Non-Invasive

Invasive CPAP type Ventilator

PREPARED BY MSME TECHNOLOGY CENTRE -

KOLKATA

COVID – 19 viruses may cause lung complications like pneumonia and in the most severe
cases it causes ARDS. The pneumonia that is caused by COVID – 19 fills the Air Sacs in the
lungs with fluid, limiting their Oxygen intake ability. In this scenario most patients are provided
invasive type pressure ventilation. Continuous Positive Airway Pressure is the most
with non-invasive
basic level of support that may be provided.
 Non-Invasive CPAP type Ventilator

Non-Invasive CPAP type

Highlights
Ventilator 

PREPARED BY MSME TECHNOLOGY CENTRE - Most patients,

KOLKATA who are provided
with noninvasive
ventilation, are
provided support
Background
In the present scenario the entire world is going
with
through mayhem, since the beginning of this calendar pressure ventilation,
year, caused by an invisible antagonist. A foe to whom we with (CPAP), which is
all are susceptible. COVID-19, the disease caused by the the most basic level
new corona virus, may cause lung complications such of support.
as pneumonia, and in the most severe cases, Acute CPAP may be
Respiratory Distress Syndrome, or ARDS. The pneumonia especially useful in
that is caused by COVID-19 tends to take hold of both patients with
lungs. Air sacs in the lungs fill with fluid, limiting their ability
congestive heart
of oxygen intake and causing shortness of breath, cough
and other symptoms. failure.

In this present scenario, most patients, who are The Non –

provided with noninvasive ventilation, are provided
Invasive CPAP Type
support with pressure ventilation, with Continuous Positive
Airway Pressure (CPAP), which is the most basic level of
Ventilator developed
support. CPAP may be especially useful in patients with by CTTC - Kolkata
congestive heart failure. has a special feature
that is, our product is
The product developed by CTTC - Kolkata has a
special feature that is, our product is totally IOT Based and
totally IOT Based and
also it can be operated through Android Devices as per it can be operated
doctor and patient convenience. and controlled
through Android
Overview Devices as per
Continuous positive airway pressure (CPAP) is a form doctor and patient
of positive airway pressure (PAP) ventilation in which a
convenience.
constant level of pressure above atmospheric pressure is
continuously applied to the upper airway.

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 Non-Invasive CPAP type Ventilator

The application of positive pressure may be intended to prevent upper airway

collapse, or to reduce the work of breathing in conditions such as acute
decompensate heart failure. CPAP improves survival and decreases the need
for steroid treatment for lungs. In resource-limited settings CPAP improves
respiratory rate and survival chances with primary pulmonary disease.
Researchers have found that nurses can initiate and manage care with once or
twice daily physician rounds.[2]

In March 2020 the USFDA suggested that CPAP devices may be used to
support patients affected by Covid-19;[3] however, they recommended
additional filtration as non-invasive ventilation may increase the risk of infectious
transmission.

Operating Principle
Non-invasive ventilation (NIV) is the delivery of Oxygen in atmospheric air
plus pure Oxygen at 37˚C 98% RH mixed together for ventilation support via a
face mask and therefore eliminating the need of an endotracheal airway. NIV
works by creating a positive airway pressure - the pressure outside the lungs
being greater than the pressure inside of the lungs. CPAP is the most basic level
of support and provides constant fixed positive pressure throughout inspiration
and expiration, causing the airways to remain open and reduce the work of
breathing. It also helps to keep the chest and lungs expanded by increasing the
functional residual capacity (the amount of air remaining in the lungs after
expiration) by maintaining PEEP (Pressure 0˜2.0KPa) after a normal (tidal)
expiration.

Technical Parameters
Ventilation Wave
Tidal Volume :650ml
Breath Frequency :12 BPM
I : E Ratio : 1:2
Breathless Time : 0.5 Sec
Inspiration Plateau : 6 m bar
PEEP : 7 m bar
Trigger Sensitivity : Pressure Triggering
Oxygen Concentration : 21%
PSV Pressure : 5 m bar
Monitor Wave and parameters : Monitor Wave p-t, V-t
Tidal volume, Breath Frequency, I:E ratio, PEEP, P peak, MV, Oxygen
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 Non-Invasive CPAP type Ventilator

Concentration, P mean Product Diagram


Alarm Parameters & Alarm Settings
Tidal volume upper limit
Tidal Volume Lower limit
Breath Frequency Upper limit
Breath Frequency Lower limit
Peak pressure upper Limit
Peak pressure lower Limit
PEEP upper limit
PEEP lower limit
Wave Form Diagram
Oxygen concentration upper limit
Oxygen concentration lower limit
MV upper limit
MV lower limit
Apnea alarm and Setting
Schematic Diagram

3-D Base Model of CPAP

Type Ventilator

List of Testing Labs

The Product parameters have been sent for
approval to the following NABL accredited
laboratories:-
TUV Rheinland (India) Pvt. Ltd. Bangalore
Swen Konformity, Vishal Nagar, Pimple Nilakh,
Pune
3-D Final Covered
Tarang Labs Product Qualification and
Compliance Planet, Bangalore Model of CPAP Type
Ventilator
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 Non-Invasive CPAP type Ventilator

Tendering Process Prototype Model

Scope of Work
The institute seeks for selection of MSMEs/Startups
with Udyog Aadhar/ companies for technology transfer
for mass production, sales and marketing of “Non-
Invasive CPAP Type Ventilator”. The technology will be
transferred to the competent firm for the commercial
production, sales and marketing of the developed Non-
Invasive CPAP Type Ventilator and an agreement shall
be signed between MSME TECHNOLOGY CENTRE,
KOLKATA & the competent firm.
The competent firm selected as Transfer Of
Technology partner shall be responsible for:
Production of the CPAP Type Ventilator based on
the documents provided by MSME TECHNOLOGY
CENTRE, KOLKATA.
Marketing, selling and installation of the product.
Provide customer support/warranty after the
products sold.
Have facilities for Assembly and testing of the
system.
Provide production documents to the TOT partner
Facilitate testing of one unit produced by the TOT
partner
MSME TECHNOLOGY CENTRE, KOLKATA will
provide the Controller with circuit.
If testing unit cannot be transported, MSME
TECHNOLOGY CENTRE, KOLKATA can facilitate
the testing with the help online platforms.

Documentation
The ToT Partner is expected to prepare detailed
documents for production in consultation with MSME
TECHNOLOGY CENTRE, KOLKATA, however the final
production documentation is entirely the responsibility
of TOT partner.

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 Non-Invasive CPAP type Ventilator

General Terms and Conditions of EoI

MSME TECHNOLOGY CENTRE, KOLKATA invites “Expression of Interest” (EOI) in
the format given in Annexure-1. The industries will be shortlisted based on the
information furnished in Annexure – I and assessment by the committee.
This invitation of EOI will be open till 20th of July, 2020. Expression of Interest
submitted before the specified end date will be evaluated within
stipulated time.
A competent committee will scrutinize the applications for follow-up
action. The applicants may be called for a presentation regarding their
strengths and business proposal.
The minimum turnover of the organization in last three years and
strengths/capabilities as one of the eligibility criteria for short listing of the
applicants.
Participation in this EOI does not guarantee any association with MSME
TECHNOLOGY CENTRE, KOLKATA unless notified by MSME TECHNOLOGY
CENTRE, KOLKATA in writing.
The technology is offered on a non exclusive basis. One agency may be
shortlisted per state, if they agree to the terms and conditions as specified
in the agreement. The agreement will be sent to the shortlisted agencies.
The shortlisted competent firm will have to enter into an agreement with
MSME TECHNOLOGY CENTRE, KOLKATA after which production can be
started.
There will be a onetime technology transfer fee of Rs. 1, 50,000.00 (INR
Rupee One Lakh & Fifty Thousand Only), which needs to be paid by the
TOT Partner during signing of agreement. There will be royalty charges
which shall be paid by the selected partner to MSME TECHNOLOGY
CENTRE, KOLKATA, based on the production of the units. The Royalty
charges plus applicable taxes will be Rs. 25,000.00 per unit manufactured
to be paid to MSME TECHNOLOGY CENTRE, KOLKATA.
The submission of the EOI shall include all such documents that are
specific herein to prove the authenticity of their offer and any claim made
therein. The burden of proving such claims shall lie with the bidder.
All cost and expenses associated with submission of EOI shall be borne by
the bidder while submitting the EOI and MSME TECHNOLOGY CENTRE,
KOLKATA shall have no liability, in any manner in this regard, or if it decides
to terminate the process of short listing for any reason whatsoever.
MSME TECHNOLOGY CENTRE, KOLKATA reserves the right of rejecting any
offer without assigning reasons.

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 Non
Non-Invasive CPAP type Ventilator

There is neither a business guarantee nor any commitment for funding

support from MSME TECHNOLOGY CENTRE, KOLKATA to the
shortlisted/selected/engaged firm.
Who Can Apply
MSMEs/Startups with Udyog Aadhar/ companies willing to take up
production, manufacturing, marketing, sales and support of Non-Invasive
Non CPAP
Type Ventilator.
Out-Come
Come of the Tendering Process
Ramaesis Realty Pvt Ltd (RRPL). Emerged out as winner of the EoI process.
RRPL,, a privately held company incorporated in the year 2010, With around
20000 sq.ft of production area in 2 workshops in West Bengal at Nodakhali &
Panagarh, RRPL has catered to different State Government projects
projec as well as
Corporate And Individual Clients.