Scribd Logo
Upload

Welcome to Scribd!

  • 207 views

    Minimum Alveolar Concentration: Ed Is Approximately 1.3 MAC

    Uploaded by

    Ok
    The minimum alveolar concentration (MAC) is the concentration of inhaled anesthetic that prevents movement in 50% of subjects in response to a surgical stimulus. MAC reflects the potency of anesthetics, with a higher MAC indicating lower potency. MAC is inversely related to anesthetic potency and is affected by factors like age, drugs, and medical conditions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Minimum Alveolar Concentration: Ed Is Approximately 1.3 MAC

    Uploaded by

    Ok
    207 views1 page
    The minimum alveolar concentration (MAC) is the concentration of inhaled anesthetic that prevents movement in 50% of subjects in response to a surgical stimulus. MAC reflects the potency of anesthetics, with a higher MAC indicating lower potency. MAC is inversely related to anesthetic potency and is affected by factors like age, drugs, and medical conditions.

    Original Title

    MAC.pdf

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The minimum alveolar concentration (MAC) is the concentration of inhaled anesthetic that prevents movement in 50% of subjects in response to a surgical stimulus. MAC reflects the potency of anesthetics, with a higher MAC indicating lower potency. MAC is inversely related to anesthetic potency and is affected by factors like age, drugs, and medical conditions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    207 views1 page

    Minimum Alveolar Concentration: Ed Is Approximately 1.3 MAC

    Uploaded by

    Ok
    The minimum alveolar concentration (MAC) is the concentration of inhaled anesthetic that prevents movement in 50% of subjects in response to a surgical stimulus. MAC reflects the potency of anesthetics, with a higher MAC indicating lower potency. MAC is inversely related to anesthetic potency and is affected by factors like age, drugs, and medical conditions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 1

    Minimum Alveolar Concentration

    CoreNotes by Core Concepts Anesthesia Review, LLC

    1. The minimum alveolar concentration (MAC) is the alveolar concentration of


    anesthetic that prevents movement in 50% of subjects in response to a surgical
    stimulus.
    2. Effectively, MAC reflects the ED50 of inhaled anesthetics; ED95 is approximately
    1.3 MAC.
    3. Anesthetic potency is inversely related to MAC.
    4. MAC is expressed as a percentage at one atmosphere, but MAC changes with
    changes in atmospheric pressure.
    5. MAC is highest during the 1st year of life and declines thereafter.
    6. MACs are additive as anesthetics are combined, e.g. N2O with desflurane.
    7. Various factors affect MAC including age, genetics, temperature, pregnancy,
    adjuvant drugs and pathophysiologic conditions.
    8. MAC-awake50 is the alveolar concentration that inhibits appropriate response to
    spoken commands in 50% of subjects. The ratio of MAC-awake to MAC is not
    consistent for volatile agents.
    9. MAC-bar50 is the alveolar concentration that inhibits autonomic responses in 50%
    of subjects to a surgical stimulus and is estimated at 1.3 to 1.66 times MAC.

    The minimum alveolar concentration (MAC) is the alveolar concentration of anesthetic


    that prevents movement in 50% of subjects in response to a surgical stimulus and is a
    very important anesthetic concept. MAC is inversely related to potency and thereby
    expresses the relative potency of inhaled anesthetics.
    Agent MAC Vapor Pressure
    @ 1 atm @ 20o C
    N2O 104% 745 psi
    Desflurane 6.6% 669 mmHg
    Isoflurane 1.17% 238 mmHg
    Sevoflurane 1.8% 157 mmHg

    A variety of factors can alter the MAC:


    Factors that Reduce MAC Factors that Increase MAC
    Increase in Age Decrease in Age
    CNS Depressants CNS Stimulants
    Acute Ethanol Ingestion Chronic Ethanol Ingestion
    Hypothermia Hyperthermia
    Pregnancy Hyperthyroidism
    Hyponatremia Hypernatremia
    Hypoxia Levodopa Administration
    Metabolic Acidosis

    Additional Reading:
    Longnecker, DE, Brown, DL, Newman MF and Zapol, WM. Anesthesiology. New York: McGraw Hill, 2012:
    607-608

    You might also like