New MRCPsych Paper II Mock MCQ Papers

New MRCPsych Paper II Mock MCQ Papers
This page intentionally left blank

New MRCPsych Paper II
Mock MCQ Papers
VELLINGIRI BADRAKALIMUTHU
MBBS, MRCPsych
Specialty Registrar in Old Age Psychiatry
PBL Tutor for CT1 and CT2 Psychiatry Trainees
Norfolk and Waveney Mental Health Foundation NHS Trust
Julian Hospital, Norwich
Foreword by
HUGO de WAAL
MD, FRCPsych
Lead Clinician for North Norfolk
Head of School, Postgraduate School of Psychiatry,
East of England Deanery
College Tutor, Norfolk and Waveney Psychiatric Training Scheme
Fellow, Higher Education Academy
CRC Press
Taylor & Francis Group
6000 Broken Sound Parkway NW, Suite 300
Boca Raton, FL 33487-2742
© 2009 by Vellingiri Badrakalimuthu

CRC Press is an imprint of Taylor & Francis Group, an Informa business
No claim to original U.S. Government works

Version Date: 20160525
International Standard Book Number-13: 978-1-138-03103-6 (eBook - PDF)
This book contains information obtained from authentic and highly regarded sources. While all reasonable efforts have been
made to publish reliable data and information, neither the author[s] nor the publisher can accept any legal responsibility or
liability for any errors or omissions that may be made. The publishers wish to make clear that any views or opinions expressed
in this book by individual editors, authors or contributors are personal to them and do not necessarily reflect the views/
opinions of the publishers. The information or guidance contained in this book is intended for use by medical, scientific or
health-care professionals and is provided strictly as a supplement to the medical or other professional’s own judgement, their
knowledge of the patient’s medical history, relevant manufacturer’s instructions and the appropriate best practice guidelines.
Because of the rapid advances in medical science, any information or advice on dosages, procedures or diagnoses should be
independently verified. The reader is strongly urged to consult the relevant national drug formulary and the drug companies’
and device or material manufacturers’ printed instructions, and their websites, before administering or utilizing any of the
drugs, devices or materials mentioned in this book. This book does not indicate whether a particular treatment is appropriate
or suitable for a particular individual. Ultimately it is the sole responsibility of the medical professional to make his or her
own professional judgements, so as to advise and treat patients appropriately. The authors and publishers have also attempted
to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission
to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us
know so we may rectify in any future reprint.
Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmitted, or utilized in
any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, micro-
filming, and recording, or in any information storage or retrieval system, without written permission from the publishers.
For permission to photocopy or use material electronically from this work, please access www.copyright.com (http://www.
copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood Drive, Danvers, MA 01923, 978-750-
8400. CCC is a not-for-profit organization that provides licenses and registration for a variety of users. For organizations that
have been granted a photocopy license by the CCC, a separate system of payment has been arranged.
Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identifi-
cation and explanation without intent to infringe.
Visit the Taylor & Francis Web site at
http://www.taylorandfrancis.com
and the CRC Press Web site at

http://www.crcpress.com
Contents
Foreword vi
Preface viii
About the author xi
About the references xii
Paper 1 1
Paper 2 47
Paper 3 93
Paper 4 137
Paper 5 183
Answers 227
Paper 1 227
Paper 2 228
Paper 3 229
Paper 4 230
Paper 5 231
Index 233
Foreword
There aren’t many books with a preface which contains an allusion to
E=MC2 and immediately go on to encourage a symbiotic relationship
with a mould-forming kitchen sink (no matter how readily recognis-
able the latter is to anyone who ever studied relativity at University, or
indeed anyone who ever revised for an exam). In fact, I would opine
there is only the one. It could be understood as symptomatic for the
breadth of Dr Badrakalimuthu’s second MRCPsych preparation work.
Once again tried and tested on the trainees in Norwich resulting in a
pass percentage that continues to be higher than the national average,
emphasising the completeness and thoroughness of the work.
This somewhat encyclopaedic feature immediately reminds one
of the life and times of the legendary Oliver Goldsmith, who posthu-
mously provided the motto to this book. Born in 1728 in Roscommon,
Ireland, Mr Goldsmith’s academic career started at the age of 16 at
Trinity College, Dublin. After graduation (it is not quite clear in what
topic of study) he became a tutor, but he was sacked after a quarrel.
He tried to emigrate to America, but missed his ship: not as easily
done as missing one’s flight from Heathrow. His next project, study-
ing law, was unwillingly shortened by gambling away the funds that
were meant to sustain him. Sometime later he shows up on a walking
tour through Flanders, having previously apparently studied medicine
in Edinburgh and possibly Leiden (Holland). He wound his way on
the roads as he did in academia, and meandered into Italy via France
and Switzerland, earning his keep by playing the flute. Returning to
London he blossomed into an author, playwright and poet and finally
reached a position of fame.
One of his earliest works was entitled Enquiry into the Present State
of Polite Learning (1759), in which he wrote:
Does the poet paint the absurdities of the vulgar, then he is low; does he
vi
FOREWORD
exaggerate the features of folly, to render it more ridiculous, he is then

very low. In short, they have proscribed the comic or satirical muse from
every walk but high life, which, though abounding in fools as well as the
humblest station, is by no means so fruitful in absurdity.
This brings us neatly to that lofty institution, which sets the curric-
ulum and exam questions you are assumed to be preparing for: you
may at times view those questions absurd to a degree, deemed lam-
entably absent by Goldsmith in ‘high life’. If so, it might be useful to
remind yourself that throughout your professional career the absurd-
ities of the vulgar are never thus: no matter what ‘station’ our patients
inhabit, the vulgar are never vulgar, their problems never absurd
and fools are few and far between. It could therefore be argued that,
whilst revising for the exam, your necessary obsession with the absurd
constitutes somewhat of a professional desensitisation: once you are
versant in the questions and answers contained in the Royal College’s
membership examinations, there won’t be much on the face of this
earth that would strike you as extraordinary, save perhaps your own
experience of having passed them.
A final remark: Goldsmith’s literary fame brought him wealth and
reputation, but his carelessness, intemperance and gambling habit
brought him down and he died penniless, broken in health and mind,
in 1774. Perhaps he would have benefited from familiarity with those
professional competencies in our College’s curriculum, which tran-
scend knowledge, are not easily tested in exams, but will prove vital
in you successfully meandering through your professional career,
whether you play the flute or not.
Hugo de Waal MD, FRCPsych

Lead Clinician for North Norfolk
Head of School, Postgraduate School of Psychiatry,
East of England Deanery
College Tutor,
Norfolk and Waveney Psychiatric Training Scheme
Fellow, Higher Education Academy
August 2009
vii
Preface
Having taken the first step towards successfully passing Paper II, your
focus should be on finding answers to the most complex and difficult
questions that you might expect in its exam. This book provides you
with that and more, but first I would like to answer (for a change)
some of the questions that trainees have often asked me.
WHEN IS THE RIGHT TIME TO SIT THE PAPER II EXAM?

In my opinion, the right time is your first opportunity to do so, as
I think that the easiest way to become a Member is to focus on one
exam at a time. However, if for any reason a person has to take Papers
I and II together, that person should view the situation as a challenge
befitting anyone who wants to pursue a career in psychiatry. Success
comes with hard work.
HOW SHOULD I PREPARE FOR THE EXAM?

I have come across people who tend to rely on crash courses and then
pass the exam on a wing and a prayer. Remember that the exam is a
path, not just to becoming a Member, but also to having adequate
knowledge to pursue a career in psychiatry. E is always equal to MC2.
If that were the focus, then reading for at least two hours a day during
the specialty (core) training years 1 to 3 would give you a head start.
Once the exam day is getting nearer, intensive revision in a symbi-
otic relationship with a mould-forming kitchen sink would take you
across the finish line in some style.
WHAT IS THE SYLLABUS FOR PAPER II?

The Department of Examinations, in their infinite wisdom, have never
been content with what should constitute Paper II. At the time when
viii
PREFACE
specialty training was introduced, the syllabus was notably different to

the syllabus that is current at the time of writing this book.
The current syllabus focuses on:
● general adult psychiatry
● epidemiology
● neuroscience
● psychopharmacology
● advanced psychological treatments.
The best way to keep track of this evolution is to visit www.rcpsych.

ac.uk/training/examinations.aspx.
WILL THERE BE QUESTIONS OUTSIDE THE SYLLABUS?

Psychiatrists reside in the comfort zone of grey shades, and this applies
to the exam, too! It is worth remembering that the idea behind the
artificial division of the subject into three papers is to make learning
a continuous activity that can be performed in manageable chunks.
However, while setting the questions the line between what is psycho-
pathology, what would be the psychopathological features of an illness
that would affect prognosis, and what psychotherapy to choose for
specific psychopathological features becomes a thin one. The College
will make every effort to ensure that the exam adheres to the syllabus
stringently, but that serves as guidance – not gospel. I would strongly
recommend that trainees at least go through the psychopharmacology
questions in New MRCPsych Paper I Mock MCQ!
DO I HAVE TO READ AND REMEMBER EVERYTHING UNDER

THE SUN?
The important thing to do is to construct whatever you read into
a question format. This should help you to recognise answers in
multiple-choice questions, as you are unlikely to be questioned
directly on what the incidence of schizophrenia is, but the question
will present you with a narrative about a specific situation in which
Mr Smith finds himself being the unfortunate last cousin of someone
with a schizoid personality, and will then ask what his risk would be.
Therefore thinking about facts and understanding their practical
ix
PREFACE
applications or theoretical underpinnings is what makes things easier

during the exam.
Has this answered the question? Perhaps not. In simpler terms,
recognising answers from sets of five options is all that you need to
do. Now that comes with practice, which is why this book contains
650 such questions. The 3250 stems (which is what the choices are
called) could be construed into individual facts, and questions could
be formed from any one of them. The more you practise, the better
the results will be.
WHAT SHALL I READ?

The important principle to remember is that the purpose of Papers 2
and 3 is to test for intensive understanding of a topic, not just super-
ficial knowledge, and to test whether you keep abreast of emerging
research evidence on the topics. I would advise you to read the British
Journal of Psychiatry, Advances in Psychiatric Treatments, and some
standard psychiatry textbooks, along with the National Institute for
Health and Clinical Excellence (NICE) guidelines.
This is why this book contains questions that are referenced to the
above-mentioned journals and the very latest textbooks – to give you
a certain advantage over your peers who might have developed tunnel
vision from restricting themselves to outdated information that has
never been revised.
WILL THERE BE QUESTIONS THAT I CANNOT ANSWER HOWEVER

HARD I TRY WHILE PREPARING?
The answer is yes. Still, these should be extremely few if you have
worked hard, and should not be a cause for concern. In a similar vein,
you will encounter some questions about which you might disagree
with the examiners over the answers purely because of what the ref-
erence for an answer is, and also because psychiatry is rather a grey
area.
And finally, best wishes with your studies. Luck can create an op-
portunity, but only hard work turns it into a success.
Vellingiri Badrakalimuthu
August 2009
x
About the author
Having completed the MBBS at Coimbatore Medical College, India,
in 2002, Vellingiri trained in psychiatry at the Institute of Mental
Health, Chennai, India. His first appointment in the UK was at the
Maudsley Hospital, after which he took up a post as Senior House
Officer on the Solent Rotation. He became a Member of the Royal
College of Psychiatrists in 2007.
He has research publications to his credit and has been commis-
sioned by Advances in Psychiatric Treatment and RCPsych-CPD
Online for various projects. He has been shortlisted for the Advance
Trainee of the Year Award (2009) by the Royal College of Psychiatrists.
He is currently a registrar in Old Age Psychiatry and PBL tutor for
CT1 and CT2 trainees. He is also studying for a Masters degree in
Neuroscience at the Institute of Psychiatry, London.
xi
About the references
JOURNALS
Advances in Psychiatric Treatment (2006, 2007, 2008 and 2009) (APT)
British Journal of Psychiatry (2006, 2007 and 2008) (BJP)
BOOKS
Hodges JR. Cognitive Assessment for Clinicians. Oxford: Oxford
University Press; 2007. (CA)
Longstaff A. Instant Notes in Neuroscience (BIOS Instant Notes).
Abingdon: Taylor & Francis; 2005. (N)
McGuffin P, Owen M, Gottesman I. Psychiatric Genetics and Genomics.
Oxford: Oxford University Press; 2004. (PG)
Morgan G, Butler S. Seminars in Basic Neurosciences. 1993; www.
rcpsych.ac.uk/pdf/semBasNeuro_prelims.pdf (SBN)
Patestas M, Gartner LP. A Textbook of Neuroanatomy. Oxford: Wiley-
Blackwell; 2006. (TN)
Sadock B, Kaplan H, Sadock V. Synopsis of Psychiatry. Behavioural
Sciences/Clinical Psychiatry (10 e). Philadelphia, PA: Lippincott
Williams & Wilkins; 2007. (KS)
Scott AIF. The ECT Handbook (2e): The Third Report of the Royal College
of Psychiatrists’ Special Committee on ECT. London: Royal College
of Psychiatrists; 2004. (ECT)
WEBSITES
www.nice.org.uk
www.rcpsych.ac.uk
xii
To Hugo and Daphne
And still they gazed, and still the wonder grew.

That one small head could carry all he knew.
The Deserted Village

Oliver Goldsmith (1728–1774)
1
Paper 1
1. With regard to premenstrual syndrome, all of the following state-

ments are true except:
a. It is a research diagnosis in DSM-IV
b. Symptoms occur in the luteal phase
c. Symptoms remit for at least 1 week in the follicular phase
d. The diagnosis is less stable over 48 months
e. To be of clinical significance the symptoms should be of
at least moderate intensity and cause severe functional
impairment (APT 2007)
2. Which of the following statements about antidepressant discon-

tinuation is true?
a. Discontinuation symptoms are dependent on the underlying
psychiatric disorder
b. Discontinuation symptoms are not associated with
mirtazapine
c. It was first reported following the discontinuation of
amitryptyline
d. The mean duration of discontinuation syndrome is 2 weeks
e. The onset of symptoms more than 1 week after
discontinuation is unusual (APT 2007)
1
NEW MRCPsych PAPER II MOCK MCQ PAPERS
3. Regarding the treatment of mania, the following statements are

all true except:
a. Antipsychotics are the most commonly used drugs for
patients hospitalised with mania
b. Blockade of α1 and H1 receptors is hypothesised to
contribute to the antimanic property of antipsychotics
c. The NNT for olanzapine in the treatment of mania is 4
d. Olanzapine acts faster in patients with non-psychotic mania
than does valproate
e. Olanzapine treatment predisposes to depression more than
treatment with haloperidol during a phase of mania (APT
2008)
4. Which of the following statements about dangerous and severe

personality disorder is true?
a. According to the Department of Health definition, the
risk presented should be functionally linked to personality
disorder
b. An admission to the DSPD unit requires one or more DSM-
IV personality-disorder diagnoses
c. Antisocial personality disorder is the second most common
diagnosis among juvenile prisoners
d. The minimum assessment required for admission to the
DSPD unit does not require assessment on the International
Personality Disorders Questionnaire
e. Risk Matrix 2000 focuses on non-sexual offending (APT
2007)
2
PAPER 1
5. Regarding the behavioural activation approach for depression, all

of the following statements are true except:
a. Behavioural activation is not about scheduling satisfying or
pleasant events
b. Behavioural activation uses the functional analysis of
cognitive processes that involve avoidance
c. Developmental formulation in behavioural activation shifts
the emphasis away from its social context
d. There is no significant difference between activity
scheduling and activity scheduling with cognitive challenges
e. There is no significant difference in 2-year outcomes
between activity scheduling and activity scheduling with
cognitive challenges to core beliefs and assumptions (APT
2008)
6. Which of the following statements is true regarding behavioural

activation for depression?
a. Goals should always include returning to normal work as
soon as possible
b. Learning theory is an alternative model to that of
behavioural activation
c. The number of sessions for treating depression is between
8 and 12
d. Secondary coping behaviours are targeted when the
individual is aware of precipitating factors
e. The Valued Living Questionnaire offers prompts for values
for the patient to decide on a Likert scale (APT 2008)
3
7. All of the following are approaches complementary to behavioural

activation except:
a. Acceptance and commitment therapy
b. Compassionate mind training
c. Family therapy
d. Exercise and healthy eating
e. Existential therapy (APT 2008)
8. Which of these statements about the epidemiology of paranoia is

true?
a. Delusions of reference are the second most common type of
delusions
b. Less than 1% of the non-clinical population have delusions
of a level of severity comparable to that of clinical psychosis
c. Odder, less plausible paranoid thoughts build on commoner,
more plausible ones
d. Persecutory delusions are found in post-traumatic stress
disorder but not in epilepsy
e. The rate of delusional beliefs in the general population is
greater than that of psychosis (APT 2006)
9. Which of the following statements about the cognitive behaviour

analysis system of psychotherapy (CBASP) is true?
a. An interpersonal discrimination exercise is a conclusion that
a patient draws with the assistance of the therapist about a
significant other in the patient’s life
b. It was developed as a treatment for acute reactive depression
c. Its key mechanism of change includes disciplined social
involvement
d. It uses its main therapy technique of situational analysis to
ameliorate psychopathology during treatment sessions
e. Its theoretical premise is that arrested maturational
development is the aetiological basis of depression (APT
2007)
4
PAPER 1
10. In CBASP, the therapist’s personal involvement in the patient’s

problems to demonstrate for the patient that behaviour has con-
sequences is part of which of the following?
a. Contingent personal responsivity
b. Disciplined personal involvement
c. Hot spot
d. Interpersonal discriminatory exercise
e. ‘Significant other’ history (APT 2007)
11. Which of the following statements about CBASP is true?

a. Contingent personal responsivity provides an opportunity to
direct the patient’s attention to the impact of the therapist’s
behaviour on the patient
b. The Coping Survey Questionnaire is a type of Likert scale
c. One way of analysing stimulus value is by using the Impact
Message Inventory
d. Situational analysis has three stages
e. There is no significant difference between CBASP combined
with drug therapy and drug therapy alone (APT 2007)
12. Which of the following statements about conversion disorder is

true?
a. According to DSM-IV criteria, conversion disorder is
characterised by the involvement of psychological factors
b. DSM-IV categorises conversion disorder and somatoform
disorders separately
c. Symptoms are common in children aged younger than
8 years
d. Symptoms are most common in young males
e. Around 10% of the patients admitted to general medical
services have had conversion symptoms at some time in their
life (APT 2009)
5
13. The Zurich criteria for hypomania include all of the following
except:
a. The absence of a past history of mania
b. At least 3 of the 7 symptoms of hypomania according to
DSM-IV
c. Euphoria, irritability or over-activity
d. Experience of negative consequences of hypomanic periods
e. Hypomanic symptoms with a duration of at least 1 day (APT
2006)
14. Indicators of bipolarity in apparently unipolar depression include

all of the following except:
a. Antidepressant-induced mania or hypomania
b. Early onset of depression
c. Multiple family members with major depression
d. Postpartum illness
e. Psychotic features after the age of 35 years (APT 2006)
15. Regarding the use of IQ tests in the diagnosis of early schizophre-

nia, all of the following statements are true except:
a. The average decline in IQ in samples with first-episode
illness is generally less than that in groups with chronic
schizophrenia
b. In cases of suspected schizophrenia, a decline of 15 or more
points indicates the presence of the disease
c. National Adult Reading Test (NART) underestimates IQ
decline in patients with schizophrenia
d. People with schizophrenia on average have a lower IQ than
the general population
e. People with schizophrenia on average have a lower IQ than
patients with bipolar disorder (APT 2008)
6
PAPER 1
16. The therapeutic aims of long-term supportive psychotherapy in

psychosis include all of the following except:
a. Establishing a therapeutic alliance
b. Holding and containing
c. Promoting awareness of transference issues
d. Promoting stability
e. Providing rehabilitation pathways (APT 2008)
17. Which of the following is the therapeutic technique of long-term

supportive psychotherapy?
a. Cognitive reattribution
b. Counselling
c. Dynamic formulation
d. Environmental interventions
e. Relaxation training (APT 2008)
18. Which of the following statements about narcolepsy is true?

a. Automatic behaviour is rare in patients with narcolepsy
b. High concentrations of orexin A have been found in the CSF
of patients with narcolepsy
c. Overnight polysomnography reveals the presence of sleep-
onset REM
d. The prevalence of narcolepsy in the general population is
2.5%
e. Sleep paralysis is seen in 75% of patients with narcolepsy
(APT 2006)
7
19. Which of the following statements about sleep disorders is

true?
a. All episodes of behavioural disorder are associated with
atonia in REM sleep disorder
b. Clonazepam is contraindicated in patients with poor sleep in
Guillain–Barré syndrome
c. Episodes of behavioural disorder occur during the first third
of sleep
d. Individuals with non-REM sleep disorder act out their
dreams
e. Methylphenidate worsens cataleptic attacks (APT 2006)
20. All of the following statements about paranoid personality dis-

order are true except:
a. Comorbidity with other personality disorders reaches up to
50%
b. High levels of delinquency in teenagers have been associated
with paranoid features
c. Its prevalence in community samples is 1.3%
d. Its prevalence among psychiatric outpatients is up to 10%
e. Around 10% of people with paranoid personality disorder
suffer from panic disorder (APT 2009)
21. With regard to the psychological processes in paranoid person-

ality disorder, all of the following statements are true except:
a. Attributional bias is a defence against low self-esteem
b. Low levels of rumination are associated with aggression
c. Paranoid thinking is associated with externalising personal
attributional bias
d. Paranoid thinking is associated with deficits in theory of
mind
e. Reciprocal determinism is a characteristic feature of the
disorder (APT 2009)
8
PAPER 1
22. All of the following are elements of the psychoanalytic theory of

depression except:
a. Ambivalence predisposes people to depression after object
loss
b. An excessively severe ego influences chronicity of depression
c. Early feeding and affective bonding experiences are of
particular importance in vulnerability to depression
d. Somatic symptoms of depression arise from inhibited
feelings of arousal
e. The triangle of conflict includes feelings of anxiety and
defence (APT 2009)
23. All of the following statements about spirituality are true

except:
a. Mental health professionals’ attitudes towards spiritual care
tend to be negative
b. One of the areas of questioning recommended in the
Spirituality and Mental Health leaflet from the Royal College
of Psychiatrists is in regard to remedies
c. Opinion polls indicate that although there has been a decline
in religious beliefs, spirituality remains strong
d. Psychiatric patients associate outcomes involving improved
capacity for problem solving with spiritual care
e. Within the literature, 20% of the studies identify spiritual or
religious beliefs as being beneficial (APT 2007)
9
24. Which of the following statements about steroids is true?

a. Anabolic steroids are prescription-only drugs
b. Anabolic steroids are controlled drugs under class D
c. Their circulating level of testosterone is typically 5% of that
in males
d. In a survey of college students in the UK, current steroid use
or use during the previous year was 5%
e. Around 10% of GPs treat patients who have engaged in
steroid misuse (APT 2006)
25. Which of the following statements about the characteristics of

steroids is true?
a. Oxymetholone causes little liver toxicity
b. Methenolone acetate causes severe water retention
c. Nandrolone causes dose-dependent hypertension
d. Stanozolol is injectable
e. Testosterone enantate is long acting (APT 2006)
26. Which of the following matches is accurate with regard to drugs

taken along with anabolic steroids?
a. Clenbuterol – worsens asthma
b. Cytomel – synthetic T3
c. Human growth hormone – high risk of hypoglycaemia
d. Insulin-like growth factor – cardiomegaly
e. Tamoxifen – oestrogen agonist (APT 2006)
10
PAPER 1
27. All of the following statements about steroids and mental illness
are true except:
a. Depression is associated with withdrawing from steroids
b. During steroid use, people score lower on schizoid
personality traits
c. The risk of developing psychotic symptoms may be related
to high-dose testosterone
d. Self-reported aggression may be the only sign of steroid
misuse
e. Steroid users have been shown to have a higher prevalence
of cluster B personality traits (APT 2006)
28. Which of the following statements about the NICE guidelines

for bipolar disorder is true?
a. The annual cost of bipolar disorder in the UK is around
£20 million
b. Carbamazepine should not be used for the treatment of
acute mania
c. Paroxetine is the drug of choice for treating severe
depression in pregnant women with bipolar disorder
d. The incidence of bipolar disorder decreases from mid to late
life
e. The use of the Mood Disorder Questionnaire is advisable
(www.nice.org.uk)
11
29. All of the following are NICE recommendations for the use of
antidepressants in bipolar disorder except:
a. Anyone under the age of 30 years should be reviewed within
1 week for suicidal ideation
b. If the patient does not respond to three adequate trials of
antidepressants, you should consider referral to a clinician
with special interest
c. Lamotrigine can be used routinely to treat depressive
episodes in bipolar type 1 disorder
d. Venlafaxine is less associated with discontinuation symptoms
than are SSRIs
e. When the symptoms have been less severe for at least
8 weeks, the discontinuing of antidepressants should be
considered (www.nice.org.uk)
30. Which of the following statements about the epidemiology of

schizophrenia is true?
a. Around 80% of people with schizophrenia have persistent
problems with social functioning
b. Around 60% of patients with schizophrenia are likely to
relapse within 5 years of a treated first episode
c. The best predictor of a long-term prognosis is poor
functioning in the first 2 years post diagnosis
d. Mortality among people with schizophrenia is 30% higher
than that of the general population
e. Young women from diverse ethnic backgrounds are at a
higher risk of suicide (KS)
12
PAPER 1
31. Which of the following statements about schizophrenia patients’

physical health is true?
a. GPs are better than psychiatrists at recognising and
treating physical health-related problems in people with
schizophrenia
b. GPs are as likely to screen individuals with schizophrenia for
cardiovascular risk as they are to screen those with asthma
c. Group intervention for smoking cessation has no significant
impact on morbidity
d. Patients with schizophrenia are less likely to attend
screening for cardiovascular disorders than other people
e. People with schizophrenia apparently do not have raised
rates of lung cancer (www.nice.org.uk)
32. Which of the following statements about the management of

a. Around 10% of schizophrenia patients receiving first-
generation antipsychotics develop tardive dyskinesia
b. Fewer than 10% of service users are managed solely in
primary care
c. Raised serum prolactin levels from antipsychotics lead to
reduced bone density
d. Services for schizophrenia account for 40% of NHS
spending on mental health
e. Up to 25% of schizophrenia patients have a poor response to
conventional antipsychotics (www.nice.org.uk)
33. Which of the following cranial nerves leaves the brainstem

through the middle cerebellar peduncle?
a. V
b. VI
c. VII
d. VIII
e. IX (TN)
13
34. The cranial nerve that arises between pyramids and olives is:
a. VIII
b. IX
c. X
d. XI
e. XII (TN)
35. The descending tract of the trigeminal nerve forms:

a. The fasciculus cuneatus
b. The fasciculus gracilis
c. The tuberculum cinereum
d. The tuberculum gracilis
e. The tuberculum cuneatus (TN)
36. Which of the following does the trigeminal ganglion occupy?

a. The diaphragm sella
b. The falx cerebri
c. The falx cerebelli
d. Meckel’s cave
e. The tentorium cerebella (TN)
37. All of the following are correct with regard to the composition of
cerebrospinal fluid except:
a. Calcium concentration is 1.0–1.4 mmol/L
b. Magnesium concentration is 0.8–1.3 mmol/L
c. pH is 7.3
d. Potassium concentration is 2.0–2.8 mmol/L
e. Protein – almost none (TN)
14
PAPER 1
38. All of the following statements about the corticospinal tract are
true except:
a. Fibres terminating in the ventral motor horn of the spinal
cord are involved in muscle contraction
b. Fibres that do not decussate form the anterior corticospinal
tract
c. It passes through the posterior limb of the internal capsule
near its genu
d. It passes through the posterior half of the posterior limb of
the internal capsule
e. It passes through the upper third of the crux cerebri (TN)
39. Which of the following statements about the corticobulbar tract

is correct?
a. The corticonuclear tract descends posterior to the
corticospinal tract
b. The corticonuclear tract projects fibres bilaterally to the
lower motor neuron of the facial nucleus that innervates
muscles in the lower half of the face
c. Its fibres terminate not only in target cranial nerve motor
nuclei but also in the sensory relay nuclei
d. The inferior colliculus relays corticonuclear fibres
e. The lower motor neuron that innervates the genioglossus
muscle receives bilateral corticonuclear projections (TN)
40. Mr Bainbridge presents with an inability to coordinate hand

movements bilaterally, with no evidence of paralysis. At what level
is his lesion?
a. Corticospinal tract at the level of corona radiata
b. Corticospinal tract at the level of crus cerebri
c. Premotor cortex
d. Primary motor cortex
e. Supplementary motor area (TN)
15
41. Neostriatum is made of caudate and which of the following?

a. Globus pallidus
b. Nucleus accumbens
c. Subthalamic nucleus
d. Ventral pallidum
e. Ventral tegmental area (TN)
42. Corticostriate fibres that terminate in the putamen use which of

the following?
a. Aspartate
b. Dopamine
c. Glycine
d. Serotonin
e. Arginine-vasopressin (TN)
43. Which of the following is the only cranial nerve to send central
processes of some of its first-order neurons to synapse directly in
the cerebellum?
a. III
b. V
c. VII
d. VIII
e. XI (TN)
44. The carotid sinus reflex would be lost in a lesion involving which
of the following?
a. The inferior ganglion of glossopharyngeal nerve
b. The jugular ganglion of vagus nerve
c. The otic ganglion of glossopharyngeal nerve
d. The superior ganglion of glossopharyngeal nerve
e. The superior ganglion of vagus nerve (TN)
16
PAPER 1
45. Which of the following is the nucleus involved in phonation?

a. Ambiguus
b. Dorsal motor nucleus of vagus
c. Hypoglossal
d. Solitarius
e. Spinal nucleus of trigeminal (TN)
46. In which of the following are the cell bodies of rods and cones
present?
a. Ganglion cell layer
b. Inner nuclear layer
c. Outer nuclear layer
d. Optic nerve fibre layer
e. Rod and cone layer (TN)
47. Which of the following statements about the optic pathway is

true?
a. The axons of the optic nerve become myelinated once they
pierce the lamina cribrosa
b. The optic chiasma sends fibres to the hypothalamus
c. The secondary visual cortex involves the middle temporal
area
d. The sublenticular portion of the geniculocalcarine tract goes
up to the cuneate gyrus
e. The first-order neurons are pseudounipolar (TN)
17
48. All of the following statements about the primary somatosensory

cortex are true except:
a. The area within the central sulcus receives input from
muscle receptors
b. It includes the dorsal part of the paracentral lobule
c. The primary auditory cortex includes the transverse
temporal gyri of Heschl
d. The primary visual cortex receives input from the macula of
retina in its rostral portions
e. A solitary nucleus transmits taste sensation to the postcentral
gyrus through the ventroposteromedial nucleus of the
thalamus (TN)
49. All of the following statements about the cortex are true except:
a. Broca’s area consists of supramarginal gyrus
b. The dorsolateral prefrontal cortex functions in working
memory
c. The secondary auditory cortical areas are connected with
Wernicke’s area
d. The somaesthetic association area is located in the superior
parietal lobule
e. Tertiary visual areas include the middle temporal area of the
cortex (TN)
50. Mr Bainbridge presents with cortical blindness. This is due to an

infarction involving which of the following?
a. The anterior cerebral artery
b. The anterior communicating artery
c. The basilar artery
d. The middle cerebral artery
e. The posterior communicating artery (TN)
18
PAPER 1
51. Mr Bainbridge presents with a deviation of both his eyes to the

right side. This is due to a lesion involving which of the fol-
lowing?
a. The left frontal eye field
b. The left primary visual area
c. The right frontal eye field
d. The right primary visual area
e. The right visual association area (TN)
52. Mr Bainbridge presents with difficulty in processing what he hears

and formulating a response. However, he can comprehend what
he hears, and his language expression is fluent. At which level is
the lesion?
a. The arcuate fasciculus
b. Broca’s area
c. The primary auditory cortex
d. The transcortical global
e. Wernicke’s area (TN)
53. Which of the following statements about pain sensation is true?

a. The activation of large myelinated mechanoreceptor
afferents can reduce some forms of pain
b. The anterior nucleus of the hypothalamus is involved in the
pathways for discriminating aspects of somaesthesia
c. Burning sensations are thought to be carried by small
myelinated Aδ fibres
d. The electrical stimulation of the raphe nucleus produces
profound hyperaesthesia
e. The spinal-cord neurons that relay pain sensation are
located in the deep laminae of the dorsal grey matter (SBN)
19
54. Which of the following statements is true?

a. Clasp knife reflex is mediated by interneurons which are
connected to 1a fibres
b. The GABA-secreting interneurons of basal ganglia are co-
localised with somatostatin
c. Group 1b afferent axons have excitatory connections with
the motor neurons that cause muscle to contract
d. The intrinsic neurons of the cerebellum exclude excitatory
granule cells
e. The motor neurons in the spinal cord form the final
common path for all motor activity (SBN)
55. Which of the following statements about visual pathways is

true?
a. Layers 1, 4 and 6 of the lateral geniculate nucleus receive
input from the ipsilateral temporal retina
b. A small portion of nasal hemiretina that receives monocular
vision is called a nasal crescent
c. The superior colliculus is responsible for directing each
fovea to its target
d. A unilateral lesion of the frontal cortex results in the inability
to direct a gaze laterally in either direction
e. The vestibular nuclei send information to the cranial nuclei
of the second nerve (SBN)
20
PAPER 1
56. Which of the following statements about vestibular reflexes is

incorrect?
a. Compensatory eye movement has two phases
b. Defects associated with the fast phase are related to reticular
formation
c. Four vestibular nuclei are located in the medulla
d. The inferior vestibular nucleus plays the key role in reflex
control of head position
e. The lateral vestibular nucleus receives inhibitory input from
the cerebellum (SBN)
57. Which of the following statements about reticular formation is

true?
a. Colliculi are involved in orienting the head towards the
direction of startle stimuli
b. EEG changes are independent of the effects of the thalamic
nuclei on the cerebral cortex
c. The startle response is independent of reticular formation
d. Stimulation of the nucleus raphe magnus produces
hyperaesthesia
e. Stimulation of the reticular formation leads to the extinction
of aversive behaviour (SBN)
58. Which of the following forms of apraxia accompanies Broca’s

aphasia?
a. Conceptual
b. Dressing
c. Ideomotor
d. Limb kinetic
e. Oral (CA)
21
59. Mr Bainbridge presents with an inability to carry out motor tasks

to command, but performs the same tasks spontaneously. At
which of the following is the lesion?
a. The basal ganglion
b. The inferior frontal region
c. The left frontotemporal area
d. The left parietal lobe
e. The right posterior parietal area (CA)
60. Mr Bainbridge presents with an inability to name or describe

visually presented items. Which of the following does the lesion
involve?
a. The bilateral posterior occipitoparietal region
b. The bilateral temporoparietal region
c. The left anterior temporal lobe
d. The left medial occipital region
e. The occipitotemporal area (CA)
61. All of the following statements about Balint’s syndrome are true
except:
a. It involves a lesion of angular gyrus
b. There is an inability to reach for visual targets
c. There is an inability to point at visual targets
d. Simultagnosia is a feature
e. Symptoms include an inability to direct voluntary eye
movements to visual targets (CA)
22
PAPER 1
62. Mr Bainbridge presents with impairment in retrieval of colour

information. This is which of the following?
a. Achromatopsia
b. Apperceptive visual agnosia
c. Colour agnosia
d. Prosopagnosia
e. Simultagnosia (CA)
63. Which of the following do phakomatoses include?

a. Arteriovenous malformations
b. Fragile X syndrome
c. Heterotopia of grey matter
d. Schizencephaly
e. Tuberous sclerosis (SBN)
64. Based on a presentation of hypertelorism, high arched palate,

absent patellae, congenital heart disease and agenesis of corpus
callosum, which of the following is the correct chromosomal
abnormality?
a. 5p deletion
b. 8 mosaic
c. 9p trisomy
d. 22 trisomy
e. XXY (SBN)
23
65. Based on a presentation of infantile hypotonia, learning disab-

ility, short stature, small hands and feet, hypoplastic genitalia,
hyperphagia and obesity, which of the following is the correct
chromosomal abnormality?
a. 5p deletion
b. 15 deletion
c. 18p deletion
d. 21 trisomy
e. XO (SBN)
66. Which of the following is the atresia of foramen of Luschka and

Magendie associated with hydrocephalus?
a. An Arnold–Chiari malformation
b. An Aicardi malformation
c. A Dandy–Walker malformation
d. Bourneville’s disease
e. Von Hippel–Lindau disease (SBN)
67. In which of the following are tuber-like astrocytic lesions seen?

a. Bourneville’s disease
b. The De Lange malformation
c. Encephalofacial angiomatosis
d. Sturge–Weber syndrome
e. Von Recklinghausen’s syndrome (SBN)
24
PAPER 1
68. Which of the following is the commonest form of primitive neu-

roectodermal tumour?
a. Astrocytoma
b. Ependymoma
c. Oligodendroglioma
d. Medulloblastoma
e. Microglioma (SBN)
69. All of the following statements about cranial tumours are true
except:
a. Anterior falx meningiomas may present with the frontal lobe
syndrome
b. Limbic encephalitis can be a non-metastatic complication of
systemic malignant disease
c. Malignant tumours are more common in the anterior
pituitary than in the posterior pituitary
d. Meningiomas commonly originate from the arachnoid cells
of leptomeninges
e. Metastases are usually from carcinomas of the lung (SBN)
70. Which of the following elements is associated with cerebellar

damage, damage to primary sensory areas, and neurasthenic syn-
drome?
a. Aluminium
b. Copper
c. Chlorine
d. Lead
e. Mercury (SBN)
25
71. Which of the following is damaged by MPTP?

a. Nucleus basalis of Meynert
b. Locus coeruleus
c. Mamillary body
d. Raphe nucleus
e. Substantia nigra (SBN)
72. Deficiency of which of these vitamins causes subacute combined

degeneration of the spinal cord?
a. Cyanocobalamin
b. Folate
c. Niacin
d. Riboflavin
e. Thiamine (SBN)
73. All of the following statements about neuropeptide Y(NPY) are

true except:
a. It is not synthesised in the cell bodies of the paraventricular
nucleus
b. It controls luteinising hormones, releasing the hormone in
the absence of oestrogen priming
c. It controls the thyrotropin-releasing hormone
d. It is co-localised with catecholamines in neurons that
originate from the brainstem
e. It is not co-localised with catecholamines in neurons that
originate from the arcuate nucleus (SBN)
26
PAPER 1
74. All of the following stimulate feeding except:

a. Galanin
b. Growth-hormone-releasing factor
c. Opioids
d. Neuropeptide Y
e. Neurotensin (SBN)
75. Which of the following inhibits feeding?

a. Cholecystokinin
b. Galanin
c. Growth-hormone-releasing factor
d. Neuropeptide Y
e. Noradrenaline through α2-receptors (SBN)
76. All of the following stimulate the release of arginine vasopressin

except:
a. Atrial peptides
b. Decreased plasma osmolality
c. Hypovolaemia
d. Nausea
e. Stress (SBN)
77. Which of the following is the hypothalamic nucleus involved in

the control of gonadotrophin-releasing hormone?
a. The arcuate nucleus
b. The paraventricular nucleus
c. The periventricular nucleus
d. The preoptic area
e. The supraoptic nucleus (SBN)
27
78. All of the following statements about the genetics of autism are
true except:
a. The candidate gene for autism is the 5HT transporter gene
b. The concordance rate among MZ twins has ranged from
36% to 90%
c. A LOD score of 2.53 is reported in a region on chromosome
7q
d. The relative increased risk to siblings of those with classic
autism is between 10 and 20
e. Tuberous sclerosis occurs in less than 5% of those with
autism (PG)
79. Which of the following is true with regard to the genetics of

childhood schizophrenia?
a. An association with abnormality of D3 receptor locus
has been reported for adult- but not childhood-onset
schizophrenia
b. The concordance rate among MZ twins is lower than that of
adult-onset schizophrenia
c. Chromosome 1p22 has been implicated
d. The rate of deletion of chromosome 22q11 is lower than
that seen in adult schizophrenia
e. The rate of non-affective psychosis among relatives of
childhood schizophrenics with premorbid speech and
language impairment is lower than that in the adult
population with schizophrenia (PG)
28
PAPER 1
80. Which of the following statements about the genetics of ADHD

is true?
a. The DAT2 gene has been implicated in ADHD
b. The DRD4 7 allele confers susceptibility with an estimated
odds ratio of between 2.5 and 3.0
c. Family studies have shown that ADHD and conduct
disorders are co-transmitted among families
d. The relative risk of ADHD among first-degree relatives is
greater among probands with ADHD that persists into adult
life than among probands with ADHD that is comorbid with
conduct disorder
e. First-degree relatives have a relative risk of between 2 and 3
(PG)
81. All of the following statements about the genetics of personality

disorders are true except:
a. An increased rate of schizophrenia has been found among
first-degree relatives of probands with schizotypal disorder
b. An increased rate of schizotypal personality disorder
has been found among the relatives of patients with
schizophrenia
c. Studies have generally reported negative results for
borderline personality disorder among first-degree relatives
of patients with depression
d. Studies have reported a higher rate of Briquet syndrome
among the female relatives of males with antisocial
personality disorder
e. Studies have reported that lying has more genetic heritability
than truancy, which shows a stronger influence from shared
environmental effects (PG)
29
82. Which of the following statements about the genetics of bipolar

disorder is true?
a. Bipolar disorder type 2 is found with less frequency in the
families of bipolar type 1 probands than in the general
population
b. The MZ concordance for narrowly defined bipolar disorder
is 30%
c. The number of affected relatives is a marker for familial
disorder, but a vulnerability to puerperal triggering of
episodes is not
d. Pre-pubertal depression has a distinct genetic aetiology
e. There is an estimated risk of 7% for bipolar disorder type 1
among first-degree relatives of cases with the same disorder
(PG)
83. All of the following statements about adrenergic receptors are

true except:
a. β2-receptors are presynaptic inhibitory autoreceptors
b. cAMP is reduced by α2-receptors
c. cAMP-mediated phosphorylation of N-type Ca2+ channels
reduces noradrenaline release
d. GO second messenger, coupled to α1-receptor, reduces gK
e. Gs is the second messenger system involved in β-receptors
(N)
84. Which of the following is true with regard to serotonin?

a. Choroid plexus lacks serotonergic innervation
b. Ecstasy increases the release of serotonin
c. The oxidative decarboxylation of serotonin by MAO yields
5-HIAA
d. Serotonergic cells are important for learning about aversive
situations
e. Serotonin synthesis is independent of the firing frequency of
neurons (N)
30
PAPER 1
85. At which of the following serotonin receptors is ketanserin an

antagonist?
a. 1a
b. 1b
c. 2a
d. 2b
e. 3 (N)
86. Ondansetron increases IP3 levels by acting at which of the follow-

ing serotonergic receptor subtypes?
a. 1a
b. 2b
c. 3
d. 4
e. 7d (N)
87. Sumatriptan is an agonist at which of the following serotonergic

receptors?
a. 1b
b. 1d
c. 2a
d. 2b
e. 3 (N)
88. Which of the following enzymes is used in the polymerase chain

reaction?
a. DNA trinucleotidase
b. Restriction endonuclease
c. Reverse transcriptase
d. RNA polymerase
e. Taq polymerase (PG)
31
89. A micro-array is called which of the following?

a. A DNA chip
b. A polymerase chain reaction
c. A primer extension
d. A restriction fragment length polymorphism
e. A short tandem repeat polymorphism (PG)
90. By which of the following methods can mRNA be assayed?

a. Central blotting
b. Eastern blotting
c. Northern blotting
d. Southern blotting
e. Western blotting (PG)
91. By which of the following methods can DNA be assayed?

a. Central blotting
b. Eastern blotting
c. Northern blotting
d. Southern blotting
e. Western blotting (PG)
92. Which of the following is Mendel’s law?

a. Dependent assortment
b. Incomplete penetrance
c. Integration
d. Segregation
e. Variable expressivity (PG)
32
PAPER 1
93. Which of the following genes has been implicated in determining

precortical volume decline in people with schizophrenia?
a. COMT
b. DISC1
c. Dysbindin
d. Neuregulin
e. PRODH (BJP 2006)
94. Which of the following genes has been implicated in learning and
memory in the disease model of schizophrenia?
a. COMT
b. DISC1
c. Dysbindin
d. Neuregulin
e. PRODH (BJP 2006)
95. Which of the following genes interacts with LIS1 to cause

lissencephaly?
a. COMT
b. DISC1
c. Dysbindin
d. Neuregulin
e. PRODH (BJP 2006)
96. Which of the following genes is associated with mitochondrial

and microtubule function?
a. COMT
b. DISC1
c. Dysbindin
d. Neuregulin
e. PRODH (BJP 2006)
33
97. All of the following statements about cognitive impairment in

bipolar disorder are true except:
a. Cognitive impairment in bipolar disorder remits during
phases of euthymia
b. Medium-term lithium treatment does not impair explicit
memory
c. The occurrence of psychotic symptoms is related to poor
performance on cognitive tasks
d. One predictor of a poor prognosis in bipolar type 2 disorder
is poor performance on executive-function tasks
e. Working memory is impaired in bipolar disorder (BJP 2006)
98. Which of the following statements about hysteria is true?

a. Hoover’s sign of paralysis has poor reliability for
differentiating conversion from organic disorder
b. La belle indifference is not a diagnostic criterion
c. La belle indifference is an important discriminant between
organic and conversion disorders
d. La belle indifference is linked to left-hemisphere pathology
e. The midline splitting of sensory loss has good reliability for
distinguishing conversion disorder from organic disorder
(BJP 2006)
34
PAPER 1
99. Which of the following statements about insight and cognition is

true?
a. The analysis of different insight scales reveals a differential
association with cognitive performance
b. Impaired insight is not associated with the severity of the
pathology
c. Impaired insight is not associated with prefrontal
dysfunction
d. Impaired insight is significantly correlated with
neurocognitive performance
e. The relationship between IQ and insight is stronger than the
relationship between insight and WCST scores (BJP 2006)
100. Which of the following statements about memory impairment in

a. A minority of community-based patients have memory
deficits
b. The Rivermead Behavioural Memory Test has 8 items
c. A significant inverse correlation exists between age and
memory scores
d. A significant correlation exists between a positive scale of
PANSS and memory scores
e. A significant correlation exists between type of antipsychotic
and memory scores (BJP 2006)
35
101. Which of the following statements about clozapine is true?

a. Carbamazepine is safe, as it does not increase the possibility
of neutropenia
b. Clozapine must be stopped immediately if the white cell
count falls below 5 × 109
c. Clozapine must be stopped immediately if the neutrophil
count falls below 3 × 109
d. Infection can be a precipitant of neutropenia in patients who
are challenged with clozapine
e. Patients who develop neutropenia should not be
rechallenged with clozapine (BJP 2006)
102. All of the following statements about panic disorder are true
except:
a. In acute-phase treatment, combined treatment is superior to
antidepressant treatment
b. Beyond its acute phase, combined treatment is superior to
antidepressant treatment
c. Beyond its acute phase, combined treatment is superior to
psychotherapy
d. The evidence for cognitive–behavioural therapy is most
conclusive
e. Pharmacotherapy is associated with significant relapse rates
even when patients are maintained on adequate doses of
antidepressants (BJP 2006)
103. An MRS study of patients with Alzheimer’s disease found their

inositol levels to be increased. In which of the following is this
change seen?
a. Frontal
b. Insular
c. Occipital
d. Parietal
e. Temporal (KS)
36
PAPER 1
104. All of the following statements about fMRI are true except:
a. fMRI shows that the neural circuit for lexical categories
involves the left anterior temporal lobe
b. fMRI shows that the area activated upon listening to speech
is also activated during auditory hallucinations in people
with schizophrenia
c. fMRI shows that patients with dyslexia show a failure to
activate Wernicke’s area
d. It gives specific information about neuronal metabolism
e. It works on the principle of detecting the levels of
oxygenation in blood (KS)
105. All of the following statements about adult ADHD are true
except:
a. About 65% of those with ADHD fulfil the criteria for partial
remission at the age of 25 years
b. ADHD symptoms are continuously distributed throughout
the population
c. ADHD symptoms show an age-dependent decline
d. Adults with ADHD respond to stimulants
e. Longitudinal studies show that ADHD and antisocial
behaviour start simultaneously (BJP 2007)
106. All of the following statements about the treatment and outcomes
of eating disorders among adolescents are true except:
a. High expressed emotion is associated with poor outcomes
b. Inpatient treatment predicts poor outcomes
c. Only about 50% of adolescents adhere to inpatient
treatment
d. There is RCT evidence for family treatment for anorexia in
adolescents
e. Those receiving lengthy inpatient treatment that results in
their regaining normal weight continue to maintain their
weight at 1-year follow-up (BJP 2007)
37
107. All of the following statements about depression and MI are true
except:
a. An ENRICHD study showed that the improvement in
depression observed at 6 months following CBT was
sustained at 30 months
b. Post-MI depression is associated with a 2- to 2.5-fold
increase in mortality
c. Sertraline is a safe drug to use in post-MI patients
d. The somatic symptoms of depression are associated with a
poor prognosis in post-MI patients
e. CBT has no effect on the risk of all-cause mortality in MI
patients with depression (BJP 2007)
108. Which of the following is an agent that binds to the same recep-
tor as an agonist for that receptor, but produces the opposite
pharmacological effect?
a. Antagonist
b. Full agonist
c. Inverse agonist
d. Mixed agonist
e. Partial agonist (KS)
109. Which of the following drugs is associated with weight loss?

a. Bupropion
b. Buspirone
c. Lithium
d. Sodium valproate
e. Topiramate (KS)
38
PAPER 1
110. Serious exfoliative dermatitis is seen with:

a. Clonazepam
b. Lamotrigine
c. Phenytoin
d. Sodium valproate
e. Vigabatrin (KS)
111. Which of the following is an antipsychotic associated with high

muscarinic blockade?
a. Aripiprazole
b. Olanzapine
c. Risperidone
d. Quetiapine
e. Ziprasidone (KS)
112. Rabbit syndrome can be treated using:

a. Buspirone
b. Clonazepam
c. Diphenhydramine
d. Orphenadrine
e. Propranolol (KS)
39
113. Which of the following statements about untreated psychosis is

true?
a. Its acute onset is associated with a substantially longer
duration of untreated psychosis
b. The duration of untreated psychosis lacks correlation with
mid-term outcomes
c. Family help-seeking is associated with a shorter duration of
the untreated illness
d. Unemployment is not related to the duration of untreated
psychosis
e. Unlike psychosis, the duration of untreated illness has no
effect on the prognosis for anxiety disorders (BJP 2006)
114. All of the following statements about vagus stimulation are true
except:
a. The acute response to vagus stimulation in resistant
depression is notably low
b. It has been found to be effective in the treatment of resistant
epilepsy
c. The leads from the device are connected to the thoracic
vagus
d. The procedure involves the subcutaneous implantation of a
pacemaker-like device
e. Vocal cord palsy has been reported to be an adverse effect of
the procedure (BJP 2006)
40
PAPER 1
115. Which of the following statements about violence and psychiatric

comorbidity is true?
a. An increased risk of violence in youth is dependent on
psychiatric comorbidity
b. A large reduction in exposure to the risk factor of hazardous
drinking at the individual level is associated with a large
overall impact on a population’s behaviour with regard to
drinking
c. People with psychotic illness pose a greater threat to random
members of the public than to people they know
d. The public health impact of violence from schizophrenia is
lower than that from substance use
e. Low self-esteem is associated with the risk of violence by
men against their partners, but somatic complaints are not
(BJP 2006)
116. All of the following statements about velocardio-facial syndrome

(VCF) and facial-expression processing are true except:
a. Facial processing networks involve occipital gyri providing
input to the superior temporal region
b. VCF is associated with chromosome 22q11 deletion
c. People with VCF perform less well on space-perception
tasks than on object-perception tasks
d. People with VCF show less activation of their right insula in
facial processing
e. People with VCF show more activation of their bilateral
occipital lobes in early facial processing (BJP 2006)
41
117. Which of the following statements about psychotherapy is true?

a. Antidepressant therapy is as effective as combined therapy in
the treatment of panic disorder without agoraphobia
b. Brief, dynamic psychotherapy is more effective than CBT
for avoidant personality disorder
c. Music therapy significantly improves the general symptoms
of schizophrenia
d. Younger patients with first- and second-episode psychosis
respond better to counselling than to CBT
e. Younger patients with first- and second-episode psychosis
show greater insight after counselling than after CBT (BJP
2006)
118. All of the following are good prognostic factors for brief psychotic
disorder except:
a. Affective symptoms
b. Confusion during onset
c. Insidious onset
d. Little affective blunting
e. Severe precipitating stressor (KS)
119. Which of the following statements about brief psychotic disorders

is true?
a. DSM-IV-TR describes four subtypes
b. Less than half of the patients with these disorders display
schizophrenia or mood disorder at long-term follow-up
c. A longer duration of symptoms is associated with a good
prognosis
d. They are more common in older patients
e. Psychodynamic formulations suggest that such psychotic
symptoms develop as defences against prohibited fantasies
(KS)
42
PAPER 1
120. Which of the following is an anger syndrome associated with

insomnia, fatigue, fear of impending death, dysphoric affect,
indigestion, and the feeling of a mass in the epigastrium?
a. Brain fag
b. Dhat
c. Hwa-byung
d. Koro
e. Locura (KS)
121. Which of the following statements about psychodynamic factors

in depression is true?
a. According to Melanie Klein, depression is an expression of
anger towards hated people
b. According to self-psychological theory, when the developing
needs of the self are unmet, a massive loss of self-esteem
results
c. Damaged early attachment predisposes people to childhood
depression
d. Disturbances in the genital phase predispose people to
subsequent vulnerability to depression
e. The projection of departed objects is a defence mechanism
for dealing with distress resulting from object loss (KS)
122. Beliefs about oneself, the world and the future are referred to as:
a. Cognitive distortion
b. The cognitive triad
c. Learned helplessness
d. Schema
e. Psychodynamic hierarchies (KS)
43
123. The forming of conclusions based on too little and too narrow
experience is referred to as:
a. Arbitrary inference
b. Magnification and minimisation
c. Oversimplification
d. Personalisation
e. Specific abstraction (KS)
124. The tendency to put experiences into all-or-nothing categories is

referred to as:
a. Absolutist thinking
b. Arbitrary inference
c. Oversimplification
d. Personalisation
e. Specific abstraction (KS)
125. All of the following statements about the course of major depress-
ive disorder are true except:
a. Around 5–10% of patients with an initial diagnosis of
depression develop a manic episode 6 to 10 years after initial
diagnosis
b. Late onset is associated with antisocial personality disorder
c. A major depressive disorder is usually preceded by a
premorbid personality disorder
d. Over a 20-year period the mean number of episodes is
between five and six
e. Untreated episodes last for about 6 to 13 months (KS)
44
PAPER 1
126. Which of the following is a selection criterion for time-limited

psychotherapy?
a. The ability to engage and disengage
b. Low ego strength
c. Being unsuitable for borderline personality disorder
d. Being unsuitable for major depressive disorder
e. The therapist being quickly able to identify a central issue
(KS)
127. For which of the following is the use of projection and splitting
as defence mechanisms specifically unsuitable?
a. Brief focal psychotherapy
b. Psychoanalytic psychotherapy
c. Short-term anxiety-provoking psychotherapy
d. Short-term dynamic psychotherapy
e. Time-limited psychotherapy (KS)
128. Abreaction is used as a major group process in:

a. Analytically oriented group therapy
b. Behavioural group therapy
c. Psychoanalysis of groups
d. Supportive group therapy
e. Transactional group therapy (KS)
129. In which of the following is socialisation outside the group always

encouraged?
45
130. Improving adaptation to the environment is a goal of:

46
2
Paper 2
1. With regard to the epidemiology of premenstrual syndrome,

which of the following statements is true?
a. Its diagnosis is associated with smoking and higher
educational levels
b. Fewer than 10% of women with the syndrome miss work
c. The lifetime rate for comorbid post-traumatic stress
disorder is high
d. Premenstrual dysphoric disorder has a prevalence of
between 15% and 20%
e. Women with this syndrome score as badly as those with
dysthymia on the Parental Factor of the Social Adjustment
Scale Self-Report (APT 2007)
2. All of the following statements about the symptoms of antidepres-

sant discontinuation are true except:
a. The discontinuation syndrome associated with
tranylcypromine is more severe than that associated with
other antidepressants
b. Dizziness and nausea are the most common symptoms
c. Dystonia has been observed with the discontinuation of
fluoxetine
d. Sensory abnormalities are specific to discontinuation of
tricyclic antidepressants
e. Brief bursts of disequilibrium symptoms are associated with
primary discontinuation syndrome (APT 2007)
47
3. Which of the following statements about cannabis is true?

a. Cannabis is the second most commonly used psychoactive
drug
b. Cannabis use is reaching a plateau phase in high-income
countries
c. Cannabis use causes more harm to public health than
tobacco use
d. Approximately one-third of UK adolescents use cannabis at
least once
e. One of the most effective ways to reduce cannabis use
among young people is through school-based interventions
(APT 2007)
4. All of the following statements about cannabis are true except:

a. Between 20% and 70% of people with severe mental illness
use cannabis
b. Cannabis use is more common among people with severe
mental illness than in the general population
c. The tetrahydrocannabinol content of skunk has doubled in
the last 10 years
d. A dose-dependent relationship exists between cannabis use
and psychosis
e. Strong evidence exists that cannabis use at a young age is
linked to the development of severe mental illness (APT
2008)
5. Cannabis use among severely mentally ill people is associated with

a. Increased criminal activity
b. Increased rates of suicide
c. Longer admissions
d. Poorer physical health
e. Reduced polysubstance use (APT 2008)
48
PAPER 2
6. With regard to the assessment tools for use with patients with
cannabis misuse and psychosis, which of the following statements
is true?
a. The Addiction Severity Index does not include psychiatric
problems
b. Patients with schizotypal personality disorder report fewer
unpleasant after-effects on the Cannabis Experiences
Questionnaire
c. The Psychiatric Research Interview for Substance and
Mental Disorders takes less time to complete than scheduled
interviews
d. The Stages of Change Readiness and Treatment Eagerness
Scale is a 15-item self-report measure
e. The Substance Use Scale for Psychosis can be used to
explore patients’ reasons for using drugs (APT 2008)
7. Examining the evidence base of psychological therapies for can-

nabis use shows that all of the following statements are correct
except:
a. The DATOS-A showed significant improvement in the
reduction of suicidal thoughts and hostility among 11- to
18-year-olds
b. The DATOS-A shows the superiority of outpatient over
inpatient programmes
c. Motivational enhancement therapy reduces the use of
cannabis among 16- to 20-year-olds
d. Psychological intervention achieves sustained abstinence in
14–22% of its patients for the 12-month period following
the interventions
e. Psychological therapy with contingency management is
associated with better outcomes than psychological therapy
alone (APT 2008)
49
8. Which of the following statements about the neuropathology of

conversion disorders is true?
a. They involve the impairment of the non-dominant
hemisphere only
b. The impairment that they cause is restricted to sub-cortical
functioning
c. They are associated with PET evidence of high blood flow
in the thalamus
d. They involve a reduction in the activity of the orbitofrontal
cortex
e. Sub-cortical asymmetry resolves with treatment (APT 2006)
9. Mr Jones suffers from conversion disorder and has been referred

to your services by a neurologist. All of the following statements
are true except:
a. Acute conversion symptoms may undergo spontaneous
resolution with the use of explanation and suggestion
b. A high level of psychiatric comorbidity is associated with
conversion disorder
c. RCT showed that the addition of hypnotherapy to a
comprehensive hospital treatment programme did not have
any additional effect on treatment outcomes
d. The recovery phase of chronic conversion disorder may
reveal an underlying psychosis
e. There is a lack of evidence to suggest that patients with
conversion disorder have above-average hypnosibility
(APT 2006)
50
PAPER 2
10. Which of the following statements about race, ethnicity, culture

and psychotherapy is true?
a. All therapists should avoid shared projection and
acculturation gaps
b. Ethnicity is a social construct that defines a group by its
members’ race, colour, nationality, ethnicity or national
origins
c. Psychotherapists need to be proficient in culture-bound
mythology
d. Race-based transference uses splitting but not projection as a
defence mechanism
e. Empirical evidence suggests that ethnic matching improves
outcomes in therapy (APT 2007)
11. Which of the following statements about the genetic and develop-
mental aspects of schizophrenia is true?
a. Clinical symptoms in first-degree relatives of patients with
schizophrenia are restricted to positive ones
b. Most people with schizophrenia have an onset in late
adolescence or adulthood
c. Older children without thought disorders tend to score
higher on thought-disorder indices than younger children
d. Schizotaxia is apparent in 10% of first-degree relatives of
people with schizophrenia
e. An underlying vulnerability to disorders in the schizophrenia
spectrum begins to manifest with positive symptoms
(APT 2007)
51
12. All of the following statements about the prodrome of schizo-

phrenia are true except:
a. An analysis of the school reports of patients with
schizophrenia showed differences in their childhood social
behaviour compared with that of the general population
b. Children at high genetic risk of schizophrenia exhibit deficits
in working memory
c. Children who later develop schizophrenia present with
lower premorbid IQ
d. Deficits in sustained attention are seen in asymptomatic
biological relatives of patients with schizophrenia
e. Studies of children who have mothers with schizophrenia
suggest that early development is normal but not sustained
(APT 2007)
13. The client factors that are suitable for long-term psychodynamic
psychotherapy include all of the following except:
a. Treatment-resistant psychosis
b. The presence of previous severe disruption to personality
development
c. The presence of a lack of consistent problem focus
d. The presence of unhelpful team reactions that have become
obstacles to offering care
e. Willingness to take responsibility for addressing problems
(APT 2008)
14. The percentage of people who show a steady progression of dis-

ability from multiple sclerosis is:
a. 1–4%
b. 5–10%
c. 11–15%
d. 16–20%
e. 21–25% (APT 2006)
52
PAPER 2
15. The lifetime risk of multiple sclerosis in the UK is:

a. 1 in 8 000 000
b. 1 in 800 000
c. 1 in 80 000
d. 1 in 8000
e. 1 in 800 (APT 2006)
16. What is the prevalence of depression among patients with mul-

tiple sclerosis as opposed to the rest of the population?
a. Twofold higher
b. Threefold higher
c. Fivefold higher
d. Tenfold higher
e. Twenty-fold higher (APT 2006)
17. The risk factors for suicide among patients with multiple sclerosis
include all of the following except:
a. Female gender
b. Past history of depression
c. Social isolation
d. Substance misuse
e. Young age of onset (APT 2006)
53
18. All of the following statements about the practice of psycho-

dynamic psychotherapy are true except:
a. A 5-year follow-up study showed that psychodynamic
psychotherapy reduced recovery time
b. An effect size of 0.76 has been found for all forms of
psychological therapy in the treatment of non-psychotic
disorders
c. An effect size of 0.68 has been found post-treatment for
psychological therapies in the treatment of depression
d. CBT shows a slight superiority to short-term
psychodynamic psychotherapy in the treatment of
depression
e. Short-term psychodynamic psychotherapy involves no more
than 10 sessions (APT 2008)
19. The levels of attainment of psychodynamic formulation include

a. Constructing an illness narrative
b. Identifying transference
c. Modelling a formulation
d. Naming the elements
e. Recognising the psychological dimension (APT 2006)
20. Which of the following statements about post-traumatic stress

disorder is true?
a. 25% of those suffering from it recover within 2 years
b. Less than a third have a diagnosis after 6 years
c. The lifetime prevalence is 2%
d. It is associated with the male gender
e. Over 50% of PTSD sufferers have another psychiatric
disorder (APT 2007)
54
PAPER 2
21. Which of the following statements about the neurobiology of

PTSD is true?
a. The amygdala stores exact details of traumatic events
b. Patients with PTSD have high cortisol levels
c. The hippocampus mediates unconscious memories
d. PTSD represents a failure of the amygdala to regulate
medial prefrontal activity
e. Small hippocampal volume is associated with PTSD (APT
2007)
22. All of the following statements about the treatment of PTSD are
true except:
a. According to NICE, paroxetine is a second-line treatment
for PTSD
b. Augmentation with olanzapine can be considered for
treatment-resistant PTSD
c. Mirtazapine in the treatment of PTSD is associated with
weight loss
d. NICE guidelines recommend that treatment should be
considered for at least 1 year
e. Sertraline is indicated for the treatment of PTSD (APT
2007)
23. Which of the following statements about dependence on steroids

is true?
a. Dependence is related to monoaminergic systems
b. Opioid use serves as a gateway for steroid use
c. Oral intake is the predominant route of administration
d. Sleepiness is a common withdrawal symptom
e. Around 10% of users trust information from drug dealers
more than they trust information from doctors (APT 2006)
55
24. All of the following statements about the management of neu-

ropsychiatric symptoms associated with hepatitis C are correct
except:
a. Anorexia responds well to paroxetine
b. Gastrointestinal haemorrhage is known to be caused by
antidepressants used for treating neuropsychiatric adverse
effects from combination treatment
c. Interferon-induced anxiety responds to SSRIs
d. Naltrexone can be useful in the management of cognitive
dysfunction
e. Recombinant human erythropoietin has been useful in the
treatment of apathy (APT under submission by the author)
25. All of the following statements about cognitive impairment and

hepatitis C are true except:
a. Abnormal P300 potentials have been seen in HCV infections
b. The cognitive adverse effects of interferon include motor
incoordination
c. Cognitive impairment from interferon does not improve
with the discontinuation of treatment
d. Elevations in basal ganglia and white-matter choline/
creatinine ratios have been found in HCV patients
e. Impairment of verbal memory is a recognised adverse effect
of interferon treatment (APT under submission by the
author)
56
PAPER 2
26. Which of the following statements about adverse neuropsychiat-

ric effects of interferon treatment is true?
a. Apathy is the most common symptom
b. Anxiety is seen in 5% of patients who are on interferon
c. Its cognitive side-effects are suggestive of frontosubcortical
impairment
d. Depression is seen in up to 10% of patients on interferon
e. The prevalence rate of adverse neuropsychiatric effects is up
to 10% (APT under submission by the author)
27. Mrs Taylor presents with dizziness, double vision and difficulty
in communication. The diagnosis is:
a. Acoustic neuroma
b. Benign paroxysmal positional vertigo
c. Labyrinthitis
d. Meniere’s disease
e. Vertebrobasilar insufficiency (TN)
28. All of the following statements about treatment with ECT are
true except:
a. Adverse psychological reactions are rare
b. It produces deficits in autobiographical and impersonal
memory
c. The extent of retrograde amnesia is not significantly
correlated with the degree of therapeutic improvement
d. Midazolam is contraindicated for patients who are agitated
in the recovery phase from ECT
e. Its mortality risk is 1 per 10 000 patients (ECT)
57
29. Which of the following statements about the interaction between

ECT and drug treatment is correct?
a. Clozapine increases the seizure threshold
b. Lithium increases the seizure threshold
c. Olanzapine increases the seizure threshold
d. SSRIs cause prolonged seizures
e. Tricyclic antidepressants are anticonvulsant (ECT)
30. All of the following statements about ECT procedure are correct
except:
a. The extent of eventual improvement is associated with the
improvement seen during the first few treatments
b. In bilateral ECT, the initial treatment dose should be at least
100% more than that of the seizure threshold
c. In unilateral ECT, the initial treatment dose should be at
least 200% more than that of the seizure threshold
d. The optimal technique for using unilateral ECT for mania
has not been established
e. The initial dose for male patients receiving unilateral ECT is
10% (ECT)
31. The tests of attention and concentration include all of the follow-
ing except:
a. The components of the Test of Everyday Attention
b. The Corsi block-tapping span
c. The Paused Auditory Serial Addition Test
d. The reverse-digit span
e. A timed test involving star cancellation (CA)
58
PAPER 2
32. Which of the following is a test of personal memory?

a. The cued word-association test
b. The Doors and People Test
c. Person-based tasks
d. Tests of verbal knowledge
e. Warrington’s Recognition Memory Test (CA)
33. The hypothalamus forms the floor of the:

a. Cerebellomedullary cistern
b. Fourth ventricle
c. Interventricular foramina of Munro
d. Interpeduncular cistern
e. Third ventricle (TN)
34. All of the following statements about the brain’s blood supply are
true except:
a. All of the arteries that supply the brain are paired except for
the basilar artery
b. The carotid artery is flanked by the oculomotor and optic
nerves
c. The brain receives 750 mL of blood per minute
d. The brain’s large vessels are thin-walled
e. A loss of blood supply for 10 to 15 seconds results in loss of
consciousness (TN)
59
35. Mr Bainbridge presents with miosis, ptosis, vertigo, dysarthria and

ipsilateral hemiataxia. This has been caused by stroke involving:
a. An aneurysm at the origin of the posterior communicating
artery
b. The basilar artery
c. A Charcot–Bouchard aneurysm
d. The middle cerebral artery
e. The posterior inferior cerebellar artery (TN)
36. The sympathetic supply to the thyroid comes from the:

a. External carotid nerves
b. Inferior cervical ganglion
c. Internal carotid nerves
d. Middle cervical ganglion
e. Superior cervical ganglion (TN)
37. All of the following nerves include a parasympathetic component

except:
a. III
b. V
c. VII
d. IX
e. X (TN)
60
PAPER 2
38. All of the following statements about efferent fibres from the
striatum are true except:
a. Fibres originate from the caudate nucleus
b. The striatonigral pathway uses substance P
c. The striatonigral fibres use acetylcholine
d. The striatopallidal fibres to the external segment use
enkephalin
e. The striatopallidal fibres use glutamate as a neurotransmitter
(TN)
39. Which of the following statements about cortico-thalamic-striatal

circuits is true?
a. Their association loop involves the pars compacta of the
substantia nigra
b. The head of the caudate is involved in the oculomotor loop
c. The lateral segment of the globus pallidus is involved in the
limbic loop
d. The premotor cortex is part of the oculomotor loop
e. The ventrolateral nucleus of the thalamus connects to the
supplementary motor cortex as part of the sensory–motor
loop (TN)
40. All of the following matches with regard to the neurons in the
basal ganglia are true except:
a. Intrastriatal interneurons – acetylcholinergic neurons that
are inhibited by dopaminergic neurons
b. Neuropeptide-releasing neurons – release GABA and
enkephalin from the same neuron
c. Pars compacta – neurons releasing dopamine have an
excitatory effect on the GABA-ergic neurons that project to
the lateral segment of the globus pallidus
d. Striatum – principally composed of GABA-releasing neurons
e. Subthalamic nucleus – gives rise to glutamate-releasing
neurons (TN)
61
41. Mr Bainbridge presents with a lesion involving the ganglia branch

of the left posterior cerebral artery. Which of the following state-
ments is true?
a. Athetosis results from the degeneration of the medial
segment of the globus pallidus
b. Dopaminergic agonists improve its symptoms
c. Left hypertonicity would be a feature
d. Primary degeneration of the GABA-ergic neurons ensues
e. Right hemiballismus would be a symptom (TN)
42. Mr Bainbridge presents with a wing-beating tremor that manifests

following extension of an upper limb. In which of the following is
this seen?
a. Friedreich’s ataxia
b. Huntington’s disease
c. Parkinson’s disease
d. Sydenham’s chorea
e. Wilson’s disease (TN)
43. Which of the following statements about reflexes is true?

a. The afferent limb of the papillary light reflex is transmitted
to the superior colliculus without synapsing at the lateral
geniculate
b. The ciliospinal centre involved in the sympathetic pathway
of the papillary dilation is situated at cord levels C1–C2
c. The efferent pathway of the blink reflex involves the nerve
VII
d. In the convergence accommodation pathway, the inferior
colliculus sends fibres to the Perlia’s nucleus of the
oculomotor complex
e. The pretectal area sends bilateral projections to the
Edinger–Westphal nucleus (TN)
62
PAPER 2
44. Which of the following is caused by a lesion of Myer’s loop?

a. Contralateral homonymous hemianopsia
b. Contralateral upper homonymous quadrantopsia
c. Contralateral lower homonymous quadrantopsia
d. Contralateral homonymous hemianopsia with macular
sparing
e. Ipsilateral nasal hemianopsia (TN)
45. All of the following statements about auditory pathways are true
except:
a. First-order neurons are bipolar
b. Fibres from the posteroventral cochlear nucleus terminate in
the ventral nucleus of the lateral lemniscus
c. Hair-receptor cells stimulate the peripheral process of first-
order neurons
d. Inferior olivary nuclei are involved in processing sound
frequency
e. The sound attenuation reflex involves the motor nucleus of
the trigeminal nerve (TN)
46. All of the following cause conduction deafness except:

a. Cerumen
b. Jervell–Lange–Nielsen syndrome
c. Otitis media
d. Otosclerosis
e. Perforation of the tympanic membrane (TN)
63
47. All of the following statements about nystagmus are true except:
a. Extensive damage at the pontomedullary junction causes
rotator nystagmus
b. Horizontal nystagmus is normal
c. The normal duration of post-rotatory nystagmus during a
rotation test is half a minute
d. Spontaneous nystagmus indicates a lesion affecting the
vestibular nuclei
e. Vertical nystagmus results from damage to the inferior
vestibular nucleus (TN)
48. Mr Bainbridge presents with an inability to recognise complex

sounds. Which of the following does the lesion involve?
a. The bilateral primary auditory area
b. The bilateral auditory association area
c. The dominant auditory association area
d. The dominant primary auditory area
e. The non-dominant primary auditory area (TN)
49. A unilateral lesion to his non-dominant hemisphere will lead

Mr Bainbridge to present specifically with which of the fol-
lowing?
a. Amusia
b. Auditory agnosia
c. Partial deafness
d. Receptive aphasia
e. Total deafness (TN)
64
PAPER 2
50. Mr Bainbridge has received a head injury leading to damage to his

non-dominant cerebral hemisphere. All of the following domains
will be impaired except:
a. Mathematical skills
b. Musical skills
c. Poetry skills
d. Recognition of faces
e. Spatial perception (TN)
51. Which of the following processes is mediated by the dominant

hemisphere?
a. Music
b. Poetry
c. Problem solving
d. Face recognition
e. Spatial perception (TN)
52. All of the following statements about the middle cerebral artery
are true except:
a. An infarction of its more posterior branches is associated
with visual agnosias
b. It supplies both Broca’s and Wernicke’s areas
c. It does not supply a narrow territory close to the sagittal
fissure
d. It supplies the medial surface of the brain
e. It forms part of the circle of Willis (SBN)
65
53. All of the following types of receptors activate G-protein-coupled

mechanisms except:
a. A2
b. α2
c. D1
d. GABAB
e. 5-HT4 (SBN)
54. Which of the following neurotransmitter receptors is fast-ion-

channel linked?
a. Adenosine
b. α1
c. Dopamine 2–4
d. GABAB
e. 5-HT3 (SBN)
55. Which of the following statements about excitatory amino acids

is true?
a. At NMDA receptors, glutamate produces rapid
trans-synaptic excitatory responses
b. Glycine partial agonists increase NMDA function
c. NMDA receptors are activated by phencyclidine
d. Strychnine-insensitive glycine receptors modulate NMDA
receptor function
e. The synthesis of glutamate that functions as a transmitter is
from glucose via Kreb’s cycle (SBN)
66
PAPER 2
56. Which of the following statements about GABA is true?

a. The activators of GAD cause tonic seizures
b. GABAA receptors presynaptically modulate GABA release
c. Glutamic acid decarboxylase is a marker of GABA-ergic
neurons
d. Picrotoxin is an antagonist at the GABA receptor
e. Schizophrenia may be related to decreased GABA activity
(SBN)
57. Which of the following statements about acetylcholine is true?

a. The action of acetylcholine is blocked by physostigmine
b. The addictive aspects of nicotine are independent of
dopaminergic systems
c. Cholinergic processes are involved in NREM sleep
d. Muscarinic receptors are not PI coupled
e. The neuronal store of acetylcholine is depleted by
hemicholinium (SBN)
58. Mr Bainbridge presents with a head injury, and you want to detect
and measure the severity of visual neglect involved. Which of the
following is the recommended test?
a. The Behavioural Assessment of the Dysexecutive Syndrome
b. The Behavioural Inattention Test
c. The Delis–Kaplan Executive Function Syndrome
d. The National Adult Reading Test
e. Raven’s Progressive Matrices (CA)
67
59. Mr Bainbridge presents with aphasia following a stroke. Which

of the following can you use to measure his auditory compre-
hension?
a. The Rey Auditory Verbal Learning Test
b. The Rey–Osterrith Complex Figure Test
c. The Test for Reception of Grammar
d. The Token Test
e. The Trail Making Test (CA)
60. Mr Bainbridge presents with attentional deficits following a head

injury. Which of the following will you use?
a. The Doors and People Test
b. The Judgement of Line Orientation Test
c. The Paced Auditory Serial Addition Test
d. The Recognition Memory Test
e. The Visual Object and Space Perception Battery (CA)
61. Mr Bainbridge has recovered from a head injury. Which of the

following will you use to assess the extent of memory impairment
recovered?
a. The National Adult Reading Test
b. The Pyramids and Palm Trees Test
c. Raven’s Progressive Matrices
d. The Recognition Memory Test
e. The Rivermead Behavioural Memory Test (CA)
68
PAPER 2
62. All of the following statements about the Cambridge Cognitive

Examination are true except:
a. It cannot distinguish different forms of dementias
b. Its cut-off value for dementia is less than or equal to 80
c. It forms part of CAMDEX
d. The maximum score on CAMCOG is 100
e. It is sensitive to mild dementia (CA)
63. Which of the following is associated with self-mutilation

behaviour?
a. Arnold–Chiari malformation
b. De Lange malformation
c. Generalised neurofibromatosis
d. Tuberous sclerosis
e. Von Hippel–Lindau disease (SBN)
64. All of the following statements about neural-tube defects are true
except:
a. Fetal ultrasound and amniotic fluid assay can identify 90% of
defects in vivo
b. Closure of the neural tube occurs within 18 to 26 days after
the formation of the zygote
c. In anencephaly, cerebral hemispheres fail to develop with
exposure to diencephalon
d. Minor neural-tube defects are present in less than 1% of the
population without neurological deficits
e. The recurrence rate for spina bifida in a second baby is 1 in
20 (SBN)
69
65. Which of the following statements about head injury is true?

a. Being aged between 25 and 30 years is a risk factor for severe
head injury
b. The parietal lobe is the most vulnerable area for contusion
damage
c. Postconcussive symptoms usually resolve within 6 months
d. Post-traumatic amnesia lasting 1 to 7 days is associated with
mild sequelae
e. The prevalence of severe disability following a head injury
among the general population is 50 in 1 000 000 (SBN)
66. A neuropathological examination reveals anterior temporal cor-

tical atrophy with balloon cells. In which of the following is this
seen?
a. Alzheimer’s disease
b. Creutzfeldt–Jacob disease
c. Huntington’s disease
d. Parkinson’s disease
e. Pick’s disease (SBN)
67. All of the following statements about Huntington’s disease are

true except:
a. The cortical form of dementia is seen
b. Choreiform movements become more pronounced as the
disorder progresses
c. Chromosome 4 is implicated in its aetiology
d. The initial presentation is often psychiatric
e. Its onset is usually in the third or fourth decade (SBN)
70
PAPER 2
68. In which of the following is glucocerebrosidase deficiency seen?

a. Gaucher’s disease
b. Gangliosidosis
c. Leigh’s disease
d. Niemann–Pick disease
e. Wilson’s disease (SBN)
69. In which of the following is α-1-iduronidase deficiency seen?

a. Hurler syndrome
b. Hunter’s syndrome
c. Leigh’s disease
d. Niemann–Pick disease
e. Tay–Sachs disease (SBN)
70. In which of the following leukodystrophies is X-linked recessive

inheritance seen?
a. Adrenoleukodystrophy
b. Krabbe’s leukodystrophy
c. Metachromatic leukodystrophy
d. Pelizaeus–Merzbacher disease
e. Sudanophilic leukodystrophy (SBN)
71. Although leukodystrophies are characterised by the extensive

degeneration of myelin, in which type of leukodytrophy can
myelins be seen preserved around blood vessels?
a. Adrenoleukodystrophy
b. Krabbe’s leukodystrophy
c. Metachromatic leukodystrophy
d. Pelizaeus–Merzbacher disease
e. Sudanophilic leukodystrophy (SBN)
71
72. All of the following conditions are associated with demyelination

except:
a. Cyanocobalamin deficiency
b. Leigh’s disease
c. Long-standing cerebral oedema
d. Marchiafava–Bignami syndrome
e. Progressive multifocal leucoencephalopathy (SBN)
73. The paraventricular nucleus is involved in controlling all of the

following except:
a. Corticotrophin-releasing hormone
b. The dopamine-mediated inhibition of prolactin
c. Somatostatin
d. The stimulation of the secretion of growth hormone,
mediated through GHRH
e. Thyrotrophin-releasing hormone (SBN)
74. All of the following statements about growth hormone (GH)

secretion are true except:
a. Acetylcholine inhibits the release of somatostatin
b. Growth hormone stimulates the peripheral production of
IGF-1
c. Nocturnal surges of GH occur during sleep stages 3 and 4
d. Somatostatin has a direct inhibitory effect on GH secretion
e. Stimulated GH secretion is lower in premenopausal women
(SBN)
72
PAPER 2
75. All of the following hormonal abnormalities are seen in anorexia

nervosa except:
a. Hypercortisolism with preserved diurnal rhythm
b. Impaired gonadotrophin secretion
c. Impaired osmotic regulation of arginine vasopressin
d. Low total T4
e. Reduced growth-hormone response to levodopa (SBN)
76. Polyspikes and wave flattening are seen in:

a. Absence seizures
b. Atonic seizures
c. Clonic seizures
d. Tonic seizures
e. Tonic–clonic seizures (SBN)
77. A regular and symmetrical 3 Hz pattern is seen in:

a. Absence seizures
b. Atonic seizures
c. Clonic seizures
d. Tonic seizures
e. Tonic–clonic seizures (SBN)
78. The lifetime risk of unipolar depression among monozygotic

co-twins of a bipolar proband is:
a. 0.5–1.5%
b. 2–5%
c. 6–9%
d. 10–13%
e. 15–25% (PG)
73
79. All of the following statements about the genetic inheritance of

bipolar affective disorder are true except:
a. An allele of a VNTR in intron 2 of the hSERT gene has
been implicated in bipolar disorder
b. Chromosome 12q23-q24 has a LOD score of 2–0-4.9
c. Individuals with trisomy 21 are more susceptible to mania
than the general population
d. A co-segregation of colour blindness and bipolar affective
disorder exists
e. Tyrosine hydroxylase maps to 11p15 are implicated in
bipolar disorder (PG)
80. All of the following statements about the genetics of bipolar

affective disorder are true except:
a. Lithium responsiveness appears to be familial
b. A low-activity allele involving COMT polymorphism may
be associated with increased susceptibility to rapid cycling
c. Gene coding for the 5-HT2a receptor has been implicated in
rapid cycling disorder
d. The serotonin transporter gene (hSERT) has been
implicated in seasonal affective disorder
e. Trinucleotide repeat expansion involving CTG18.1 has been
implicated in bipolar disorder (PG)
81. The lifetime risk of schizophrenia-related psychosis among fra-

ternal twins of patients with schizophrenia is:
a. 6%
b. 9%
c. 13%
d. 17%
e. 48% (PG)
74
PAPER 2
82. The lifetime risk of developing schizophrenia-related psychosis

among the grandchildren of patients with schizophrenia is:
a. 2%
b. 4%
c. 5%
d. 6%
e. 9% (PG)
83. Which of the following is an agonist at the 5-HT1A receptor?

a. Buspirone
b. Ergotamine
c. LSD
d. Methiothepin
e. Sumatriptan (N)
84. Which of the following statements about acetylcholine is true?

a. Acetylcholine produces long-term potentiation in the
hippocampus by opening the K M channels
b. All of the pathways of the autonomic system use
acetylcholine as a neurotransmitter except for the
preganglionic neurons
c. Cholinergic interneurons are absent in the nucleus
accumbens
d. The laterodorsal tegmental nucleus is an important
cholinergic pathway for regulating sleep and wakefulness
e. The motor neurons in the dorsal horn of the spinal cord are
cholinergic (N)
75
85. All of the following statements about acetylcholine are true

except:
a. The supply of acetyl CoA is the rate-limiting step in the
synthesis of acetylcholine
b. The acetylcholine vesicle transporter is coded by the first
exon of the ChAT gene
c. AChE enhances the response of cerebellar neurons to
glutamate
d. The Na+-dependent choline transporter is saturated at
plasma choline concentrations
e. Nicotinic receptors mediate fast-ACh transmission,
stimulating the dopamine-reward pathways (N)
86. Which of the following statements about purines is true?

a. A1 receptors increase cAMP levels
b. Adenosine mediates the deleterious effects of oxidative stress
on neurons
c. ATP acts as a transmitter in the CA3 region of the
hippocampus
d. ATP is synaptically activated by an ecto-5’-nucleotidase
e. The P2ya receptor is an ionotropic cation channel (N)
87. All of the following statements about peptide and tachykinin

neurotransmission are true except:
a. The mRNA encoding a peptide neurotransmitter is
transcripted on ribosomes
b. Peptides containing vesicles are moved by motor proteins
along microtubules
c. The release of substance P in peripheral terminals results in
neurogenic inflammation
d. Substance P is an excitatory tachykinin
e. Substance P is the preferred ligand for the NK1 receptor (N)
76
PAPER 2
88. The enzyme used in the polymerase chain reaction is:

a. DNA trinucleotidase
b. Restriction endonuclease
c. Reverse transcriptase
d. RNA polymerase
e. Taq polymerase (PG)
89. A micro-array is called:

a. A DNA chip
b. A polymerase chain reaction
c. A primer extension
d. A restriction fragment length polymorphism
e. A short tandem repeat polymorphism (PG)
90. Mr Bainbridge cannot copy an image shown to him. This form of

agnosia is:
a. Apperceptive agnosia
b. Associative agnosia
c. Autatopagnosia
d. Colour agnosia
e. Mirror agnosia (CA)
91. NF-1 is caused by a mutation of a gene on the long arm of chro-

mosome:
a. 1
b. 9
c. 11
d. 15
e. 17 (KS)
77
92. The following are true regarding variant Creutzfeldt–Jakob dis-

ease except:
a. Absence of periodic sharp waves on EEG
b. Delayed neurological signs
c. Marked accumulation of protease-resistant prion protein
d. Mean age at death 60 years
e. Pulvinar sign in more than 75% of cases (SBN)
93. Which of the following statements about cognitive-stimulation

therapy in dementia is true?
a. CST improves cognition but not depression
b. It is composed only of reality orientation
c. CST benefits quality of life but not cognition
d. RCT evidence is available indicating that social groups
improve cognition
e. A high probability exists that CST is more cost-effective
than treatment as usual (BJP 2006)
94. Which of the following statements about comorbid substance

misuse and schizophrenia is true?
a. Comorbid substance use and less severe negative symptoms
have been reported
b. IQ is not associated with an early age of onset of illness
among substance misusers
c. A negative correlation exists between cannabis use in
adolescence and the development of schizophrenia in
adulthood
d. Stimulants and hallucinogens are the most commonly used
substances among people who present with schizophrenia
e. Substance misuse is a risk factor for relapse but not for onset
(BJP 2006)
78
PAPER 2
95. Which of the following statements about complementary medi-

cines is true?
a. Around 5–10% of all psychiatric patients rely on
complementary medicines
b. Around 10% of all cancer patients take psychoactive
substances
c. Evidence is available that melatonin can treat tardive
dyskinesia
d. Passionflower is potentially useful as a sedative
e. Evidence is lacking that selenium complements
antidepressant treatment (BJP 2006)
96. Increased bleeding time is associated with:

a. Ginkgo
b. Hydergine
c. Panax ginseng
d. Solanaceous plants
e. Valerian (BJP 2006)
97. Which of the following drugs interacts with cholinesterase inhib-

itors?
a. Ginkgo
b. Hydergine
c. Panax ginseng
d. Solanaceous plants
79
98. Which of the following statements about the 5-HTTLPR geno-

type is true?
a. The SERT-s allele is associated with a 25% reduction in
volume of the anterior cingulate
b. The SERT-l allele is associated with a 25% reduction in
volume of the amygdala
c. Suicide is dependent upon major depression for contributing
to the enlargement of the thalamus
d. The 5-HTTLPR genotype is associated with a 20%
reduction in the number of neurons in the pulvinar nucleus
e. The history of antidepressant treatment is associated with an
increase in thalamic volume (BJP 2008)
99. Which of the following statements about attribution style and

depression is true?
a. Attributional style is not a mediator of the genetic influences
on depression
b. Attributional style is unrelated to current mood
c. People who are experiencing their first episode of depression
are more likely to attribute it to an internal cause than
people who are experiencing recurrent depression
d. People who are likely to view the causes of events as global
are less likely to develop depression in future
e. People who are likely to view the causes of negative events as
internal are less likely to develop depression in future (BJP
2008)
80
PAPER 2
100. Which of the following statements about neural circuits in OCD

is true?
a. Adults with OCD perform well on motor and interference
inhibition but not on task switching
b. A dysfunction of the frontocerebellar attention networks is
evident during the cognitive forms of inhibition
c. fMRIs show that inhibition failure in adolescents with OCD
is associated with mesial frontal over-activation
d. Frontostriatal over-activation is seen during inhibitory tasks
e. An improvement in impaired inhibitory performance is a
marker of symptom improvement (BJP 2008)
101. All of the following statements about CBT are true except:
a. A 12-week comprehensive treatment programme consisting
of CBT, body awareness therapy and graded exercise is more
effective than antidepressant therapy in chronic fatigue
syndrome
b. According to the Nottingham Study of Neurotic Disorder,
cognitive therapy and self-help were more effective for
depressed people with comorbid personality disorder than
for people without personality disorder
c. CBT with a problem-solving component has a positive effect
on self-harm
d. People with a personality disorder who respond to cognitive
therapy show sustained responses
e. Schema-focused therapy has been found to reduce self-harm
in patients with borderline personality disorder (BJP 2008)
81
102. All of the following statements about schizophrenia are true

except:
a. Any craniofacial/midline anomaly is associated with an
increased risk of schizophrenia-spectrum disorder
b. Febrile seizures are not associated with adult schizophrenia
c. Impaired extrastriate visual processing of fear is associated
with negative symptoms
d. Increased semantic priming is associated with thought
disorders
e. The recognition of negative facial affect is impaired in
people with schizophrenia (BJP 2008)
103. Which of the following statements about schizophrenia is true?

a. Atypical antipsychotics are more effective than typical
antipsychotics in the treatment of delusional parasitosis
b. Cognitive remediation therapy is not associated with durable
improvements in working memory
c. Fewer than 1% of the people who harm themselves die in
the subsequent year
d. Patients with positive symptoms show a higher degree of
impairment of their mentalisation than do disorganised
patients
e. Population density interacts with poor pre-morbid cognitive
functioning (BJP 2007)
104. All of the following influence caregiver stress in schizophrenia

except:
a. The caregiver being the patient’s parent
b. The highest burden being in relation to the supervision of
the patient
c. The patient being male
d. The patient’s marital status
e. The patient’s symptoms (BJP 2007)
82
PAPER 2
105. Which of the following statements about schizophrenia is true?

a. Awareness of the illness is associated more with impaired
working memory
b. Cortical microstructure disruption is seen in the temporo-
occipital lobes
c. Motor-cortex reactions are weaker in both patients and their
twin siblings
d. Patients who use cannabis show normal anterior cingulate,
in contrast to those who do not use it
e. Age has a positive effect on the integrity of the left superior
longitudinal fasciculus (BJP 2007)
106. All of the following statements about depression are true

except:
a. Ceasing to cohabit with a partner precipitates depression
b. ECT is the most effective treatment for depression
c. ECT patients are more medically ill
d. Personality disorders affect outcomes in depressed people
who are being treated with interpersonal therapy
e. rTMS augments antidepressant treatment (BJP 2007)
107. Which of the following statements about PTSD is true?

a. Basal cortisol levels are low in morning samples
b. Cortisol activates neuronal defensive reactions
c. Serotonin from the amygdala inhibits the hypothalamus
from secreting corticotrophin-releasing hormone
d. Sexual abuse is associated with higher basal cortisol levels
e. Trauma-focused CBT is as effective as EMDR (BJP 2007)
83
108. Which of the following statements about neuroleptic malignant

syndrome (NMS) is true?
a. Bromocriptine, but not amantadine, reduces its mortality
rate
b. Dantrolene takes 24 hours to produce a clinical effect
c. Its mortality rate is less than 10% with NMS from depot
antipsychotic medications
d. Its prevalence is 0.02–2.4%
e. Untreated symptoms resolve within 7 days (KS)
109. Mr Bainbridge presents with hyperthermia, muscle rigidity,

palpitation, hypotension, rhabdomyolysis and disseminated intra-
vascular coagulation. This can be caused by:
a. Amphetamine
b. Atropine
c. Lead poisoning
d. Reserpine
e. Succinylcholine (KS)
110. In which of the following are β-adrenergic antagonists definitely

effective?
a. Adjunctive therapy for alcohol withdrawal
b. Adjunctive therapy for aggressive behaviour
c. Antidepressant augmentation
d. Antipsychotic augmentation
e. Lithium-induced tremor (KS)
84
PAPER 2
111. The adverse effects of β-adrenergic receptor antagonists include

a. Diarrhoea
b. Hypotension
c. Hyperglycaemia
d. Impotence
e. Peyronie’s disease (KS)
112. All of the following statements about amantadine are true

except:
a. Amantadine coadministered with MAOIs can cause a
significant increase in blood pressure
b. Amantadine is contraindicated in people who are sensitive to
anticholinergic effects
c. Amantadine has benefits in the treatment of ejaculatory
inhibition
d. Amantadine is excreted unmetabolised in urine
e. Livedo reticularis has been seen in 5% of people taking
amantadine (KS)
113. All of the following statements about psychotic symptoms among

the general population are true except:
a. An excess of apparent hallucinations has been reported
among men compared with women
b. Established psychotic symptoms may be present in milder
forms in the general population
c. A 1-year incidence of around 5% has been reported for
hallucinations among the general population
d. Similarities exist between the risk factors for psychotic
symptoms and schizophrenia among the general population
e. An association exists between baseline neurosis and incident
psychotic symptoms among the general population (BJP
2006)
85
114. All of the following are risk factors for self-reported psychotic
symptoms among the general population except:
a. Harmful pattern of drinking
b. Living in an urban area
c. More adverse life events
d. Having a small primary support group
e. Smoking tobacco (BJP 2006)
115. All of the following statements about the risk factors for psychi-
atric illnesses among women from low-income countries are true
except:
a. Being married
b. Living in a relatively large household
c. Poverty
d. Reporting chronic physical illnesses
e. Use of tobacco (BJP 2006)
116. The risk factors for severe postpartum psychosis include all of the
following except:
a. Caesarean section
b. Delivery complications
c. Delivering a female baby
d. Multiparity
e. Having a relatively shorter gestation period (BJP 2006)
86
PAPER 2
117. All of the following statements about the neuropathology of hal-

lucinations are true except:
a. Hallucinations increase N100 in amplitude
b. The primary auditory cortex is involved
c. Reduced left temporal responsivity is present
d. The right cortical area is the most important one for
direction discrimination
e. When Broca’s area alone dominates, inner speech is
perceived (BJP 2007)
118. Dysthymic disorder has a prevalence of:

a. 0.5–1%
b. 1–3%
c. 3–6%
d. 7–8%
e. 9–14% (KS)
119. The lifetime prevalence of hypomania is:

a. 0–1.2%
b. 1.2–2.4%
c. 2.6–7.8%
d. 8–12.5%
e. 12.8–14.8% (KS)
87
120. All of the following statements about gender differences between

affective disorders are true except:
a. Bipolar type 1 disorder has a higher prevalence among men
b. Manic episodes are more common in men
c. Major depressive disorders are twice as prevalent in women
as in men
d. There is a higher rate of rapid cyclers among women
e. Women present with a more mixed picture than men when
presenting with a manic episode (KS)
121. All of the following are indicators of a good prognosis in depres-

sion except:
a. The absence of a comorbid personality disorder
b. Early age of onset
c. Having had no more than one previous hospitalisation
d. A relatively short hospital stay
e. Having had strong friendships during adolescence (KS)
122. Which of the following statements about the course of bipolar

disorder is true?
a. Bipolar type 1 disorder most often starts with mania
b. The incidence of bipolar disorder in children and
adolescents is about 1%
c. Fewer than 5% of people with bipolar disorder can be
classified as rapid cyclers
d. Around 15% of patients with bipolar type 1 disorder do not
have a recurrence of symptoms
e. Around 30% of patients with bipolar disorder achieve
significant control over their symptoms with lithium (KS)
88
PAPER 2
123. Positive relationship transference without interpretation is a tech-

nique used in which of the following?
a. Brief psychodynamic approach
b. Cognitive behavioural therapy
c. Dialectical behaviour therapy
d. Interpersonal therapy
e. Psychodynamic therapy (KS)
124. Therapists associated with interpersonal therapy include all of the

following except:
a. Jacobson
b. Klerman
c. Meyer
d. Sullivan
e. Weissman (KS)
125. All of the following are the patient variables most suited for inter-
personal therapy except:
a. A focused dispute with a partner or significant other
b. A modest to moderate need for direction and guidance
c. Pragmatic thinking
d. Responsiveness to environmental manipulation
e. Social or communication problems (KS)
89
126. Which of the following is the confirmation of reality by compar-

ing one’s own conceptualisations with those of other members in
the group?
a. Acceptance
b. Cohesion
c. Consensual validation
d. Corrective family experience
e. Reality testing (KS)
127. Self-disclosure is also known as:

a. Catharsis
b. Contagion
c. Empathy
d. Transference
e. Ventilation (KS)
128. Which of the following is the process during which the group
leader formulates the meaning or significance of a patient’s resist-
ance?
a. Acceptance
b. Consensual validation
c. Identification
d. Interpretation
e. Reality testing (KS)
129. The roles in a psychodrama include all of the following except:

a. Auxiliary ego
b. Director
c. Group
d. Narrator
e. Protagonist (KS)
90
PAPER 2
130. Which of the following types of family therapy emphasises indi-

vidual maturation in the context of the family system and is free
from unconscious patterns of anxiety and projection rooted in the
past?
a. Bowen model
b. General systems model
c. Psychodynamic–experiential model
d. Social network model
e. Structural model (KS)
91
3
Paper 3

premenstrual syndrome is true?
a. Basal plasma and urinary cortisol levels do not distinguish
women with premenstrual syndrome from controls
b. Its estimated heritability is approximately 20%
c. The exacerbation of serotonergic activity by tryptophan
manifests as premenstrual syndrome
d. Patients’ levels of allopregnanolone increase after treatment
with antidepressants, suggesting a causal pathway involving
the GABA system
e. Lower β-endorphin levels are found in the luteal phase only
(APT 2007)
2. Which of the following statements about the epidemiology of the

antidepressant discontinuation syndrome is true?
a. Of the SSRIs, paroxetine is least associated with
discontinuation symptoms
b. A study with venlafaxine showed that approximately 25% of
the sample developed discontinuation symptoms
c. Its symptoms are less common when higher doses are
discontinued
d. Its symptoms are not associated with the duration of the
treatment
e. Clinical studies show no difference between gradual and
abrupt discontinuation (APT 2007)
93
3. The basic principles of motivational interviewing include all of

the following except:
a. Express empathy
b. Develop discrepancy
c. Reward reflections
d. Roll with resistance
e. Support self-efficacy (APT 2008)
4. The components of a relapse prevention programme include all

of the following except:
a. The creation of a self-help sheet
b. Identifying alternative pleasurable activities
c. The management of anger using problem-solving techniques
d. Rewarding reflections
e. Role play (APT 2008)
5. All of the following statements about the neuropathology of cata-

tonia are true except:
a. The presence of abnormal metabolism in the thalamus and
frontal lobes
b. The bottom-up modulation of the basal ganglia due to a
deficiency of GABA
c. Clozapine-withdrawal catatonia is due to cholinergic and
serotonergic rebound hyperactivity
d. A dysfunction in glutamate
e. A sudden block of dopamine receptors (APT 2007)
94
PAPER 3
6. Which of the following statements about the diagnosis and classi-

fication of catatonia is true?
a. The Bush–Francis Catatonia Rating Scale aids in
distinguishing between catatonia and extrapyramidal
symptoms
b. Ictal catatonia is due to the involvement of the temporal lobe
c. Catatonia is more commonly a consequence of a mood
disorder than of schizophrenia
d. Catatonia due to physical causes is diagnosed as other
catatonic disorder according to ICD-10
e. Systematic catatonia is linked to chromosome site 15q15
(APT 2007)
7. All of the following statements about the treatment of catatonia

are true except:
a. Antipsychotics precipitate neuroleptic malignant syndrome
in patients with catatonia
b. Death due to pulmonary embolism is more common in the
second week
c. Organic catatonia responds to benzodiazepines
d. Patients who do not respond to benzodiazepines require
ECT
e. Recurrence rates are higher for catatonia from schizophrenia
than that from affective disorders (APT 2007)
95
8. Which of the following statements about the neurodevelopmental

aspects of schizophrenia is true?
a. A combination of risperidone and CBT has been found to be
effective in people at risk of the development of psychosis
b. Delayed developmental milestones are a specific
neurodevelopmental precursor of schizophrenia
c. Environmental interventions in childhood do not have a
positive impact on reducing schizotypy in later life
d. Impaired cognitive functioning is not related to early onset
e. Obstetric complication is not associated with poorer
outcomes (APT 2007)
9. Which of the following statements about first-episode psychosis

is true?
a. Attenuated symptoms is a category under trait factors
according to the Melbourne criteria
b. Cannabis use does not promote psychotic experiences in
people without a pre-existing vulnerability
c. A change in mental state lasting at least 1 month is a state
character
d. Only 10% of the general population identified as cases using
the Bonn Scale for the Assessment of Basic Symptoms go on
to develop a disorder
e. The rate of transition to psychosis using the Melbourne
criteria has been reported to be between 28% and 40%
(APT 2006)
96
PAPER 3
10. Which of the following statements about the management of

people at risk of psychosis is true?
a. Delays in access to early-intervention services are due to the
ego-dystonic nature of the symptoms
b. High scores on the GAF are a predictor of progress towards
psychosis
c. A 1-year treatment with olanzapine offers a significant
advantage
d. Risperidone at a low dose combined with CBT and needs-
based intervention prevents the onset of psychosis
e. A significant lowering of the transition rate is associated with
CBT (APT 2006)
11. All of the following are tasks that could be used to measure every-
day memory functioning in patients receiving ECT except:
a. The Autobiographical Memory Index
b. The Everyday Memory Interview
c. The nine-point mood rating scale
d. The landmark location task
e. The virtual map task (APT 2007)
12. All of the following are recommended elements of a cognitive

rehabilitative programme for ECT except:
a. A comprehensive neuropsychological assessment
b. Feedback to the patient and family
c. Psychoeducation for the patient and caregiver
d. Strategy learning focusing on decompensation
e. The transfer of acquired skills to all domains of the patient’s
life (APT 2007)
97
13. MRI evidence suggests that patients with multiple sclerosis who
exhibit mania with psychotic symptoms have plaques in:
a. The dorso-lateral frontal cortex
b. The non-dominant parietal lobe
c. The orbitofrontal cortex
d. The pre-frontal cortex
e. The temporal horn (APT 2006)
14. All of the following drugs have been used for the treatment of
pathological laughing and crying in multiple sclerosis except:
a. Amantadine
b. Amitryptyline
c. Carbamazepine
d. Fluoxetine
e. Levodopa (APT 2006)
15. The drug for which there is evidence with regard to treating cog-
nitive impairment in multiple sclerosis is:
a. Donepezil
b. Galantamine
c. Memantine
d. Rivastigmine
e. None of the above (APT 2006)
98
PAPER 3
16. All of the following statements about the epidemiology of

Munchausen’s syndrome are true except:
a. Nearly a quarter of the people with Munchausen’s syndrome
have been working in occupations associated with the
medical profession
b. Simple fictitious disorders involve health workers in their
thirties
c. The typical onset is below the age of 30 years
d. Being an unmarried male is an indicator of severe
Munchausen’s syndrome
e. Women are more frequently affected than men (APT 2008)
17. Which of the following statements about the diagnosis of

Munchausen’s disease is true?
a. The absence of visits by family members has been proposed
to be of diagnostic significance
b. Asher described three types of psychological manifestations
c. Cutaneous type was one of the subtypes proposed by Asher
d. DSM-IV categorises Munchausen’s disease into physical,
psychological and mixed subtypes
e. The dyad of Munchausen’s disease involves pseudologia
fantastica but not peregrination (APT 2008)
18. All of the following statements about PTSD are correct except:
a. A genetic factor has been shown to account for 34% of cases
of PTSD
b. High levels of neuropeptide Y have been found in combat
veterans with PTSD
c. Increased levels of corticotrophin-releasing hormone are
found in the CSF of patients with PTSD
d. Numbing is strongly associated with chronicity
e. The prevalence of PTSD among people directly affected by
terrorism is between 12% and 16% (APT 2007)
99
19. Which of the following statements about PTSD is correct?

a. It involves decreased platelet 5-hydroxy tryptamine levels
b. It involves decreased plasma dopamine levels
c. It involves diminished glucocorticoid-receptor sensitivity
d. The DRD2 gene is associated with comorbid psychosis with
PTSD
e. The hyper-suppression of cortisol with dexamethasone
suppression test is indicated (APT 2007)
20. Which of the following statements about schizophrenia and vio-

lence is correct?
a. Approximately 5% of those found guilty of non-fatal
violence have schizophrenia
b. The annual risk that a patient with schizophrenia will
commit homicide is 1 in 10 000
c. Fewer than 5% of those awaiting trial for murder have a
schizophrenic disorder
d. Minor forms of assault are more common in schizophrenia,
at 20% per year
e. Schizophrenia is five times more common among prisoners
than in the general population (APT 2006)
100
PAPER 3
21. Which of the following statements about the diagnosis of bipolar

affective disorder is true?
a. Approximately 10% of patients with bipolar affective
disorder have been diagnosed with schizophrenia
b. About 25% of patients with depression have irritable mood
c. Bipolar type 2 disorder is the only major DSM-IV syndrome
not associated with significant social or occupational
dysfunction
d. Bipolar type 2 disorder is more common than bipolar type 1
disorder
e. Only about 50% of patients with a diagnosis of bipolar
affective disorder have ever been treated on monotherapy
with a mood stabiliser (www.psychiatrycpd.co.uk)
22. Polypharmacy in schizophrenia is associated with all of the follow-

ing except:
a. Approximately 15% of patients being discharged on
antipsychotic polypharmacy
b. An increase in at least one adverse event
c. The increasing fragmentation of services
d. Long-term antipsychotic polypharmacy during the year after
discharge being less than 5%
e. A prevalence as high as 50% among inpatients
(www.psychiatrycpd.co.uk)
101
23. All of the following statements about the management of falls are
true except:
a. According to the Cochrane Review, multifactor risk
assessment is one of the effective factors for the management
of falls
b. Cardiogenic syncope is more likely to be fatal than
neurogenic syncope
c. Fludrocortisone is used as an option in the management of
postural hypotension when non-pharmacological measures
fail
d. One of the aims of the NSF is to provide advice on
prevention through a specialised falls service
e. There is robust evidence supporting the use of hip
protectors to prevent fractures in community populations
(www.psychiatrycpd.co.uk)
24. All the following increase urinary frequency without retention

except:
a. Alcohol
b. Benzodiazepines
c. Caffeine
d. Calcium-channel blockers
e. Diuretics (www.psychiatrycpd.co.uk)
25. All of the following matches with regard to ECT and age are cor-
rect except:
a. Adult – posterior beta
b. Adult – anterior alpha
c. Infant – low amplitude
d. Old age – decrease in delta
e. 2–6 years – mature rhythms (SBN)
102
PAPER 3
26. As which of the following do focal cerebral lesions show on the

EEG?
a. Dominant theta
b. Normal record with fast activity
c. Slow rhythms
d. Spike and wave pattern
e. Unreactive delta (SBN)
27. In which of the following is frontal intermittent rhythmic delta

activity seen?
b. Metabolic encephalopathy
c. Myoclonic epilepsy
d. Presenile dementias
e. Renal encephalopathy (SBN)
28. Which of the following does the neural basis of phonology in-
volve?
a. The anterior temporal lobe
b. Broca’s area
c. The inferior temporal lobe
d. The left anterior hemisphere
e. The left superior temporal lobe (CA)
29. In which of the following are the basal ganglia involved?

a. Phonology
b. Prosody
c. Semantics
d. Syntax
e. None of the above (CA)
103
30. Lesions posterior to the sylvian fissure cause difficulties in:

a. Comprehension
b. Fluency
c. Naming
d. Repetition
e. All of the above (CA)
31. In which of the following aphasic syndromes is repetition pre-

served?
a. Broca’s
b. Conduction
c. Global
d. Transcortical motor
e. Wernicke’s (CA)
32. Which of the following is a word–picture matching test of single-

word comprehension?
a. The Beach Scene Test
b. The Boston Diagnostic Aphasia Examination
c. The Boston Naming and Graded Naming Test
d. The Doors and People Test
e. The Peabody Picture Vocabulary Test (CA)
33. Mr Bainbridge presents with miosis, ptosis, anhydrosis and eno-

phthalmos. Which of the following is the possible cause?
a. Horner’s syndrome
b. Lambert–Eaton syndrome
c. Shy–Drager syndrome
d. Wallenberg syndrome
e. All of the above (TN)
104
PAPER 3
34. In Lambert–Eaton syndrome, against which of the following are

antibodies produced?
a. The acetylcholinesterase enzyme
b. The acetylcholine transporter
c. The muscarinic receptors
d. The nicotinic receptors
e. The voltage-gated calcium channels (TN)
35. All of the following types of receptors show slow adaptation

except:
a. The Golgi tendon organs
b. Merkel’s tactile discs
c. Nociceptors
d. Peritrichial nerve endings
e. Ruffini’s organs (TN)
36. Which of the following receptors sends nerve fibres through the
anterolateral system?
a. Free nerve endings
c. Meissner’s corpuscles
d. Pacinian corpuscles
e. Peritrichial nerve endings (TN)
37. With which of the following are Aα myelinated fibres associated?

a. The Golgi tendon organs
c. Nociceptors
d. Peritrichial nerve endings
e. Ruffini’s organs (TN)
105
38. All of the following are cerebellar nuclei except:

a. Dentate
b. Emboliform
c. Fastigius
d. Globose
e. Red (TN)
39. Taurine is used as a neurotransmitter in the cerebellum by which

of the following cell types?
a. Basket
b. Granule
c. Inner stellate
d. Outer stellate
e. Purkinje (TN)
40. Which of the following cell types in the cerebellum is excitatory?

a. Basket
b. Golgi
c. Granule
d. Outer stellate
e. Purkinje (TN)
41. All of the following statements about the lobes of the cerebellum
are true except:
a. The anterior lobe is the spinocerebellum
b. The flocculonodular lobe consists of the pontocerebellum
c. The posterior lobe is also known as the neocerebellum
d. The posterior lobe is involved with non-stereotype skilled
movement
e. The vermis is part of the anterior lobe (TN)
106
PAPER 3
42. The efferent fibres that pass through the superior cerebellar ped-
uncle include all of the following except:
a. The cerebelloreticular fibres
b. The dentatorubrothalamic pathway
c. The fastigiothalamic tract
d. The fastigiovestibular tract
e. The interpositorubrothalamic pathway (TN)
43. Which of the following statements about the olfactory pathway

is true?
a. The medial olfactory stria is the main central pathway of the
olfactory system
b. The olfactory bulbs are outgrowths of the metencephalon
c. The olfactory receptor cells give rise to myelinated axons
d. The olfactory tract carries both afferent and efferent fibres
e. The primary olfactory cortex projects to the
ventroposteromedial nucleus of the thalamus (TN)
44. All of the following statements about the limbic system are true
except:
a. The dentate gyrus is part of the archicortex
b. The hippocampus forms a prominence on the lateral wall of
the inferior horn of the lateral ventricle
c. The output target of the hippocampus includes the
mammillary body
d. The subcallosal gyri form a part of it
e. The polymorphic layer of the hippocampus consists of
interneurons (TN)
107
45. Which of the following statements about the hippocampus is

true?
a. CA2 zone cells are the primary cells contributing to the
memory process through long-term potentiation
b. The cingulate gyrus connects the hippocampus to the
hypothalamus
c. The entorhinal cortex provides major input to the
hippocampal formation
d. The hippocampal archicortex consists of four layers
e. A lesion of the hippocampal formation causes an inability to
retrieve information from long-term memory (TN)
46. The production of oxytocin and ADH is under the control of:
a. The preoptic nucleus
b. The medial preoptic nucleus
c. The lateral preoptic nucleus
d. The suprachiasmatic nucleus
e. The supraoptic nucleus (TN)
47. Which of the following is the satiety centre?

a. The arcuate nucleus
b. The dorsomedial nucleus
c. The periventricular nucleus
d. The paraventricular nucleus
e. The ventromedial nucleus (TN)
108
PAPER 3
48. Which of the following statements about the ventricular system

is true?
a. The choroid plexus secretes 500 mL of CSF every day
b. CSF is transported back into the ventricular system through
the foramen of Luschka
c. The aqueduct of Sylvius is situated above the tectum in the
midbrain
d. The body of the lateral ventricle is situated below the corpus
callosum
e. The fourth ventricle lies above the cerebellum (SBN)
49. Which of the following statements about the ascending sensory

tracts is true?
a. The affective component of pain appreciation is dependent
on the somatosensory cortex
b. The axons from the lumbar and sacral columns form the
cuneate column
c. The axons that branch to the dorsal horn mediate the
polysynaptic reflexes
d. The second-order neurons of the spinothalamic tract cross
two segments above their spinal cord levels
e. The second-order fibres that carry somaesthetic sensation
from the head terminate in the inferior end of the
postcentral gyrus (SBN)
109
50. Which of the following statements about the visual pathway is

true?
a. The fibres from the lower field pass to the superior bank of
the calcarine fissure
b. A homonymous defect in an upper quadrant of the visual
field suggests a disorder of the ipsilateral temporal lobe
c. The input to the superior colliculi serves as the efferent to
visual avoidance reflexes
d. The receptors synapse with the ganglion cells
e. The rods outnumber the cones in all areas of the retina
(SBN)
51. Which of the following statements about the hearing pathway is

true?
a. High-frequency sound is localised by the superior olivary
nucleus
b. The superior cochlear nuclei are situated around the inferior
cerebellar peduncle
c. The auditory pathway is entirely crossed
d. The third-order neuron crosses in the midline in the
trapezoid body
e. Unilateral lesions of Heschl’s gyrus are accompanied by
unilateral deafness (SBN)
52. All of the following are characteristics of an upper motor neuron

lesion except:
a. The absence of superficial reflexes
b. A Babinski sign
c. Hypertonia
d. Spastic paralysis
e. Wasting (SBN)
110
PAPER 3
53. Which of the following statements about dopamine is true?

a. DOPA decarboxylase is the rate-controlling enzyme
b. The extra-neuronal metabolism of dopamine is by COMT
c. Increasing tyrosine increases the level of catecholamaines
d. The nigrostriatal system has a higher turnover of dopamine
than the mesolimbic system
e. Plasma HVA shows a very long lag in its response to
neuroleptics (SBN)
54. Which of the following statements about dopamine receptors is

true?
a. Apomorphine is their D2-receptor antagonist
b. Domperidone is their D2-receptor antagonist
c. Clozapine has a higher D5-to-D4 receptor binding
d. Pergolide is their D1-receptor agonist
e. Sulpiride is their D4-receptor antagonist (N)
55. Which of the following statements about noradrenaline is true?

a. In the adrenal medulla, noradrenaline is converted to
adrenaline by demethylation
b. MHPG does not cross the blood–brain barrier
c. The non-neuronal metabolism of noradrenaline occurs
through MAO-A
d. Noradrenaline is derived from dopamine by noradrenaline-
β-hydroxylase
e. Noradrenergic projection to the forebrain occurs in two
bundles (SBN)
111
56. Which of the following statements about adrenergic receptors is

true?
a. Adrenaline is a stronger agonist as a β-receptor than is
isoprenaline
b. The β1-receptors are rich in the cerebellum
c. Prazosin is their α2-antagonist
d. Presynaptic α2-receptors control the release of noradrenaline
e. Yohimbine is their α2-agonist (SBN)
57. Which of the following statements about serotonin is true?

a. Platelets store 5% of the serotonin in the blood
b. 5-HIAA has a lumbo-cervical concentration gradient
c. Alanine competes for the same transmitter as tryptophan
d. High levels of 5-HIAA are associated with arson
e. Tryptophan hydroxylase is the rate limiter of synthesis
(SBN)
58. Which of the following is the test of abstract behaviour?

a. The Doors and People Test
b. The National Adult Reading Test
c. The Rivermead Behavioural Memory Test
d. The Stroop Test
e. The Wisconsin Card Sorting Test (CA)
59. Which of the following is a test of the right parietal lobe?

a. The Boston Naming Test
b. The Doors and People Test
c. The Graded Naming Test
d. The Hayling and Brixton test
e. The Judgement of Line Orientation Test (CA)
112
PAPER 3
60. Which of the following is a verbal subscale of WAIS-R?

a. Block design
b. Digit–symbol substitution
c. Picture arrangement
d. Picture completion
e. Similarities (CA)
61. Which of the following is a performance subscale on WAIS?

a. Arithmetic
b. Digit span
c. Digit–symbol substitution
d. Information
e. Vocabulary (CA)
62. Which of the following is not a WMS subscale?

a. Digit span
b. Information and orientation
c. Logical memory
d. Mental control
e. Picture completion (CA)
63. All of the following are tests of the frontal lobe except:
a. The Benton Verbal Fluency Test
b. The Benton Visual Retention Test
c. The Halstead Category Test
d. The Trail Making Test
e. The Wisconsin Card Sorting Test (SBN)
113
64. Which of the following is a specific test for spatial dyslexia and
dyscalculia?
a. The arithmetic scale of the Luria–Nebraska Battery
b. The Rey Complex Figure
c. The Left–Right Disorientation Test
d. The Speech Sound Perception Test
e. The Trail Making Test (SBN)
65. All of the following statements about head injuries are true
except:
a. The Galveston Orientation and Memory Test is a specific
test of post-traumatic amnesia
b. Neuropsychological assessment has a sensitivity of 90–95%
c. The prognostic value of post-traumatic amnesia is most
closely seen in closed and blunt head injuries
d. Retrograde amnesia is a reliable index of the severity of brain
damage but not of its prognosis
e. Retrograde amnesia results from lacerations to the frontal
and temporal regions (SBN)
66. All of the following are tests of language function except:

a. The Benton Verbal Fluency Test
b. The Boston Diagnostic Aphasia Examination
c. Repeating ‘no ifs, ands or buts’ in Addenbrooke’s Cognitive
Examination
d. The Rey Auditory Verbal Learning Test
e. The Revised Token Test (SBN)
114
PAPER 3
67. Which of the following is a test of laterality?

a. The Dichotic Listening Test
b. Finger Oscillation
c. Finger-Tip Number Writing
d. Right–Left Orientation
e. The Trail Making Test (SBN)
68. In which of the following is vascular malformation of the retina

seen?
a. Bilateral acoustic neurofibromatosis
b. Sturge–Weber syndrome
c. Tuberous sclerosis
d. von Hippel–Lindau disease
e. von Recklinghausen’s neurofibromatosis (SBN)
69. In which of the following is IgA deficiency seen?

a. Ataxia telangiectasia
b. Bilateral acoustic neurofibromatosis
c. Sturge–Weber syndrome
e. von Hippel–Lindau disease (SBN)
70. In which of the following is gene deletion on chromosome 22

seen?
a. Ataxia telangiectasia
b. Bilateral acoustic neurofibromatosis
c. Sturge–Weber syndrome
e. von Hippel–Lindau disease (SBN)
115
71. The autosomal dominant form of phakomatoses with an abnor-

mality of chromosome 17 is called:
72. Subungual angifibromas are seen in:

73. High-amplitude clusters of mixed delta waves and multifocal

spikes occurring particularly during sleep are characteristic of:
a. Grand mal
b. Hypsarrhythmia
c. Lennox–Gastaut syndrome
d. Myoclonus
e. Petit mal (SBN)
74. Slow 2 Hz complexes with gradual cessation and the discharge

enhancing in non-REM sleep are characteristic of:
a. Grand mal
b. Hypsarrhythmia
c. Lennox–Gastaut syndrome
d. Myoclonus
e. Petit mal (SBN)
116
PAPER 3
75. All of the following statements about cognitive-event-related

potentials are true except:
a. Attenuated cognitive negative variants have been reported in
psychopathy
b. Children with developmental dysphasia show an abnormal
P3b recovery cycle
c. In contingent negative variation experiments, barbiturates
produce positive shifts
d. In schizophrenia there is generally an increase in the
amplitude of P3
e. P3b may be a marker for conscious thought (SBN)
76. All of the following statements about evoked potentials are true
except:
a. As measured by auditory evoked potentials, cochlear but not
brainstem lesions alter early waves
b. In multiple sclerosis there is a delay in onset of P100
c. In myoclonic epilepsy there is a low-amplitude evoked action
potential
d. Leukodystrophies produce delayed evoked potentials
e. The pathological nature of somatosensory evoked potential
seen in multiple sclerosis is due to degeneration of axon
from the first-order neuron (SBN)
117
77. All of the following statements about the genetics of personality

are true except:
a. Assortative mating is much greater for personality than for
cognitive ability
b. Functional serotonin transporter polymorphism is associated
with neuroticism
c. Heritabilities in the range 30–50% are typical of personality
results
d. Individuals with longer DRD4 alleles have significantly
higher novelty-seeking scores
e. Openness has less non-additive genetic variance than
conscientiousness (PG)
78. Linkage studies have implicated all of the following loci in schizo-
phrenia except:
a. 1q21-q22
b. 6p24-22
c. 6q
d. 8p22-21
e. 21q11 (PG)
79. All of the following statements about the genetics of schizophre-

nia are true except:
a. T>C polymorphism at nucleotide 102 in the HTR2A gene
has been implicated
b. Homozygosity for Ser9Gly polymorphism in exon 1 of the
DRD3 gene has been implicated
c. Unidentified CAG/CTG repeats are less common in people
with schizophrenia than in the general population
d. Variable findings have been reported with regard to the
DRD2 gene that codes for the D2 receptor
e. The (1;11) (q42;q14.3) balanced reciprocal translocation
generates a LOD score of 3.6 in the schizophrenia phenotype,
but of 4.5 in the affective disorders phenotype (PG)
118
PAPER 3
80. Which of the following statements about the genetics of alcohol

misuse is true?
a. The frequency of ADH2 has been reported to be
significantly decreased in members of the Hispanic
population with alcoholism
b. An increased risk of developing alcoholism is associated with
the number and proximity of affected relatives
c. The heritability of alcoholism is 0.25 for males, compared
with 0.5 for females
d. The linkage region on chromosome 11 associated with
alcohol misuse is close to the gene that encodes for β1
GABA
e. A protective locus has been found on the chromosome t that
codes for aldehyde dehydrogenase (PG)
81. All of the following statements about alcohol misuse are true
except:
a. The A1 allele of Taq1 polymorphism close to the DRD2
gene is associated with alcohol dependence
b. The ALDH2 responsible for acetaldehyde oxidation maps to
chromosome 12q24.2
c. At intoxicating levels, ADH4 may account for up to 40% of
ethanol oxidation
d. Cytochrome P450IIEI is inhibited by ethanol consumption
e. The GABAAβ2 gene on chromosome 2 has been implicated
in alcohol dependence (PG)
119
82. The following genes have been implicated in the opiate response
in mouse models. All of them have been correctly matched except
for:
a. DAT – increased reward response
b. GluR-A – reduced tolerance
c. Mu opioid – physical dependence
d. Nociceptin receptor – loss of tolerance
e. SubP – increase in withdrawal (PG)
83. Which of the following is a weak agonist at the μ-receptor?

a. Fentanyl
b. Meperidine
c. Methadone
d. Morphine
e. Buprenorphine (N)
84. Which of the following is a drug that shows agonist activity at the
μ-receptor and antagonist activity at the κ-receptor?
a. Buprenorphine
b. Nalorphine
c. Naltrexone
d. Naloxone
e. Pentazocine (N)
85. Which of the following is a drug that shows agonist activity at the
δ- and κ-receptors and antagonistic activity at the μ-receptor?
a. Buprenorphine
b. Nalorphine
c. Naltrexone
d. Naloxone
e. Pentazocine (N)
120
PAPER 3
86. Which of the following statements about opioid receptors and

endogenous ligands is true?
a. β-endorphin is equipotent on all three types of opioid
receptors
b. δ-receptors are supraspinal in distribution
c. Dynorphin is least potent at the κ-receptor
d. Enkephalins are most potent at the κ-receptor
e. Spinal receptors are exclusively of the μ type (N)
87. Which of the following is an antagonist at all three types of opioid

receptors?
a. Buprenorphine
b. Fentanyl
c. Nalorphine
d. Naltrexone
e. Pentazocine (N)
88. On which of the following chromosomes is the APP gene

located?
a. 3
b. 10
c. 14
d. 17
e. 21 (PG)
121
89. On which of the following chromosomes is the presenilin-1 gene

located?
a. 3
b. 10
c. 14
d. 17
e. 21 (PG)
90. Presenilin is involved in controlling:

a. α-secretase
b. β-secretase
c. γ-secretase
d. δ-secretase
e. μ-secretase (PG)
91. The polymorphic form that may be protective against developing

dementia is:
a. ApoE1
b. ApoE2
c. ApoE3
d. ApoE4
e. ApoE5 (PG)
92. The most common genotype associated with type III hyperlipi-
daemia is:
a. ApoE1
b. ApoE2
c. ApoE3
d. ApoE4
e. ApoE5 (PG)
122
PAPER 3
93. Which of the following is associated with prolonged QTc inter-

vals?
a. Chamomile
b. Hops
c. Kava
d. Passionflower
94. All of the following statements about the course of affective dis-
a. Agoraphobia without panic disorder lacks evidence for
influencing course
b. Anxiety disorders present during relative euthymia predict a
worse prognosis
c. Current comorbid anxiety disorder is associated with a risk
of earlier relapse
d. A longer time period since the resolution of a previous
episode predicts subsyndromal symptoms in recurrent
unipolar depression
e. Social anxiety disorder is associated with poor outcomes of
bipolar disorder (BJP 2006)
95. Which of the following statements about crisis resolution/home

treatment teams (CRHTs) is true?
a. Adding assertive outreach teams to existing services did not
produce a significant change in hospital admissions
b. CRHTs significantly reduce the admission of younger adults
c. Changes in admission patterns are not sustained for
3 months following the setting up of CRHTs
d. CHRTs cause a significant reduction in the number of
admissions of older men
e. None of the above (BJP 2006)
123
96. Which of the following statements about benzodiazepine discon-

tinuation is true?
a. Around 1% of the general population uses benzodiazepines
b. The augmentation of systematic discontinuation with group
CBT is no more effective than systematic discontinuation
alone
c. The augmentation of systematic discontinuation
with carbamazepine is more effective than systematic
discontinuation alone
d. The odds ratio for minimal intervention is 2.8 compared
with treatment as usual
e. Systematic discontinuation programmes are significantly
more effective than simple advice (BJP 2006)
97. All of the following statements about debriefing are true except:
a. Debriefing in people with high baseline levels of arousal
increases their likelihood of developing PTSD
b. Emotional ventilation debriefing is safer than educational
debriefing
c. Psychoeducation provided as part of debriefing may increase
awareness of stress symptoms
d. There is no empirical evidence to support single-session
debriefing for anxiety
e. There is evidence for adverse effects of debriefing for PTSD
(BJP 2006)
124
PAPER 3
98. All of the following statements about schizophrenia are true

except:
a. Group II metabotropic glutamate-receptor antagonists show
antipsychotic efficacy
b. Group II metabotropic receptors are autoreceptors that
inhibit glutamate release
c. Lexical verbal fluency is less impaired with schizophrenia
than is semantic verbal fluency
d. Schizophrenia involves an increased speed of activation in
semantic memory
e. Semantic verbal fluency may be the best candidate for
cognitive endophenotype (BJP 2008)
99. All of the following statements about affective disorders are true
except:
a. Family therapy is neither more nor less effective than crisis
management for bipolar disorder
b. Group psychoeducation as an adjunct to pharmacological
therapy may be effective for relapse prevention in bipolar
disorder
c. Internet-delivered brief CBT may be effective in the
treatment of depression
d. Male gender and depression are associated with self-harm in
first-episode psychosis
e. Progressive severity of depressive episodes is dependent on
the patient’s age at the onset of the disorder (BJP 2008)
125
100. Which of the following statements about eating disorders is

true?
a. Women with anorexia are more likely to experience preterm
birth than women with bulimia
b. The lifetime risk of bulimia nervosa in adult women is 3%
c. The rate of partial syndrome in eating disorder is less than
that of anorexia nervosa
d. Women with anorexia nervosa are more likely to deliver
babies of normal birth weight than those in the general
population
e. Women with bulimia have significantly higher rates of past
miscarriages than those in the general population (BJP 2007
and 2008)
101. All of the following statements about the genetics of schizophre-

nia are true except:
a. Delta-9-tetrahydrocannabinol acts through the CNR1
receptor
b. CHRNA7 variation alters the risk of schizophrenia
c. Higher than normal levels of glutamine are found in the
anterior cingulate of never-treated patients
d. Paternal age is consistently associated with the risk of
schizophrenia
e. Tobacco alleviates neurophysiological deficits through
activity at the α7-nicotinic cholinergic receptor (BJP 2007)
126
PAPER 3
102. Which of the following statements about early psychosis is

true?
a. The 3-year prevalence of adolescent-onset schizophrenia is
3 per 100 000 in the general population
b. Impaired emotional recognition is not seen among the
healthy siblings of patients with schizophrenia
c. Later childhood growth is associated with schizophrenia
spectrum disorder
d. There is an association between relatively slow early growth
and schizophrenia in women
e. There is no association between a lack of insight and the
stability of substance-induced psychosis diagnosis (BJP 2007)
103. Urea can be measured by using:

19
a. F
b. 1h
c. 2h
14
d. N
31
e. P (KS)
104. pO2 can be measured by using:

19
a. F
1
b. H
c. 2H
14
d. N
31
e. P (KS)
127
105. pH can be measured by using:

19
a. F
b. 1H
c. 2H
14
d. N
31
e. P (KS)
106. The rCBF technique involves:

a. Fluorine-18
b. Iodine-123
c. Nitrogen-13
d. Technetium-99 m
e. Xenon-133 (KS)
107. Blood flow is measured by using:

a. Fluorine-18
b. l-hexamethyl-propylene amine oxime
c. Iodine-123
d. Nitrogen-13
e. Xenon-133 (KS)
108. Renal calculi are an adverse effect of:

a. Gabapentin
b. Levitracetam
c. Pregabalin
d. Tiagabine
e. Topiramate (KS)
128
PAPER 3
109. Which of the following statements about paraldehyde is true?

a. It blocks the sedating effects of alcohol
b. Disulfiram increases the metabolism of paraldehyde
c. An overdose leads to respiratory acidosis
d. The unmetabolised drug is expired by the lungs
e. It has a wide therapeutic range (KS)
110. Gaboxadol acts at which of the following α-subunits of the GABA

receptor?
a. 1
b. 2
c. 3
d. 4
e. 5 (KS)
111. All of the following statements about flumazenil are true except:
a. It can reverse the effects of zaleplon
b. It can precipitate seizures
c. It does not reverse the effects of opioids
d. It should be used only once at a dosage of 2 mg
e. Sedation can return in up to 3% of people who are treated
with flumazenil (KS)
112. All of the following are interactions of bupropion except:

a. Carbamazepine – increases the concentration of bupropion
b. Levodopa – delirium
c. Lithium – CNS toxicity
d. MAOIs – hypertensive crisis
e. Metoprolol – sinus bradycardia (KS)
129
113. All of the following statements about executive function and

stroke are true except:
a. Antidepressants foster long-term but not short-term
improvement in executive function after a stroke
b. Antidepressants improve outcome after a stroke which is
dependent on the improvement of depression
c. Nortriptyline improves the activities of daily living
d. Antidepressants reorganise brain circuitry by their effect on
brain-derived neurotrophic factor
e. Sertraline improves morbidity (BJP 2007)
114. Which of the following statements about frontal-release signs is

true?
a. In patients with schizophrenia, frontal-release sign scores
show an inverse correlation with IQ
b. In patients with schizophrenia, right-grasp reflex scores
correlate negatively with the number of perseverative errors
on the Wisconsin Card Sorting Test
c. Single sign scores correlate with clinical pathology
d. They do not occur in healthy young people
e. Strong evidence exists for the heritability of neurological
soft signs (BJP 2007)
115. All of the following statements about lithium are true except:
a. About 50% of patients with bipolar disorder are prescribed
lithium
b. Glomerular dysfunction is more common than tubular
dysfunction
c. It reduces the lethality of suicide attempts
d. It is retained in monotherapy for much longer than other
mood stabilisers
e. Treatment adherence is a strong predictor of suicidal
behaviour (KS)
130
PAPER 3
116. Which of the following statements about psychotherapy is true?

a. Brief CBT influences long-term outcomes in patients with
acute PTSD
b. E-CBT reduces the symptom burden of people with social
phobia
c. Integrated therapy for patients with bipolar disorder and
substance misuse is no more effective than group drug
counselling
d. Psychoeducation may be as beneficial as CBT in the
prevention of relapses of bipolar disorder
e. There is level A evidence for debriefing as a treatment of
post-traumatic stress disorder (BJP 2008)
117. Which of the following genes has been linked to depression?

a. 4q
b. 9p
c. 15q
d. 18p
e. 22p (PG)

affective disorders is true?
a. Bipolar type 1 disorder is more common among married
men than others
b. A higher than average incidence of bipolar type 1 disorder is
found among people in lower socio-economic groups
c. The lifetime incidence of OCD is twice as high among
patients with major depression as it is among those with
bipolar type 1 disorder
d. The mean age of onset of bipolar type 1 disorder is 30 years
e. The mean age of onset of depression is 20 years (KS)
131
119. All of the following statements about the role of amines in affect-
ive disorders are true except:
a. Cholinergic agonists can exacerbate the symptoms of
depression
b. A correlation exists between the down-regulation of
β-adrenergic receptors and the clinical antidepressant
response
c. The D1-receptor may be hypoactive in depression
d. GABA-receptors are upregulated by antidepressants
e. The platelets of people with suicidal impulses have a high
concentration of serotonin uptake sites (KS)
120. Which of the following statements about the neuroendocrine

pathology of affective disorders is true?
a. The gene coding for neurokinin-mediated BDNF increases
after chronic stress
b. Hypercortisolaemia in depression suggests increased activity
from acetylcholine
c. Increased CSF somatostatin levels have been reported in
depression
d. In affective disorders there is increased feedback inhibition
from the hippocampus over the hypothalamo–pituitary–
adrenal axis
e. Around 10% of depressed individuals show a blunted TSH
response to a TRH challenge (KS)
121. Which of the following patient variables is necessary for psy-

chodynamic psychotherapy?
a. The ability to modulate regression
b. A modest to moderate need for direction and guidance
c. Responsiveness to behavioural thinking
d. Responsiveness to environmental manipulation
e. Social or communication problems (KS)
132
PAPER 3
122. All of the following are limitations of psychodynamic theory

except:
a. Enduring structural change transcends symptomatic relief
b. Its focus on intrapsychic phenomena may obscure other
factors
c. Long-term open-ended treatment is uneconomical
d. Personality alteration can be too ambitious
e. Transference regression can lead to over-idealisation of the
therapist (KS)
123. All of the following are indications for pharmacotherapy in

depression except:
a. Depressive stupor
b. Early-morning wakening
c. Loss of control over thinking
d. Low self-esteem
e. Marked vegetative signs (KS)
124. All of the following statements about phototherapy are true

except:
a. It is well tolerated
b. The light range that it uses is between 500 and 1000 lux
c. Longer treatment durations are associated with better
responses
d. Sleep disorders in geriatric patients can improve with bright
light during the day
e. It is used between 1 and 2 hours before dawn (KS)
133
125. With which of the following is priapism seen?

a. Duloxetine
b. Maprotiline
c. Nefazadone
d. Trazadone
e. Trimipramine (KS)
126. The hallmark of which of the following therapies is its patients’

ability to be their true selves in the face of familial or other pres-
sures that threaten them with the loss of social position or love?
a. The Bowen model
b. The general systems model
c. The psychodynamic–experiential model
d. The social network model
e. The structural model (KS)
127. In which of the following is the patient encouraged to engage in

unwanted behaviour?
a. The Bowen model
b. Conjoint therapy
c. The general systems model
d. Paradoxical therapy
e. Reframing (KS)
128. The most common form of marital therapy is:

a. Combined therapy
b. Conjoint therapy
c. Four-way session
d. Individual therapy
e. Individual couple therapy (KS)
134
PAPER 3
129. The form of couples therapy in which a different therapist sees

each partner, with regular joint sessions in which all of the par-
ticipants take part, is called:
a. Combined therapy
b. Conjoint therapy
c. Four-way session
d. Individual therapy
e. Individual couple therapy (KS)
130. The modes of treatment in DBT include all of the following

except:
a. Consultation team
b. Group skills training
c. Individual therapy
d. Telephone consultation
e. Termination letter (KS)
135
4
Paper 4
1. With regard to the treatment of premenstrual syndrome, all of

the following statements are false except:
a. Danazol worsens mastalgia
b. Dosing in the luteal phase is less efficacious than treatment
throughout the cycle
c. Fluoxetine is safer than other treatments, as it does not alter
the length of the menstrual cycle
d. SSRIs are efficacious in treating both physiological and
psychological symptoms
e. The onset of improvement following SSRI treatment is
much slower than with depressive disorder (APT 2007)
2. All of the following statements about the withdrawal symptoms

seen in neonates due to maternal use of antidepressants are true
except:
a. They are associated with maternal SSRI use in late
pregnancy
b. They are associated with maternal use of tricyclic
antidepressants in late gestation
c. Such symptoms are absent at birth
d. Such symptoms include tremor and feeding difficulties
e. Such symptoms usually resolve within 2 weeks (APT 2007)
137
3. All of the following statements about the Clinical Antipsychotic

Trials of Intervention Effectiveness (CATIE) are true except:
a. The Brief Psychiatric Rating Scale was their measure of
primary outcome
b. They involved double-blind randomised trials
c. The duration of the study was 18 months
d. Patients with tardive dyskinesia were excluded from the
perphenazine arm
e. Their proxy for effectiveness was the discontinuation of
treatment for any cause (APT 2008)
4. All of the following were outcomes from the CATIE except:

a. Discontinuation due to intolerable side-effects was greatest
with olanzapine
b. The initial large improvement from olanzapine was not
sustained by the end of the study
c. Olanzapine treatment was less costly than treatment with
perphenazine
d. The overall rate of discontinuation of the antipsychotics was
74%
e. There was no significant difference between the drugs with
regard to the incidence of extrapyramidal side-effects (APT
2008)
138
PAPER 4
5. All of the following were features of the Cost Utility of the

Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS)
except:
a. The clinicians used haloperidol infrequently
b. The patients on second-generation antipsychotics showed a
trend towards greater improvement in terms of quality of life
than others
c. It was a multi-centre trial
d. It found no clear patient preference with regard to choice of
antipsychotics
e. Its specific hypothesis was that new antipsychotics would
be associated with a clinically significant improvement in
quality of life for 1 year over that of older drugs (APT 2008)
6. Mr Allen is to be started on an atypical antipsychotic. He knows

that his father suffered from parkinsonism due to having been on a
typical antipsychotic. He would like to know what the predisposing
factors are for atypical antipsychotic drug-induced parkinsonism.
All of the following are predisposing factors except:
a. A higher than BNF maximum dose
b. A higher starting dose
c. Being male
d. Increasing age
e. An individual predisposition to a high rate of dopaminergic
neuron loss (APT 2008)
139
7. Mr Redbridge has a diagnosis of chronic schizophrenia. You

suspect that he has negative symptoms, whilst the neurologist’s
opinion is that he has parkinsonian features. All of the following
factors support your diagnosis except:
a. Avoidance of eye contact
b. Loss of intonation of speech
c. Preserved articulation of speech
d. Preserved spontaneous generation of words
e. Restricted range and depth of mood (APT 2008)
8. All of the following statements about EEG monitoring of ECT

are true except:
a. A study conducted in India found that 10–15% of its sample
had prolonged seizures on EEG
b. The end point is the most likely point at which the
immediate post-ictal tracing begins
c. The incidence of prolonged ECT was 1% in the Edinburgh
ECT clinic
d. The potential clinical application of ictal EEG does not
include a prediction of eventual treatment response
e. There is a lack of significant correlation between post-ictal
suppression and clinical improvement (APT 2007)
9. To which of the following is the quality of ictal EEG significantly

related?
a. Age
b. Concurrent medications
c. Electrode placement
d. Previous ECT episodes
e. Threshold dose (APT 2007)
140
PAPER 4
10. All of the following statements about ethnicity and psychiatric

disorders in the UK are true except:
a. The EMPIRIC report showed that higher rates of Pakistani
women reported common mental disorders compared with
the general population
b. The EMPIRIC report showed that lower rates of
Bangladeshi women reported common mental disorders
compared with the general population
c. The EMPIRIC report showed that there was twice as much
psychotic illness in people of African and Caribbean origin
compared with the general population
d. People of African and Caribbean origin are more likely to be
detained against their will
e. Young people of African-Caribbean origin continue to be at
five times less risk of suicide and self-harm than white British
people (APT 2008)
11. For which of the following herbal remedies does evidence exist
for its effectiveness in treating anxiety?
a. Ginkgo biloba
b. Lavandula angustifolia
c. Melissa officinalis
d. Piper methysticum
e. Valeriana officinalis (APT 2007)
12. Which of the following has been shown to be an ineffective rem-

edy for treating depression?
a. Crocus sativus
b. Ginkgo biloba
c. Hypericum perforatum
d. Lavandula angustifolia
e. All of the above (APT 2007)
141

medically unexplained psychological symptoms is true?
a. Around 5–10% of all primary care consultations are for
medically unexplained psychological symptoms
b. Less than 25% of patients who have debilitating fatigue
lasting more than 6 months also have fibromyalgia
c. ‘Medically unexplained symptom’ is the term preferred by
GPs
d. Most patients with medically unexplained symptoms do
not allow their doctors an opportunity to address their
psychological needs
e. The number of such symptoms over a person’s lifetime
shows a linear correlation with the number of anxiety but
not depressive disorders the person has experienced (APT
2008)
14. Which of the following statements about the aetiological under-

standing of medically unexplained symptoms is true?
a. Children of parents with medically unexplained symptoms
are at lower risk of such a presentation than the children of
parents with organic conditions
b. Children with higher academic competence show a higher
rate of medically unexplained symptoms
c. GPs tend to have the attitude that such symptoms should be
managed in primary care
d. Intergenerational transmission is understood purely as social
learning
e. Physical and emotional, but not sexual, abuse in childhood is
related to such symptoms (APT 2008)
142
PAPER 4
15. Which of the following statements about the treatment of medic-

ally unexplained psychological symptoms is true?
a. The benefits from antidepressant treatment are dependent
on the presence of depression
b. No treatment has been demonstrated to be effective in
secondary care
c. One session of psychological therapy may reduce the
number of GP visits
d. A somatic symptom that lasts for more than 1 year is
indicative of a poor prognosis
e. The reattribution model of treatment has five stages (APT
2008)
16. With which of the following are passivity phenomena associated?

a. Hypoactivation of the right inferior parietal cortex
b. Hypoactivation of the right parietal cortex
c. Hyperactivation of the supplementary motor area
d. Reduced grey matter in the dominant parietal lobe
e. Reduced grey matter in the non-dominant prefrontal cortex
(APT 2006)
17. Which of the following statements about abnormal bodily percep-

tions and delusions is true?
a. Somatic hallucinations activate the primary somatosensory
and posterior parietal cortex
b. Body dysmorphic disorder is associated with abnormal
putamen circuits
c. Conversion disorder with motor symptoms is associated with
inhibition of the orbitofrontal cortex
d. They involve hyperperfusion of the left temporo-parietal
cortex
e. Reduced striatal D2-receptor binding occurs in Cotard’s
syndrome (APT 2006)
143
18. All of the following observations about self-harm are true

except:
a. Around 40% of the people who attend A&E following self-
harm have taken an overdose
b. Cutting may be twice as prevalent as overdosing in
community samples
c. The majority of the people who self-injure do not go to a
hospital
d. One important factor in not seeking hospital treatment is a
previous poor experience in A&E
e. One quarter of all suicides are preceded by self-harm
episodes during the year before they occur (APT 2007)
19. Which of the following observations about self-injury is true?

a. Among young adults, significantly more females use self-
injury to kill themselves than do males
b. In a household survey, 5% of the men who were surveyed
admitted to self-harm without suicidal intent
c. People who present with cutting are less likely to present
with suicidal intent than people who present with self-
poisoning
d. Repeated self-injury is associated with sexual abuse in
women but not in men
e. The UK has one of the highest incidences of self-injury
among schoolchildren of any country (APT 2006)
144
PAPER 4
20. All of the following observations about self-injury are true

except:
a. Among children and adolescents, females are more likely
than males to say that they have to tried to obtain relief from
an unbearable state of mind
b. Individuals who present with self-cutting behaviour have
reported feeling less pain than matched controls
c. Individuals who poison themselves are more impulsive than
those who cut themselves
d. In females, body shame is positively correlated with self-
harming behaviour
e. Self-poisoning is a strong predictor of suicide in people with
schizophrenia (APT 2006)
21. Which of the following statements about the treatment strategy

for self-injury is true?
a. Manual-assisted CBT is a cost-effective method for
reducing self-harming behaviour in patients with borderline
b. Naltrexone at a dose of 50 mg/day can reduce self-harming
behaviour when other measures have failed
c. Self-harming behaviour in borderline personality disorder
with dissociative states has been shown to benefit little from
dialectical behaviour therapy in secure units
d. Significant evidence suggests that people grow out of self-
harming behaviour
e. Evidence exists which suggests that safety agreements
between staff and patients reduce self-harming behaviour
(APT 2006)
145
22. All of the following statements about smoking are true except:
a. Approximately 50% of smokers with mental illness in the
UK have shown a desire to quit smoking
b. High rates of smoking are significantly associated with an
increased risk of other smoking-related illnesses in people
with mental illness
c. People whose mental illness has remitted are at no greater
risk of subsequent smoking than people with active disorders
d. People with mental illness are three times more likely to
smoke than the general population
e. Smoking increases the risk of mental illness even after
correcting for major risk indicators of a mental disorder
(APT 2008)
23. EEG in subacute sclerosing panencephalitis shows:

a. Irregular theta activity
b. Low-voltage EEG
c. Triphasic waves
d. Periodic complex
e. 3 Hz spike and wave (SBN)
24. With which of the following changes in EEG are negative symp-
toms in schizophrenia correlated?
a. Decreased alpha activity
b. Increased beta activity
c. Increased delta wave
d. Low mean alpha frequency
e. Paroxysmal activity (SBN)
146
PAPER 4
25. Which of the following does EEG of autistic spectrum disorders

show?
a. Alpha deficits
b. Beta deficits
c. Beta excess
d. Delta excess
e. Theta excess (SBN)
26. All of the following are characteristics of alpha waves except:

a. They are measured at 8 to 12 Hz
b. They are attenuated with attention
c. They are bilateral and frontal
d. They have a higher amplitude on the dominant side
e. They are seen in a relaxed state with the eyes closed (SBN)
27. A generalised epileptiform pattern of EEG is seen with:

a. Alcohol
b. Benzodiazepine
c. Cannabis
d. Cocaine
e. Phencyclidine (SBN)
28. The shoulder is supplied by:

a. C3
b. C4
c. C5
d. C6
e. C7 (TN)
147
29. With which of the following are the Ib fibres associated?

a. Pressure
b. Primary sensory output from muscle spindles
c. Secondary sensory terminals of muscle spindles
d. Sensory fibres of Golgi tendon organs
e. Touch (TN)
30. With which of the following fibre types does the fusimotor to
intrafusal fibres of muscle spindles function match?
a. Aβ afferent
b. Aδ afferent
c. C afferent
d. Aα efferent
e. Aγ efferent (TN)
31. In which of the following are contralateral pain and temperature

sensation loss with ipsilateral weakness and loss of proprioception
seen?
a. Brown–Sequard syndrome
b. Ependymoma
c. Syringomyelia
d. Tabes dorsalis
e. Spina bifida (TN)
32. In which of the following are the gyri of Heschl?

a. Broca’s area
b. The primary auditory cortex
c. The primary motor area
d. The primary somaesthetic area
e. Wernicke’s area (TN)
148
PAPER 4
33. Which of the following statements about the anterolateral system

is true?
a. It is involved in the transmission of discriminative touch
b. Its first-order neurons are bipolar
c. Unmyelinated C fibres in the pain pathway transmit
sensations that elicit an affective response
d. Around 15% of its nociceptive fibres project to the thalamus
via a relay in the reticular formation
e. The spinothalamic tract sends inputs to the dorsolateral
nucleus of the thalamus (TN)
34. All of the following statements about the vibration sense are true
except:
a. Decussation is in the medial lemniscus
b. The cell bodies of first-order neurons are located in the
dorsal root ganglion
c. The cell bodies of second-order neurons are located in the
dorsal horn
d. The VPL nucleus of the thalamus hosts the cell bodies of
third-order neurons
e. Third-order neurons terminate in the postcentral gyrus
(TN)
149
35. Which of the following statements about the ascending sensory

tracts to the cerebellum is true?
a. The anterior cerebellar tract terminates in the ipsilateral
anterior lobe of the cerebellum
b. The cell bodies of first-order neurons are located in the
dorsal root ganglion
c. Second-order neuron cell bodies belonging to the
cuneocerebellar tract are located in the dorsal horn
d. Most of the proprioception information reaches conscious
levels
e. The rostral spinocerebellar tract coordinates the movements
of the lower limb muscles (TN)
36. Mr Bainbridge presents with muscle weakness, loss of vibratory

sense, two-point discrimination and proprioception. This is due
to:
b. Friedrich’s ataxia
c. Subacute combined degeneration
d. Syringomyelia
e. Tabes dorsalis (TN)
37. Mr Bainbridge presents with loss of pain and temperature sen-

sation from the skin of both shoulders and upper extremities,
followed by weakness and atrophy of the intrinsic muscles of the
hand. This is due to:
b. Friedrich’s ataxia
c. Subacute combined degeneration
d. Syringomyelia
e. Tabes dorsalis (TN)
150
PAPER 4
38. Which of the following are the afferent fibres that pass through
the inferior cerebellar peduncle?
a. The anterior spinocerebellar tract
b. The ceruleocerebellar fibres
c. The rubrocerebellar fibres
d. The tectocerebellar fibres
e. The trigeminocerebellar fibres (TN)
39. From which of the following do the monoaminergic fibres that

terminate only in the granular and molecular layers of the cerebel-
lar cortex originate?
a. The deep cerebellar nuclei
b. The hypothalamus
c. The locus coeruleus
d. The pontine raphe nuclei
e. The ventral midbrain tegmentum (TN)
40. Mr Bainbridge presents with an inability to maintain equilib-

rium. An examination reveals no evidence of ataxia, hypotonia or
tremor. He tends to sway from side to side when he walks. The
examination also reveals nystagmus. To which of the following is
this probably due?
a. Flocculonodular syndrome
b. Left hemispheric zone disorder
c. Paravermal zone disorder
d. Vermal zone disorder
e. Right hemispheric zone disorder (TN)
151
41. With which of the following cranial nerves is the pterygopalatine

ganglion associated?
a. III
b. V
c. VII
d. IX
e. X (TN)
42. The sensory ganglion belonging to the trigeminal nerve is the:

a. Ciliary
b. Geniculate
c. Gasserian
d. Scarpa’s
e. Submandibular (TN)
43. Which of the following nuclei regulates the release of reproduc-

tive hormones from the adenohypophysis?
a. Arcuate
b. Lateral preoptic
c. Periventricular
d. Preoptic
e. Supraoptic (TN)
44. Which of the following is the body’s master clock?

a. Arcuate
b. Mamillary
c. Medial preoptic
d. Supraoptic
e. Suprachiasmatic (TN)
152
PAPER 4
45. Which of the following is the thalamic nucleus involved in learn-

ing and memory?
a. The anterior
b. The dorsal midline
c. The ventral midline
d. The pulvinar
e. The parvocellular (TN)
46. In which of the following is the medial geniculate body involved?

a. Hearing
b. The integration of somatosensory information
c. Sensorimotor integration
d. Taste
e. Vision (TN)
47. Mr Bainbridge presents with allodynia, hyperpathia and dysesthe-

sia. To which of the following is this due?
b. Dejerine–Roussy syndrome
c. Guillain–Barré syndrome
d. Kluver–Bucy syndrome
e. Stevens–Johnson syndrome (TN)
48. Which of the following is a feature of a right-hemisphere lesion?

a. Acalculia
b. Alexia without agraphia
c. Broca’s aphasia
d. Colour anomia without agraphia
e. Prosopagnosia (SBN)
153
49. All of the following are features of a left-hemisphere lesion

except:
a. Agraphia without alexia
b. Alexia with agraphia
c. Constructional apraxia
d. Gerstmann’s syndrome
e. Wernicke’s aphasia (SBN)
50. All of the following statements about hypothalamic connections

are true except that they go:
a. To the amygdala via the amygdalofugal bundle
b. To the amygdala via the stria terminalis
c. To the anterior thalamus via the mammillothalamic tract
d. To the hippocampus via the fornix
e. To the septum via the lateral forebrain bundle (SBN)
51. Which of the following statements about the anatomy of the

limbic system is true?
a. The amygdala lies in the medial aspect of the frontal lobe
b. The limbic system controls the autonomic nervous system
via the medial longitudinal fasciculus
c. Major output from the mammillary bodies flows to the
posterior nucleus of the thalamus
d. The mammillary bodies receive a number of axons through
the stria terminalis
e. The septal nuclei have reciprocal connections with the
hippocampus via the fornix (SBN)
154
PAPER 4
52. Which of the following statements about the arousal system is

true?
a. The cholinergic pathways are independent of the arousal
system
b. During relaxed wakefulness, descending reticulospinal
projections increase the sensitivity of the stretch reflex arcs
c. Projections from the reticular nuclei of the thalamus
produce a characteristic beta-wave form on an EEG
d. The reticular formation in the midbrain surrounds the
aqueduct of Sylvius
e. The reticular formation projects to the ventroposterolateral
nucleus of the thalamus (SBN)
53. Which of the following statements about serotonergic receptors

is true?
a. 5-HT1A receptors are found in raphe cell bodies
b. 5-HT1c is found in the heart
c. β-Blockers are agonists at 5-HT1B
d. LSD is an agonist at 5-HT3
e. Ritanserin is an agonist at 5-HT2A (SBN)
54. Which of the following statements about serotonin is true?

a. Decreasing concentration produces bizarre stereotyped
behaviour
b. High CSF 5-HIAA predicts impulsivity
c. Increasing concentrations lead to insomnia
d. The postsynaptic 5-HT1 receptor mediating prolactin
release is blunted in depression
e. Selective uptake blockers cause weight gain (SBN)
155
55. Which of the following statements about opioid receptors is

true?
a. β-Endorphin is an antagonist at the μ-receptor
b. Enkephalins are endogenous agonists of the δ-receptor
c. Naloxone is an agonist at the μ-receptor
d. Naltrexone is an agonist at the μ-receptor
e. Pentazocine is an antagonist at the κ-receptor (SBN)
56. All of the following statements about peptides are true except:
a. CCKA is involved in emotional behaviour
b. CRH stimulates locus firing
c. Injections of CRH produce decreased appetite
d. TRH is three amino acids long
e. Two different types of CCK receptors have been identified
(SBN)
57. Non-urgent CT is indicated in all of the following except:

a. Encephalitis
b. Confusion for which no metabolic or toxic cause has been
found
c. Marked and persistent or variable drowsiness
d. Schizophrenia developing after the age of 40 years
e. Progressive cognitive decline developing after the age of
65 years (SBN)
156
PAPER 4
58. Mr Bainbridge is a 60-year-old man. He presents with a bitem-

poral headache which he describes as being a pressure-like pain.
He has had a history of migraine and is on medications. The most
plausible diagnosis is:
a. Cluster headache
b. Cranial arteritis
c. Malignant hypertension
d. Migraine
e. Tension headache (SBN)
59. Mr Bainbridge presents with a headache on waking which seems

to improve with a change of posture. The diagnosis is:
a. Arteriovenous malformations
b. Cluster headache
c. Hypertensive encephalopathy
d. Obstructive hydrocephalus
e. Temporal arteritis (SBN)
60. Mr Bainbridge presents with an occipital headache, vertigo, diplo-

pia, blurring of vision and lethargy. The diagnosis is:
a. Cluster headache
b. Cranial arteritis
c. Hypertensive encephalopathy
d. Migraine
e. A space-occupying lesion (SBN)
157
61. An EEG shows a 2/s spike and wave form in a person with a clin-
ical history of absences. The diagnosis is:
a. Benign rolandic epilepsy
d. Lennox–Gastaut syndrome
e. Temporal-lobe epilepsy (SBN)
62. All of the following statements about blepharospasm are true

except:
a. It is associated with demyelinating disorders
b. It is more common in men than in women
c. l-DOPA can cause blepharospasm
d. Spontaneous remission occurs in only 10% of patients
e. Its symptom presents bilaterally (SBN)
63. All of the following tests form a part of the Halstead–Reitan

Battery except:
a. The Aphasia Screen
b. The Seashore Rhythm Test
c. The Stroop Colour–Word Interference Test
d. The Tactual Performance Test
e. The Wechsler Adult Intelligence Scale (Revised) (SBN)
64. All of the following are clinical scales of the Standardised Luria–
Nebraska Battery except:
a. Expressive speech
b. Motor
c. Power
d. Receptive speech
e. Rhythm (SBN)
158
PAPER 4
65. All of the following statements about the timing of the course of
events occurring after an occlusion of a cerebral vessel are true
except:
a. Less than 12 hours – no microscopic or macroscopic changes
by conventional methods
b. 12 to 24 hours – increasing swelling of damaged area with
normal staining of the brain
c. 1 to 3 days – inflammatory cell response
d. 1 to 2 weeks – astrocytosis
e. Months or years – tissue destruction with remaining
astrocytic scar or cavity formation (SBN)
66. All of the following statements about intracranial haemorrhages

are true except:
a. Extradural haemorrhages are commonly due to a laceration
of the middle meningeal artery
b. Lacunar disease presents more commonly in relation to basal
ganglia when it involves grey matter
c. Oral contraception increases the risk of a subarachnoid
haemorrhage
d. Subacute subdural haematomas are due to the rupturing of
the veins that join the superior sagittal sinus
e. The most common cause of subarachnoid haemorrhages
is an extension from a bleed elsewhere within the cranium
(SBN)
67. The most common cause of acute bacterial meningitis in people

of any age is:
a. E. coli
b. Haemophilus influenzae
c. Neisseria meningitidis
d. Staphylococcus aureus
e. Streptococcus pneumoniae (SBN)
159
68. In the intermediate lobe of the pituitary, all of the following are
derived from pro-opiomelanocortin except:
a. α-Melanocyte-stimulating hormone
b. Adrenocorticotrophic hormone
c. β-Endorphin
d. γ-Lipotrophin
e. Corticotrophin-like intermediate lobe peptide (SBN)
69. Guanylate cyclase is activated by:

a. ACTH
b. Adenosine
c. Angiotensin II
d. Arginine vasopressin
e. Atrial natriuretic peptide (SBN)
70. Adenylyl cyclase is inhibited by:

a. ACTH
b. Adenosine
c. Angiotensin II
d. Arginine vasopressin
e. Atrial natriuretic peptide (SBN)
71. Adenylyl cyclase is activated by all of the following except:

a. Calcitonin
b. Follicle-stimulating hormone
c. Glucagon
d. Insulin
e. Thyroid-stimulating hormone (SBN)
160
PAPER 4
72. Phosphoinositide turnover is controlled by:

a. Glucagon
b. Histamine
c. Human chorionic gonadotropin
d. Insulin
e. Thyrotropin-releasing hormone (SBN)
73. All of the following statements about the genetics of cognitive

abilities are true except:
a. An allele of APOE is associated with cognitive decline in an
unselected population of elderly men
b. Differences in the number of fragile X sequences in the
normal range are correlated with the differences in ‘g’
c. The genes found to be associated with spatial ability are
likely to be associated with verbal ability
d. Heterozygotes for phenylketonuria show slightly lowered IQ
scores
e. There is no genetic link between severe learning disability
and normal variations in IQ (PG)
74. All of the following are autosomal dominant disorders except:

a. Apert syndrome
b. Hurler syndrome
c. Noonan syndrome
d. Treacher–Collins syndrome
e. Tuberous sclerosis (PG)
161
75. In which of the following conditions does IQ gradually deterior-

ate after the age of 2 years?
a. Apert syndrome
b. Hurler syndrome
c. Noonan syndrome
d. Treacher–Collins syndrome
e. Tuberous sclerosis (PG)
76. In which of the following is aphasia seen?

a. ATR-X syndrome
b. Coffin–Lowry syndrome
c. Fragile X syndrome
d. Rett syndrome
e. X-linked hydrocephalus (PG)
77. In which of the following are abnormalities involving MECP2 on

Xq28 seen?
a. ATR-X syndrome
b. Coffin–Lowry syndrome
c. Fragile X syndrome
d. Rett syndrome
e. X-linked hydrocephalus (PG)
162
PAPER 4
78. Which of the following statements about substance misuse is

true?
a. Family influence predominantly influences maintenance
more than initiation
b. Its heritability is greater for females than for males
c. Sedative use does not have a heritable component
d. The Vietnam Era Twin Registry Study reported that heroin
shows an effect for non-additive genetics
e. The Virginia Twin Registry Study strongly implicated family
environment for cocaine use in men but not in women (PG)
79. The following genes have been implicated in the cocaine response
in mouse models. They have all been correctly matched except
for:
a. 5-HT1B – increased locomotor activity
b. DRDR1 – increased locomotor activity
c. GABAA Ab3 – increased locomotor activity
d. Retinoic acid receptors – blunted response
e. NAChR beta2 – reduced conditioned place preference (PG)
80. All of the following are ligand-gated ion channels except:

a. 5-HT3
b. GABAB
c. GluR6
d. Glycine
e. nAChR (N)
163
81. Which of the following statements about the ionic receptor family
is true?
a. Benzodiazepine prolongs the length of time for which the
chloride channel is open
b. The binding site on nAChR is the β-subunit
c. GABAA subunits do not share homology with nAChR
d. The GluR1 subunit of AMPA receptors stimulates the
growth of dendritic spines on the cortical pyramidal cells
e. NMDA receptors favour calcium permeation (N)
82. Which of the following statements about G proteins is true?

a. Adenylyl cyclase converts cAMP to ATP
b. GTP binds to the β-subunit
c. Gs is the second messenger coupled to the GABAB receptor
d. Gq activates phospholipase C to cleave PIP2
e. Opioid receptors are coupled to the Gq second-messenger
system (N)
83. All of the following statements about DNA are true except:
a. Adenine is always paired with thymine
b. DNA polymerisation occurs in a 5′ to 3′ direction
c. The human genome consists of 3.3 × 10 9 bases
d. Transcription involves the formation of RNA from a DNA
template
e. Around 30% of the bases encode proteins (PG)
164
PAPER 4
84. Which of the following statements about the processing of the

genetic code is true?
a. cDNA is the DNA formed from mRNA by the process of
reverse transcription
b. The promoter region is located near the 3′ end of a gene
c. RNA polymerase I initiates transcription
d. Splicing involves the removal of exons to produce
contiguous mRNA composed only of introns
e. tRNA has a specific three-base codon sequence (PG)
85. Which of the following statements about the genetic code is

true?
a. AGU is the initiation codon for polypeptide synthesis
b. All newly synthesised polypeptides start with methionine
c. An open reading frame is a translation sequence interrupted
by a stop codon
d. UGG is a stop codon
e. 5′UTR, but not 3′UTR, are not translated (PG)
86. The sequence of DNA that is situated at a defined position on a

chromosome is:
a. An allele
b. A gene
c. A locus
d. mRNA
e. tRNA (PG)
165
87. Which of the following statements about mutation is true?

a. Nonsense mutations are also known as silent mutations
b. Non-synonymous substitution results in a change of amino
acids
c. The replacement of a DNA sequence with a different one is
called an insertion
d. RNA editing involves changing of the nucleotides in RNA
before transcription
e. When the allele frequency is less than 0.01, the variants are
referred to as mutations (PG)
88. All of the following statements about the 5-HTTLPR gene and
depression are true except:
a. The 5-HTTLPR gene has been associated with neuroticism
b. Significant interactions take place between the 5-HTTLPR
gene and environmental risk among adolescent women but
not adolescent men
c. The ‘l’ allele increases vulnerability to adverse events
d. The ‘s’ allele reduces the transcriptional efficiency of the
serotonin promoter
e. There is no direct relationship between the 5-HTTLPR
gene and the onset of depression (BJP 2006)
166
PAPER 4
89. Which of the following statements about adherence therapy is

true?
a. Adherence therapy has a significant advantage over non-
specific counselling
b. Adherence therapy is no more effective than health
education for improving quality of life
c. Adherence rates for prescribed antipsychotic medication are
approximately 75%
d. Clinical interventions for reducing non-adherence are
effective in the long term
e. The relapse rate among a non-adherent sample is twice that
of an adherent sample with schizophrenia (BJP 2006)
90. Which of the following statements about inflammatory response

and depression is true?
a. A reduction in CRP occurs following SSRI treatment among
patients whose depression resolves, but not among those
whose depression remains unresolved
b. An increased level of CRP is independent of an increased
IL-6 concentration
c. It involves an increased number of neutrophils but not
monocytes
d. Negative acute-phase proteins are increased
e. SSRIs have an anti-inflammatory effect (BJP 2006)
167
91. Which of the following statements about manic switch following

treatment with antidepressants is true?
a. Paroxetine has shown a higher switch rate than venlafaxine
b. The rate of switching to mania or hypomania is greater with
bupropion than with desipramine
c. Switch rates are higher with the newer antidepressants than
with tricyclic antidepressants
d. There is an association between noradrenergic affinity and
switch to manic or hypomanic episodes
e. There is no significant difference between sertraline,
venlafaxine and bupropion in causing manic switch (BJP
2006)
92. Which of the following statements about treatment with aripipra-

zole is true?
a. It has no effects on the cognitive symptoms of schizophrenia
b. It may cause more insomnia than typical antipsychotics
c. It prolongs QTc intervals more than risperidone does
d. It is more effective than haloperidol in the treatment of the
negative symptoms of schizophrenia
e. Fewer than 5% of patients who receive this treatment report
weight gain (BJP 2006)
168
PAPER 4
93. Which of the following statements about personality disorder and

depression is true?
a. The assessment of personality status early in treatment does
not predict the outcome
b. ECT is associated with poorer outcomes as a treatment for
depression that is comorbid with personality disorder than
are other therapies
c. Interpersonal therapy for women with depression and
personality disorder is associated with better outcomes than
other therapies
d. The odds ratio for poor outcomes in depressive disorder that
is comorbid with personality disorder is 2.18
e. Significant evidence has been found to suggest that
psychotherapy is associated with poor treatment for
depression that is comorbid with personality disorder (BJP
2006)

a. Glial cell densities are reduced when schizophrenia is
present
b. Neuronal density is greater in the left than the right
hemisphere when schizophrenia is present
c. The pyramidal neurons are larger in the left hemisphere
when schizophrenia is present
d. The reversal of asymmetry is most significant in cortical
layer 2 when schizophrenia is present
e. The size and shape of pyramidal neurons do not differ
between the two sides in schizophrenia (BJP 2006)
169
95. Robust evidence has been found for an association between

urbanisation and all of the following disorders except:
a. Anorexia nervosa
b. Bulimia nervosa
c. Depression
d. Psychosis
e. Schizophrenia (BJP 2006)
96. Which of the following statements about expressed emotion is

true?
a. Critical comments among carers are associated with
dependent coping strategies among them
b. High expressed emotion is an artefact of patient morbidity
c. A high level of depression in patients is associated with
higher levels of expressed emotion among their carers
d. Hostile but not over-involved family relationships lead to
relapses of schizophrenia
e. Low carer self-esteem is not related to low self-esteem
among their patients (BJP 2006)
97. All of the following statements about the treatment of bipolar

disorder with eicosapentaenoic acid (EPA) are true except:
a. A 1 g dose of ethyl-EPA is less effective than a 2 g dose
b. EPA may inhibit protein kinase C
c. The incorporation of EPA into cell membranes inhibits the
action of phospholipase A2
d. More significant improvement is seen on the Hamilton
Rating Scale for Depression with adjunctive EPA treatment
than with placebo
e. More significant improvement is seen on adjunctive CGI
with EPA than with a placebo (BJP 2006)
170
PAPER 4
98. The triad of optic ataxia, oculomotor apraxia and simultagnosia

constitutes:
a. Apperceptive visual agnosia
b. Anton’s syndrome
c. Balint’s syndrome
d. Gerstmann’s syndrome
e. Central achromatopsia (KS)
99. Lesions of the dominant parietal lobe cause all of the following
except:
a. Acalculia
b. Apperceptive visual agnosia
c. Agraphia
d. Finger agnosia
e. Right–left disorientation (KS)
100. All of the following are derived from the telencephalon except the:
a. Amygdala
b. Cerebral cortex
c. Hippocampus
d. Striatum
e. Thalamus (KS)
101. All of the following are major anatomical structures involved in

semantic memory except the:
a. Anterior thalamic nuclei
b. Fornix
c. Inferolateral temporal lobes
d. Mammillary body
e. Prefrontal cortex (KS)
171
102. All of the following statements about action potentials are true
except:
a. Activation of K+ channels results in hyperpolarisation
b. The duration of an action potential in a neuron is 0.1–2 msec
c. E Cl− = −81 mV
d. E Na+ = 97 mV
e. The spike threshold of a neuron is approximately −55 mV
(KS)
103. Muscarinic receptors can be measured by using:

a. Fluorine-18
b. 1-hexamethylpropylene amine oxime
c. Iodine-123
d. Nitrogen-13
e. Xenon-133 (KS)
104. Dopaminergic receptors can be measured by using:

a. Fluorine-18
b. l-hexamethylpropylene amine oxime
c. Iodine-123
d. Nitrogen-13
e. Xenon-133 (KS)
105. A metabolic rate can be measured by using:

a. Fluorine-18
b. Oxygen-15
c. Iodine-123
d. Nitrogen-13
e. Xenon-133 (KS)
172
PAPER 4
106. An EEG abnormality seen during caffeine withdrawal is:

b. A diffuse slowing of delta waves
c. Increased beta activity
d. Increased voltage of theta activity
e. Non-specific change (KS)
107. An EEG abnormality seen with inhalant use is:

b. A diffuse slowing of delta waves
c. Increased beta activity
d. Increased voltage of theta activity
e. Non-specific change (KS)

a. Its annual incidence is 0.5 to 1.0 per 10 000
b. The fertility rate for people with schizophrenia is close to
that of the general population
c. The lifetime prevalence of alcoholism within schizophrenia
is 25%
d. Maternal influenza in the third trimester of pregnancy is a
risk factor for schizophrenia
e. Up to 50% of all patients with schizophrenia have significant
physical illnesses (KS)
173
109. All of the following statements about gender differences in schizo-

phrenia are true except:
a. It is equally prevalent in men and women
b. Less than half of all male patients but only one-third of all
female patients are admitted to a psychiatric hospital before
the age of 25 years
c. Men are more likely to experience impairment due to
negative symptoms
d. Its onset is earlier in men than in women
e. Women show a bimodal distribution, with the second peak
occurring in middle age (KS)
110. In which of the following populations is the prevalence of schizo-

phrenia approximately 12%?
a. Children of two parents with schizophrenia
b. Dizygotic twins of parents with schizophrenia
c. The general population
d. Monozygotic twins of parents with schizophrenia
e. Non-twin siblings of patients with schizophrenia (KS)
111. All of the following are excellent candidate genes for schizophre-
nia except:
a. COMT
b. DISC 1
c. GRM 3
d. 5-HTTLPR
e. NRG 1 (KS)
174
PAPER 4

a. Anterior cingulate basal ganglia thalamocortical circuit
dysfunction underlies its negative symptom pathology
b. It involves a decreased number of D2 receptors in the
caudate
c. It involves an increase in the size of the parahippocampal
gyrus
d. The medial dorsal nucleus of the thalamus shows a reduced
number of neurons
e. It involves reduced symmetry of the frontotemporal but not
the occipital lobes (KS)
113. All of the following statements about migration are true except:
a. Excluding African-Caribbean people, in the UK the risk of
bipolar disorder among migrants is reduced to insignificant
levels
b. The mean relative risk of any mood disorder among
migrants does not depend on the relative risk among the
African-Caribbean population
c. The mean risk of developing bipolar disorder among
migrants is 2.47
d. The relative risk of developing schizophrenia in people with
a family history of migration is 2.9
e. White people with bipolar disorder present more often with
hypomanic symptoms than do others (BJP 2007)
175
114. The presence of mood-incongruent psychotic features increases

with evidence for linkage on which of the following chro-
mosomes?
a. 1q21
b. 3q21
c. 9q21
d. 9p21
e. 13q21 (BJP 2007)
115. All of the following are statements about factors involved in

inhibition and timing in cortical circuits except:
a. Interneuron alterations in schizophrenia are likely to have
substantial effects on cognitive processes
b. The IPSPs generated by non-FS neurons reflect the
perisomatic location of the synaptic contacts
c. Some interneurons contain somatostatin
d. Some interneurons express the calcium-binding protein
calretinin
e. Synapses formed by PV neurons are found at or close to
pyramidal cell bodies (BJP 2007)
116. All of the following statements about social problem-solving

therapy for personality disorders are true except:
a. It aims to improve social competence
b. It can be offered as a brief intervention
c. It has been evaluated as a treatment for self-harm
d. Problem solving with psychoeducation reduces anger
expression
e. It produces a significant improvement on measures of service
use (BJP 2007)
176
PAPER 4
117. All of the following statements about bibliotherapy in the treat-

ment of social phobia are true except:
a. The amount of reading is not related to outcomes of
bibliotherapy
b. Bibliotherapy is a successful treatment for anxiety disorders
c. People with anxiety disorders prefer to deal with difficulties
themselves
d. Self-help shows sustained benefits in the treatment of social
phobia
e. Therapist-augmented bibliotherapy is effective for social
phobia (BJP 2007)
118. All of the following statements about sleep in affective disorders

are true except:
a. Abnormal sleep patterns are associated with poor responses
to psychotherapy
b. Abnormal sleep patterns involve decreased phasic REM
sleep
c. Depression is associated with an increase in nocturnal
arousal
d. There is an increased core body temperature
e. There is a reduction in the first period of non-REM sleep
(KS)
177
119. Which of the following statements about brain imaging in affect-

ive disorders is true?
a. It involves a decreased frequency of hyperintensities in the
subcortical region in depression
b. A decrease in glucose metabolism is associated with intrusive
ruminations during depressive episodes
c. It involves more greatly decreased metabolism in the right
than in the left anterior brain in depression
d. It involves increased caudate nuclear volume in depression
e. The right prefrontal cortex is implicated in avoidance
behaviours (KS)
120. The BCR gene is located on chromosome:

a. 18p
b. 21p
c. 22p
d. 21q
e. 22q (KS)
121. Which of the following statements about dysthymic disorders is

true?
a. Dysthymia is common among 1–2% of the general
population
b. Dysthmic disorders involve increased REM latency
c. A major defence mechanism is reaction formation
d. Around 5–10% of those with childhood onset progress to
manic or hypomanic episodes post-puberty
e. Around 10% of those who have dysthmic disorders progress
to bipolar type 1 disorder (KS)
178
PAPER 4
122. An understanding of childhood disappointments as antecedents

to adult depression can be gained through:
a. Behaviour therapy
b. Cognitive therapy
c. Family therapy
d. Interpersonal therapy
e. Insight-oriented psychotherapy (KS)
123. All of the following statements about cyclothymic disorder are

true except:
a. Around 3–5% of all psychiatric outpatients have cyclothymia
b. Around 25% of all patients with this disorder have an onset
between the ages of 15 and 25 years
c. The cyclothymic state is postulated to be the ego’s attempt
to overcome a punitive superego
d. The female:male ratio for this disorder is 3:2
e. Its lifetime prevalence is 1% (KS)
124. Which of the following statements about anxiety disorders is

true?
a. β-Carboline-3-carboxylic acid produces anxiety symptoms
through activity on the GABA receptor
b. CRH activates endocrine programmes for reproduction
c. The NPY-Y2 receptor is implicated in the anxiogenic effects
of neuropeptide Y
d. Panic disorder is provoked by α2-adrenoceptor agonists
e. Stress reduces serotonin turnover in the amygdala (KS)
179
125. What is the term used for the requirement that the patient must
tell everything that comes into their head?
a. Analyst as mirror
b. The fundamental rule
c. The principle of evenly suspended attention
d. The rule of abstinence
e. Transference (KS)
126. The risk of OCD in the general population is:

a. 0.1–0.5%
b. 0.5–1.0%
c. 1.0–1.5%
d. 1.5–3%
e. 3–5% (KS)
127. The most effective instruments in biofeedback include all of the

following except:
a. EEG
b. EMG
c. GSR
d. Thermistor
e. The Visual Analogue Scale (KS)
128. What is the term used for having patients direct their attention
to specific bodily areas and hear themselves think certain phrases
that reflect a relaxed state?
a. Adaptation of progressive muscular relaxation
b. Applied relaxation
c. Applied tension
d. Autogenic therapy
e. Biofeedback (KS)
180
PAPER 4
129. What is the term used for the step of applied relaxation in which
patients relax just before entering the target situation, and stay in
the situation for 10 to 15 minutes?
a. Application training
b. Cue-controlled relaxation
c. Differential relaxation
d. Progressive relaxation
e. Release-only relaxation (KS)
130. What is the term used for the technique in which patients act out
real-life problems under a therapist’s observation or direction?
a. Assertiveness training
b. Behaviour rehearsal
c. Psychodrama
d. Social skills training
e. Therapeutic graded exposure (KS)
181
5
Paper 5
1. Which of the following statements about the psychological treat-

ment of premenstrual syndrome is true?
a. Cognitive therapy is superior to information-focused
therapy
b. Combining fluoxetine and CBT is more effective than either
treatment alone
c. The National Association for Premenstrual Syndrome is run
by patient-only groups
d. Relaxation training is superior to coping-skills training
e. Support groups have a good level of evidentiary support
(APT 2007)
2. All of the following statements about suicide and antidepressants

are true except:
a. Anxiety disorder is a high-risk factor for suicidal acts for
patients who are taking antidepressants
b. The natural history of the disorder accounts for up to 10%
of the placebo response
c. The risk of suicidal acts for patients taking fluoxetine is 1.9
relative to those taking a placebo
d. The CI for risk of suicidal acts for patients with bulimia who
are taking fluoxetine is 0.3–6.9
e. The risk of suicidal acts for patients taking SSRIs is 1.6
relative to those taking other antidepressants (APT 2006)
183
3. All of the following statements about the cognitive–behavioural

therapy model for OCD are true except:
a. According to this model, intrusive thoughts are universal,
with a content indistinguishable from that of clinical
obsessions
b. Avoidance is not a part of the definition of OCD
c. Excessive attentional bias on monitoring intrusive thoughts
is specific to OCD
d. Rumination covers both the obsession and any
accompanying mental compulsion
e. Thought–action fusion is also known as magical thinking
(APT 2007)
4. Mrs Bentley is being considered for CBT for OCD. All of the
following aspects are related to her treatment except:
a. Combining actual and imagined exposure is superior to
actual exposure alone
b. The degree of family involvement is an area to be covered in
the assessment
c. In response prevention, patients are never forced to stop a
compulsion
d. The Obsessive-Compulsive Inventory is an objectively rated
tool
e. Prolonged exposure and response-prevention sessions with
frequent homework will result in symptom reduction (APT
2007)
184
PAPER 5
5. All of the following statements about the practice of psychological

therapies for OCD are true except:
a. Among those who are adherent to therapy, approximately
75% show improvement
b. CBT is superior to exposure and response prevention
c. Challenging a patient’s appraisal of intrusive thoughts is
associated with less success than challenging their content
d. Hazardous CBT involves the therapist becoming engaged in
subtle requests for reassurance
e. Around 25% of all patients refuse or drop out from exposure
and response prevention (APT 2007)
6. Mrs Schmidt is being considered for CBT for OCD. The psy-
chologist in your team wants to know from your assessment the
factors for her prognosis. The poor prognostic factors include all
of the following except:
a. Comorbid schizoid personality
b. Expressed hostility from family members
c. Hoarding
d. Overvalued ideation
e. Severe avoidance (APT 2007)
7. All of the following statements about CBT for paranoia are true
except:
a. Clinicians need to be flexible with regard to the length of the
sessions
b. The evidence is strongest for negative symptoms such as
apathy
c. It is an exploratory approach
d. It reduces recovery time for acute psychosis
e. Self-help includes testing out suspicious thoughts (APT
2006)
185
8. Which of the following is an ineffective remedy in the treatment

of anxiety?
a. Crataegus oxyacantha
b. Melissa officinalis
c. Passiflora incarnate
d. Piper methysticum
e. Valeriana officinalis (APT 2007)
9. The herbal remedy that interacts with phenothiazide to cause

epileptic seizures is:
a. Evening primrose oil
b. Kava
c. Lemon balm
d. St John’s Wort
e. Valerian (APT 2007)
10. The herbal remedy that interacts with levodopa to produce extra-
pyramidal symptoms is:
a. Evening primrose oil
b. Kava
c. Maidenhair tree
d. St John’s Wort
e. Valerian (APT 2007)
11. Which of the following is the symptom with the highest fre-
quency among core manic symptoms in hypomania?
a. Decreased sleep
b. Disinhibition
c. Increased activity
d. Increased plans or ideas
e. Increased talkativeness (APT 2006)
186
PAPER 5
12. All of the following are substances associated with hypomania

except:
a. Amphetamine
b. Alcohol
c. Cannabis
d. Cocaine
e. MDMA (APT 2006)
13. All of the following correlations are true except:

a. Chronic fatigue syndrome – reduced activity in orbitofrontal
cortex
b. Chronic functional pain – down-regulation of anterior
cingulate cortex
c. Eating disorder – activation of the right amygdala
d. Functional angina – activation of anterior cingulate cortex
e. Somatisation – reduced metabolism in bilateral caudate
nuclei (APT 2006)
14. All of the following associations between stroke and mood dis-
a. Antidepressants are effective in treating emotionalism
irrespective of a diagnosis of depression
b. Bromocriptine aggravates apathy following a stroke
c. The standardised mortality rate from suicide following a
stroke increases by threefold
d. There is more evidence of lability of mood in mood
disorders associated with a stroke
e. Tricyclic antidepressants are more effective than SSRIs
(APT 2006)
187
15. Which of the following statements about epilepsy is true?

a. CBT is ineffective in the treatment of non-epileptic seizures
b. Episodic psychosis is unrelated to prescribed drug use
c. The lifetime prevalence of panic disorder is 10%
d. The prevalence of neuropsychiatric disorder in people with
epilepsy is 3%
e. Up to 50% of people who are referred to specialist epilepsy
centres have non-epileptic episodes (APT 2006)
16. Which of the following statements about neuropsychiatric disor-

ders and Parkinson’s disease is true?
a. Anxiety is common in older patients with Parkinson’s disease
b. Depression is common among women patients
c. Delusions are found in 1% of patients with Parkinson’s
disease
d. The prevalence of all psychiatric syndromes among patients
with Parkinson’s disease is 30%
e. Around 5% of patients with Parkinson’s disease with no
dementia have cognitive impairment (APT 2006)
17. All of the following statements about drug treatment and

Parkinson’s disease are correct except:
a. Clozapine at a dose greater than 100 mg/day is the treatment
of choice for psychosis
b. Dopamine agonist treatment is associated with hypomania in
pre-existing bipolar affective disorder
c. Dopaminergic drugs are associated with psychosis
d. SSRIs exacerbate extrapyramidal symptoms
e. Tricyclic antidepressants may improve motor symptoms
(APT 2006)
188
PAPER 5
18. Which of the following statements about smoking cessation treat-

ments is correct?
a. Bupropion induces weight gain
b. The gold standard is pharmacotherapy plus individual or
group support
c. Pre-loading with nicotine replacement therapy reduces
cessation rates
d. Nortriptyline is less effective than SSRIs
e. Varenicline is less effective than bupropion (APT 2008)
19. Which of the following statements about nicotine replacement

therapy (NRT) is correct?
a. Its nasal spray form is not available in the UK
b. The risk ratio of abstinence for any form of NRT relative to
control is 1.58
c. The risk ratio is significantly greater for gum than for
lozenges
d. A single form of replacement is more effective than
combined forms
e. Using NRT for short periods before quitting delays
abstinence (APT 2008)
20. Which of the following statements about pharmacological treat-

ments for smoking is true?
a. Carbamazepine decreases the level of hydroxybupropion
b. Nortriptyline’s mode of action is independent of its
antidepressant effect
c. Rimonabant is a selective μ-receptor agonist
d. The most common side-effect of bupropion is sleepiness
e. Varenicline is a nicotinic receptor antagonist (APT 2008)
189
21. All of the following statements about psychological treatments

for smoking are true except:
a. The evidence of success of brief interventions provided by
nurses is weak
b. Exercise has a positive effect on cigarette cravings
c. Group therapy is more effective than self-help
d. Self-help material has an additive effect when used alongside
NRT
e. Simple advice from a physician has a significant odds ratio of
1.74 (APT 2008)
22. Which of the following statements about smoking and mental

illnesses is true?
a. The daily consumption of 15 or more cigarettes per day is
required for the metabolism of mirtazapine
b. During smoking cessation, doses of clozapine but not of
olanzapine need to be reduced to 75% to prevent toxicity
c. The incremental cost per life-year saved for NRT is £500
d. The use of both NRT and CBT doubles the cessation rates
for patients with depression
e. Although bupropion reduces relapse rates, it is associated
with the worsening of psychotic symptoms (APT 2008)
23. Which of the following statements about alcohol and EEG is

true?
a. Chronic alcoholism shows similar changes to intoxication
b. Intoxication is associated with fast activity in the temporal
area
c. Intoxication is associated with decreased beta waves
d. It takes 6 to 12 months for slow-wave sleep to become
normal following abstinence
e. Withdrawal is associated with slow waves (SBN)
190
PAPER 5
24. Which of the following statements about the NICE guidelines

for OCD is correct?
a. Adults who show mild impairment but are unable to engage
in low, intense CBT should not be considered for high,
intense CBT
b. Adults with moderate functional impairment should be
offered CBT combined with SSRI treatment
c. Adding an SSRI to CBT is contraindicated for children aged
between 8 and 11 years
d. Initial offers of treatment should include exposure and
response prevention
e. Step 5 involves inpatient treatment (www.nice.org.uk)
25. According to the NICE guidelines for OCD, all of the following
statements are true except:
a. Therapists need to advise patients that there is no
convincing evidence for the effectiveness of psychoanalysis
b. Therapists need to consider giving cognitive therapy in
addition to exposure and response prevention, to enhance
long-term symptom reduction
c. Therapists need to consider cognitive therapy for patients
who refuse to engage in exposure and response prevention
d. Therapists need to consider using rewards for motivation
e. Therapists need to discourage patients’ families from using
exposure and response prevention should new symptoms
emerge (www.nice.org.uk)
191
26. According to the NICE guidelines, which of the following state-

ments is true?
a. Therapists need to carry out an ECG before commencing
clomipramine
b. Therapists need to inform patients that it might take up to
12 weeks for an improvement to be noticed
c. Drug treatment may be continued for up to 12 months if it
is effective
d. SSRI treatment for children should be continued for
6 months after remission if a response is observed
e. Therapists should offer clomipramine as a first-line drug
treatment for adults (www.nice.org.uk)
27. All of the following statements about the NICE guidelines for
bipolar affective disorder are true except:
a. If a patient is taking an antidepressant at the onset of manic
symptoms, that antidepressant should not be stopped
abruptly
b. If antipsychotics are ineffective in the treatment of mania,
augmenting them with valproate should be considered
c. The guidelines recommend olanzapine for long-term
treatment
d. Patients should not routinely continue antidepressants as a
long-term treatment
e. Risperidone is licensed for the acute treatment of mania
(www.nice.org.uk)
28. Which of the following does the angular gyrus receive?

a. Auditory input
b. Smell input
c. Somaesthetic input
d. Taste input
e. Visual input (TN)
192
PAPER 5
29. All of the following are parts of the limbic lobe except the:
a. Cingulate gyrus
b. Parahippocampal gyrus
c. Paraolfactory gyrus
d. Precuneus
e. Preterminal gyrus (TN)
30. Afferent fibres from the thalamus are found in the:

a. External granular layer
b. External pyramidal layer
c. Fusiform layer
d. Internal pyramidal layer
e. Molecular layer (TN)
31. Stellate neurons are found in the:

a. External granular layer
b. External pyramidal layer
c. Fusiform layer
d. Internal pyramidal layer
e. Molecular layer (TN)
32. The right and left amygdalas are connected by the:

a. Anterior commissure
b. Genu of corpus callosum
c. Hippocampal commissure
d. Posterior commissure
e. Rostrum of the corpus callosum (TN)
193
33. Mr Bainbridge presents with right hemiparesis, loss of proprio-

ception and loss of his vibratory sense. To which of the following
is this due?
a. The left anterior spinal artery at the medulla
b. The left anterior spinal artery at the spinal level
c. A left posterior spinal-artery occlusion
d. The right anterior spinal artery at the spinal level
e. A right posterior spinal-artery occlusion (TN)
34. Which of the following is predominantly released by the pyrami-

dal cells in the cortex?
a. Acetylcholine
b. Dopamine
c. Glutamate
d. Glycine
e. Serotonin (TN)
35. Which of the following is the function of the red nucleus?

a. Coordination of eye and neck movements
b. Orientation of the head
c. The reflex movements of the axial and limb musculature
d. Sensory modulation
e. The voluntary movements of the upper limb muscles (TN)
36. In which of the following are the pyramidal cells that contribute
to the corticospinal and corticobulbar tracts situated?
a. Layer I
b. Layer II
c. Layer III
d. Layer IV
e. Layer V (TN)
194
PAPER 5
37. All of the following statements about the premotor cortex are true
except:
a. Its key function is in the planning phase of motor activity
b. It involves area 6
c. It is on the lateral aspect of the frontal lobe
d. Once an intended activity begins, its activity continues to
increase
e. Its principal function is the control of axial and proximal
limb musculature (TN)
38. Mr Bainbridge presents with a wrinkled forehead, raised eyebrow,

drooping eyelid, dilated pupil, and downward and abducted eye
on the left half of his face. Which of the following does the lesion
involve?
a. The left abducens nerve
b. The left oculomotor nerve
c. The left trochlear nerve
d. The right facial nerve
e. The right oculomotor nerve (TN)
39. Mr Bainbridge presents with a diplopia that becomes very promi-

nent when descending stairs and while reading. It also tilts his
head to the right side. This could be due to a lesion involving:
a. The left trochlear nerve
b. The left trochlear nucleus
c. The right abducens nerve
d. The right facial nerve
e. The right trochlear nerve (TN)
195
40. Which of the following is mediated by the mesencephalic nucleus

of the trigeminal nerve?
a. The contraction of the muscles of mastication
b. The jaw-jerk reflex
c. Pain and thermal sensation from the mandibular division of
the nerve
d. Taste from the anterior two-thirds of the tongue
e. Touch and pressure sensation from the maxillary division of
the nerve (TN)
41. On eye testing, Mr Bainbridge can gaze to the right with no

apparent difficulty. On attempting to gaze to the left, his right eye
cannot move inward and his left eye moves outward. He is able
to look at a pen placed directly in front of him with no difficulty.
The lesion involves the:
a. Right abducens
b. Right medial longitudinal fasciculus
c. Right ophthalmic nerve
d. Right optic nerve
e. Right trochlear nerve (TN)
42. All of the following statements about the taste pathway are true
except:
a. The anterior two-thirds of the tongue are supplied by the
facial nerve
b. The fibres from the ventroposteromedial nucleus end in the
parietal operculum
c. The nodose ganglion receives the fibres from the posterior
third of the tongue
d. Some fibres from the solitary nucleus pass to the
parabrachial nucleus
e. Taste fibres pass through the posterior limb of the internal
capsule (TN)
196
PAPER 5
43. Which of the following statements about the cytoarchitecture of

the cerebral cortex is true?
a. Aspiny cells release glutamate
b. The cells of Martinotti are bipolar
c. Fusiform cells have their dendritic projections to deep
cortical layers
d. The horizontal cells of Cajal are situated in deep cortical
layers
e. Pyramidal cells release aspartate (TN)
44. All of the following statements about the cell layers of the neo-
cortex are true except:
a. The external granular layer consists mainly of stellate cells
b. The internal pyramidal layer is the source of the majority of
the corticofugal fibres
c. Layer IV is the main efferent station of the cerebral cortex
d. The pyramidal cell axons of the external pyramidal layer are
the principal source of the corticocortical fibres
e. The most numerous cells in the plexiform layer are the
horizontal cells of Cajal (TN)
45. The arcuate fasciculus is part of the:

a. Inferior longitudinal fibres
b. Inferior occipitofrontal fasciculus
c. Short-association fibres
d. Superior occipitofrontal fasciculus
e. Superior longitudinal fasciculus (TN)
197
46. All of the following statements about the internal capsule are true
except:
a. Its anterior limb includes corticothalamic radiations
b. Its genu transmits corticobulbar fibres
c. It has sub- and retrolenticular limbs
d. Its posterior limb is between the head of the caudate nucleus
and the lentiform nucleus
e. Its retrolenticular limb carries visual information (TN)
47. All of the following statements about the motor cortex are true
except:
a. Part of the precentral gyrus controlling the movements of
the tongue is located at its inferior aspect
b. The premotor cortex receives fibres from the cerebellum
through the ventral lateral nucleus of the thalamus
c. Its primary motor area corresponds to Brodmann’s area 4
d. Its secondary motor cortex is localised exclusively to the
frontal lobe
e. Its supplementary motor area receives input from the basal
ganglia (TN)
48. Which of the following equations regarding the composition of

intracellular fluid is accurate?
a. Na+ = 152 mmol/L
b. Cl− = 117 mmol/L
c. HCO3− = 27 mmol/L
d. Proteins = 74 mmol/L
e. Ca2+ = 5 mmol/L (SBN)
198
PAPER 5
49. All of the following statements about cell membranes are true
except:
a. They behave as if there were pores
b. They are permeable to large molecules
c. They are permeable to lipophilic substances
d. They are permeable to water
e. They are selectively permeable to ions (SBN)
50. Which of the following statements about action potentials is

true?
a. At equilibrium, the electrical force that prevents an efflux of
potassium ions is opposed by the concentration gradient that
promotes efflux
b. There are two different types of calcium channels
c. ECl = –95 mV
d. Their refractory period is due to the voltage-dependent
inactivation of the K+ channels
e. A sodium pump contributes –127 mV to their resting
membrane potential (SBN)
51. The fibres with the fastest conduction velocity are the:
a. Aα fibres
b. Aβ fibres
c. Aγ fibres
d. Aδ fibres
e. C fibres (SBN)
199
52. Which of the following statements about higher-order somato-

sensory processing is true?
a. Its large peripheral innervations have a small cortical
representation
b. Its lateral inhibition involves GABA-mediated inhibition by
interneurons on adjacent second-order neurons
c. Its lateral inhibition is a mechanism for limiting the spread
of excitation between couples inputs
d. Its lateral inhibition is one form of feedback inhibition
e. There are only two different representations of the body’s
surface in the cortex (SBN)
53. All of the following are features of surface dyslexia except:

a. A breakdown of whole-word reading
b. Difficulty in reading irregularly spelt words
c. An inability to read non-words
d. A lesion in the left temporoparietal region
e. Making phonologically possible errors
54. Which of the following is a characteristic feature of peripheral

dysgraphia?
a. Better concrete than abstract spelling
b. A breakdown of the lexical route for spelling
c. Oral spelling remaining intact with defective copying
d. Semantic errors
e. Being unable to spell non-words (CA)
200
PAPER 5
55. All of the following lesions are correctly matched except:

a. Acalculia – left angular gyrus
b. Alexia without agraphia – left medial occipital lobe
c. Dyspraxic dysgraphia – dominant temporal lobe
d. Lexical dysgraphia – left temporoparietal region
e. Neglect dysphasia – right hemisphere lesion (CA)
56. All of the following tests are correctly matched except:

a. The ability to point to numbers test – dyscalculia
b. The Cambridge Semantic Battery – visual agnosias
c. The meaningful and meaningless gesture test – sensory
neglect
d. The single-letter identification test – dyslexia
e. The spontaneous writing of sentences test – dysgraphia (CA)
57. Mr Bainbridge presents with a breakdown of fine motor coordi-

nation. He has difficulty copying meaningless hand gestures, but
can copy meaningful ones. This is:
a. Conceptual apraxia
b. Ideational apraxia
c. Ideomotor apraxia
d. Limb kinetic apraxia
e. Oral apraxia (CA)
201
58. Which of the following statements about spasmodic torticollis is

true?
a. Its annual incidence is 1 in 1 000 000
b. Anticholinergic treatment is effective in more than 50% of
patients with this condition
c. Botulinum toxin is a rare cause of spasmodic torticollis
d. It is the most common focal dystonia
e. Remission occurs in 40% of patients with this condition
(SBN)
59. Which of the following statements about neuroleptic-induced

movement disorders is true?
a. α but not β adrenoceptor antagonists are useful in the
treatment of akathisia
b. Dopamine agonists worsen the symptoms of neuroleptic
malignant syndrome
c. The incidence of acute dystonia can be as high as 10% for
high-potency neuroleptics
d. Fewer than 50% of those affected with tardive dyskinesia
have symptoms restricted to their face
e. Tremors are the first feature to develop in drug-induced
parkinsonism (SBN)
60. Mr Bainbridge presents with daytime somnolence associated with

hypoxia and recurrent waking during the night. The diagnosis is:
a. Alzheimer’s dementia
b. Cataplexy
c. Kleine–Levin syndrome
d. Narcolepsy
e. Pickwickian syndrome (SBN)
202
PAPER 5
61. Mr Bainbridge presents with narcolepsy, sleep paralysis and hyp-

nogogic hallucinations. This is:
a. Ganser syndrome
b. Gelineau syndrome
c. Kleine–Levin syndrome
d. Kluver–Bucy syndrome
e. None of the above (SBN)
62. All of the following are disorders of neural-tube defects except:

a. Chiari malformation
b. Encephalocele
c. Holoprosencephaly
d. Meningocele
e. Spina bifida (SBN)
63. Which of the following conditions results from a persistent

infection by the measles virus with inclusions in neurons and
oligodendrocytes?
a. Binswanger’s disease
b. Lacunar disease
c. Subacute sclerosing panencephalitis
d. Perivenous encephalomyelitis
e. Progressive multifocal leukoencephalopathy (SBN)
203
64. All of the following statements about neurosyphilis are true

except:
a. There is dorsal column involvement that leads to loss of
proprioception
b. Optic atrophy may occur
c. The pupils are small
d. The pupils respond to light but not accommodation
e. Its vascular forms may be associated with raised intracranial
pressure (SBN)
65. All of the following statements about neurofibrillary tangles are

true except:
a. They are absent in progressive supranuclear palsy
b. They can be found in the locus coeruleus
c. They consist of intracellular paired helical filaments
d. They are formed by abnormal phosphorylation of the tau
protein
e. They are present in post-encephalitic parkinsonism (SBN)
66. Swollen cortical pyramidal cells are seen in:

d. Parkinson’s disease
e. Pick’s disease (SBN)
204
PAPER 5
67. In which of the following is the ‘fried-egg’ appearance seen?

a. Anaplastic astrocytomas
b. Astrocytomas
c. Ependymomas
d. Glioblastoma multiforme
e. Oligodendrogliomas (SBN)
68. The expression of steroid receptors in tumours can be studied

using:
a. Indomethacin
b. Reboxetine
c. Riluzole
d. Tamoxifen
e. Viloxazine (SBN)
69. Which of the following is the enzyme that inactivates circulating

cortisol in tissues that express mineralocorticoid receptors?
a. 9-hydroxysteroid dehydrogenase
b. 9-cortisol cyclase
c. 11-hydroxysteroid dehydrogenase
d. 11-cortisol cyclase
e. 11-hydroxysteroid decarboxylase (SBN)
70. All of the following are associated with insulin resistance except:
a. Acanthosis nigricans
b. Hypertriglyceridaemia
c. Lipodystrophy
d. Polycystic ovaries
e. Testicular feminisation (SBN)
205
71. All of the following statements about insulin-like growth factor

(IGF) binding proteins are true except:
a. IGF-1 has a 60% homology with proinsulin
b. IGF-1 mediates the functions of growth hormone
c. IGF binding protein 1 (IGFBP-1) binds to both IGF-1 and
IGF-2
d. IGFBP-1 shows diurnal variation
e. IGFBP-1 shows a gradual decline from childhood to puberty
(SBN)
72. Which of the following controls the posterior pituitary?

a. The ventroposterolateral nucleus
b. The magnocellular paraventricular nucleus
c. The preoptic nucleus
d. The suprachiasmatic nucleus
e. All of the above (SBN)
73. All of the following statements about fragile X syndrome are true
except:
a. It is associated with a loss of expression of the FMR2 gene
b. It is associated with attentional difficulties and hyperactivity
c. It is the single commonest known inherited cause of mental
retardation
d. Its mutation involves CGG repeats within the first exon of
the FMR1 gene
e. The rate of fragile X syndrome is higher among children
with autism than among those with a learning disability (PG)
206
PAPER 5
74. As which of the following does the microdeletion of chromosome

7q11 present?
a. Angelman syndrome
b. Di George syndrome
c. Smith–Magenis syndrome
d. Turner’s syndrome
e. Williams syndrome (PG)
75. Which of the syndromes listed below is characterised by a

prevalence of 1 to 2 per 2000, males affected by it being charac-
teristically tall and having lower IQs than the general population,
and an association with minor criminality?
a. Klinefelter’s syndrome
b. Prader–Willi syndrome
e. XYY syndrome (PG)
76. Bainbridge Junior presents with a mild learning difficulty, a cleft

palate, hypocalcaemia, and speech and swallowing difficulties.
This is a presentation of:
207
77. Bainbridge Junior presents with onychotillomania, polyembo-

lokoilamania and self-hugging. This is a presentation of:
78. Which of the following statements about excitatory amino acids

is true?
a. Around 20% of all synapses use glutamate as a transmitter
b. Glutaminase converts glutamate to glutamine
c. The hippocampal pyramidal cells use glutamate as a
transmitter
d. Glutamate is converted to glutamine in neurons
e. In rough endoplasmic reticulum, glutamate is formed from
glutamine (N)
79. All of the following statements about inhibitory amino acids are
true except:
a. Cerebellar Purkinje cells use GABA as a neurotransmitter
b. GABA is synthesised from glutamate by glutamic acid
decarboxylase
c. The glycine receptor is activated by strychnine
d. The Renshaw cells of the spinal cord use glycine as a
neurotransmitter
e. Vigabatrin inhibits the catabolism of GABA to succinic
semialdehyde (N)
208
PAPER 5
80. All of the following statements about dopamine are true except:
a. Around 80% of all dopaminergic neurons are found in the
substantia nigra
b. Aldehyde dehydrogenase metabolises dopamine to
homovanillic acid
c. The amacrine cells of the retina use dopamine as a
neurotransmitter
d. Dopaminergic neurons are unmyelinated
e. The hydroxylation of tyrosine is the rate-limiting step in the
synthesis of dopamine (N)
81. Which of the following statements about dopamine is true?

a. D1 receptors are autoreceptors
b. The D2 family is coupled to Gs
c. D3 receptors are postsynaptic autoreceptors
d. Striatum expresses D4 receptors
e. The vesicular monoamine transporter is blocked by
reserpine (N)
82. Which of the following statements about noradrenaline is true?

a. Amphetamine increases stores of noradrenaline
b. DOPEG excretion is used as a measure of noradrenaline
turnover
c. The noradrenaline transporter is a non-saturable Na+/Cl−-
dependent transporter
d. The locus coeruleus contributes to the dorsal noradrenergic
bundle
e. Phenylethanolamine N-methyl transferase is the rate-
limiting factor in the synthesis of norepinephrine (N)
209
83. The process that involves two different chromosomes fusing at

or near the centromere is called:
a. Deletion
b. Duplication
c. Inversion
d. Robertsonian translocation
e. Substitution (PG)
84. The mechanism by which the variation in the rate at which a gene
is expressed can be inherited in the absence of a change in the
primary DNA sequence is called:
a. Anticipation
b. Epigenetic inheritance
c. A frame-shift mutation
d. A trinucleotide repeat
e. Uniparental isodisomy (PG)
85. In which of the following is methylation involved?

b. Rett syndrome
86. In which of the following is anticipation seen?

b. Fragile X syndrome
210
PAPER 5
87. In which of the following is uniparental isodisomy involving

maternal chromosome 15 seen?
b. Prader–Willi syndrome
88. Which of the following statements about brain-derived neuro-

trophic factor (BDNF) and bipolar disorder is true?
a. The BDNF gene is associated with the early onset of bipolar
disorder
b. GT(n) polymorphism is not associated with rapid cycling
disorder
c. Mania may be caused by under-activity of the central BDNF
function
d. Val66Met polymorphism is associated with susceptibility to
bipolar disorder
e. Val66Met polymorphism is associated with susceptibility to
rapid cycling (BJP 2006)
89. All of the following statements about borderline personality dis-

order (BPD) are true except:
a. Around 75% of people with BPD show remission within
6 years after presentation
b. Individuals with BPD have a hyperactive attachment system
c. Psychiatrists must take an expert role rather than an
inquisitive stance in treating BPD
d. The recurrence rate of BPD is no more than 10% over
6 years
e. BPD patients’ relative risk of attempted suicide following
treatment with dialectical behaviour therapy is –1.38 (BJP
2006)
211
90. All of the following statements about brain volume in first-episode

schizophrenia are true except:
a. The average volume deficit is less than 3%
b. The left ventricle is more enlarged than the right ventricle
c. No significant long-term change has been observed in the
volumetric deficits seen at diagnosis involving the insula and
the thalamus
d. It involves a reduction in whole brain volume but not in the
volume of the hippocampus
e. Ventricular volume is increased (BJP 2006)
91. Which of the following statements about coronary heart disease

and severe mental illness (SMI) is true?
a. Coronary heart disease is second only to suicide when the
mortality rates from different causes are compared
b. Excess coronary heart disease is completely accounted
for by a combination of medication and socio-economic
circumstances
c. The mortality rate from coronary heart disease has
decreased with the advent of atypical antipsychotics
d. The odds ratio of the association between SMI and HDL-
cholesterol is 4.0
e. There is no significant association between SMI and diabetes
(BJP 2006)
212
PAPER 5
92. All of the following statements about CBT are true except:
a. Adjunctive CBT is only of benefit to people who have had
fewer than 12 episodes of bipolar affective disorder
b. A long-term study of the use of CBT for treating comorbid
schizophrenia and substance misuse found that it had no
effect on the percentage of days of abstinence
c. CBT can reduce interpersonal difficulty among people at
high risk for psychosis
d. CBT is effective for problems associated with amphetamine
use
e. A reduction in compliance with command hallucination
with a reduction in voice activity occurs following CBT for
psychosis (BJP 2006)

common mental illnesses is true?
a. In the UK, household income and geographical localisation
have a significant effect on people’s mental health
b. Quantifying between-place differences using population
density alone is the best way of interpreting the role of
geographical localisation in mental health
c. Socioeconomic factors have a greater impact on the duration
of episodes of mental illness than the time of their onset
d. Suicide rates are higher in the urban areas of England but
not of Wales
e. Those living in rural areas have better mental health than
those living in non-rural areas (BJP 2006)
213
94. All of the following epidemiological observations are true

except:
a. Agoraphobia occurs at 2 per 100 person-years at risk
b. Baseline agoraphobia without spontaneous panic disorder
does not predict the first incidence of panic disorder
c. Cluster B disorders are associated with early institutional
care
d. Other phobias predict the incidence of agoraphobia
e. The prevalence of personality disorder is highest among
men (BJP 2006)
95. Which of the following statements about the psychological

impact of stillbirth is true?
a. The father’s psychological morbidity is not associated with
the presence of other children in the family
b. Stillbirth is a category C event for the development of
PTSD in women
c. Stillbirth is a risk factor for anxiety but not for depression
among women during subsequent pregnancies
d. Stillbirth is associated with prescribed drug use but not with
alcohol use among fathers
e. It involves a significant difference in trait anxiety between
mothers and fathers, both antenatally and at follow-up (BJP
2006)
214
PAPER 5
96. Which of the following statements about changes in grey matter

is true?
a. A dominant unilateral increase in the volume of putamen
takes place in adolescents with Tourette’s syndrome
b. The dorsal striatum is impaired in the cortico–striatal–
thalamic–cortical circuitry implicated in Tourette’s syndrome
c. Grey matter increases in the left hippocampus of adolescents
with Tourette’s syndrome
d. A number of soft neurological signs are associated with a
reduction in grey matter in the prefrontal cortex
e. A number of soft neurological signs are associated with a
reduction in grey matter in the lingual gyrus (BJP 2006)
97. All of the following statements about group therapies are true
except:
a. Group CBT has a significant impact on schizophrenia
relapse rates
b. Group CBT reduces feelings of hopelessness in patients with
schizophrenia
c. Group CBT reduces low self-esteem among patients with
schizophrenia
d. Group IPT has a significant effect on depression, which is
maintained at 6-month follow-up
e. Group psychoeducational interventions offered to women in
primary care reduce depressive symptoms (BJP 2006)
215
98. All of the following statements about a synapse are true except:
a. Changes in the structure of synapses are mediated by growth
factors
b. Conjoint synapses have both electrical and chemical
characteristics
c. Nitric oxide, but not carbon monoxide, acts as a
neurotransmitter in a synapse
d. The propagation of an action potential along an axon is an
all-or-nothing phenomenon
e. The synaptic compartment represents less than 1% of the
brain (KS)
99. Which of the following types of receptor is involved in seizures?

a. α1
b. D1
c. H1
d. M1
e. 5-HT1A (KS)
100. Which of the following is the neurotransmitter in most primary

afferent sensory neurons?
a. Acetylcholine
b. Corticotropin-releasing factor
c. Neuropeptide Y
d. Neurotensin
e. Substance P (KS)
216
PAPER 5
101. All of the following statements about structural neuroimaging

techniques are true except:
a. Areas of the brain with an abnormally high water content
appear brighter on a T2 image
b. Bony structures absorb the largest amount of radiation
during a CT scan
c. CSF is dark on a T1 image
d. FLAIR is useful for detecting sclerosis of the hippocampus
caused by temporal lobe epilepsy
e. MRI images are obtained in the axial and coronal planes but
not in the sagittal plane (KS)
102. Which of the following statements about magnetic resonance

spectroscopy (MRS) is true?
a. Dopamine cannot be detected using MRS
b. Just like MRI, MRS detects hydrogen nuclei only
c. An MRS of hydrogen-1 nuclei is used to detect the pH of
the different regions of the brain
d. An MRS of hydrogen-1 nuclei is used to measure ATP
e. The resolution of MRS is equal to that of PET (KS)
103. EEGs show increased alpha activity with the use of which of the
following?
a. Alcohol
b. Barbiturates
c. Caffeine
d. Opioids
e. Nicotine (KS)
217
104. An EEG pattern of increased alpha activity in the frontal area,

but with overall slow alpha activity, is seen with the use of which
of the following?
a. Alcohol
b. Barbiturates
c. Cocaine
d. Opioids
e. Nicotine (KS)
105. Which of the following is an EEG feature of cerebrovascular

accidents?
a. A diffuse asynchronous high-voltage slowing
b. A diffuse generalised slowing of wake frequencies
c. Focal delta activity
d. Focal delta slowing
e. Triphasic waves (KS)
106. Which of the following is a steroid-like hormone?

a. ACTH
b. β-Endorphin
c. FSH
d. LH
e. Thyroxine (KS)
218
PAPER 5
107. Which of the following is a research area that uses a range of

bioinformatic approaches to analyse the expression and function
of proteins within specific systems, cells or organisms?
a. Epigenetics
b. Linkage analysis
c. Multifactorial analysis
d. Polygenics
e. Proteomics (KS)

a. A blunted prolactin response is seen in association with
positive symptoms
b. The brains of people with schizophrenia show lower levels
of phosphomonoester compared with the general population
c. People with schizophrenia have higher concentrations of
n-acetyl aspartate in the hippocampus compared with the
general population
d. The neuropathology of schizophrenia involves increased
levels of T-cell interleukin-2 production
e. Around 25% of people with schizophrenia present with eye-
movement dysfunction (KS)
109. All of the following factors are associated with a good prognosis
in schizophrenia except:
a. Symptoms of depressive disorder
b. A family history of mood disorders
c. A history of assaultiveness
d. Being married
e. Having positive symptoms (KS)
219
110. Which of the following statements about the comorbidities asso-

ciated with schizophrenia is true?
a. People with schizophrenia tend to have higher rates of
chronic obstructive pulmonary disease than people in the
general population, independent of smoking
b. An inverse relationship exists between rheumatoid arthritis
and schizophrenia
c. A lack of awareness of a movement disorder is associated
with a lack of insight into a primary psychiatric disorder
d. Patients with schizophrenia are at no higher risk of HIV
than the general population
e. All of the above are true (KS)
111. All of the following are risk factors for suicide among inpatients
with common mental illnesses except:
a. Involvement with the police
b. Previous suicidal behaviour
c. The presence of hallucinations
d. Suffering a recent bereavement
e. Engaging in violence against property (BJP 2006)
112. All of the following are risk factors for suicide among patients
discharged from hospital care except:
a. A lack of continuity of care
b. The lack of a social network
c. Suicidal ideation prior to discharge
d. Unemployment
e. An unplanned discharge (BJP 2006)
220
PAPER 5
113. Which of the following statements about schizoaffective disorder

is true?
a. The depressive type may be more common in young adults
b. The lifetime prevalence of schizoaffective disorder is less
than 0.5%
c. Lithium is ineffective in the treatment of schizoaffective
disorder
d. Mood disorder dominance is associated with a poor
prognosis
e. The disorder’s prevalence is significantly lower in married
men than in women (KS)
114. Which of the following statements about delusional disorder is

true?
a. Its annual incidence is less than 1 case per 100 000 patients
b. Its diagnostic criteria include the presence of a non-bizarre
delusion for at least 3 months
c. The mean age of onset is around 40 years
d. More than 25% of its cases are reclassified as schizophrenia
or a mood disorder at follow-up
e. A slight male preponderance exists (KS)
115. All of the following statements about the aetiology of delusional

disorder are true except:
a. According to classic psychodynamic theory, the dynamics
underlying the formation of delusions are independent of
gender
b. Family history is not significantly associated with delusional
disorder
c. The neurological conditions most commonly associated with
delusional disorder involve the basal ganglia
d. Reaction formation is a primary defence mechanism used by
patients with delusional disorder
e. Sensory isolation is associated with delusional disorder (KS)
221
116. Mr Bainbridge presents with a belief that his wife can assume the
guise of strangers. This is called:
a. Capgras syndrome
b. Delusional intermetamorphosis
c. Folie impose
d. Fregoli’s phenomenon
e. Illusion de sosies (KS)
117. All of the following personality disorders involve high suscept-

ibility to developing psychotic symptoms except:
a. Borderline personality disorder
b. Antisocial personality disorder
c. Paranoid personality disorder
d. Schizoid personality disorder
e. Schizotypal personality disorder (KS)
118. All of the following statements about genetic factors in affective

disorder are true except:
a. The monozygotic concordance rate for mood disorders is
70–90%
b. The presence of more severe illnesses in a family conveys a
greater risk than other factors
c. The risk of a child having an affective disorder if one parent
is affected is 10–25%
d. Twin-study findings show that genes account for only 30%
of the aetiology of mood disorders
e. Unipolar disorder is the most common form of disorder in
families of bipolar probands (KS)
222
PAPER 5
119. The CREB1 locus is located on chromosome:

a. 1
b. 2
c. 18
d. 21
e. 22 (KS)
120. Which of the following statements about psychosocial factors in

affective disorders is true?
a. The development of depression is associated with losing a
parent before the age of 14 years
b. The environmental stressor that is most strongly associated
with the prevention of remission is the loss of a partner
c. People who are unemployed are three times more likely to
report symptoms of an episode of major depression than
employed people
d. People with antisocial personality disorder are more
predisposed to depression than people with anankastic
e. People with a histrionic personality trait use projection to
protect themselves from their inner rage (KS)
121. The term used to describe the frustration of the emotional needs
and wishes that patients may have in relation to the analyst is:
a. Analyst as mirror
b. Counter-transference
c. The principle of evenly suspended attention
d. The rule of abstinence
e. Transference (KS)
223
122. In which stage of psychoanalysis does transference emerge?

a. 1
b. 2
c. 3
d. 4
e. 5 (KS)
123. The supportive techniques of psychoanalytic therapy include all

of the following except the:
a. Evocative
b. Relationship-oriented
c. Repressed
d. Suggestive
e. Suppressive (KS)
124. Which of the following is an indication for insight-oriented

psychotherapy?
a. Meaningful object relations
b. Poor frustration tolerance
c. Poor reality testing
d. Significant ego defects of a long-term nature
e. A tenuous ability to form a therapeutic alliance (KS)
125. All of the following statements about brief focal psychotherapy

are true except:
a. Its duration is up to 1 year
b. Its focus is on internal conflict present since childhood
c. Its goal is to clarify the nature of the patient’s defence
d. Its selection criteria include prospective patients having the
ability to think in feeling terms
e. It involves 12 treatment hours (KS)
224
PAPER 5
126. Which of the following involves a cognitive profile that includes

an inflated view of self, experience and the future?
a. Anxiety disorder
b. Conversion disorder
c. Depressive disorder
d. Hypomanic disorder
e. Paranoid personality disorder (KS)
127. Which of the following is the part of cognitive therapy that

involves explaining the cognitive triad, schemas and faulty logic
to the patient?
a. Eliciting automatic thoughts
b. Didactic aspects
c. Identifying maladaptive assumptions
d. Testing automatic thoughts
e. Testing the validity of maladaptive assumptions (KS)
128. In hypnosis, which of the following is the ability to reduce peri-

pheral awareness, resulting in greater focal attention?
a. Absorption
b. Dissociation
c. Response attentiveness
d. Suggestibility
e. Trance development (KS)
225
129. All of the following are non-verbal behavioural components of

social skills training except:
a. Facial expression
b. Eye contact
c. Paralinguistic features
d. Posture
e. Proxemics (KS)
130. Which of the following statements about the phases of interper-

sonal psychotherapy is true?
a. Three sessions are dedicated to the initial phase
b. The initial phase involves the identification of areas and
warning signs of anticipated future difficulty
c. Relating issues about psychiatric symptoms to the
interpersonal problem area is part of the intermediate stage
d. Reviewing significant relationships in the past and present is
a component of the intermediate phase
e. Sessions 10 to 15 constitute the termination phase (KS)
226
Answers
Paper 1
1. d 2. e 3. e 4. a 5. c 6. a 7. e
8. e 9. d 10. b 11. c 12. a 13. a 14. e
15. c 16. e 17. d 18. c 19. a 20. e 21. b
22. b 23. e 24. a 25. c 26. b 27. b 28. e
29. d 30. a 31. e 32. c 33. a 34. e 35. c
36. d 37. d 38. e 39. c 40. e 41. b 42. a
43. d 44. a 45. a 46. c 47. a 48. d 49. a
50. c 51. c 52. a 53. a 54. e 55. c 56. d
57. a 58. e 59. d 60. d 61. a 62. c 63. e
64. b 65. b 66. c 67. a 68. d 69. c 70. e
71. e 72. a 73. b 74. e 75. a 76. c 77. d
78. d 79. c 80. c 81. e 82. e 83. a 84. d
85. c 86. c 87. b 88. e 89. a 90. c 91. d
92. d 93. a 94. e 95. b 96. b 97. a 98. b
99. d 100. c 101. d 102. c 103. c 104. d 105. e
106. e 107. a 108. c 109. a 110. b 111. b 112. a
113. c 114. c 115. d 116. c 117. d 118. c 119. e
120. c 121. b 122. b 123. c 124. c 125. c 126. b
127. d 128. e 129. d 130. d
227
Paper 2
1. c 2. d 3. b 4. e 5. e 6. e 7. b
8. e 9. e 10. a 11. b 12. e 13. e 14. b
15. d 16. b 17. a 18. a 19. b 20. e 21. e
22. c 23. a 24. a 25. c 26. c 27. e 28. d
29. d 30. b 31. b 32. a 33. e 34. a 35. e
36. d 37. b 38. e 39. e 40. c 41. e 42. e
43. e 44. b 45. d 46. b 47. e 48. b 49. a
50. a 51. c 52. c 53. b 54. e 55. d 56. c
57. e 58. b 59. d 60. c 61. e 62. d 63. b
64. d 65. c 66. e 67. a 68. a 69. a 70. a
71. d 72. b 73. d 74. e 75. e 76. b 77. a
78. e 79. c 80. c 81. d 82. c 83. a 84. d
85. b 86. c 87. a 88. e 89. a 90. a 91. e
92. c 93. e 94. a 95. d 96. a 97. b 98. a
99. a 100. b 101. b 102. b 103. e 104. b 105. b
106. e 107. e 108. d 109. e 110. e 111. c 112. b
113. a 114. b 115. b 116. d 117. a 118. c 119. c
120. a 121. b 122. b 123. d 124. a 125. c 126. c
127. e 128. d 129. d 130. c
228
ANSWERS
Paper 3
1. a 2. e 3. c 4. d 5. b 6. c 7. e
8. a 9. e 10. e 11. a 12. d 13. e 14. c
15. a 16. a 17. a 18. b 19. e 20. b 21. d
22. d 23. e 24. d 25. c 26. e 27. b 28. e
29. b 30. b 31. d 32. e 33. a 34. e 35. d
36. a 37. a 38. e 39. d 40. c 41. b 42. a
43. d 44. b 45. c 46. e 47. e 48. d 49. c
50. a 51. b 52. e 53. e 54. b 55. e 56. d
57. c 58. c 59. e 60. e 61. c 62. e 63. b
64. a 65. d 66. d 67. a 68. d 69. a 70. b
71. e 72. c 73. b 74. c 75. d 76. c 77. a
78. e 79. c 80. b 81. d 82. e 83. c 84. a
85. e 86. a 87. d 88. e 89. c 90. c 91. b
92. b 93. d 94. d 95. b 96. d 97. b 98. a
99. e 100. e 101. b 102. d 103. d 104. a 105. e
106. e 107. b 108. e 109. d 110. d 111. d 112. a
113. b 114. a 115. b 116. b 117. c 118. d 119. e
120. b 121. a 122. a 123. d 124. b 125. d 126. a
127. d 128. b 129. c 130. e
229
Paper 4
1. d 2. c 3. a 4. c 5. b 6. c 7. d
8. d 9. c 10. e 11. d 12. b 13. c 14. c
15. c 16. c 17. e 18. a 19. e 20. c 21. b
22. d 23. d 24. c 25. e 26. c 27. e 28. c
29. d 30. e 31. a 32. b 33. c 34. c 35. b
36. c 37. d 38. e 39. c 40. a 41. b 42. c
43. d 44. e 45. a 46. a 47. b 48. e 49. c
50. e 51. e 52. d 53. a 54. d 55. b 56. a
57. a 58. e 59. d 60. d 61. d 62. b 63. c
64. c 65. b 66. e 67. e 68. b 69. e 70. b
71. d 72. e 73. b 74. b 75. b 76. e 77. d
78. d 79. b 80. b 81. e 82. d 83. e 84. a
85. b 86. c 87. b 88. c 89. b 90. e 91. d
92. b 93. d 94. e 95. a 96. c 97. a 98. c
99. b 100. e 101. c 102. d 103. c 104. c 105. b
106. d 107. d 108. b 109. b 110. b 111. d 112. d
113. e 114. e 115. b 116. e 117. d 118. b 119. e
120. e 121. c 122. e 123. b 124. a 125. b 126. d
127. e 128. d 129. a 130. b
230
ANSWERS
Paper 5
1. a 2. b 3. c 4. d 5. c 6. a 7. b
8. a 9. a 10. b 11. c 12. b 13. b 14. b
15. e 16. b 17. a 18. b 19. b 20. b 21. d
22. d 23. a 24. d 25. e 26. e 27. a 28. e
29. d 30. c 31. a 32. a 33. a 34. c 35. e
36. e 37. d 38. b 39. a 40. b 41. b 42. c
43. e 44. c 45. e 46. d 47. d 48. d 49. b
50. a 51. a 52. b 53. b 54. c 55. c 56. c
57. d 58. d 59. c 60. e 61. b 62. c 63. c
64. d 65. a 66. e 67. e 68. d 69. c 70. e
71. e 72. b 73. e 74. e 75. e 76. b 77. c
78. c 79. c 80. b 81. e 82. d 83. d 84. b
85. b 86. b 87. b 88. e 89. b 90. d 91. d
92. e 93. e 94. b 95. a 96. d 97. a 98. c
99. d 100. e 101. e 102. a 103. e 104. c 105. c
106. e 107. e 108. b 109. c 110. b 111. c 112. b
113. e 114. c 115. b 116. d 117. b 118. d 119. b
120. c 121. d 122. b 123. a 124. a 125. e 126. d
127. b 128. a 129. c 130. c
231

New MRCPsych Paper II Mock MCQ Papers

Uploaded by

Copyright:

Available Formats

New MRCPsych Paper II Mock MCQ Papers

Uploaded by

Document Information

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

New MRCPsych Paper II Mock MCQ Papers

Uploaded by

Copyright:

Available Formats

What is the purpose of the document?

What is the purpose of the document?

What topics are covered in the document?

What topics are covered in the document?

New MRCPsych Paper II Mock MCQ Papers

This page intentionally left blank

© 2009 by Vellingiri Badrakalimuthu

No claim to original U.S. Government works

International Standard Book Number-13: 978-1-138-03103-6 (eBook - PDF)

and the CRC Press Web site at

exaggerate the features of folly, to render it more ridiculous, he is then

Hugo de Waal MD, FRCPsych

WHEN IS THE RIGHT TIME TO SIT THE PAPER II EXAM?

HOW SHOULD I PREPARE FOR THE EXAM?

WHAT IS THE SYLLABUS FOR PAPER II?

specialty training was introduced, the syllabus was notably different to

● advanced psychological treatments.

The best way to keep track of this evolution is to visit www.rcpsych.

WILL THERE BE QUESTIONS OUTSIDE THE SYLLABUS?

DO I HAVE TO READ AND REMEMBER EVERYTHING UNDER

applications or theoretical underpinnings is what makes things easier

WHAT SHALL I READ?

WILL THERE BE QUESTIONS THAT I CANNOT ANSWER HOWEVER

And still they gazed, and still the wonder grew.

The Deserted Village

1. With regard to premenstrual syndrome, all of the following state-

2. Which of the following statements about antidepressant discon-

3. Regarding the treatment of mania, the following statements are

4. Which of the following statements about dangerous and severe

5. Regarding the behavioural activation approach for depression, all

6. Which of the following statements is true regarding behavioural

7. All of the following are approaches complementary to behavioural

8. Which of these statements about the epidemiology of paranoia is

9. Which of the following statements about the cognitive behaviour

10. In CBASP, the therapist’s personal involvement in the patient’s

11. Which of the following statements about CBASP is true?

12. Which of the following statements about conversion disorder is

14. Indicators of bipolarity in apparently unipolar depression include

15. Regarding the use of IQ tests in the diagnosis of early schizophre-

16. The therapeutic aims of long-term supportive psychotherapy in

17. Which of the following is the therapeutic technique of long-term

18. Which of the following statements about narcolepsy is true?

19. Which of the following statements about sleep disorders is

20. All of the following statements about paranoid personality dis-

21. With regard to the psychological processes in paranoid person-

22. All of the following are elements of the psychoanalytic theory of

23. All of the following statements about spirituality are true

24. Which of the following statements about steroids is true?

25. Which of the following statements about the characteristics of

26. Which of the following matches is accurate with regard to drugs

28. Which of the following statements about the NICE guidelines

30. Which of the following statements about the epidemiology of

31. Which of the following statements about schizophrenia patients’

32. Which of the following statements about the management of

33. Which of the following cranial nerves leaves the brainstem

35. The descending tract of the trigeminal nerve forms:

36. Which of the following does the trigeminal ganglion occupy?

39. Which of the following statements about the corticobulbar tract

40. Mr Bainbridge presents with an inability to coordinate hand

41. Neostriatum is made of caudate and which of the following?