Scribd Logo
Upload

Welcome to Scribd!

  • 28 views

    Note - Dyslipidemia

    Uploaded by

    Mohamed Hussien
    This document discusses the treatment of dyslipidemia and provides information about statins. It notes that statins should not be used in pregnant or lactating women. Side effects of statins include muscle pain and elevated liver enzymes. When taking statins, creatine kinase and liver enzymes should be monitored. The document also provides equivalent doses of different statin medications and identifies which statins need or do not need dosage adjustment when taken with certain other drugs or grapefruit juice. It briefly discusses other medications for treating dyslipidemia such as bile acid sequestrants, fibric acid derivatives, niacin, ezetimibe, and omega-3 fatty acids.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Note - Dyslipidemia

    Uploaded by

    Mohamed Hussien
    28 views1 page
    This document discusses the treatment of dyslipidemia and provides information about statins. It notes that statins should not be used in pregnant or lactating women. Side effects of statins include muscle pain and elevated liver enzymes. When taking statins, creatine kinase and liver enzymes should be monitored. The document also provides equivalent doses of different statin medications and identifies which statins need or do not need dosage adjustment when taken with certain other drugs or grapefruit juice. It briefly discusses other medications for treating dyslipidemia such as bile acid sequestrants, fibric acid derivatives, niacin, ezetimibe, and omega-3 fatty acids.

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    This document discusses the treatment of dyslipidemia and provides information about statins. It notes that statins should not be used in pregnant or lactating women. Side effects of statins include muscle pain and elevated liver enzymes. When taking statins, creatine kinase and liver enzymes should be monitored. The document also provides equivalent doses of different statin medications and identifies which statins need or do not need dosage adjustment when taken with certain other drugs or grapefruit juice. It briefly discusses other medications for treating dyslipidemia such as bile acid sequestrants, fibric acid derivatives, niacin, ezetimibe, and omega-3 fatty acids.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    28 views1 page

    Note - Dyslipidemia

    Uploaded by

    Mohamed Hussien
    This document discusses the treatment of dyslipidemia and provides information about statins. It notes that statins should not be used in pregnant or lactating women. Side effects of statins include muscle pain and elevated liver enzymes. When taking statins, creatine kinase and liver enzymes should be monitored. The document also provides equivalent doses of different statin medications and identifies which statins need or do not need dosage adjustment when taken with certain other drugs or grapefruit juice. It briefly discusses other medications for treating dyslipidemia such as bile acid sequestrants, fibric acid derivatives, niacin, ezetimibe, and omega-3 fatty acids.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 1

    Dyslipidemia:

    Statin: HMG-CoA reductase inhibitors (rate-limiting step)

    # Not use: in pregnant and lactating woman (Category X)


    # SE: Muscle pain (rhabdomyolysis, myopathy), Elevate liver enzyme, exaggerated glucose level
    # Monitor: Creatin Kinase, liver enzyme (if increase X 3 fold from upper limit à Hepatotoxic à DC)
    # Decrease myopathy with statin co-administration with Co-enzyme Q10
    # Statin + Gemfibrozil or Valproic acid à severe Rhabdomyolysis

    Administration of Statin:

    SRP statins need dose adjustment: Simvastatin, Rosuvastatin, Pravastatin


    AF statin NOT need adjustment: Atorvastatin, Fluvastatin

    FAR is statin ☀ / 🌙: Fluvastatin, Atorvastatin, Rosuvastatin


    SPFL is statin 🌚 : Simvastatin, Pravastatin, Fluvastatin, Lovastatin

    FPRP are statin safe when taken with grape fruit juice 🍇 : Fluvastatin, Pitovastatin,
    Rosuvastatin, Pravastatin

    Equivalent doses of Statin:

    Pharmacist Rock At Saving Lives & Preventing Flu.

    Pitavastatin 2 mg = Rosuvastatin 5 mg = Atorvastatin 10 mg = Simvastatin 20 mg =


    Lovastatin 40 mg = Pravastatin 40 mg = Fluvastatin 80 mg
    # Atorva 40mg = Rovista 20mg

    Bile acid Sequestrants: (Resins)


    Cholestyramine # Not use in pregnant and CI in Hypertriglyceridemia (increase TG)

    Fibric acid derivative: (Fibrates)


    Fenofibrate, gemfibrozil
    # Not use with statin à severe Rhabdomyolysis

    Act on triglycerides and cholesterols: Simvastatin


    Acts on triglycerides: gemfibrozil

    Others:
    - Niacin (Vit B3)
    - Cholesterol absorption inhibitors (Ezetimibe). # Can use it with statin
    - Omega – 3 – fatty acid

    You might also like