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    Gujarat Technological University

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    Jainesh
    This document is an exam for a pharmacology course that contains 7 questions asking students to summarize various pharmacological testing methods and models. It begins by listing the instructions for the exam, including attempting 5 of the 7 questions and making assumptions when necessary. The questions then cover topics like qualitative tests for mydriatic activity, in vitro detection of diuretic activity, definitions of pharmacological terms, models for evaluating antiasthmatic, anti-Parkinson's and local anesthetic agents, induction of dyslipidemia and various animal models, techniques for screening anti-ulcer, antiepileptic and antiarrhythmic drugs, and methods for determining mechanisms of action and differentiating ganglion from adrenergic neuron blockers.

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    Gujarat Technological University

    Uploaded by

    Jainesh
    20 views1 page
    This document is an exam for a pharmacology course that contains 7 questions asking students to summarize various pharmacological testing methods and models. It begins by listing the instructions for the exam, including attempting 5 of the 7 questions and making assumptions when necessary. The questions then cover topics like qualitative tests for mydriatic activity, in vitro detection of diuretic activity, definitions of pharmacological terms, models for evaluating antiasthmatic, anti-Parkinson's and local anesthetic agents, induction of dyslipidemia and various animal models, techniques for screening anti-ulcer, antiepileptic and antiarrhythmic drugs, and methods for determining mechanisms of action and differentiating ganglion from adrenergic neuron blockers.

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    2920103

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    This document is an exam for a pharmacology course that contains 7 questions asking students to summarize various pharmacological testing methods and models. It begins by listing the instructions for the exam, including attempting 5 of the 7 questions and making assumptions when necessary. The questions then cover topics like qualitative tests for mydriatic activity, in vitro detection of diuretic activity, definitions of pharmacological terms, models for evaluating antiasthmatic, anti-Parkinson's and local anesthetic agents, induction of dyslipidemia and various animal models, techniques for screening anti-ulcer, antiepileptic and antiarrhythmic drugs, and methods for determining mechanisms of action and differentiating ganglion from adrenergic neuron blockers.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    20 views1 page

    Gujarat Technological University

    Uploaded by

    Jainesh
    This document is an exam for a pharmacology course that contains 7 questions asking students to summarize various pharmacological testing methods and models. It begins by listing the instructions for the exam, including attempting 5 of the 7 questions and making assumptions when necessary. The questions then cover topics like qualitative tests for mydriatic activity, in vitro detection of diuretic activity, definitions of pharmacological terms, models for evaluating antiasthmatic, anti-Parkinson's and local anesthetic agents, induction of dyslipidemia and various animal models, techniques for screening anti-ulcer, antiepileptic and antiarrhythmic drugs, and methods for determining mechanisms of action and differentiating ganglion from adrenergic neuron blockers.

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    of 1

    Seat No.: ________ Enrolment No.

    ________
    GUJARAT TECHNOLOGICAL UNIVERSITY
    M. Pharm. – SEMESTER – II • EXAMINATION – WINTER 2013
    Subject Code: 2920103 Date: 28-11-2013
    Subject Name: Pharmacometrics and Methods of Biological Evaluation of Drugs
    Time: 10.30 am - 01.30 pm Total Marks: 80
    Instructions:
    1. Attempt any five questions.
    2. Make suitable assumptions wherever necessary.
    3. Figures to the right indicate full marks.
    Q.1 (a) Describe a qualitative test for evaluation of mydriatic activity giving special 06
    emphasis on principles, procedure and evaluation.
    b) Enlist in-vitro methods of detection of diuretic activity and explain any two of 05
    them in detail.
    (c) Explain briefly following terms: 05
    a) Teratogenicity b) Mutagenicity
    c) LD 50 d) ED 50 e) Sub-Acute toxicity study
    Q.2 (a) Discuss the principle involved in evaluation of anti asthmatic agents using 06
    different models.
    (b) Enlist various pyrogen tests and describe official pyrogen test in detail. 05
    (c) Write a note on Alpha-chymotrypsin induced glaucoma model 05

    Q.3 (a) Discuss the principle and use of the following : 06


    i) Plus maze apparatus ii) Analgesiometer
    (b) Give various models for screening of agents as anti-Parkinson’s Disease. 05
    Explain the highly acceptable model.
    (c) Describe the method of evaluation of local anaesthetics through surface 05
    aesthesia.
    Q.4 (a) Describe various methods for induction of dyslipidemia 06
    (b) Write about any one model for screening of drugs useful for IBD. 05
    (c) Write about the evaluation techniques for nootropic drugs 05

    Q.5 (a) Enumerate different models for screening of anti-ulcer agents. Write about the 06
    pylorus ligation model in detail.
    (b) Compare and contrast the maximal electro shock (MES) and chemically 05
    induced convulsion models for antiepileptic activity.
    (c) Discuss chemical and electrical methods of inducing arrhythmias 05

    Q. 6 (a) Write a short note on diabetic animal models. 06


    (b) Write about different techniques for microbiological assays of antibiotics. 05
    (c) Discuss application of potentiation of hexobarbital sleeping time. 05

    Q.7 (a) How will you find out possible mechanisms of action of a drug that is 06
    antihypertensive?
    (b) Describe methods to differentiate ganglion blocker and adrenergic neuron 05
    blockers
    (c) Define Bioassay and give its merits and demerits. Write briefly about 05
    bioassay of Digitalis.
    ***************

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