P4 JAN 19 Tutorial 2 Without Answer For Pharmaceutics IV

PHARMACEUTICS 1V JAN 19
TUTORIAL 2
Calculation of density
1. If 250 mL of alcohol weighs 2.3 g, what is the density? Ans:
2. A piece of copper metal weighs 53.6 g, and has a volume of 6 ml, Calculate
the density. Ans:
Calculation of Specific Gravity

Specific Gravity (sp gr) = Weight of substance (g)
Volume of substance (mL)
3. If 150 mL of sorbitol solution weigh 170 g, what is its specific gravity?
Ans:
4. If a liter of a cough syrup weighs 1285 g, what is its specific gravity?

Ans:
5. If 500 mL of ferric chloride solution weighs 650 g, what is its specific gravity?
Ans:
Calculation of Weight or Volume using Specific Gravity.

6. What is the weight, in kg, of 5 L of Sulfuric Acid with a specific gravity of
1.84?
Ans:
7. A pharmacist receives the following prescription but does not have

hydrocortisone powder on hand. However, the pharmacist does have an
injection containing 100 mg of hydrocortisone per milliliter of injection. A
search of the literature indicates that the injection has a specific gravity of 1.5
Rx Hydrocortisone 1.5 %
Cold cream qs 30 g
a) How many grams of hydrocortisone are needed to fill the prescription?
Ans =
b) How many millimeters of the hydrocortisone injection would provide the
correct amount of hydrocortisone? Ans =
c) How many grams of cold cream are required? Ans =
Weight – in – Volume Calculations

8. Clobex lotion contains 0.05 % w/v clobetasol propionate in 118 mL
containers. Calculate the content of drug in milligrams.
Ans =
9. If 100 mL of a pharmaceutical preparation contains 20 uL (microliter) of a 50%

w/v solution of benzalkonium chloride, what is the percentage strength of that
agent in the solution? Ans =
10. A pharmacist emptied the contents of eight capsules, each containing 300
mg
of clindamycin phosphate, into a liquid vehicle to prepare 60 mL of a
suspension. Calculate the percentage strength of clindamycin phosphate in
the preparation. Ans =
11. The biotechnology drug interferon gamma-1b contains 100 mcg/0.5 ml.
Calculate the percentage strength of the solution. Ans
=
12. Neupogen (filgrastim) prefilled syringes contain 480 mcg od active

constituent
in each 0.8 ml. The equivalent concentration is: Ans =
13. Levofloxacin injection containing 5 mg/mL of levofloxacin and 5 % of

dextrose.
How much of each would be delivered to a patient upon the administration
of
a 100 mL injection? Ans =
14. How many ml of a 0.9% (w/v) solution of sodium chloride can be prepared
from 50 tablets, each containing 2.25 g of sodium chloride? Ans =
15. The antibacterial agent moxifloxacin HcL is available in 250-mL bags for
intraveneous infusion containing 400 mg of drug and 0.8% w/v NaCL.
a) the present strength of moxifloxacin Hydrochloride Ans =
b) the quantity of sodium chloride in grams, in the infusion Ans =
16. A prefilled syringe contains 50 mg of lidocaine hydrochloride per 5 mL of
injection. Express the percentage concentration of lidocaine hydrochloride in
the injection. Ans =
17. A pharmacist adds 10 mL of a 20 mL % w/v solution of a drug to 500 mL of

D5W for parenteral infusion. What is the percentage of the drug in the
infusion solution?
Ans =
Volume-in- Volume Calculations

18. What is the percentage strength (v/v) if 225 g of liquid having a specific
gravity of 0.8 is added to enough water to make 1.5 L of the solution?
Ans =
19. The formula for 1 L of an elixir contains 0.25 mL of a flavoring oil. What is
the
percentage (v/v) of the flavoring oil in the elixir? Ans =
20. A dermatological lotion contains 1.25 mL of liquefied phenol in 500 mL.

Calculate the percentage (v/v) of liquefied phenol in the lotion. Ans =
Weight-in-Weight Calculations
21. Each gram of Lotrisone lotion contains 10 mg of clotrimazole and 0.643 mg
of betamethasone dipropionate. Calculate the percentage concentration of
each of these two agents in the lotion. Ans =
22. A hemorrhoidal ointment contains, on a weight-in-weight basis, 46.6%

mineral
oil, 1 % pramoxine HCL, and 12.5 % zinc oxide in an ointment base.
Calculate
the grams of each ingredient, including the ointment base, in each 30-g
tube.
Ans =
23. If 500 g of dextrose are dissolved in 600 mL of water with a resultant final
volume of 1 l, what is the percentage strength of dextrose in the solution on a
w/w basis? Ans =
24. Hydromorphone HCL suppositories contain 3 mg of active ingredient and

weigh approximately 2 g each. What is the equivalent percentage strength?
Ans =
25. A metronidazole vaginal gel contains 0.75 % of drug in 70 g tubes. An

applicator will hold 5 g of gel for each administration. How much drug will be
contained in each application? Ans =
26. Alclomethasone dipropionate ointment contains 0.05 % w/w of the drug in

15
g and 45 g tubes. Calculate the differences in the quantity of drug between
the two tube sizes. Ans =
27. How many grams of azelaic acid are contained in 50 g tubes of the 15 %
w/w
gel? Ans =

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PHARMACEUTICS 1V JAN 19

Calculation of Specific Gravity

4. If a liter of a cough syrup weighs 1285 g, what is its specific gravity?

Calculation of Weight or Volume using Specific Gravity.

7. A pharmacist receives the following prescription but does not have

Weight – in – Volume Calculations

9. If 100 mL of a pharmaceutical preparation contains 20 uL (microliter) of a 50%

12. Neupogen (filgrastim) prefilled syringes contain 480 mcg od active

13. Levofloxacin injection containing 5 mg/mL of levofloxacin and 5 % of

17. A pharmacist adds 10 mL of a 20 mL % w/v solution of a drug to 500 mL of

Volume-in- Volume Calculations

20. A dermatological lotion contains 1.25 mL of liquefied phenol in 500 mL.

22. A hemorrhoidal ointment contains, on a weight-in-weight basis, 46.6%

24. Hydromorphone HCL suppositories contain 3 mg of active ingredient and

25. A metronidazole vaginal gel contains 0.75 % of drug in 70 g tubes. An

26. Alclomethasone dipropionate ointment contains 0.05 % w/w of the drug in

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