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Antimicrobial Disk Diffusion Zone Interpretation Guide

Working Paper · January 2011

DOI: 10.13140/RG.2.2.13801.70240

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 Antimicrobial Disk Diffusion Zone Interpretation Guide
Zone Diameter Interpretive Stds (mm)

Antimicrobial Agent Code Disk Potency Resistant Intermediate Susceptible

Amikacin AN-30 30 ug ≤14 15-16 ≥17
Amoxicillin/Clavulanic Acid AMC-30 20/10 ug ≤13 14-17 ≥18
Staphylococci ≤19 * ≥20
Ampicillin AM-10 10 ug ≤13 14-16 ≥17
Staphylococci ≤28 * ≥29
beta-hemolytic streptococci ≤18 19-25 ≥26
Azithromycin AXM-15 15 ug ≤13 14-17 ≥18
Bacitracin B-10 10 u ≤8 9-12 ≥13
Carbenicillin CB-10 100 ug ≤19 20-22 ≥23
Cefaclor CEC-30 30 ug ≤14 15-17 ≥18
Cefamandole MA-30 30 ug ≤14 15-17 ≥18
Cefazolin CZ-30 30 ug ≤14 15-17 ≥18
Cefixime CFM-5 5 ug ≤15 16-18 ≤19
Cefonicid CID-30 30 ug ≤14 15-17 ≥18
Cefoperazone CFP-75 75 ug ≤15 16-20 ≥21
Cefotaxime CTX-30 30 ug ≤14 15-22 ≥23
Cefotan CTT-30 30 ug ≤12 13-15 ≥16
Cefoxitin FOX-30 30 ug ≤14 15-17 ≥18
Cefpodoxime CPD-10 10 ug ≤17 18-20 ≥21
Ceftazidime CAZ-30 30 ug ≤14 15-17 ≥18
Ceftiofur (Naxcel) XNL-30 30 ug ≤17 18-20 ≥21
Ceftizoxime ZOX-30 30 ug ≤10 11-19 ≥20
Ceftriaxone CRO-30 30 ug ≤24 25-26 ≥27
Cefuroxime CXM-30 30 ug ≤14 15-17 ≥18
Cepahlothin CF-30 30 ug ≤14 15-17 ≥18
Cefovecin (Covenia) CEF-30 30 ug ≤20 21-23 ≥24
Chloramphenicol C-30 30 ug ≤12 13-17 ≥18
Ciprofloxacin CIP-5 5 ug ≤15 16-20 ≥21
Clarithromycin CLR-15 15 ug ≤13 14-17 ≥18
Streptococcus ≤16 17-20 ≥21
Clindamycin CC-2 2 ug ≤15 16-18 ≥19
Staphylococci ≤14 15-20 ≥21
Doxycycline D-30 30 ug ≤12 13-15 ≥16
Enrofloxacin ENO-5 5 ug ≤16 17-20 ≥21
Erythromycin E-15 15 ug ≤13 14-22 ≥23
Streptococcus ≤15 16-20 ≥21
Gentamicin GM-10 10 ug ≤12 13-14 ≥15
Impenem IPM-10 10 ug ≤13 14-15 ≥16
Kanamycin K-30 30 ug ≤13 14-17 ≥18
Marbofloxacin (Zeniquin) MAR-5 5 ug ≤14 15-19 ≥20
Mezlocillin MZ-75 75 ug ≤17 18-20 ≥21
P. aeruginosa ≤15 * ≥16
Nafcillin NF-1 1 ug ≤10 11-12 ≥13
Nalidixic Acid NA-30 30 ug ≤13 14-18 ≥19
Neomycin N-30 30 ug ≤12 13-16 ≥17
Nitrofurantoin FM-300 300 ug ≤14 15-16 ≥17
Norfloxacin NOR-10 10 ug ≤12 13-16 ≥17
Novobiocin NB-30 30 ug ≤17 18-21 ≥22
Ofloxacin OFX-5 5 ug ≤12 13-15 ≥16
Orbifloxacin OBX-10 10 ug ≤17 18-22 ≥23
Oxacillin OX-1 1 ug ≤10 11-12 ≥13
S. aureus ≤17 * ≥18
Oxytetracycline T30 30 ug ≤15 16-25 ≥26
Penicillin P-10 10 U ≤19 20-27 ≥28
Staphylococci ≤28 * ≥29
Piperacillin PIP-100 100 ug ≤17 18-20 ≥21
P. aeruginosa ≤17 * ≥18
Pirlimycin HCL PRL-2 2 ug ≤12 * ≥13
Polimyxin PB-300 300 ug ≤8 9-11 ≥12
Rifampin RA-5 5 ug ≤16 17-19 ≥20
Sulfisoxazole G-.25 250 ug ≤12 13-16 ≥17
Tetracycline TE-30 30 ug ≤14 15-18 ≥19
Streptococcus ≤18 19-22 ≥23
Ticarcillin TIC-75 75 ug ≤14 15-19 ≥20
P. aeruginosa ≤14 * ≥15

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 Antimicrobial Disk Diffusion Zone Interpretation Guide
Ticarcillin/Clavulinic Acid (Timentin) TIM-85 75/10 ug ≤14 15-19 ≥20
P. aeruginosa ≤14 * ≥15
Staphylococci ≤22 * ≥23
Tobramycin NN-10 10 ug ≤12 13-14 ≥15
Trimethoprim TMP-5 5 ug ≤10 11-15 ≥16
Trimethoprim/Sulfamethoxazole SXT 1.25/23.7 ug ≤10 11-15 ≥16
Vancomycin VA-30 30 ug ≤9 10-11 ≥12

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