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    Antipyretic Therapy: K.E. Elizabeth

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    Shruthi Ky
    The letter discusses antipyretic therapy and notes that an article on the topic omitted mention of mefenamic acid except in passing. Mefenamic acid is an analgesic, antipyretic, and anti-inflammatory drug used widely by pediatricians to control high fever, often with a single dose followed by paracetamol. The letter also questions the recommendation in the article regarding use of iced versus tepid water for sponging to reduce fever, as some evidence suggests iced water could increase core body temperature. In response, another author clarifies that mefenamic acid has no clear therapeutic advantage over other NSAIDs and can cause side effects, so it is not generally recommended for children or pregnant women

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    Antipyretic Therapy: K.E. Elizabeth

    Uploaded by

    Shruthi Ky
    56 views1 page
    The letter discusses antipyretic therapy and notes that an article on the topic omitted mention of mefenamic acid except in passing. Mefenamic acid is an analgesic, antipyretic, and anti-inflammatory drug used widely by pediatricians to control high fever, often with a single dose followed by paracetamol. The letter also questions the recommendation in the article regarding use of iced versus tepid water for sponging to reduce fever, as some evidence suggests iced water could increase core body temperature. In response, another author clarifies that mefenamic acid has no clear therapeutic advantage over other NSAIDs and can cause side effects, so it is not generally recommended for children or pregnant women

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    The letter discusses antipyretic therapy and notes that an article on the topic omitted mention of mefenamic acid except in passing. Mefenamic acid is an analgesic, antipyretic, and anti-inflammatory drug used widely by pediatricians to control high fever, often with a single dose followed by paracetamol. The letter also questions the recommendation in the article regarding use of iced versus tepid water for sponging to reduce fever, as some evidence suggests iced water could increase core body temperature. In response, another author clarifies that mefenamic acid has no clear therapeutic advantage over other NSAIDs and can cause side effects, so it is not generally recommended for children or pregnant women

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    56 views1 page

    Antipyretic Therapy: K.E. Elizabeth

    Uploaded by

    Shruthi Ky
    The letter discusses antipyretic therapy and notes that an article on the topic omitted mention of mefenamic acid except in passing. Mefenamic acid is an analgesic, antipyretic, and anti-inflammatory drug used widely by pediatricians to control high fever, often with a single dose followed by paracetamol. The letter also questions the recommendation in the article regarding use of iced versus tepid water for sponging to reduce fever, as some evidence suggests iced water could increase core body temperature. In response, another author clarifies that mefenamic acid has no clear therapeutic advantage over other NSAIDs and can cause side effects, so it is not generally recommended for children or pregnant women

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    of 1

    LETTERS TO THE EDITOR

    Antipyretic Therapy mg tablets. The dose is 6-7 mg/kg per dose


    of 20 mg/kg per day in 3 divided doses.
    The article on antipyretic therapy was Regarding physical antipyresis, it is not
    relevant and informative(l). However, the concluded in the article whether to use iced
    role of Mefenamic acid was omitted except water or tepid water for sponging. Some
    for a passing mention along with pediatricians use tepid water for external
    Nimesulide. Mefenamic acid is widely sponging to prevent vasoconstriction and
    seud by practising pediatricinas. It is an give iced water to drink to lower the core
    antipyretic, analgesic and antiprosta- temperature.
    glandin anti-inflammatory drug. It is found K.E. Elizabeth,
    to be highly effective in controlling high fe- Department of Pediatrics,
    ver. Often a single dose is found beneficial Medical College,
    which can be followed by paracetamol af- Trivandrum 695 011.
    ter six to eight hours. It is claimed to be safe
    in liver diseases and pregnancy. The REFERENCES
    contraindications are peptic ulcer and 1. Rajeshwari K. Antipyretic therapy. Indian
    diarrheal diseases. The side effects are gas- Pediatr 1997; 34: 407-413.
    trointestinal upset and occasional hemolyt- 2. Philip J. Nonsteroidal anti-inflammatory
    ic anemia, thrombocytopenia, bronchos- drugs. In: Drug Formulary, 1st edn. Ed.
    pasm and drowsiness(2). It is available as Pillai AM. Thiruvananthapuram IMA
    50 mg syrup and 100 mg, 250 mg and 500 Kerala State Branch, 1992; p 232.

    Reply water is indicated for sponging. Use of iced


    water for sponging though more effective,
    causes patient discomfort and increases
    The article was intended to apprise the core body temperature. Published clinical
    pediatricians about the recommended data demonstrating the use of iced water to
    drugs for antipyresis in children. drink to decrease core temperature are dif-
    Mefenamic acid, a fenamate belongs to the ficult to find.
    family of Non Steroidal Anti Inflammatory
    K. Rajeshwari,
    Drugs (NSAIDs), which are derivatives of
    Department of Pediatrics,
    N phenylanthranilic acid. By inhibiting
    Hidnu Rao Hospital,
    cyclo-oxygenase, they have anti-inflamma-
    Delhi 110 007.
    tory, antipyretic and analgesic properties.
    It has no therapeutic superiority over other REFERENCE
    NSAIDS and causes side effects such as di- 1. Insel PA. Analgesic-antipyretic and anti-
    arrhea in 25% of patients. These drugs are inflammatory agents and drugs em-
    not recommended for use in children and ployed in the treatment of gout. In:
    pregnant women(l). It is primarily indicat- Goodman and Gilman's-the Pharmaco-
    ed for analgesia in adults. logic Basis of Therapeutics, 9th edn.
    Hardman JG, Limbard LE. New York,
    Regarding physical antipyresis, tepid McGraw Hill, 1996; pp 635-636.

    750

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