Scribd Logo
Upload

Welcome to Scribd!

  • 249 views

    Immunology MCQ BY: Dr. Algassim

    Uploaded by

    mohamed
    This document contains an immunology multiple choice question (MCQ) exam with 6 questions and explanations. The questions cover topics like the cells that produce antibodies, antibodies that cross the placenta, the cause of neonatal symptoms in a baby born to a mother with Graves' disease, the diagnosis for a child with recurrent infections and granulomas, the requirements for B-cell class switching except one, and the vaccine that does not produce long-standing memory cells.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Immunology MCQ BY: Dr. Algassim

    Uploaded by

    mohamed
    249 views4 pages
    This document contains an immunology multiple choice question (MCQ) exam with 6 questions and explanations. The questions cover topics like the cells that produce antibodies, antibodies that cross the placenta, the cause of neonatal symptoms in a baby born to a mother with Graves' disease, the diagnosis for a child with recurrent infections and granulomas, the requirements for B-cell class switching except one, and the vaccine that does not produce long-standing memory cells.

    Original Title

    Immunology_MCQ_sample

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    This document contains an immunology multiple choice question (MCQ) exam with 6 questions and explanations. The questions cover topics like the cells that produce antibodies, antibodies that cross the placenta, the cause of neonatal symptoms in a baby born to a mother with Graves' disease, the diagnosis for a child with recurrent infections and granulomas, the requirements for B-cell class switching except one, and the vaccine that does not produce long-standing memory cells.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    249 views4 pages

    Immunology MCQ BY: Dr. Algassim

    Uploaded by

    mohamed
    This document contains an immunology multiple choice question (MCQ) exam with 6 questions and explanations. The questions cover topics like the cells that produce antibodies, antibodies that cross the placenta, the cause of neonatal symptoms in a baby born to a mother with Graves' disease, the diagnosis for a child with recurrent infections and granulomas, the requirements for B-cell class switching except one, and the vaccine that does not produce long-standing memory cells.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 4

     

    IMMUNOLOGY  MCQ  
     
    BY:  
    Dr.  Algassim  
     
     
     
     
     
     
     
     
    Q1:  Which  of  the  fallowing  cells  produces  Anti-­‐bodies?  
      A:  macrophage.  
      B:  B-­‐cells.  
      C:  T-­‐cells  
      D:  plasma  cells  
     
    The  answer  is  D.  
    Explanation:  when  B-­‐cell  receptor  (BCR)  ie:  IgD&IgM.  Come  in  
    contact   with   an   antigen.   B-­‐cells   proliferate   and   differentiate   into  
    plasma  cells  with  the  help  of  Th2.    
     
    Q2:  Which  of  the  following  Antibodies  cross  the  placenta?  
      A:  IgA.  
      B:  IgE.  
      C:  IgG.  
      D:  IgD.  
           
    The  Answer  is  C.  
      Explanation:   you   should   know   that   IgA   is   bound   to   mucous  
    membranes,   IgE   on   mast   cells,   and   IgD   &   IgM   act   as   BCR.   IgGs  
    circulate  blood.  Remember  that  some  Auto  antibodies  are  IgGs.  
     
     
    Q3:   a   37   weaker   primagravida.   Delivers   a   2200   grams   baby.   The  
    delivery   was   uneventful.   Apgar   score   were   7   at   1   ,and   9   at   5.   On  
    examination  you  notice  a  tachycardia,  hyperactivity  and  restlessness  
    warm   moist   skin   and   goiter.   Upon   further   inquiry   the   mother   tells  
    you   that   she   had   Garves’   disease   treated   with   radioactive   iodine   3  
    years  ago.  Now  she  is  on  levothyroxine  100  microgram  daily.  What  is  
    the  best  explanation  for  these  neonatal  findings?  
     
      A:  Congenital  multi-­‐nodular  goiter.    
          B:  DiGeorge  syndrome  (22q11).  
      C:  Mother’s  Thyroid  Stimulating  Antibody  (TSI).  
      D:  Multiple  endocrine  neoplasia  type  B1.  
     
     
     
    The  answer  is:  C  
      Explanation:   Don’t   let   the   long   question   fool   you   and   think   of  
    the   basics.     If   you   recall   the   explanation   of   Q2   above   you   will   find   the  
    answer,   which   is   obvious.   Although   the   mother   went   through  
    radioiodine   therapy   that   resulted   in   HYPOthyriodism,   her   immune  
    system   still   produces   TSI.   TSI   can   cross   the   placenta   giving   the  
    picture   of   neonatal   graves   disease.   Neonatal   graves’   usually   has   a  
    benign   course   lasting   3-­‐6   months   (which   is   the   life   of   maternal  
    antibodies)  and  observation  is  sufficient.    
     
    Q4:   a   24   months   old   boy   with   recurrent   superficial   infections,   and  
    lymphadenopathy.   Presented   with   fever,   left   leg   pain,   swelling,  
    erythema   and   inguinal   lymphadenopathy.   You   diagnosis   was  
    cellulitis.   After   admission   and   IV   antibiotics   an   inguinal   lymph   node  
    biopsy  was  taken  for  acid-­‐fast  stain  and  culture.  Pathology  reports  a  
    non-­‐caseating   granuloma   and   culture   growing   Serratia   Spp.   What   is  
    the  diagnosis?  
     
      A:  Chronic  granulomatous  disease.  
      B:  ataxia  telangiectasia.  
      C:  SCID.  
      D:  Wiscott-­‐Aldrich  syndrome.  
       
      The  Answer  is  A.  
    Explanation:   The   pathology   report   hinted   the   answer.   In  
    chronic   granulomatous   disease   (CGD)   the   phagocytic   cells   fail   to  
    produce  O2  free  radical  to  kill  bacteria  due  to  congenital  deficiency  in  
    NADPH   oxidase.   The   result   is   chronic   granuloma,   hence   the   name.    
    Serratia   Spp   are   common   organisms.   Other   catalase   positive  
    organisms  can  be  found  as  will.    
     
     
    Q5:  All  the  fallowing  is  required  in  B-­‐cell  class  switch,  except?  
     
    A:  Peptide  Antigen.    
    B:Th1  Cytokines  profile.  
    C:CD40-­‐CD40L  
    D:  MHC  ll-­‐TCR  
    E:  IL4-­‐IL5  
    The  Answers  is  B.  
     
     
     
    Explanation:  when  antigen  presented  to  Th2  Through  MHCll  on  
    the   B-­‐cell.   Other   interactions   happen   at   the   same   time   sometimes  
    called   immunologic   synapse.   Some   of   these   interactions   are  
    mentioned   above.   You   have   to   remember   that   for   every   T-­‐dependent  
    B  cell  activation  a  peptide  must  be  on  the  top  of  MHC  ll  molecule.  
     
     
    Q6:   in   all   the   fallowing   vaccines   which   one   doesn’t   produce   long-­‐
    standing  memory  cells?  
     
      A:  Pneumococcal  polysaccharide  vaccine  (PPSV)  
      B:  Haemophilus  influenzae  type  B  vaccine  (Hib)  
      C:  heptavalent  pneumococcal  conjugate  vaccine  (PCV  7)  
      D:  measles  mumps  and  rubella  vaccine  (MMR)  
     
    The  Answer  is:  A  
    Explanation:   when   examining   the   above   choices   you   must  
    notice   that   all   have   peptide   part   that   can   be   presented   to   Th   cells  
    except   PPSV   which   is   all   polysaccharides.   Remember   that   MHCl   &   ll  
    only   present   peptides   to   TCR.   The   end   result   of   PPSV   is   T-­‐  
    independent  B  cell  activation  with  no  memory  cells.  
     
     
     
     
    Acronyms:  
    TCR:  T  cell  receptor    
    BCR:  B  cell  receptor  
    MHC:  major  histio-­‐compatibility  complex.  
    Th1,2=  T  Cell  helper  1,2  
    SCID:  sever  combined  immunodeficiency    
     
     
     
     
     
     
     
     
     
     

    You might also like