Anti-Inflammatory Studies REV OZ - Gamma Oryzanol

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Gist of some studies regarding anti-inflammatory properties of Gamma-Oryzanol

S. No. Title / Author / Journal Year Type of study Findings Link Code

1 Gamma-oryzanol Prevents LPS- 2019 in-vivo The results of this study suggest that chronic https://www.ncbi.nlm. 87
induced Brain Inflammation and consumption of γ-oryzanol can revert the LPS- nih.gov/pmc/articles/
Cognitive Impairment in Adult Mice / induced cognitive and memory impairments by PMC6520753/
Andrea Mastinu, Sara Anna Bonini, promoting hippocampal antioxidant and anti-
Wiramon Rungratanawanich, inflammatory molecular responses.
Francesca Aria, Mariagrazia
Marziano, Giuseppina Maccarinelli,
Giulia Abate, Marika Premoli,
Maurizio Memo, and Daniela Uberti /
2 Nutrientsand
Anti-Inflammatory MDPI
Antioxidative 2017 in-vivo In this study, Oryzanol showed protective effect https://www.hindawi. 84
Stress Effects of Oryzanol in against glaucoma by its antioxidative stress and com/journals/joph/20
Glaucomatous Rabbits / Shital S. anti-inflammatory property. Treatment with 17/1468716/
Panchal, Rajesh K. Patidar, Abhishek oryzanol can reduce optic nerve damage.
B. Jha, Ahmed A. Allam, Jamaan
Ajarem and Shital B. Butani1 /
Journal of Ophthalmology
3 2016 in-vivo The results of this study indicated that Gamma https://pubmed.ncbi. 86
Dietary gamma oryzanol plays a Oryzanol supplemented in the dietary oils play a nlm.nih.gov/2769379
significant role in the anti- significant role in reducing the secretion of pro- 4/
inflammatory activity of rice bran oil inflammatory mediators by macrophages. Hence
by decreasing pro-inflammatory Gamma Oryzanol in RBO significantly
mediators secreted by peritoneal contributed to the anti-inflammatory properties of
macrophages of rats / Y Poorna RBO.
Chandra Rao, D Sugasini, B R Lokesh
/ Biochemical and biophysical
research communications
4 Rice bran prevents high-fat diet- 2015 in-vivo In this study pro-inflammatory biomarkers in https://pubmed.ncbi.
induced inflammation and macrophage white adipose tissue (WAT) such as IL-6 and IL- nlm.nih.gov/2626693
content in adipose tissue / Maria 1β were significantly decreased in high-fat fed 2/
Luisa Justo, Carmen Claro, mice treated with rice bran enzymatic extract
Maximilian Zeyda, Thomas M Stulnig, (RBEE) containing Gamma Oryzanol. From the
María Dolores Herrera, Rosalía findings of this study, it was concluded that
Rodríguez-Rodríguez / European RBEE containing Gamma Oryzanol may be
Journal of Nutrition considered an alternative nutritional complement
over metabolic syndrome and its complications.

1
5 Antioxidant and anti-inflammatory 2011 in-vitro The results of this study indicate that Gamma https://www.research 83
activities of gamma-oryzanol rich Oryzanol rich extracts from rice bran are acting gate.net/publication/
extracts from Thai purple rice bran / as a lipophilic radical scavenger better than a 271185161_Antioxid
Chalermpong Saenjum, Chaiyavat hydrophilic radical scavenger. Moreover, these ant_and_anti-
Chaiyasut, Sunee Chansakaow, extracts exert a potent anti-inflammatory activity. inflammatory_activiti
Maitree Suttajit and Busaban es_of_gamma-
Sirithunyalug / Journal of Medicinal oryzanol_rich_extrac
Plants Research ts_from_Thai_purple
_rice_bran
6 Anti-inflammatory effects of 2009 in-vivo From the findings of this study it was concluded https://bpspubs.onlin 82
phytosteryl ferulates in colitis induced that phytosteryl ferulates (a component of elibrary.wiley.com/do
by dextran sulphate sodium in mice / Gamma Oryzanol) could be new potential i/full/10.1038/bjp.200
M S Islam T Murata M Fujisawa R therapeutic and/or preventive agents for 8.137
Nagasaka H Ushio A M Bari M gastrointestinal inflammatory diseases. Their
Hori H Ozaki / British Journal of anti-inflammatory effect could be mediated by
Pharmacology inhibition of NF-κB activity, which was at least
partly due to the antioxidant effect of the FA
moiety in the structure of phytosteryl ferulates.
7 Anti-inflammatory effects of γ- 2003 in-vivo In this study γ-oryzanol inhibited the increase in https://www.research
oryzanol /S. Terada and K. Haruta / swelling of the hind paw in a dose dependent gate.net/publication/
Journal of Natural Medicines manner (1-100 mg/kg). These results suggested 286942681_Anti-
that γ-oryzanol had therapeutic potential for inflammatory_effects
inflammatory disease. _of_g-oryzanol

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