Paracetamol - Infusion: Presentation Dose

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King Edward Memorial Hospital

Obstetrics & Gynaecology

ADULT

PARACETAMOL - INFUSION
This document should be read in conjunction with this DISCLAIMER

Presentation Infusion Bag: 1g/100mL

Dose Pain and Fever


IV Infusion:
>50 kg: 1g every 4 to 6 hours; maximum 4g daily
<50 kg: 15mg/kg every 4 to 6 hours; maximum 60mg/kg daily
Maximum dose: Usually 4g daily; doses up to 6 g daily may be used in
palliative care and for 3 to 5 days by specialist pain services for acute pain
Renal/hepatic impairment: ensure doses are at least 6 hours apart

Administration IV Infusion
Administration: Infuse undiluted over 15 minutes.
Optional dilution before use: Diluted to 1mg/mL with Glucose 5% or
Sodium chloride 0.9%. Infuse within 1 hour of preparation.

Pregnancy 1st Trimester: Safe to use


2nd Trimester: Safe to use
3rd Trimester: Safe to use

Breastfeeding Safe to use

Monitoring Higher than recommended doses can cause serious liver damage. Check
that no other forms of paracetamol are prescribed (e.g. oral or rectal) and
that the safe maximum total dose of paracetamol is not exceeded for adults
and children.
Take care not to confuse the dose for IV paracetamol in mg and mL. If a
dose is calculated in mg and given in mL, the patient will receive a 10-fold
overdose. Calculate and double check the dose required before each
administration.
Clinical Post-Operative Analgesia
Guidelines and Palliative Care
Policies Acute Pain Service
Epidural Analgesia in Labour
Intravenous Medications - Procedure for Reconstitution and Administration

Adult Medication Monograph Page 1 of 2


Paracetamol Infusion – Adult Medication Monograph

Standard Procedures for Reconstitution and Administration of IV Drugs


(Adults)
Australian Medicines Handbook. Paracetamol. In: Australian Medicines
References Handbook [Internet]. Adelaide (South Australia): Australian Medicines
Handbook; 2017 [cited 2017 Oct 03]. Available from:
https://amhonline.amh.net.au/

Society of Hospital Pharmacists of Australia. Paracetamol. In: Australian


Injectable Drugs Handbook [Internet]. [St Leonards, New South Wales]:
Health Communication Network; 2017 [cited 2017 Oct 03]. Available from:
http://aidh.hcn.com.au

The Royal Women's Hospital. Paracetamol. In: Pregnancy and


Breastfeeding Medicines Guide [Internet]. Parkville (Victoria): The Royal
Women's Hospital; 2016 [cited 2017 Oct 03]. Available from:
https://thewomenspbmg.org.au/

Keywords: Paracetamol infusion, Pain, Fever, Acetaminophen infusion IV paracetmaol


Publishing: Intranet Internet
Document owner: Chief Pharmacist
Author / Reviewer: KEMH Pharmacy Department
Date first issued: Aug 2015 Version: 3.0
Last reviewed: Oct 2017 Next review date: Oct 2020
Endorsed by: Medicines and Therapeutics Committee Date: Dec 2017
Standards Applicable: NSQHS Standards:
1 Clinical Care is Guided by Current Best Practice
4 Medication Safety
Printed or personally saved electronic copies of this document are considered uncontrolled.
Access the current version from the WNHS website.

© Department of Health Western Australia 2017

Adult Medication Monograph Page 2 of 2

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