Amendment 49 IFRA STANDARD

Citronellal

CAS-No.: 106-23-0 Molecular C10H18O

5949-05-3 formula:
The scope of this Standard
includes, but is not limited to Structure:
the CAS number(s) indicated
above; any other CAS
number(s) used to identify this
fragrance ingredient should be
considered in scope as well.

Synonyms: 106-23-0:
2,3-Dihydrocitral
3,7-Dimethyl-6-octenal
3,7-Dimethyloct-6-enal
6-Octenal, 3,7-dimethyl-
Citronellal Extra (Commercial name)
Rhodinal (Commercial name)

5949-05-3:
6-Octenal, 3,7-dimethyl-, (3S)-
I-Citronellal

History: Publication date: 2020 (Amendment 49) Previous Not

Publications: applicable.

Implementation For new submissions*: February 10, 2021

dates: For existing fragrance compounds*: February 10, 2022
*These dates apply to the supply of fragrance mixtures (formulas) only, not to the finished
consumer products in the marketplace.

RECOMMENDATION: RESTRICTION

RESTRICTION LIMITS IN THE FINISHED PRODUCT (%):

Category 1 0.41 % Category 7A 0.077 %

Category 2 0.16 % Category 7B 0.077 %

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Amendment 49 IFRA STANDARD

Citronellal

Category 3 0.026 % Category 8 0.017 %

Category 4 0.49 % Category 9 1.4 %

Category 5A 0.33 % Category 10A 1.4 %

Category 5B 0.051 % Category 10B 2.3 %

Category 5C 0.10 % Category 11A 0.017 %

Category 5D 0.017 % Category 11B 0.017 %

Category 6 0.82 % Category 12 No Restriction

FLAVOR REQUIREMENTS: Due to the possible ingestion of small amounts

of fragrance ingredients from their use in
products in Categories 1 and 6, materials must
not only comply with IFRA Standards but must
also be recognized as safe as a flavoring
ingredient as defined by the IOFI Code of
Practice (www.iofi.org). For more details see
chapter 1 of the Guidance for the use of IFRA
Standards.

CONTRIBUTIONS FROM OTHER SOURCES: SEE ANNEX I

ANNEX I
Natural Complex Substances (NCS) containing Citronellal
Concentration CAS number Name of Essential oil
Botanical name CAS number of NCS
in NCS (%) of ingredient NCS category
Melissa officinalis
1.3 106-23-0 Balm oil 8014-71-9 E2.12
L.
0.2 106-23-0 Citron oil Citrus medica L. 68991-25-3 G2.5
Cymbopogon
Citronella oil,
4.5 106-23-0 nardus (L.) 8000-29-1 E2.12
Ceylon type
Rendle
Citronella oil, Cymbopogon
36 106-23-0 8000-29-1 E2.12
Java type winterianus Jowitt
Citrus hystrix
11.7 106-23-0 Citrus hystrix DC 91771-50-5 G2.5
extract
Clementine Citrus clementina
0.1 106-23-0 93686-22-7 G2.5
oil Hort. Ex Tan
Corymbia
Eucalyptus
75 106-23-0 citriodora (Hook.) 85203-56-1 E2.12
citriodora oil
K.D. Hill & L.A.

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Johnson
Fir balsam Abies balsamea
0.6 106-23-0 8024-15-5 K2.16
oleoresin (L.) Mill.
Pelargonium
0.15 106-23-0 Geranium oil graveolens 8000-46-2 E2.12
l'Hertier ex Aiton
Zingiber officinale
0.4 106-23-0 Ginger oil 8007-08-7 A2.12
Rosc.
Citrus paradisi
0.1 106-23-0 Grapefruit oil 8016-20-4 G2.5
Macf.
Grapefruit Citrus paradisi
0.1 106-23-0 68916-46-1 G2.6
oil, folded Macf.
Grapefruit
Citrus paradisi
3.2 106-23-0 oil, 68916-46-1 G2.29
Macf.
terpeneless
Kumquat oil,
Fortunella (Lour.)
3 106-23-0 Fortunella 938464-05-2 G2.5
Swingle
margarita
Lemon Citrus limon (L.)
0.03 106-23-0 84929-31-7 G2.20
extract Burm. f.
Lemon oil Citrus limon (L.)
1 106-23-0 8008-56-8 G2.6
folded (5X) Burm. f.
Lemon oil Citrus limon (L.)
2 106-23-0 8008-56-8 G2.6
folded (10X) Burm. f.
Lemon oil Citrus limon (L.)
3 106-23-0 68648-39-5 G2.29
terpeneless Burm. f.
Lemon oil, Citrus limon (L.)
0.1 106-23-0 8008-56-8 G2.24
distilled Burm. f.
Lemon oil, Citrus limon (L.)
0.1 106-23-0 8008-56-8 G2.5
expressed Burm. f.
Lemon oil,
Citrus limon (L.)
0.1 106-23-0 furocoumarin 68916-89-2 G2.33
Burm. f.
free
Lemon oil. Citrus limon (L.)
0.1 106-23-0 8008-56-8 G2.10
essence Burm. f.
Cymbopogon
Lemongrass
flexuosus (Nees
0.7 106-23-0 oil, East 8007-02-1 E2.12
ex Steudel) Will.
Indian
Watson
Lemongrass Cymbopogon
0.3 106-23-0 oil, West citratus (DC) 8007-02-1 E2.12
Indian Stapf.
Lime oil, cold
Citrus aurantifolia
pressed,
1.4 106-23-0 (Christman) 68916-83-6 G2.33
furocoumarin
Swingle
free
Citrus aurantifolia
Lime oil,
1.4 106-23-0 (Christman) 8008-26-2 G2.5
expressed
Swingle
Lime oil. Citrus aurantifolia
5 106-23-0 expressed (Christman) 93685-55-3 G2.6
folded (2-5X) Swingle
Litsea
Litsea
1.1 106-23-0 Cubeba(Lour.) 68855-99-2 G2.12
cubeba oil
Pers.
Mandarin oil, Citrus reticulata
3 106-23-0 68917-20-4 G2.29
terpeneless Blanco
Meyer lemon
0.2 106-23-0 Citrus x meyerii 1370641-98-7 G2.5
oil. cold

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Citronellal

pressed
Citrus reticulata
Murcote oil,
0.1 106-23-0 spp. murcote, 93686-22-7 G2.5
expressed
Swingle
Orange peel
Citrus sinensis
2 106-23-0 oil, sweet 68606-94-0 G2.29
(L.) Osbeck
terpeneless
Orange
Citrus sinensis
2 106-23-0 sweet oil 8008-57-9 G2.6
(L.) Osbeck
folded
Persian lime
Citrus latifolia
1.4 106-23-0 oil, 8008-26-2 G2.5
Tanaka
expressed
Citrus aurantium
Petitgrain
0.05 106-23-0 L. spp. Amara 8014-17-3 E2.12
bigarade oil
Link
Petitgrain Citrus limon (L.)
1 106-23-0 8048-51-9 E2.12
lemon oil Burm. f.
Petitgrain Citrus reticulata
0.05 106-23-0 8014-17-3 E2.12
mandarin oil Blanco
Petitgrain
Citrus reticulata
0.1 106-23-0 mandarin oil 84929-38-4 E2.29
Blanco
terpeneless
Rosa x
0.1 106-23-0 Rose oil 8007-01-0 F2.12
damascena Mill.
Tangelo oil, Citrus x tangelo
0.1 106-23-0 72869-73-9 G2.5
expressed Ingram and Moore
Citrus reticulata
0.1 106-23-0 Tangerine oil 8016-85-1 G2.5
blanco
Tangerine oil Citrus reticulata
3 106-23-0 68607-01-2 G2.29
terpeneless blanco
Tangor oil, Citrus reticulata x
0.1 106-23-0 93686-22-7 G2.5
expressed Citrus sinensis

This is a non-exhaustive indicative list of typical natural presence for Citronellal and is intended to be used in the
absence of own analytical data. If analysis has shown that the level of the restricted ingredient in a natural complex
substance is different from what is provided in this Annex I, then the analytically determined level should be used in
place of the indicative level.
It should further be noted that natural complex substances themselves can be restricted by an IFRA Standard.
For a detailed list of natural contributions, please refer to the Annex I of IFRA Standards, publicly available on the IFRA
website (www.ifrafragrance.org).

INTRINSIC PROPERTY DRIVING RISK DERMAL SENSITIZATION AND SYSTEMIC

MANAGEMENT: TOXICITY

RIFM SUMMARIES:

Recommended concentration levels are based on a comprehensive safety assessment,

considering various endpoints. Depending on the outcome of the safety assessment, it might be
one or more endpoint(s) that will drive the derivation of the concentration levels. If more than one
endpoint is of relevance, the recommended concentration levels for each product category is
derived from comparing maximum permitted level per endpoint consideration (dermal

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Citronellal

sensitization and/or systemic toxicity). Such recommended concentration levels correspond to

the lowest level obtained per category.

Additional information is available in the RIFM safety assessment for Citronellal, which can be
downloaded from the RIFM Safety Assessment Sheet Database:
http://fragrancematerialsafetyresource.elsevier.com/.

EXPERT PANEL FOR FRAGRANCE SAFETY RATIONALE / CONCLUSION:

The Expert Panel for Fragrance Safety reviewed all the available data for Citronellal and
recommends the limits for the 12 different product categories, which are the acceptable use
levels of Citronellal in the various product categories.

REFERENCES:

The IFRA Standard on Citronellal is based on at least one of the following publications:

• The RIFM Safety Assessment on Citronellal if available at the RIFM Safety Assessment Sheet
Database: http://fragrancematerialsafetyresource.elsevier.com

• Api A.M., Belsito D., Bruze M., Cadby P., Calow P., Dagli M. L., Dekant W., Dent M., Ellis G.,
Fryer A. D., Fukayama M., Griem P., Hickey C., Kromidas L., Lalko J., Liebler D.C., Miyachi Y.,
Politano V.T., Renskers K., Ritacco G., Salvito D., Schultz T.W., Sipes I. G., Smith B., Vitale D.,
Wilcox D.K. (2015). Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety
evaluation process for fragrance ingredients. Food Chem Toxicol. 2015 Aug;82 Suppl:S1-S19
(http://fragrancematerialsafetyresource.elsevier.com/sites/default/files/Criteria_Document_Final.p
df).

• IDEA project (International Dialogue for the Evaluation of Allergens) Final Report on the QRA2:
Skin Sensitisation Quantitative Risk Assessment for Fragrance Ingredients, September 30, 2016
(http://www.ideaproject.info/uploads/Modules/Documents/qra2-dossier-final--september-
2016.pdf).

• Salvito D.T., Senna R. J., Federle T.W. (2002). A framework for prioritizing fragrance materials
for aquatic risk assessment. Environ Toxicol Chem. 2002;21:1301-1308
(https://www.ncbi.nlm.nih.gov/pubmed/12069318).

Additional information on the application of IFRA Standards is available in the Guidance for the
use of IFRA Standards, publicly available at www.ifrafragrance.org.

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