Review Poison N Toxicology
Review Poison N Toxicology
Review Poison N Toxicology
Classification of poison
a) According to kingdom
1. animal − ex. Characteristic
2. vegetable − ex. Strychnine
3. mineral − ex. Hydrochloric acid
b) According to chemical properties.
1. Inorganic poisons.
a. Volatile and non–volatile − ex. Bromine, chlorine, iodine, sulfuric avid.
b. Mineral acids − ex. Hydrochloric acid
c. Mineral alkalies − ex. Sodium hydroxides
2. Organic poisons
a. volatile − ex. Alcohol, chloroform
b. alkalcids − ex. Strychnine
c. animal poisons − ex. Snake venom
d. bacterial − ex. ptomains
e. organic aid − ex. salisilic acid
f. glucosides − ex. digitalis
c) according to physiological action
1. Corrosive − highly irritant poisons which cause local destruction of tissues and characterized by nausea,
vomiting and great local distress.
Ex. strong acid and alkalies
2. Irritants − produces irritation of inflammation of the mucus membrane and characterized by vomiting,
pain in the abdomen, and purging.
Ex. arsenic, cantharides
3. Narcotics − poison which produce stuper, complete insensibility, or loss of feeling.
Ex. opium, demerd, cocaine
4. Neurotics − one which act chiefly on the nervous system producing delirium, convulsion, and coma, with
disordered circulation and respiration as the outstanding symptoms.
Ex. alcohol, opium, CO, strychnine
5. Tetanics − substance which act directly upon the spinal cord producing such spasmodic and continuos
contraction of muscles as a result of stiffness or immobility of the parts to which they are attached.
6. Depressant or sedatives − agents which retard or depress the physiological action of the organ.
Ex. nicotine, cocaine
7. Asthenics or exhaustives − agents which produce exhaustion marked loss of vital or muscular power.
Ex. hydrocyanic acid
d) According to pharmacological action
1. Substances characterized by local action − Ex. volatile oils, skin irritants
2. Substances characterized by their action after absorption − Ex. alkaloids
3. Heavy metals and metalloids − Ex. P, As, and Hg
e) According to methods of isolation
1. Volatile poison and those isolated by distillation with or without current of system.
Ex. alcohol, phenol, chloroform
2. Non-volatile poisons − those that are isolated by extraction with organic solvents.
Ex. alkaloids, organic acids
3. Metallic poisons − Ex. As, Hg
4. Substances for which special methods of isolation are required.
Ex. acids, alkaloids and salts of alkali metals are extracted with water
1
TYPE OF POISONING
a) From the medical point of view
b) From the legal point of view
ENTRANCE OF POISON
2
POISON MAY ENTER THE BODY THROUGH:
1. mouth and are absorbed into the circulation after passing through the stomach and intestinal wall
2. nose and enter the blood from the upper respiratory passages or lungs
3. eyes
4. rectum, vagina, urethra, bladder and ureter by ection.
5. Hypodermic injection
6. Intravenous injection
ELIMINATION OF POISONS
POISON MAY BE ELIMINATED BY:
1. emesis
2. respiration
3. feces
4. urine
5. milk
6. savila
7. sweat
8. tears
3
Classes of emetics
1. Local emetics
2. General emetics
c) Cathartics − agent which produce intestinal evacuation
d) Demulcents − substances which soo the and protect the part with which they are applied.
e) Precipitants − these are substances which prevent absorption of poisons by precipitating them and rendering
them soluble.
Investigation of fatal cases − in the investigation of fatal poisoning cases, it is not necessary that an investigator
should be an expert on poisons, since he will be assisted in this investigation by a medico legal officer and a
toxicologist but it is important and will be of great help to him to know the following:
1. symptoms of various kinds of poisoning
2. the lethal dose of a poison
3. the length of time that may elapse after the poison has been taken, before death occurs.
4. Where the poison was obtained
5. The chemical formula of the poison
6. Other names of it is known in the market
7. Uses of poison
8. Antidotes for the poison.
EVIDENCE OF POISONING IN THE LIVING BODY
The evidence of poisoning will depend upon whether the poisoning is acute or chronic. In acute poisoning
the symptoms appear suddenly while the individual is in good health. The person is usually affected with a group
of symptoms of a definite characteristics out of consonance with his previous state of health. In chronic poisoning,
the onset of the symptoms is more gradual and insidious due to small quantity of poison which has been
administered on such occasion since the intention of the poisoner is kill his victim slowly in order to avert
suspicion.
EVIDENCE OF POISONING IN THE DEATH
In all cases of poisoning whether homicidal or suicidal, fatal or not, the presence of oison must be proved
and proofs of poisoning in the dead may be obtained fom:
1. post-mortem examination or autopsy − an examination of a death body especially to determine the
cause of death.
2. Evidence from chemical analysis of the organs taken from the body.
POST MORTEM APPEARANCE POISONS INDICATED
1. Lessions of the mouth.
a. blackening and severe corrosion − sulfuric acid
b. brownish-yellowish stain − strong mineral acid, oxalic acid, carboxylic acid lysol
c. corrosion and softening of the tissue of the
mouth and throat. − alkalies
d. Severe corrosion without blackening. − hydrochloric acid
e. Severe corrosion and yellow stain nitric acid
f. Lips swollen, bronchopneumonia if death is
delayed − ammonia
g. Mucous membrane whitened − oxalic acid
h. Blue and blackline on gums − Pb, Bi, Hg, Ag
i. Yellow stains about the lips, soluble in NH 3 − iodine
j. Reddening of mucuous membrane of mouth,
eye and glands. − formalin
− strong acid
2. Lessions of the gastro-intestinal tract. − caustic alkalies
a. corrosion − oxalic acid
b. soapiness − acetic acid
c. dark brown gelatinous mass in the stomach
4
d. stomach grayish white − picric acid, potassium dichromate
e. stomach yellow or reddish yellow
− hydrocyanic acid, cyanides, CO
3. other lessions and changes − potassium, sodium nitrite, CO
a. bright red, spots on skin − opium and some of its derivatives in some cases
b. tissue abnormally red − belladonna, scopolamine
c. odors marked on opening the body − ergot
d. pupils contracted
e. dry gangrene of extremities
Interpretation of toxicological analysis
Post mortem examination confirmed the strong possibility of poisoning but toxicological analysis failed to
show the pressure of the poison. The negative result of the toxicological examination must be interpreted to
explain the discrepancy between the clinical and post mortem findings and that of the toxicological analysis.
a) some poison maybe rapidly altered in the body to a form which is not detectable by the methods of a nalysis
employed.
b) Some poisons with or without previous chemical change maybe rapidly exerted but not in the tissues and may
only be detectable in the urine but not in the body tissues and organs.
c) Sometimes symptoms of poisoning may appear which maybe fatal, following the administration of even small
and ordinarily harmless quantity of a substance classes as a poison.
In every case of poisoning the expert is often confronted with forensic questions which he should explain in order
to help the investigator in assessing the evidence.
5
Comma or death 0.35 − 0.50 1. complete unconsciousness
2. subnormal temperature
3. anesthesia
4. impairment of circulation
5. stetorous breathing
COMMON POISONS
1. Caffeine − found in coffee
2. Salicylic acid − found in ap – ap solution
3. Formalin − embalming fluid
4. Cocaine − found in coca leaf
5. Picrotoxin − fish berries
6. Ethyl alcohol or ethanol − alcohol found in wine; also called grain alcohol
7. Ergot − develops on rye plant
8. Barbiturate − a sleeping pill; a derivatives of malonyl urea
9. Strychnine − alkaloid found in nux vomica
10. Nicotine − found in leaves of tobacco plant
11. Morphine − found in poppy plant (papaver somniferum)
12. Physostigmine − also called aserine
13. Chloral hydrate − used as knock-out drops
14. Carbolic acid or phenol − obtained from coal tar
15. Arsenic − a rat poison
16. Lysol − a disinfectant
17. Methyl alcohol or methanol − causes blindness; solvent for vanish; anti-freeze in automobile; also called wood
alcohol.
6
23. Aspirin − an analgesic; its chemical name is acetosalicylic acid
24. Atropine − obtained from the plant group in cactus
25. Amygdalin − white crystalline substance found in bitter almond
26. Phosphorus − glows in the dark
27. Peyote − same as mescaline; found in cactus
28. Ptomaine − found in dead or decaying matter
29. Isopropyl alcohol − present in rubbing alcohol
30. Cannabinoids − found in marijuana
31. Methamphetamine hydrochloride − commonly called “shabu”; regulated drug
32. Heroin or diacetyl morphine − a derivatives of morphine
33. Acetosalicylic acid − aspirin
34. Potassium cyanide − jeweler’s solution
35. Opium −found in poppy plant
Morphine heroin
Poppy plant − poppy capsule − opium − Codein
Thebaine
Meconic acid
36. Benzene − also called Benzol; a solvent for recin; gums, rubber and fats
37. Nitrobenzene − a pale yellow oily liquid which resembles oil of bitter almond
38. Acetone − a solvent for cellulose acetate and nitrocellulose and has a characteristic fruity odor.
39. Carbon disulfide − a solvent for sulfur and burns giving off CO 2 and SO2
40. Ether − a transparent, colorless mobile liquid which is highly volatile and inflammable.
7
acid, paris green, salt of lead, slat of zinc, tartar emetic, white hellebore, or any drug, chemical or preparation
which according to standard works of medicine or materia medica liable to be destructive to human life in
quantities of four grams less without prescription of a physician, should label the receptables containing them as
in above provided for violet poisons, but shall not be required to resister the same.
Sec. 757 − Receptacles for poisonous drugs
The poisonous drugs specified in the two proceeding sections shall be kept in a cabines to be provided in
every pharmacy carrying such drugs in stock for the reatil trade; and the same shall be kept securely locked when
not in use.
SYMPTOMS OF CHLOROFORM POISONING
Three (3) stages in chloroform poisoning by inhalation
1. Stage of excitement − characterized by a feeling of warmth, first in the face, then the entire body and followed
by a tingling sensation of the skin.
2. Stage of surgical anaesthesia − characterized by a relaxation of the muscles and the patient lies perfectly still
with regular but slow and shallow respiration and is entirely insensible to pain.
3. Stage of paralysis − characterized by a fall blood pressure and the failure of the respiration and the heart. The
skin becomes cyanotic, the pupils are widely dilated, and death due to failure of respiration.
COMMON VOLATILE, NON-VOLATILE AND METALLIC POISONS
Alkaloid − a nitrogeneous organic basic compound with bitter taste containing usually oxygen that occur especially
in seed palnts.
1. Benzene − also called benzol. A solvent for rubber, gums, resins, fats
2. Carbon disulfide − solvent for sulfur, burns with bluish flame giving carbon dioxide and sulfur dioxide.
3. Nitrobenzene − a pale yellow, oily liquid with sweet odor. Resembles oil of bitter almond.
4. Acetone − used as solvent for cellulose acetate and nitrocellulose. Colorless liquid of characteristic fruity odor.
5. Ether − highly volatile and inflammable liquid. Transparent, colorless mobile liquid. Used as general
anaesthesia. Safer than chloroform.
6. Caffeine − found in coffee
7. Salisylic acid − found in ap-ap solution
8. Formalin − an embalming liquid/fluid
9. Cocaine − found in coca leaf
10. Picrotoxin − derived from fish berries (fruit of picrotoxin); locally known as “lagtang”
11. Ethyl alcohol or ethanol − alcohol found in wine; also called grain alcohol
12. Ergot − develops on rye plant. A fungus that grows on kernels of rye and other cereal grain.
13. Barbiturate − a sleeping pill; a derivative of malonyl urea or barbituric acid.
Ex. secobarbital, phenobarbital, amobarbital.
14. Strychnine − an alkaloids found in dried ripe seeds of nux vomica.
15. Nicotine − found in leaves of tobacco plant
16. Morphine − found in poppy plants (papaver somniferum); an alkaloid present in opium by about 9%; a white
crystals.
17. Physostigmine − also called aserine; found in calabar beans
18. Chlorol hydrate − used as “knock-out” drops
19. Carbolic acid or phenol − obtained from coal tar
20. Arsenic − a rat poison; brittle, steel gray
21. Lysol − a disinfectant; a brown liquid from cresol and soap emulsion
22. Methyl alcohol or methanol − causes blindness; a solvent for varnish; an anti-freeze in automobiles; also
called wood alcohol
23. Chloroform − a colorless liquid with a sweet taste and suffocating odor; an anaesthesia.
24. Carbon tetrachloride − a dry cleaning agent; found in “PYRENE” fire extinguisher
25. Formic acid − acid found in ants and spiders
26. Hydrogen cyanide − found in kamoteng kahoy; also called hydrocyanic acid or prussic acid
27. Acetic acid − acid found in venegar. In pure form is called glacial acetic acid.
Other Notes:
Drug − is a substance that has an effect upon the body mind
Drug dependence − is a state of psychological or physical dependence or both which result from chronic, periodic
or continuous use.
Habituation − is the psychological desire to repeat the use of drug intermittently or continuously because of
emotional reasons.
Addiction − physical dependence upon a drug. Its scientific definition includes the development of tolerance with
withdrawal.
R.A. 9162− The Dangerous Drug Act of 1972 as amended. Dangerous drug − refer to either prohibited drug or
regulated drug.
9
Under Sec. 4, Article II − Sale, administration, delivery, distribution and transportation of prohibited drugs
(pushers). The penalty of life imprisonment to death and fine of P20,000 to P30,000.
Under Sec. 8, Article II − Illegal sale, possession/use of prohibited drugs (except marijuana) users. The
penalty of 12 years imprisonment and fine of P2012,000 to P20,000.
Under section 15, Article III − Illegal sale, administration, dispensation, delivery, transportation and
distribution of regulated drugs. The penalty of life imprisonment to death and fine P20,000 to P30,000.
Under Sec. 16, Article II − Possession/use (without prescription) of regulated drugs. The penalty of six
years and I to 2 years imprisonment and fine P6,000 to P12,000 (user).
Under Sec. 27, Article III − Possession or use of any prohibited and drugs including marijuana during
party/social gathering/group of 5 person or more. The penalties are (pot session):
Methamphetamine hydrochloride (SHABU) − a white crystalline powder. Has melting points of 172 to
174OC. has bitter taste, soluble in H 2O; soluble in alcohol, chloroform. Practically insoluble in ether. A 1% aqueous
solution is neutral or slightly acid to litmus paper. It is central hervous system stimulant.
Marijuana.
Marijuana plant − grows from 3 feet tall. Has 4 inches to 20 inches interval of nodes where branches arise. Leaf
rows up to 6 inches long and 1½ inches wide. Above each leaf grows a branch which produces its own leaves and
flowering tops.
Marijuana leaves − has palmate structure. Leaflet has serrated edges. Upper layer has short hair called cystolith
hair swollen at the base with calcium carbonate and it it shiny due to resin. Under surface has long slender hair
without CaCO3.
Marijuana seeds −
1. like coconut without husk
2. has whitish vein or surface
3. avoid in shape
4. greenish yellow to light brown
5. inside contains white substance resembling coconut meat
Prepared by:
10