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    Tammaro2020 Covid 19

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    eva yustiana
    This letter discusses two cases of patients with COVID-19 who developed isolated herpetiform skin lesions on their trunks. The authors observed over 100 COVID-19 patients in Rome and Barcelona and found two patients with these types of lesions. They believe the lesions were caused by members of the Herpesviridae family like HHV-1, HHV-2, or VZV. More studies are needed to understand the relationship between skin manifestations and COVID-19.

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    Tammaro2020 Covid 19

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    eva yustiana
    17 views7 pages
    This letter discusses two cases of patients with COVID-19 who developed isolated herpetiform skin lesions on their trunks. The authors observed over 100 COVID-19 patients in Rome and Barcelona and found two patients with these types of lesions. They believe the lesions were caused by members of the Herpesviridae family like HHV-1, HHV-2, or VZV. More studies are needed to understand the relationship between skin manifestations and COVID-19.

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    tammaro2020 covid 19

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    This letter discusses two cases of patients with COVID-19 who developed isolated herpetiform skin lesions on their trunks. The authors observed over 100 COVID-19 patients in Rome and Barcelona and found two patients with these types of lesions. They believe the lesions were caused by members of the Herpesviridae family like HHV-1, HHV-2, or VZV. More studies are needed to understand the relationship between skin manifestations and COVID-19.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    17 views7 pages

    Tammaro2020 Covid 19

    Uploaded by

    eva yustiana
    This letter discusses two cases of patients with COVID-19 who developed isolated herpetiform skin lesions on their trunks. The authors observed over 100 COVID-19 patients in Rome and Barcelona and found two patients with these types of lesions. They believe the lesions were caused by members of the Herpesviridae family like HHV-1, HHV-2, or VZV. More studies are needed to understand the relationship between skin manifestations and COVID-19.

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    of 7

    Accepted Article

    PROF. ANTONELLA TAMMARO (Orcid ID : 0000-0002-4230-100X)

    Article type : Letter to Editor

    Title: Cutaneous manifestations in COVID-19: the experiences of Barcelona and Rome

    Key words: COVID-19, SARS-CoV-2, skin manifestations, cutaneous, herpetiform lesions, trunk

    Manuscript word count: 430

    Figure count: 2

    Authors: A. Tammaro1, G. A. R. Adebanjo1, F. R. Parisella2, A. Pezzuto3, J. Rello4,5,6

    Institutions:

    1NESMOS Dermatology Department, Sapienza University of Rome, Rome, Italy

    2University of Queensland, Brisbane, Australia

    3 Cardiovascular-Respiratory Science Department, Sant'Andrea Hospital-Sapienza University of


    Rome, Rome, Italy

    4 Centro de Investigación Biomedica en Red de Enfermedades Respirorias (CIBERES), Instituto


    Salud Carlos III, Madrid, Spain

    This article has been accepted for publication and undergone full peer review but has not been
    through the copyediting, typesetting, pagination and proofreading process, which may lead to
    differences between this version and the Version of Record. Please cite this article as doi:
    10.1111/JDV.16530
    This article is protected by copyright. All rights reserved
    5 Clinical Research/Epidemiology in Pneumonia and Sepsis (CRIPS). Vall d’Hebron Institut of
    Accepted Article
    Research (VHIR), Barcelona, Spain

    6Clinical Research, CHU Nîmes, Université Montpellier-Nimes, Nîmes, France

    Corresponding author:

    Antonella Tammaro

    NESMOS Department - Dermatology

    Sant’Andrea Hospital, Via di Grottarossa, 1035-1039

    Sapienza University of Rome, Rome, Italy

    Email: [email protected]

    Phone: +39 0633775907

    Funding sources: none reported.

    Conflict of interest:

    Dr. Tammaro has nothing to disclose.

    Dr. Adebanjo has nothing to disclose.

    Dr. Parisella has nothing to disclose.

    Dr. Pezzuto has nothing to disclose.

    Dr. Rello has nothing to disclose.

    This article is protected by copyright. All rights reserved


    Accepted Article
    Dear Editor,

    In December 2019, a new virus called severe acute respiratory syndrome coronavirus 2 (SARS-
    CoV-2) causing Coronavirus disease 2019 (COVID-19) emerged in Wuhan, Hubei Province,
    China1–3. SARS-CoV-2 is transmitted through respiratory droplets and object infected with
    droplets containing the virus1,2. The diagnosis is made employing quantitative reverse transcriptase
    polymerase chain reaction to identify the viral nucleic acid in respiratory specimens or blood
    samples2. The symptoms that have been associated to COVID-19 are dry cough, fever, runny nose,
    dyspnea, anorexia and even nausea and diarrhea1,2. In severe cases the patients may develop
    coagulation dysfunction, acute respiratory distress syndrome (ARDS), arrhythmia and septic
    shock1,2.
    Since December 2019, the virus has spread in Europe and other regions of the world: Italy and
    Spain have been among the most affected countries4,5.
    As dermatologists we tried to comprehend the cutaneous involvement in COVID-19 as there is not
    much information in this regard in the literature6,7.
    We identified and visited 130 patients affected by COVID-19 in Sant’Andrea Hospital in Rome
    and 2 (1.5%) of them presented with isolated herpetiform lesions on their trunk that had appeared
    during their inpatient stay (Fig.1). Such lesions were characterized by vesicles surrounded by
    erythematous halos and were accompanied by mild pruritus. In one of the patients the vesicles had
    started to form crusts.
    Furthermore, we visited COVID-19 patients in Vall d’Hebron Hospital in Barcelona and found
    one patient who presented with numerous vesicular isolated lesions on her back which appeared 8
    days after she had been diagnosed with COVID-19 (Fig.2).

    This article is protected by copyright. All rights reserved


    The lesions that we found in both hospitals are suggestive and typical of the infections caused by
    Accepted Article
    the members of the Herpesviridae family. We could speculate that they could be caused by either
    Human herpes virus 1 (HHV-1), Human herpes virus 2 (HHV-2) or Varicella Zoster Virus (VZV,
    HHV-3).
    To date, there is only one report that investigates the prevalence and nature of dermatological
    manifestations associated to the disease caused by severe acute respiratory syndrome coronavirus
    2 (SARS-CoV-2)6. 148 COVID-19 patients were visited Lecco Hospital, Lombardy, Italy and 88
    were found eligible for data collection: 20.4% of them were found to have remarkable cutaneous
    manifestations that were mainly localized on the trunk6. The manifestations reported were
    erythematous rash (15.9%), generalized urticaria (3.41%) and chickenpox-like lesions (1.14%)6.
    Unfortunately, no pictures of such lesions could be provided 6.

    The findings of the report from Lecco Hospital are in line with the ones that we found. However,
    more studies should be performed to investigate the nature of the relation between the appearance
    of skin lesions, in particular chickenpox-like manifestations, and COVID-19.

    Acknowledgments: The patients in this manuscript have given written informed consent to
    publication of their case details

    References

    1. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138


    Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
    JAMA. 2020;

    2. Yang P, Wang X. COVID-19: a new challenge for human beings. Cell Mol Immunol. 2020;1–
    3.

    3. Wu F, Zhao S, Yu B, Chen Y-M, Wang W, Song Z-G, et al. A new coronavirus associated
    with human respiratory disease in China. Nature. 2020;579(7798):265–9.

    This article is protected by copyright. All rights reserved


    4. Saglietto A, D’Ascenzo F, Zoccai GB, De Ferrari GM. COVID-19 in Europe: the Italian
    Accepted Article
    lesson. Lancet Lond Engl. 2020;

    5. Novel Coronavirus (2019-nCoV) situation reports [Internet]. [cited 2020 Apr 5]. Available
    from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports

    6. Recalcati S. Cutaneous manifestations in COVID-19: a first perspective. J Eur Acad Dermatol


    Venereol JEADV. 2020;

    7. Zheng Y, Lai W. Dermatology staff participate in fight against Covid-19 in China. J Eur Acad
    Dermatol Venereol JEADV. 2020;

    Legends

    Fig. 1 – Vesicular lesions surrounded by erythema on the trunk of a patient

    Fig. 2 – Vesicular lesions on the back of a patient

    This article is protected by copyright. All rights reserved


    Accepted Article

    jdv_16530_f2.tif

    This article is protected by copyright. All rights reserved

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