Scribd Logo
Upload

Welcome to Scribd!

  • 107 views

    Parkinson-Plus Syndrome

    Uploaded by

    Ruth May de Villa
    Parkinson-Plus Syndrome is a group of neurodegenerative diseases that can affect the substantia nigra and produce parkinsonian symptoms along with other neurological signs. Some of the syndromes included are Progressive supranuclear palsy, Cortical-basal ganglionic degeneration, Hemi parkinsonism-hemiatrophy syndrome, Normal Pressure Hydrocephalus, and Multiple System Atrophy which includes striatonigral degeneration, Shy-Drager syndrome, Olivopontocerebellar Atrophy, and parkinsonism-amyotrophy syndrome. Disorders with prominent and often early dementia include Diffuse Lewy body disease and Alzheimer's disease.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd

    Parkinson-Plus Syndrome

    Uploaded by

    Ruth May de Villa
    107 views2 pages
    Parkinson-Plus Syndrome is a group of neurodegenerative diseases that can affect the substantia nigra and produce parkinsonian symptoms along with other neurological signs. Some of the syndromes included are Progressive supranuclear palsy, Cortical-basal ganglionic degeneration, Hemi parkinsonism-hemiatrophy syndrome, Normal Pressure Hydrocephalus, and Multiple System Atrophy which includes striatonigral degeneration, Shy-Drager syndrome, Olivopontocerebellar Atrophy, and parkinsonism-amyotrophy syndrome. Disorders with prominent and often early dementia include Diffuse Lewy body disease and Alzheimer's disease.

    Original Title

    parkinson-plus syndrome

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    DOC, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Parkinson-Plus Syndrome is a group of neurodegenerative diseases that can affect the substantia nigra and produce parkinsonian symptoms along with other neurological signs. Some of the syndromes included are Progressive supranuclear palsy, Cortical-basal ganglionic degeneration, Hemi parkinsonism-hemiatrophy syndrome, Normal Pressure Hydrocephalus, and Multiple System Atrophy which includes striatonigral degeneration, Shy-Drager syndrome, Olivopontocerebellar Atrophy, and parkinsonism-amyotrophy syndrome. Disorders with prominent and often early dementia include Diffuse Lewy body disease and Alzheimer's disease.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    107 views2 pages

    Parkinson-Plus Syndrome

    Uploaded by

    Ruth May de Villa
    Parkinson-Plus Syndrome is a group of neurodegenerative diseases that can affect the substantia nigra and produce parkinsonian symptoms along with other neurological signs. Some of the syndromes included are Progressive supranuclear palsy, Cortical-basal ganglionic degeneration, Hemi parkinsonism-hemiatrophy syndrome, Normal Pressure Hydrocephalus, and Multiple System Atrophy which includes striatonigral degeneration, Shy-Drager syndrome, Olivopontocerebellar Atrophy, and parkinsonism-amyotrophy syndrome. Disorders with prominent and often early dementia include Diffuse Lewy body disease and Alzheimer's disease.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    of 2

    RUTH MAY DE VILLA BSPT - IV

    PARKINSON-PLUS SYNDROME

    1. Parkinson-Plus Syndrome – a group of neurodegenerative diseases can affect


    the substantia nigra and produce parkinsonian symptoms along other
    neurological signs. Some are the ff:

     Progressive supranuclear palsy (PSP)


    o known as the Steele-Richardson-Olszewski syndrome.
    o Olszewski, Steele, and Richardson reviewed autopsies of
    patients who had a syndrome of pseudobulbar palsy, supranuclear
    ocular palsy (chiefly affecting vertical gaze), extrapyramidal
    rigidity, gait ataxia, and dementia. They found a consistent pattern
    of neuronal degeneration and neurofibrillary tangles (NFTs),
    chiefly affecting the pons and midbrain.

     Cortical-basal ganglionic degeneration


    o It is characterized pathologically by enlarged achromatic
    neurons in cortical areas (particularly parietal and frontal lobes)
    along with nigral and striatal neuronal degeneration. The onset is
    insidious and typically unilateral, with marked rigidity dystonia on
    the involved arm. Cortical signs of apraxia, alien limb phenomena,
    cortical sensory loss, cortical reflex myoclonus, and occasionally
    aphasia are also seen. Speech is hesitant, gait is poor, and
    occasionally action tremor is evident.

     Hemi parkinsonism-hemiatrophy syndrome


    o This relatively benign syndrome consists of
    hemiparkinsonism in association with ipsilateral body hemiatrophy
    or contralateral brain hemiatrophy. The parkinsonism usually
    begins in young adults and often remains as hemiparkinsonism,
    sometimes with hemidystonia. It tends to be nonprogressive or
    slowly progressive compared with PD. The disorder is thought to
    result from brain injury early in life, possibly even perinatally. It
    sometimes responds to medications.

     Normal Pressurem Hydrocephalus


    o Features of urinary incontinence and dementia occur
    later. Tremor is rare. The grossly enlarged ventricles lead to the
    correct diagnosis, with the symptoms often improving on removal
    or shunting of CSF. The gait disorder is in striking contrast to the
    lack of parkinsonism in the upper part of the body. The major
    differential diagnoses for lower body parkinsonism include
    vascular parkinsonism and the idiopathic gait disorder of the
    elderly.

     Disorders with cerebellar/autonomic/pyramidal manifestations:


     Also called Multiple System Atrophy (MSA)
     has been applied to a group of four syndromes previously
    considered distinct and separate entities:

    o striatonigral degeneration – pure parkinsonism,


    parkinsonism without tremor.

    o Shy-Drager syndrome – autonomic dysfunction,


    preganglionic sympathetic neurons are lost, but the
    postganglionic sympathetic neurons are intact.
    Orthostatic hypotension is a major disabling symptom

    o Olivopontocerebellar Atrophy (OPCA) – ataxia-, a mixture


    of parkinsonism and cerebellar syndrome

    o parkinsonism-amyotrophy syndrome – amyotrophy -


    progressive wasting of muscle tissues. Muscle pain is
    also a symptom

     Disorders with prominent and often early dementia:

     Diffuse Lewy body disease (DLBD) - a progressive


    neurodegenerative disorder characterized by the presence of
    parkinsonian symptoms and neuropsychiatric disturbances
    commonly accompanied by dementia.

     Alzheimer’s disease - the most common cause of dementia, is


    an acquired cognitive and behavioral impairment of sufficient
    severity that markedly interferes with social and occupational
    functioning.

    You might also like