RISK Factor Alzheimers
RISK Factor Alzheimers
RISK Factor Alzheimers
Risk factors associated with Alzheimer’s disease can be divided into two parts: risk that
you can change and risk that you can’t change or avoided.
Age
Dementia is not a normal part of aging. However, age is the strongest known risk
factor for Alzheimers. The older you become, the higher the risk.
One in 20 Canadians over age 65 has Alzheimer’s disease. After 65, the risk of
developing Alzheimer’s disease doubles approximately every five years, with one in four
Canadians over 85 having Alzheimer’s disease.
Gender
Women have a higher risk of developing Alzheimer’s disease than men. While the
reasons for this are still unclear, some of the potential contributors include women living
longer on average than men and changes in estrogen levels over a woman’s lifetime.
Genetics
We don’t yet fully understand the role of genes in the development of dementia. We do
know that most cases of Alzheimer’s disease are sporadic—they do not run in
families. Only rare instances of Alzheimer’s disease are inherited or familial, accounting
for 2-5% of all cases.
Scientists have found over 20 genes that may increase the risk of developing Alzheimer’s
disease. Three of these genes directly cause Alzheimer’s disease: PS1, PS2, and APP.
If a person has an alteration in any of these genes they will almost certainly develop
familial Alzheimer’s disease, often well before the age of 65. If a parent has any of these
faulty genes, their children have a 50% chance of inheriting the disease.