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    Pathology Tables

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    Sam
    This document contains three tables summarizing: 1. Important molecules involved in leukocyte trafficking and the diseases associated with defects in these molecules. 2. Mediators of inflammation from different cell sources and their actions. 3. Cytokines involved in acute and chronic inflammation and their principal sources and actions.

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    Pathology Tables

    Uploaded by

    Sam
    165 views3 pages
    This document contains three tables summarizing: 1. Important molecules involved in leukocyte trafficking and the diseases associated with defects in these molecules. 2. Mediators of inflammation from different cell sources and their actions. 3. Cytokines involved in acute and chronic inflammation and their principal sources and actions.

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    This document contains three tables summarizing: 1. Important molecules involved in leukocyte trafficking and the diseases associated with defects in these molecules. 2. Mediators of inflammation from different cell sources and their actions. 3. Cytokines involved in acute and chronic inflammation and their principal sources and actions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    165 views3 pages

    Pathology Tables

    Uploaded by

    Sam
    This document contains three tables summarizing: 1. Important molecules involved in leukocyte trafficking and the diseases associated with defects in these molecules. 2. Mediators of inflammation from different cell sources and their actions. 3. Cytokines involved in acute and chronic inflammation and their principal sources and actions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 3

    Some important tables

    Endothelium WBC Chronic


    P & E-selections X Sialyl-lewis Rolling
    GlyCAM-1, CD34 L-selection Rolling
    VCAM-1 VLS-4 Adhesion
    ICAM-1 CD11/CD18 (LFA1,MAC1) Adhesion
    CD31 (PECAM-1) CD31 Transmigration

    Disease Defect
    Leukocyte adhesion deficiency 1 CD18 unit of integrin
    Leukocyte adhesion deficiency 2 Sialyl-lewis X
    Neutrophil-specific granule deficiency Absent specific granules
    Membrane component of NADPH
    Chronic Granulomatous Disease, X-linked
    oxidase
    Chronic Granulomatous Disease, autosomal Cytoplasmic component of NADPH
    recessive oxidase
    Myeloperoxidase (MPO) deficiency Absent MPO-H2O2 system
    Chediak-Higashi disease Organelle trafficking

    Mediator Source Action


    Mast cells, basophils, Vasodilation, increased vascular
    Histamine
    platelets permeability, endothelial activation
    Prostaglandins Mast cells, leukocytes Vasodilation, pain, fever
    Increased vascular permeability,
    Leukotrienes Mast cells, leukocytes chemotaxis, leukocyte adhesion, and
    activation
    Local: endothelial activation
    Macrophages,
    Cytokines (TNF, IL- (expression of adhesion molecules).
    endothelial cells,
    1, IL6) Systemic: fever, metabolic
    mast cells
    abnormalities, hypotension (shock)
    Leukocytes, activated
    Chemokines Chemotaxis, leukocyte activation
    macrophages
    Vasodilation, increased vascular
    Platelet-activating Leukocytes, mast permeability, leukocyte adhesion,
    factor cells chemotaxis, degranulation, oxidative
    burst
    Leukocyte chemotaxis and
    Plasma (produced in activation, direct target killing
    Complement
    liver) (membrane attack complex),
    vasodilation (mast cell stimulation)
    Increased vascular permeability,
    Plasma (produced in
    Kinins smooth muscle contraction,
    liver)
    vasodilation, pain
    Action Eicosanoid
    Prostaglandins PGI2 (prostacyclin), PGE1,
    Vasodilation
    PGE2, PGD2
    Vasoconstriction Thromboxane A2, leukotrienes C4, D4, E4
    Increased vascular permeability Leukotrienes C4, D4, E4
    Chemotaxis, leukocyte adhesion Leukotrienes B4
    Smooth muscle contraction Prostaglandins PGC4, PGD4, PGE4

    Cytokine Principal Sources Principal Actions in Inflammation


    In Acute Inflammation
    Stimulates expression of endothelial
    Macrophages, mast cells, T
    TNF adhesion molecules and secretion of
    lymphocytes
    other cytokines; systemic effects
    Macrophages, endothelial
    IL-1 Similar to TNF; greater role in fever
    cells, some epithelial cells
    IL-6 Macrophages, other cells Systemic effects (acute-phase response)
    Macrophages, endothelial Recruitment of leukocytes to sites of
    Chemokines cells, T lymphocytes, mast inflammation; migration of cells in
    cells, other cell types normal tissues
    Recruitment of neutrophils and
    IL-17 T lymphocytes
    monocytes
    In Chronic Inflammation
    Dendritic cells,
    IL-12 Increased production of IFN-γ
    macrophages
    Activation of macrophages (increased
    IFN-γ T lymphocytes, NK cells
    ability to kill microbes and tumor cells)
    Recruitment of neutrophils and
    IL-17 T lymphocytes
    monocytes
    Reaction of
    Principal Mediators
    Inflammation
    Histamine
    Vasodilation
    Prostaglandins
    Histamine
    Increased vascular C3a and C5a (by liberating vasoactive amines from
    permeability mast cells, other cells)
    Leukotrienes C4, D4, E4
    TNF, IL-1
    Chemotaxis, leukocyte
    Chemokines
    recruitment and
    C3a, C5a
    activation
    Leukotriene B4
    IL-1, TNF
    Fever
    Prostaglandins
    Prostaglandins
    Pain
    Bradykinin
    Lysosomal enzymes of leukocytes
    Tissue damage
    Reactive oxygen species

    Bacterial Mycobacterium tuberculosis


    Mycobacterium Leprae
    Treponema pallidum
    Bartonella henslae
    Parasitic Scistosomiasis
    Fungal Histoplasma capsulatum
    Blastomycosis
    Cryptococcus neoformans
    Coccidioides immitis
    Inorganic metals Silicosis, Byrelliosis
    Foreign body Suture, other prosthesis, keratin
    Unknown Sarcoidosis

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