date of Admission for course :7-09-2012

5) Title of the topic :

PHARMACOGNOSTICAL AND CLINICAL EVALUATION OF TECTONA

GRANDIS Linn. IN DARUNAKA (DANDRUFF)
6) Brief resume of the intended work
6.1) Need for the study:

Shaka which is botanically identified as Tectona grandis Linn. which belong

to verbenaceae family1.It is a large sized deciduous tree dominant in mixed hardwood

forests and found throughout India.The tree is well known for its high trade timber. shaka

has references in Susrutasamhita, AshtangaHridaya and in various Nighantus. On

screening ayurvedic literatures we get references regarding its usage in various ailments.

According to Ayurveda, Darunaka is classified as one among the

Kshudrarogas in Susrutha Samhita2 and Kapala Roga in Ashtanga Hridaya3.This is a

condition manifested due to vitiation of vata and kaphadoshas which results in dryness

and itching in the scalp further leading to scaling

Dandruff is an extremely common disease, affecting around 50% of the world's

population irrespective of gender and ethnicity. It is prevalent in the age group15 – 504. No

population in any geographical region would have passed freely through, without being

affected by dandruff at some stage in their life. Its a global phenomenon and many people

find that dandruff can cause social or self-esteem problems.

As per the textual reference, the trial drug has kaphavatahara, kushtahara and

pramehahara property5. Oil prepared from the drug is widely used by the folklore

practioners over the years in Malappuram district, kerala. There are ample remedies

available for dandruff in market but the cost factor of many such formulations inspire for

further researches in this field. Shakapatra is an easily available, cost effective and safe

drug .Hence the present study is to establish scientifically the efficacy of Tectona grandis

Linn. in dandruff.
6.2) Review of the literature
The review will include collection of references available regarding the subject

matter from all classical, modern literature, contemporary texts and other available

sources like journals, internet will be reviewed.

6.3) Previous workDone6

1.Manjumdar and Mrityunjoy – Evaluation of Tectona grandis Linn. leaves for Wound

healing activity RGUHS Banglore 2005.

2.Shavas MM An experimental evaluation on Ashmari Bhedana property of Shaka and

kathaka a comparitive study ALN RaoAyurvedic Medical College RGUHS 2010.

3.Usha Rani M Clinical management of Darunaka with Dardura Patraditailam Dr B K R

R Government Ayurvedic college A P University, vijayawada1996.

6.4) Objective of the study

 To evaluate the drug Tectona grandis Linn. Pharmacognostically.

 To evaluate the drug Tectona grandis Linn.Phytochemically.

 Invitro evaluation of the Anti fungal activity of Tectona grandis Linn.

 To evaluate the clinical efficacy of the drug Tectona grandis Linn. in DARUNAKA.

7) Materials and Methods

7.1) Source of data

a) Literary source: All classical literature and latest informations like website will be
reviewed and documented.

b) Source of plant: will be identified authentically and collected from the natural sources.

c) Pharmacognostically and Phytochemical laboratories

d) Clinical study will be carried out in patients suffering from the disease DARUNAKA.
The study will be conducted on the patients selected from the OPD of Alva’s Ayurveda
Medical college & Hospital,Moodbidri.

7.2) Method of collection of data

a) Pharmacognostical & Phytochemical study

The drug will be identified botanically and collected authentically from the natural

sources and will be taken for pharmcognostic and Phytochemical studies.

b) Anti fungal study7

The anti fungal study will be conducted and inhibition capacity of Tectona grandis Linn.

extract on Fungi Pityrospora Ovale will be assessed.

c) Clinical study design

Sample size and group: 40 patients will be selected and assigned into two groups of

20 each, group A is Control and group B is Trial.

Group A: patients suffering from DARUNAKA will be given coconut oil for topical

application on head.

Group B: patients suffering from DARUNAKA will be given oil prepared from Tectona

grandis Linn. Leaves for topical application on head.

d)Method of administration
Medicated oil is prepared8 from the plant, Tectona grandis linn. as per literature

reference with kashaya of leaf as dravadravya, tender leaf paste as Kalka and coconut oil

as sneha. This oil will be applied gently on the scalp for 15 minutes daily once in the

morning.

Dose- As required for application.

e) Diagnostic criteria3

 Kandu
 Swaapa
 Roukshya
 Keshachyuthi
 Sa sookshma sphudanam twacha
f) Inclusion criteria
Patients fulfilling the diagnostic criteria
Patients of age group 15-50 years
g) Exclusion criteria

Patients suffering from:-

 Other Systemic diseases.

 Allergic manifestation.

 Psychological diseases.

 Alopecia.

h) Study duration

Study will be carried out for 30 days with an intervention once in 15 days and

follow up will be done for 60 days with an intervention once in 30 days.

i) Interventions

Duration of treatment –30 days

Patients are assessed once in 15 days

j) Hypothesis

1. H0- Tectona grandis Linn. do not have significant effect on Darunaka (Dandruff)

2. H1 –Tectona grandis Linn. has significant effect on Darunaka (Dandruff)

k) Assessment criteria
Effect of treatment will be assessed statistically on the basis of gradation of

symptom before and after treatment.

7.3) Does the study require any investigation and interventions to be conducted on

patients or other humans or animals? If so please describe briefly:

The study will be conducted only on patients suffering from Darunaka. No animal

experimentation will be carried out.

Laboratory Investigation-

Hb%, A.E.C, T.C, D.C, E.S.R.

7.4) Has ethical clearance been obtained from your institution in case of 7.3

Yes clearance has been obtained through the ethical committee formulated in

institution.

8) List of references

1. Dr Nadkarni KM-Indian Materia Medica, published by Popular Prakashan Private

Limited Mumbai third revised edition 1982 volume1page no:1197

2.Acharya Susrutha- Susrutha samhita,Nibanda Sangraha commentary of Sri Dalhana

Acharya and the Nyayachandrika panjika of Sri Gayadasacharya on chikitsasthana edited
by Vaidya Jadavji Trikamji Acharya from the beginning to 9th adhyaya of Chikitsasthana
and rest by Narayana Ram Acharya kavyatirtha published by chowkhambha sanskrit
santhan varanasi, reprint edition 2009 page no 479

3.Vagbhata, Ashtanga Hrudaya Uttarasthana siroroga vijnaneeya adhyaya with

commantaries of sarvangasundara of Arunadattaand Ayurveda rasayana of Hemadri,
edited by Shastri sadasiva paradakara bhisagacarya published by Choukhambha
surbharati prakashan,Varanasi Revised edition.2007 pg.no.859.

4. http://www.eisrjc.com/journals/journal_1/eisrj-vol-2-issue-3-9.pdf

5. Narahari Pandit, Raja Nighantu, Edited and Translated by Prof. Priyamvata Sharma and
Dr.GuruPrasadSharma,ChukhambaOrientalia Varanasi First Edition 1979 page no:150
6.Vaidya M S Baghel – Researches in ayurveda publication by Mridu Ayurvedic
publication and sales,Jamnagar ,2005 pg- 381

7.Godkar. B. Praful and Godkar . P. Darshan, Textbook of Medical Laboratory

Technology, Published by Bhalani Publishing House, Mumbai, Second edition, Pg no.
587

8.AcharyaSarngadhara, Sarngadharasamhitha, Madhyamakhanda, chapter nine,

Snehakalpana edited by Murthy.P. Himasagara Chandra published by choukhambha
Sanskrit series office, Varanasi, second edition 2007, pg.no.199.

9) Signature of candidate :

10) Remarks of Guide :

11) Name and Designation of

11.1 Guide : Dr. Subrahmanya. P. M. D, Ph.D (Ayu)

Prof: and H.O.D
Dept.of P.G. Studies in DravyagunaVijnana
Alva’s Ayurveda Medical College, Moodbidri
11.2 Signature and seal :

11.3 Co- guide : Dr.Mahesh T.S M. D. (Ayu) Ph.D ,M.B.A.,

Assistant.Professor.,
Dept. of P.G. Studies in DravyagunaVijnana
Alva’s Ayurveda Medical College,
Moodbidri.
11.4 Signature and seal :

11.5 Head of the department : Dr. Subrahmanya. P. M. D, (Ayu) Ph.D

Professor and H.O.D
Dept. of P.G. Studies in DravyagunaVijnana
Alva’s AyurvedaMedicalCollege,
Moodbidri

11.6 Signature and seal :

12. Remarks of the principal :

12.1 signature and seal :